AutismKB 2.0

Annotation Detail for VDAC2


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Basic Information Top
Gene Symbol:VDAC2 ( FLJ23841,POR )
Gene Full Name: voltage-dependent anion channel 2
Band: 10q22.2
Quick LinksEntrez ID:7417; OMIM: 193245; Uniprot ID:VDAC2_HUMAN; ENSEMBL ID: ENSG00000165637; HGNC ID: 12672
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa05016Huntington's disease
hsa05012Parkinson's disease
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of VDAC2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of VDAC2 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of VDAC2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VDAC2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of VDAC2 mRNAincreases expression 20458559
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of VDAC2 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of VDAC2 mRNAdecreases expression 16644059
C099555 CD 437 CD 437 results in decreased expression of VDAC2 mRNAdecreases expression 12958071
D007657 Ketone Bodies Ketone Bodies results in increased expression of VDAC2 mRNAincreases expression 16807920
D010634 Phenobarbital Phenobarbital results in increased expression of VDAC2 mRNAincreases expression 12082028
C017947 sodium arsenite sodium arsenite affects the expression of VDAC2 mRNAaffects expression 19590694
D018038 Sodium Selenite Sodium Selenite results in increased expression of VDAC2 mRNAincreases expression 18175754
C066340 tolcapone tolcapone binds to VDAC2 proteinaffects binding 19783845
D014212 Tretinoin Tretinoin results in decreased expression of VDAC2 mRNAdecreases expression 16604517
D014501 Uranium Uranium affects the expression of VDAC2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of VDAC2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.466195326
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2919825857 11798837
MESH:D018248 Adenoma, Liver Cell Phenobarbital 3.9917620307
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.3211080934
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000544 Alzheimer Disease tolcapone 3.2820150427
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.1816206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.1816197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916124888 15721981 10355542 15673190 15700767 16227642 16097048 16050911 16011737 16192424 18705752 3786805
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.1216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.123084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 14.1215553829 14691202 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.1218788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.121701930 20007298 20935162 17173139 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.1216507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.121917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6918572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6916096774 16051514
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.756135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7519524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tretinoin 2.679407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6810525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.6814991402 17551590 8800419 9224671 9125849 9142499 10589399 16925845 9664655 9211117
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003866 Depressive Disorder tolcapone 4.317768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.9010440460
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.0521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.0514986274 18071297 16485898 11461765 10663392 19739265 19923254 18713872 11834606 11287661 17562736 19416960 11739529 10915739 16393943 17906064 16177239 14725611 19370779 16781746 11743745 12705907 19420014 12153990 15619225 12540782 11529661 11421492 16081117 12594235 19164858 15968718 17522070 14550746 12392966 12958197 19085960 10774834 16109766 16227642 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.0515968718 7179309 16177239 10915739 19085960 19336974 11566570 15027814 15998439 6884620 4309450 2869522 16227642 3786805 6623471 10092053 9327722 7120509 7440962 21278145 17522070 3732212
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.0515131321
MESH:D056486 Drug-Induced Liver Injury tolcapone 12.0519783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.4311455177
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004489 Edema, Cardiac Tretinoin 4.5018230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9011558140 3922381
MESH:D004827 Epilepsy marker/mechanism 17893921
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3112903497
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.9819578428
MESH:D005124 Eye Abnormalities Tretinoin 3.589664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 7.8815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.8819224547 15959796 16045604 12795759 16239168 12631006 17595544 61145
MESH:D005355 Fibrosis Carbon Tetrachloride 8.8518705752
MESH:D005355 Fibrosis Tretinoin 8.8517994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.909664655 14991402
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 3.5016109766
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007248 Infertility, Male sodium arsenite 2.9915346721 12646999
MESH:D007333 Insulin Resistance Sodium Selenite 3.2814714311
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 5.9712587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 5.9720008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9816705839
MESH:D007938 Leukemia arsenic trioxide 6.3415070760
