AutismKB 2.0

Annotation Detail for VEGFC


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Basic Information Top
Gene Symbol:VEGFC ( Flt4-L,VRP )
Gene Full Name: vascular endothelial growth factor C
Band: 4q34.3
Quick LinksEntrez ID:7424; OMIM: 601528; Uniprot ID:VEGFC_HUMAN; ENSEMBL ID: ENSG00000150630; HGNC ID: 12682
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04150mTOR signaling pathway
hsa05219Bladder cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by VEGF
Hemostasis
Pathway IDPathway Name
200161Signaling events mediated by VEGFR1 and VEGFR2
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00018Gastric cancer
Desease IDDesease Name
1781Rheumatoid arthritis
1934Cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of VEGFC mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of VEGFC mRNAdecreases expression 16788091
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of VEGFC mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of VEGFC mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of VEGFC mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VEGFC mRNAaffects expression 16483693
D000728 Androgens Androgens affects the expression of VEGFC mRNAaffects expression 16964283
D000728 Androgens Androgens affects the reaction [RALA protein affects the expression of VEGFC mRNA]affects expression|affects reaction 16964283
D001151 Arsenic Arsenic results in decreased expression of VEGFC mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of VEGFC mRNAdecreases expression 19804631
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of VEGFC mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VEGFC mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of VEGFC mRNAincreases expression 17200665
15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of VEGFC proteinincreases expression 17200665
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased secretion of VEGFC proteinincreases secretion 17200665
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of VEGFC mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of VEGFC mRNAaffects expression 12734012
C402665 CP 31398 CP 31398 results in increased expression of VEGFC mRNAincreases expression 15155752
D004317 Doxorubicin VEGFC protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D005665 Furosemide Furosemide results in increased expression of VEGFC mRNAincreases expression 16526316
D006851 Hydrochloric Acid Hydrochloric Acid results in increased expression of VEGFC mRNAincreases expression 15046208
C008493 methylselenic acid methylselenic acid results in decreased expression of VEGFC mRNAdecreases expression 12517777
D009151 Mustard Gas IL10 protein affects the reaction [Mustard Gas affects the expression of VEGFC mRNA]affects expression|affects reaction 16173061
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of VEGFC mRNAincreases expression 16777990
C014707 nitrosobenzylmethylamine Plant Preparations inhibits the reaction [nitrosobenzylmethylamine results in increased expression of VEGFC mRNA]decreases reaction|increases expression 16777990
C030110 oxaliplatin oxaliplatin results in increased expression of VEGFC proteinincreases expression 18790786
D028321 Plant Preparations Plant Preparations inhibits the reaction [nitrosobenzylmethylamine results in increased expression of VEGFC mRNA]decreases reaction|increases expression 16777990
D015474 Isotretinoin Isotretinoin results in decreased expression of VEGFC mRNAdecreases expression 15982314
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFC mRNA]affects reaction|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VEGFC mRNAincreases expression 16214954
12167310
D014212 Tretinoin Tretinoin metabolite results in increased expression of VEGFC mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of VEGFC mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of VEGFC mRNAdecreases expression 16788091
D014747 Vinblastine VEGFC protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D015032 Zinc Zinc results in decreased expression of VEGFC mRNAdecreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of VEGFC mRNAdecreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 7.8818769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8814514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.7618769834
MESH:D000138 Acidosis Ammonium Chloride 16.5118287403
MESH:D000138 Acidosis Hydrochloric Acid 16.5116144966 12771618 20872349 15920416 19262391 11574821
MESH:D000138 Acidosis Zinc Sulfate 16.517265320
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.5317183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.5620597076
MESH:D017486 Acneiform Eruptions Isotretinoin 6.0316232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.2318769834 16185265
MESH:D000169 Acrodermatitis Zinc 5.1617190629 16889938 17202136
MESH:D055371 Acute Lung Injury Hydrochloric Acid 4.5615970105 19060228 19760209 16759491 11953099 11850527 19094174
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3519825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 4.3517418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9617306315
MESH:D000419 Albuminuria Doxorubicin 4.3121441931
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Androgens 4.6917917157 17182789
MESH:D000544 Alzheimer Disease Zinc 4.6916410023 17119284 16325427 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.6716916123
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D000860 Anoxia Hydrochloric Acid 10.7915090967
MESH:D000860 Anoxia Zinc Sulfate 10.797265320
