AutismKB 2.0

Annotation Detail for VGF


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Basic Information Top
Gene Symbol:VGF ( - )
Gene Full Name: VGF nerve growth factor inducible
Band: 7q22.1
Quick LinksEntrez ID:7425; OMIM: 602186; Uniprot ID:VGF_HUMAN; ENSEMBL ID: ENSG00000128564; HGNC ID: 12684
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2134Amyotrophic lateral sclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of VGF mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VGF mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of VGF mRNAincreases expression 18687144
D002330 Carmustine Carmustine results in decreased expression of VGF mRNAdecreases expression 15980968
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of VGF mRNAaffects cotreatment|increases expression 18606552
C056507 gemcitabine gemcitabine results in decreased expression of VGF mRNAdecreases expression 17039268
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of VGF mRNAaffects cotreatment|increases expression 18606552
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of VGF mRNAdecreases expression 15046208
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of VGF mRNAincreases expression 17616710
D010126 Ozone Ozone results in decreased expression of VGF mRNAdecreases expression 16330353
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of VGF mRNAaffects cotreatment|increases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VGF mRNAincreases expression 19933214
D014635 Valproic Acid Valproic Acid results in increased expression of VGF mRNAincreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of VGF mRNAaffects cotreatment|increases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5915322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.598875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 11.0118287403
MESH:D000138 Acidosis Hydrochloric Acid 11.0111574821 16144966 19262391 15920416 12771618 20872349
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 5.8417183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 5.9120597076
MESH:D055371 Acute Lung Injury Hydrochloric Acid 4.8419060228 19094174 19760209 15970105 11850527 11953099 16759491
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000860 Anoxia Hydrochloric Acid 5.3915090967
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6517854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 2.0019232924 15238991 18775368 18316065 18177632 17157402 16609825 20603192 19460635 17507914 18396377 17688650 18940202 18558336 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1020046352 17594078
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 9.5615920416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.138888407
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms gemcitabine 2.3718382427 17039268
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 9.0812378975
MESH:D016535 Bronchial Hyperreactivity Ozone 9.0818315731 17626835 18417511 16777450 19059883 15516495 14754758
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.5615578804
MESH:D002100 Cachexia Ozone 4.8216183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18850075 18670907
MESH:D009202 Cardiomyopathies Zalcitabine 4.7410591146
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 15668235 8697196 15340226 12621046
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8017688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8019769572
MESH:D003556 Cystitis Hydrochloric Acid 5.5612853844 19279288 20719367 12599022
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 5.9117714534
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.311733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6811462148
MESH:D004362 Drug Toxicity Zalcitabine 8.687515130
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004935 Esophageal Diseases Hydrochloric Acid 5.8819566590
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7916704527 15878914 15264214 15547721 16510608 16805852 15623463 15150132 15547733
MESH:D004941 Esophagitis Hydrochloric Acid 6.0812928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.1111346197 20516732 14621274
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Valproic Acid 8.6419224547 14986274
MESH:D005234 Fatty Liver Zalcitabine 8.6418299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1918558336 8888407
MESH:D005355 Fibrosis Hydrochloric Acid 9.3018497604
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3020067830
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.5612378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.3920616304 12212954 20545468 20516732 19957777 19951613
MESH:D005909 Glioblastoma Carmustine 3.9616187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006356 Heartburn Hydrochloric Acid 5.8819566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6616080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D015658 HIV Infections Zalcitabine 4.3617457083
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 15340226 16354765 16959395 8697196
MESH:D006940 Hyperemia Hydrochloric Acid 5.7312646421
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.4216984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.4919262391
MESH:D007022 Hypotension Hydrochloric Acid 4.8211574821
MESH:D007249 Inflammation Hydrochloric Acid 5.4411574821
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4412200463 12878042
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007410 Intestinal Diseases Hydrochloric Acid 5.0411574821
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Vitamin E 2.8312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.4616498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.4611510729
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.1016984587
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3516169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008171 Lung Diseases Hydrochloric Acid 12.7316784557
MESH:D008171 Lung Diseases Ozone 12.7319066396 8266340
MESH:D008171 Lung Diseases Vitamin E 12.7316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 15.7917365036
MESH:D055370 Lung Injury Hydrochloric Acid 15.7919644408 18573544 21114838 15044056 18497604 21311175 17627322 11395602 20597076 19262391 16129981 18339021 15090967 15607125
MESH:D055370 Lung Injury Ozone 15.7920417186
MESH:D008175 Lung Neoplasms Ozone 3.477614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.4711062179
MESH:D008223 Lymphoma Zalcitabine 4.689488045 8764131 11980663 8840982 17941976 18798262 9205081
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7915318939
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.4018303189 16966607 16166281
MESH:D008654 Mesothelioma Selenium 6.4015107826
MESH:D008679 Metaplasia Ozone 5.2010496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction Hydrochloric Acid 3.8318534312
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.179205081 9488045 8764131
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009437 Neuralgia Zalcitabine 6.4017292584
MESH:D009436 Neural Tube Defects Valproic Acid 3.1616359493 8888407
MESH:D009784 Occupational Diseases Hydrochloric Acid 4.8112378975
MESH:D010190 Pancreatic Neoplasms gemcitabine 3.5518992248 11504793 17440100 18383843 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 11.1518606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 11.1518606552
MESH:D010538 Peritonitis Ozone 4.2016369182
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D011014 Pneumonia Ozone 4.4818007984 18929643 18381685
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.4518573544 15970105 18497604 15607125
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7411118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.7420603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6411422049 12752131
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.1120597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.3115090967
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0517975199 15814490 17322281 17365031
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 4.8216784557 17627322 18549715 16129981 18339021
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.4611510729
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.2620516732
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7711044598 16876388 3137016 14763951 15475178 1511512 11738929 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3217575124 12958204
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.2816755016 15309881 17189318
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37305
    • No data
    Releated disease ID Related disease Name
    PA445131Obesity
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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