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.4919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4916932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8817050201 20471514 16467208 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.6419075265 15748426 16891316 15336539 16823087 16966277 15213294 11161223 15622746 17217047 17649720 17712046 9834237 12018890 19225113 19642359 16112521 17869043 19035177 17107899 16330433 11468182 16331271 12712474 12679006
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6416823087 17339181 16935935 17712046 17301526 9834237 17649720 16788101 17361223 12679006 16891316 15748426 17294898 19029980 19075265 16766008 17506722 19225113 16331271 17368321 19642359 19035177 16140955 17107899 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6421278145 11903743 17334410 16943688 11408273 17174718 16239168 16221502 17157831
MESH:D008103 Liver Cirrhosis Phenobarbital 6.6421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4915876570 17766677 18210741 16097048 18429990 16638106 12958196 17869086 15996030 17922224 18156304 18412020 13678700 17698563 12586293 18472094 16192424 17823541 17805973 15057751 16248980 18472332 17525996 15052691 16027843 14748882 12632512 12389079 15673190 16116963 17640975 12666154 15338365 18006644 18205269 14620537 18279442 18277467 12667390 18251166 15730626 15925388 10355542 15650968 15362042 16011737 12445421 18339082 12632514 20821823 17761835 18263696 12741479 12898905 18418968 15123356 17631135 17557913 17721639 17708605 18481824 11481614 12649538 16136751 18166357 17976157 18376398 12445418 18705752 17714472 17565644 14716833 18187930 16015684 18395095 16033810 17481882 14724832 17900296 12609069 12546737 18395914 14716496 18317297 18420326 15370692 15931870 15893842 14512876 15959796 15818738 17944888 18054572
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.4919460945 16611625 11587558 12969438 16610002 19014921 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.4915830285 17285989 16964402 15720792 16246199
MESH:D008107 Liver Diseases Phenobarbital 6.4919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.277678174
MESH:D008113 Liver Neoplasms arsenic trioxide 14.2714682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.2719294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.278742319 19812893 21047994 19073162 15975961 19482888
MESH:D008113 Liver Neoplasms sodium arsenite 14.2716712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.152876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.1520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.1515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.151399818 2563599 18308698 6150874 17172636
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5319825857 11798837
MESH:D008175 Lung Neoplasms sodium arsenite 2.5317306315 16712894 15276417 19931552 17077188
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma sodium arsenite 3.3416487513 19082730
MESH:D008545 Melanoma Tretinoin 3.3416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1115949261 14977855 19417148 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3917596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009369 Neoplasms sodium arsenite 5.1111559025
MESH:D009369 Neoplasms Tretinoin 5.1116594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009421 Nervous System Malformations Tretinoin 3.799125849
MESH:D009436 Neural Tube Defects arsenic trioxide 12.1710525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.1712854658
MESH:D009436 Neural Tube Defects Tretinoin 12.179142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.3619769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms CD 437 11.3617474084
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.3617306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3616936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6315580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.6316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.6315976015
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010300 Parkinson Disease tolcapone 3.601977408 19783845 8635184 17089403 11746615 9591521 7566641 9305320 20216409 10651109 16758261 11432539 11586115 20334432 9708959 18328768 19578428 9754991 9333106 11793426 8739811
MESH:D011230 Precancerous Conditions Phenobarbital 3.622563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6119131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6116039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6118760546
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012640 Seizures Phenobarbital 5.934039156 16876388 3137016 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012878 Skin Neoplasms sodium arsenite 9.5318572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.538532709
MESH:D012878 Skin Neoplasms Tretinoin 9.5316467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4617007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4617261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.0019014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.001399818
MESH:D013964 Thyroid Neoplasms Tretinoin 12.0016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.9819578428
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.0012845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms CD 437 12.0016720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.0016452187 16712894 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.4211813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.4216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D014820 Vitiligo tolcapone 11.1310573327
MESH:D014820 Vitiligo Tretinoin 11.1316761959
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:05016 Huntington's disease
KEGG:05012 Parkinson's disease
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01375 antagonist Dihydroxyaluminium
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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