MESH:D020261 Arsenic Poisoning Arsenic 2.8018414634 12569548 16251483 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 2.9316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Mustard Gas 7.5410378619
MESH:D001249 Asthma Tretinoin 7.5416456186
MESH:D001249 Asthma Zinc 7.5417085522
MESH:D050197 Atherosclerosis Arsenic 3.1112928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001768 Blister Mustard Gas 4.9119167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.2116206674
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 20.2115920416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4514601052
MESH:D001930 Brain Injuries Zinc 4.4517109824
MESH:D001932 Brain Neoplasms Doxorubicin 3.6017150277
MESH:D001943 Breast Neoplasms alitretinoin 2.8616344269
MESH:D001943 Breast Neoplasms Androgens 2.8617018787
MESH:D001943 Breast Neoplasms Doxorubicin 2.8615692762 16096432 17983394 18234424 18382427 18628466 16115903 15668708 15994142 19526202 16322301 15634643 15136595 17369602 16826403 18695136 16935488 16595493 11325840 16264153 15993339 15939500 15567936 17426702
MESH:D001943 Breast Neoplasms Plant Preparations 2.8617398067
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8616443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.3912378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.2215578804
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7317687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416124888 10355542 18705752 3786805 16192424 16050911 16227642 15721981 16097048 16011737 15700767 15673190
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4515504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.4416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.4417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.4416217749 11135700 15553829 15073043 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4418788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.4418059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.5716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.571485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 17.1418922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 17.146189445
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 17.1411237771
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 17.1417418620
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 17.1416096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 17.1416543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8618640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.3716651473 17308081 17924179 17351982 17382496 16242529 15811867 16269455 17928571 17007740 16952015 16612575 16278810 15476868 15792986 16455267 16731534 18627295 17329180 16109756 15505089 17974986 17131338 16364871 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8616243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 11.4517938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Plant Preparations 11.4516862667
MESH:D002318 Cardiovascular Diseases Zinc 11.4516936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.1016973168 18022660
MESH:D016893 Carotid Stenosis Plant Preparations 5.8915158307
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.5620889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4215668235 16354765 15340226 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms oxaliplatin 3.1316024531 16004971 16510598
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.6920501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.6918802399 18259882
MESH:D015179 Colorectal Neoplasms oxaliplatin 4.6917401013 17695437 18509181 18448328 17255274 17594712
MESH:D015179 Colorectal Neoplasms Vinblastine 4.6918802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D003324 Coronary Artery Disease Plant Preparations 3.9015158307
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.0410525206
MESH:D019465 Craniofacial Abnormalities Isotretinoin 7.049879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.0415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.0414991402 9224671 9664655 9142499 17551590 8800419 10589399 9211117 9125849 16925845
MESH:D019465 Craniofacial Abnormalities Zinc 7.0419302082
MESH:D016638 Critical Illness Androgens 5.8116670151
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7718551238
MESH:D003556 Cystitis Hydrochloric Acid 5.2212599022 19279288 12853844 20719367
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.5617714534
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D003920 Diabetes Mellitus Zinc 4.0016479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.1916227642 11743745 16081117 10915739 16485898 11739529 2444490 11287661 12594235 12540782 16109766 18071297 12958197 17906064 19420014 14550746 17522070 12153990 10774834 11529661 11421492 18713872 19370779 10663392 19085960 12392966 16393943 16177239 15619225 19164858 15968718 19739265 19416960 14986274 11461765 14725611 17562736 12705907 19923254 16781746 11834606
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.1911566570 17522070 3786805 10915739 3732212 19085960 7440962 15968718 7120509 9327722 16227642 2869522 19336974 4309450 15998439 15027814 6623471 6884620 21278145 10092053 16177239 7179309
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.1917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.1920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Doxorubicin 12.8418602426
MESH:D004362 Drug Toxicity Plant Preparations 12.8411033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.8411462148
MESH:D004417 Dyspnea Furosemide 4.6916935035
MESH:D004487 Edema Furosemide 10.3611834646
