AutismKB 2.0

Annotation Detail for VHL


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Basic Information Top
Gene Symbol:VHL ( HRCA1,RCA1,VHL1 )
Gene Full Name: von Hippel-Lindau tumor suppressor
Band: 3p25.3
Quick LinksEntrez ID:7428; OMIM: 608537; Uniprot ID:VHL_HUMAN; ENSEMBL ID: ENSG00000134086; HGNC ID: 12687
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200122Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
200161Signaling events mediated by VEGFR1 and VEGFR2
Pathway IDPathway Name
P00030Hypoxia response via HIF activation
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
Cancers
Cancers of the urinary system and male genital organs
H00236Congenital polycythemia
H00021Renal cell carcinoma
Desease IDDesease Name
1724Vascular disease
1739Oral cancer
1799Epilepsy
1832Congenital abnormality
1878Ischemia
1934Cancer
2120Rabies
2222Polycythemia
Desease Name
von Hippel-Lindau type 2A
germline mutations
renal cancer
renal cell carcinoma
CANCER
non-papillary renal cell carcinomas
von Hippel-Lindau syndrome (VHL).
VISION
retinal hemangioblastomas
No data
Desease Name
Polycythemia, benign familial
Renal cell carcinoma, somatic
Hemangioblastoma, cerebellar, somatic
von Hippel-Lindau syndrome
Pheochromocytoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of VHL mRNAaffects expression 21346803
C524042 3,5-bis(2-fluorobenzylidene)piperidin-4-one VHL protein promotes the reaction [3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of HIF1A protein]decreases expression|increases reaction 18682687
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of VHL mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of VHL mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VHL mRNAaffects expression 16483693
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]affects binding|increases reaction 17973296
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]]affects binding|decreases reaction|increases reaction 17973296
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of VHL mRNAaffects cotreatment|affects expression 18636392
D003474 Curcumin VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]decreases expression|increases reaction 18682687
C014347 decitabine decitabine affects the expression of VHL mRNAaffects expression 16954373
C014347 decitabine VHL protein promotes the reaction [decitabine results in increased expression of ABCG2 mRNA]increases expression|increases reaction 16954373
C014347 decitabine VHL protein promotes the reaction [decitabine results in increased expression of ABCG2 protein]increases expression|increases reaction 16954373
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of VHL mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VHL mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of VHL mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of VHL mRNAincreases expression 18035473
C022838 nickel chloride nickel chloride inhibits the reaction [VHL protein binds to HIF1A protein]affects binding|decreases reaction 16649251
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of VHL mRNAaffects cotreatment|affects expression 18636392
D011794 Quercetin Quercetin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [HIF1A protein binds to VHL protein]]affects binding|decreases reaction|increases reaction 17973296
D011794 Quercetin Quercetin inhibits the reaction [HIF1A protein binds to VHL protein]affects binding|decreases reaction 17973296
D011794 Quercetin Quercetin results in increased expression of VHL mRNAincreases expression 14715546
C017947 sodium arsenite sodium arsenite results in decreased expression of VHL mRNAdecreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VHL mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury Chlorine 4.3320601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000236 Adenoma marker/mechanism 16061637
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.753712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1117887948
MESH:D000544 Alzheimer Disease Curcumin 4.4015590663
MESH:D000544 Alzheimer Disease Ozone 4.4015513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2417084956
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.8416807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8415570426
MESH:D001249 Asthma Ozone 2.6416373670 17854713
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0015336622
MESH:D050197 Atherosclerosis Curcumin 3.3218704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Curcumin 10.9119761891
MESH:D001327 Autoimmune Diseases Quercetin 10.9119761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.051440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D002545 Brain Ischemia Curcumin 4.3516770732
MESH:D001932 Brain Neoplasms Curcumin 3.9417596214
MESH:D001943 Breast Neoplasms Curcumin 1.9918462866 19250217 18593918 16243823
MESH:D001943 Breast Neoplasms decitabine 1.9918320071 19208741
MESH:D001943 Breast Neoplasms Quercetin 1.9918628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6815516495 18417511 19059883 17626835 14754758 18315731 16777450
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002105 Cadmium Poisoning Quercetin 5.5816962696
MESH:D002277 Carcinoma marker/mechanism 16061637
MESH:D002277 Carcinoma Curcumin 8.2918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.883084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.8812508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.8816507464 15276417 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9818414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9717234771