MESH:D004487 Edema Mustard Gas 10.369260866 11428647 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.3611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.0617359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.0616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9118037988
MESH:D004890 Erythema Mustard Gas 4.919357497
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.5519566590
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.1620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 13.1612903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 13.1616510608 16805852 15264214 15878914 15623463 15547721 15150132 16704527 15547733
MESH:D004938 Esophageal Neoplasms Plant Preparations 13.1616510608
MESH:D004938 Esophageal Neoplasms Zinc 13.1616543248
MESH:D004941 Esophagitis Hydrochloric Acid 5.7512928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 5.7720516732 14621274 11346197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 7.1415073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.1461145 16239168 12795759 17595544 12631006 16045604 19224547 15959796
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.2218705752
MESH:D005355 Fibrosis Hydrochloric Acid 19.2218497604
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.2220067830
MESH:D005355 Fibrosis Tretinoin 19.2217994277
MESH:D005534 Foot Diseases Arsenic 5.316392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.2212378975
MESH:D005756 Gastritis Acetaminophen 10.3316983495
MESH:D005756 Gastritis Zinc 10.3317241300
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.0920516732 19957777 12212954 20616304 19951613 20545468
MESH:D005909 Glioblastoma Doxorubicin 6.7217150277
MESH:D005909 Glioblastoma Tretinoin 6.7217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006130 Growth Disorders Zinc 3.8117217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.3015692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3016096774
MESH:D034381 Hearing Loss Furosemide 4.6217868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006356 Heartburn Hydrochloric Acid 5.5519566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.119664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.3216244372 18006777 17875725 12587719 16330681 16495754 17888722 16144979 16707910 16244371 14766674 16879835 18674790
MESH:D006333 Heart Failure Doxorubicin 11.2117481944
MESH:D006333 Heart Failure Furosemide 11.2112660669 16845234 16011733
MESH:D006333 Heart Failure Zinc 11.2117162251
MESH:D006335 Heart Injuries Zinc 5.5217074742
MESH:D016481 Helicobacter Infections Zinc 4.3117241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619110552 19900420
MESH:D006527 Hepatolenticular Degeneration Zinc 10.5117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.5117063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6516120746 15340226 12621046
MESH:D006628 Hirsutism Androgens 5.8317019078 16914592
MESH:D006689 Hodgkin Disease Doxorubicin 7.1215147373 18501091 17606976
MESH:D006689 Hodgkin Disease Vinblastine 7.1218501091 18180244
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 16959395 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 12.0416870215
MESH:D006930 Hyperalgesia oxaliplatin 12.0417418472
MESH:D006930 Hyperalgesia Tretinoin 12.0416870215
MESH:D017588 Hyperandrogenism Androgens 5.4817019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006934 Hypercalcemia Furosemide 4.8517652376
MESH:D053565 Hypercalciuria Furosemide 5.4117652376
MESH:D006940 Hyperemia Hydrochloric Acid 5.4012646421
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2417050553
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.6315086907
MESH:D006973 Hypertension Arsenic 4.919931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 10.6115338365
MESH:D006975 Hypertension, Portal Hydrochloric Acid 10.6116984587
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.0416612254
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.2819262391
MESH:D006987 Hypesthesia Arsenic 5.3116093927
MESH:C537153 Hypomagnesemia primary Furosemide 5.4111041285
MESH:D007019 Hypoproteinemia Furosemide 5.6316096441
MESH:D007022 Hypotension Furosemide 14.2011041285
MESH:D007022 Hypotension Hydrochloric Acid 14.2011574821
MESH:D007022 Hypotension Zinc Sulfate 14.207265320
MESH:D007024 Hypotension, Orthostatic Furosemide 5.1715811171
MESH:D007249 Inflammation Hydrochloric Acid 7.7511574821
MESH:D007249 Inflammation Mustard Gas 7.7517524151 11402378 8975870 11428631 9357497 11428620 9260866 16001271 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7512200463 12878042
MESH:D007410 Intestinal Diseases Hydrochloric Acid 9.3211574821
MESH:D007410 Intestinal Diseases Tretinoin 9.3217994277
MESH:D007511 Ischemia Zinc 4.3916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007642 Keratosis Arsenic 4.7412749816 16930632
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3916144296
MESH:D007674 Kidney Diseases Acetaminophen 13.3815629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 13.3815699352 15369732 16775033
MESH:D007674 Kidney Diseases Furosemide 13.3811041285
MESH:D007674 Kidney Diseases Zinc 13.3816960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.4516707910
MESH:D007676 Kidney Failure, Chronic Zinc 9.4516518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.7816705839
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.1116498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.1111510729
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.0615237267
MESH:D007938 Leukemia arsenic trioxide 5.9315070760
MESH:D007938 Leukemia Tretinoin 5.9317143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9116085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7220471514 19850784 17050201 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7217596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 11.8617339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.8617649720 19075265 16966277 15748426 11161223 16331271 19225113 19642359 16823087 16112521 17869043 11468182 15622746 17712046 12679006 12018890 17217047 16330433 9834237 17107899 16891316 15213294 12712474 15336539 19035177
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.8619029980 19642359 16935935 9834237 17506722 17712046 17301526 16140955 17294898 15748426 19225113 16331271 16788101 16766008 16823087 17339181 12679006 19035177 17217047 19075265 17107899 17368321 17361223 17649720 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6217174718 17157831 16239168 16943688 21278145 11903743 17334410 11408273 16221502
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 6.6216984587
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4218395914 18705752 18251166 18420326 15730626 12389079 18339082 14620537 18210741 15893842 12632514 18054572 17708605 17900296 15123356 15370692 16027843 18006644 12741479 16097048 15673190 18277467 12586293 17869086 16248980 17922224 12546737 18187930 18376398 16033810 17714472 17481882 18429990 12649538 15362042 15338365 15996030 18412020 17761835 14724832 12898905 20821823 15818738 17565644 17557913 15650968 15052691 16116963 18317297 18481824 10355542 17721639 16192424 12632512 17805973 17631135 18279442 18156304 14716496 14748882 18472094 12666154 18418968 15925388 17525996 11481614 12667390 15959796 17698563 16136751 17640975 12445421 16015684 14716833 18263696 18166357 15876570 16011737 16638106 12958196 17944888 13678700 18472332 18205269 17976157 15931870 17823541 15057751 12445418 12609069 14512876 17766677 18395095
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.4216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 6.4217724770
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.1412587719 19460945 19784758 11587558 16610002 16611625 19014921 12969438
MESH:D008107 Liver Diseases Arsenic 6.1411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1416246199 15720792 16964402 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7016899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 9.9316368122
MESH:D008113 Liver Neoplasms arsenic trioxide 9.9314682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.9319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.9316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.8820377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.8812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.8816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.8812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1715213294
MESH:D008171 Lung Diseases Hydrochloric Acid 7.4116784557
MESH:D008171 Lung Diseases Mustard Gas 7.4118702808 18161513
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.7817365036
MESH:D055370 Lung Injury Hydrochloric Acid 8.7818497604 15044056 21311175 18573544 21114838 18339021 11395602 17627322 19644408 19262391 15090967 20597076 16129981 15607125
MESH:D008175 Lung Neoplasms alitretinoin 10.2116413115
MESH:D008175 Lung Neoplasms Arsenic 10.2117976673 19168569 17306315
MESH:D008175 Lung Neoplasms arsenic trioxide 10.2119825857 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 10.2117418594 6189445
MESH:D008175 Lung Neoplasms Isotretinoin 10.2115899809
MESH:D008175 Lung Neoplasms Mustard Gas 10.213148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.2119555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.2916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.8715458769
MESH:D008325 Mammary Neoplasms, Experimental Zinc 5.8712773700
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma marker/mechanism 17562445
MESH:D008545 Melanoma Doxorubicin 7.0216827129
MESH:D008545 Melanoma Isotretinoin 7.0217237267
MESH:D008545 Melanoma Tretinoin 7.0216752155
MESH:D008545 Melanoma Vinblastine 7.0216432458 18176117 18505091 16809738 18332650 15577323 16248763 12374674 15577320 17761969
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.1116966607 18303189 16166281
MESH:D008654 Mesothelioma Doxorubicin 6.1117638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2815792986
MESH:D009062 Mouth Neoplasms Plant Preparations 4.5917418620
MESH:D052016 Mucositis Doxorubicin 4.5417415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9319417148 11468182 14977855 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9317596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.9819429709 15857846
MESH:D009203 Myocardial Infarction Hydrochloric Acid 5.9818534312
MESH:D017202 Myocardial Ischemia Arsenic 8.3615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8618259882
MESH:D009369 Neoplasms alitretinoin 4.9916946489
MESH:D009369 Neoplasms Tretinoin 4.9916594593 16946489
MESH:D009397 Nephrocalcinosis Furosemide 5.6315086907
MESH:D009401 Nephrosis Doxorubicin 4.5316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7915640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 8.739125849
MESH:D009436 Neural Tube Defects Arsenic 11.2816620997
MESH:D009436 Neural Tube Defects arsenic trioxide 11.2810525206
MESH:D009436 Neural Tube Defects Tretinoin 11.289142499
MESH:D009447 Neuroblastoma Doxorubicin 6.9415555623
MESH:D009447 Neuroblastoma Isotretinoin 6.9417368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.1517056641
MESH:D009503 Neutropenia Mustard Gas 8.867688884 16761898