MESH:D002292 Carcinoma, Renal Cell marker/mechanism 11171960
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.687296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.6518462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.6519215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.6518572023
MESH:D006332 Cardiomegaly Quercetin 6.8119794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8118670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.226135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.227505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.2219524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.8719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8715861022 16919318 17110522 17681005 17333356 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Curcumin 4.1916782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.5518809619
MESH:D003110 Colonic Neoplasms Curcumin 5.9516340194 19359593
MESH:D003110 Colonic Neoplasms decitabine 5.9517616700
MESH:D003110 Colonic Neoplasms Quercetin 5.9511134977 19056647 16640504 17191121 19440933 15741050 17148506
MESH:D015179 Colorectal Neoplasms decitabine 2.7018981723
MESH:D015179 Colorectal Neoplasms Quercetin 2.7018852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.9118497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8214531868 11298694 2524372 8156756 11906362 18759878 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.503621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7319496084
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4118403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.0118204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.9518289764 6679447 9022650 16192314 18692083 6482804 18648102 7440962 9328219 1440618 9653073 11289319 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9514986274 11743745 16081117 12153990 17562736 18071297 16485898 11287661 15619225 19739265 11834606 11461765 16177239 14550746 19370779 10915739 10774834 16393943 12594235 12392966 19923254 11529661 16227642 19416960 2444490 16781746 19085960 10663392 19164858 16109766 19420014 12540782 12958197 12705907 15968718 18713872 17522070 17906064 14725611 11421492 11739529
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004381 Duodenal Ulcer Curcumin 4.0617351913
MESH:D004417 Dyspnea Chlorine 4.6520016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1519294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
OMIM:263400 ERYTHROCYTOSIS, FAMILIAL, 2 marker/mechanism
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Curcumin 7.9019297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D005355 Fibrosis Curcumin 14.9718705752
MESH:D005355 Fibrosis Quercetin 14.9719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9720067830
MESH:D005739 Gas Poisoning Chlorine 5.0420016425
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005909 Glioblastoma Curcumin 7.4417596214
MESH:D005909 Glioblastoma Quercetin 7.4419804834
MESH:D005910 Glioma Quercetin 3.0517643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Curcumin 8.0118462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 8.0119215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.0517701891
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia Curcumin 4.0618704882
MESH:D006943 Hyperglycemia Quercetin 4.0318262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9515034207
MESH:D006973 Hypertension Quercetin 5.2318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male decitabine 11.2417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.2417937319
MESH:D007248 Infertility, Male sodium arsenite 11.2415346721 12646999
MESH:D007249 Inflammation Curcumin 8.3916956363 17151092 18403477
MESH:D007249 Inflammation Flavonoids 8.3917296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3912200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2118596194 18200517
MESH:D007251 Influenza, Human Quercetin 4.5416624496
MESH:D007414 Intestinal Neoplasms Curcumin 4.2210783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.058074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007627 Keloid Quercetin 4.9717086741
MESH:D007674 Kidney Diseases Acetaminophen 10.1215629191 12587719
MESH:D007674 Kidney Diseases Quercetin 10.1216962696
MESH:D007674 Kidney Diseases sodium arsenite 10.1220008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.376582329
MESH:D007889 Leiomyoma Curcumin 4.5818555241
MESH:D007938 Leukemia Curcumin 10.6218462866
MESH:D007938 Leukemia decitabine 10.6218980019 19235587
MESH:D007938 Leukemia Quercetin 10.6217468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2116106398
MESH:D007951 Leukemia, Myeloid decitabine 4.0117236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3817679729 18206229 18704418 19010910 18460780 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4918055864
MESH:D015458 Leukemia, T-Cell Curcumin 4.7716106398
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.209327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.5718705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5712741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 4.1011587558 16611625 19014921 12969438 16610002 19460945 19784758 12587719
MESH:D008107 Liver Diseases Curcumin 4.1016956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.737678174
MESH:D008113 Liver Neoplasms Quercetin 10.7318980244