MESH:D009503 Neutropenia Vinblastine 8.8617378895
MESH:D053206 Nocturnal Enuresis Furosemide 5.6317945291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.6716049721 12819281
MESH:D009784 Occupational Diseases Hydrochloric Acid 8.6712378975
MESH:D012516 Osteosarcoma Doxorubicin 3.9215930896
MESH:D010051 Ovarian Neoplasms Arsenic 7.4817306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.4812452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4816936753
MESH:D010146 Pain Acetaminophen 5.9416870215
MESH:D010146 Pain Tretinoin 5.9416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.9915580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9915976015
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7415371236 16905509 6392382
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9117983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6510923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9117638057
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.1215970105 18497604 18573544 15607125
MESH:D011041 Poisoning Mustard Gas 3.5715727166
MESH:D011141 Polyuria Furosemide 5.4117945291
MESH:D017499 Porokeratosis alitretinoin 5.7516144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011225 Pre-Eclampsia Zinc 3.9917114810
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 9.0318769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0311399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Androgens 1.9015389811 16998812 17909013
MESH:D011471 Prostatic Neoplasms Arsenic 1.9016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9016729912 16888761 15897917 18437689 16868541 15749863
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9016205645
MESH:D011471 Prostatic Neoplasms Zinc 1.9016606632 12429649 16517595 16700911
MESH:D011507 Proteinuria Arsenic 8.5221343184
MESH:D011507 Proteinuria Tretinoin 8.5216636307
MESH:D011537 Pruritus Mustard Gas 3.8518058305
MESH:D011596 Psychomotor Disorders Isotretinoin 5.6718769834
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 5.7720597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 4.9615090967
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.5917322281 17365031 15814490 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.5917894541 17266442 10334151 17620002 17720292
MESH:D051437 Renal Insufficiency Doxorubicin 3.9817922066
MESH:D015427 Reperfusion Injury Furosemide 3.7916526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 9.0416096441 15912074 12394941
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 9.0417627322 18549715 16129981 18339021 16784557
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.1111510729
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 4.9220516732
MESH:D012162 Retinal Degeneration Zinc 3.9516584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.7815675481 17710206 15625365 17203757 18313854 16767912
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.5016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.5014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5417846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3718551238
MESH:D012871 Skin Diseases Arsenic 4.9219834688 17938729 18709164 17548696 16353154 6392382 16759981 17453740 16702368 15952646 17050553
MESH:D012871 Skin Diseases Mustard Gas 4.9212880345 15451306 16961503
MESH:D012878 Skin Neoplasms Arsenic 16.7019538983 17050553 17976673 17029826 15504454 16251483
MESH:D012878 Skin Neoplasms Doxorubicin 16.7015692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.708532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.7016192470
MESH:D012878 Skin Neoplasms Tretinoin 16.7016467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3216767912 17203757 15625365
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5917007042
MESH:D013274 Stomach Neoplasms Furosemide 4.5917052386
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.5917575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.5917261132
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.0216755016 17189318 15309881
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.9619014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.9617909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 9.2716051514
MESH:D014062 Tongue Neoplasms Zinc 9.2716543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7215213294
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.8016049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.8011144890 15987713 19322015 19429237 18640142 17306315 17976673
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.8011780464 12973940 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.8017653716
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 14.8011251952
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0710091137
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014625 Vaginal Neoplasms Vinblastine 4.8015577323
MESH:D014652 Vascular Diseases Arsenic 4.4917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9817678736 16364871 17638931 17334414
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
Pathway ID Pathway Name
KEGG:05219 Bladder cancer
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04150 mTOR signaling pathway
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
KEGG:05211 Renal cell carcinoma
REACT:12529 Signaling by VEGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37304
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA162372840sunitinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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