MESH:D008113 Liver Neoplasms sodium arsenite 10.7316712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.146135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.143712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.1419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1412151625
MESH:D008171 Lung Diseases Ozone 7.5219066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.5219095001
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms marker/mechanism 16061637
MESH:D008175 Lung Neoplasms Curcumin 6.6119359593 18462866 16243823
MESH:D008175 Lung Neoplasms Ozone 6.618597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 6.6116280456
MESH:D008175 Lung Neoplasms sodium arsenite 6.6115276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6111884234 19555203
MESH:D008223 Lymphoma Curcumin 7.7818462866
MESH:D008223 Lymphoma decitabine 7.7819470736
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7116173963
MESH:D008545 Melanoma Curcumin 5.2117885582 18462866
MESH:D008545 Melanoma decitabine 5.2117785578 16505122
MESH:D008545 Melanoma sodium arsenite 5.2116487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008569 Memory Disorders Curcumin 4.1617263510
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D009101 Multiple Myeloma Curcumin 7.5319372569
MESH:D009101 Multiple Myeloma decitabine 7.5318172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.9417962980
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3819010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction Quercetin 2.9919595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7919207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.3818495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.473581430
MESH:D009369 Neoplasms decitabine 8.4019116145 17925555 19470736
MESH:D009369 Neoplasms Quercetin 8.4015185748
MESH:D009369 Neoplasms sodium arsenite 8.4011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.5612497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.6618462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.276679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.2712854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.3717929310
MESH:D009765 Obesity Curcumin 2.7519297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.8916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.894026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D010024 Osteoporosis Curcumin 3.4718719352
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.2219495926
MESH:D010051 Ovarian Neoplasms Curcumin 11.3618462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 11.3619331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 11.3619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.3615276417 17306315
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 8.7717440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms decitabine 8.7719294695
MESH:D010190 Pancreatic Neoplasms Quercetin 8.7716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.507296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D010673 Pheochromocytoma marker/mechanism
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.506228378
MESH:D011014 Pneumonia Ozone 4.4118007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Quercetin 3.9819056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111118676 11896295 11399792 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.7417616702
MESH:D011471 Prostatic Neoplasms Curcumin 2.6918156803 11398177 12497104 10851300 15129424 18769126 18226269
MESH:D011471 Prostatic Neoplasms Quercetin 2.6914715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6916039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.5319168576
MESH:D012120 Respiration Disorders Chlorine 5.2418579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0310666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.383692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.4119155313
MESH:D012509 Sarcoma Curcumin 4.1218462866
MESH:D012554 Schistosomiasis japonica Quercetin 5.5816862918
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5418551238
MESH:D018805 Sepsis Curcumin 4.0818389075
MESH:D012878 Skin Neoplasms sodium arsenite 5.6018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013276 Stomach Ulcer Curcumin 3.5016631530 19188055
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.251399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms decitabine 7.2517967635
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 19.9216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.928074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 19.9218593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 19.9217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 19.9216720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 19.9217306315 16452187 11723127 16712894
MESH:D014565 Urogenital Neoplasms Curcumin 5.2818462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014604 Uveal Neoplasms decitabine 4.9417785578
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D006623 von Hippel-Lindau Disease marker/mechanism 11171960
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05211 Renal cell carcinoma
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37307
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA444685Kidney Neoplasms
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449773glucose
    PA164778686pyruvic acid
    PA164747225l-citrulline
    PA130232992bevacizumab
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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