AutismKB 2.0

Annotation Detail for EZR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EZR ( CVIL,CVL,DKFZp762H157,FLJ26216,MGC1584,VIL2 )
Gene Full Name: ezrin
Band: 6q25.3
Quick LinksEntrez ID:7430; OMIM: 123900; Uniprot ID:EZRI_HUMAN; ENSEMBL ID: ENSG00000092820; HGNC ID: 12691
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05130Pathogenic Escherichia coli infection
hsa04971Gastric acid secretion
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200007RhoA signaling pathway
200061LKB1 signaling events
200067FAS (CD95) signaling pathway
200164Syndecan-2-mediated signaling events
No data
Pathway IDPathway Name
500098Recycling pathway of L1
500088Netrin-1 signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1824Bone disease
1832Congenital abnormality
1901Endometriosis
1904Diabetes mellitus
1934Cancer
2052Infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of EZR mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of EZR mRNAaffects expression 17562736
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of EZR mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EZR mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of EZR proteindecreases expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of EZR mRNAincreases expression 12205029
D003913 Dextroamphetamine SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of EZR mRNA]decreases reaction|increases expression 12205029
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EZR mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EZR mRNAincreases expression 18247414
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EZR mRNAdecreases expression 19150397
C053541 bicalutamide bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]decreases reaction|increases expression 16873375
C053541 bicalutamide bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]decreases reaction|increases phosphorylation 16873375
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of EZR mRNAdecreases expression 12419474
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of EZR mRNAaffects expression 17484886
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EZR mRNAaffects cotreatment|affects expression 17602206
D004041 Dietary Fats Dietary Fats results in increased expression of EZR mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EZR mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EZR mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of EZR mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of EZR mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of EZR proteinincreases expression 15737688
D004958 Estradiol Estradiol results in increased expression of EZR mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EZR mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of EZR mRNAincreases expression 17557909
17108234
D005419 Flavonoids Flavonoids results in decreased expression of EZR mRNAdecreases expression 18035473
D019833 Genistein Genistein results in increased expression of EZR mRNAincreases expression 15289156
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of EZR mRNAincreases expression 17412507
D015741 Metribolone bicalutamide inhibits the reaction [Metribolone results in increased expression of EZR mRNA]decreases reaction|increases expression 16873375
D015741 Metribolone bicalutamide inhibits the reaction [Metribolone results in increased phosphorylation of EZR protein]decreases reaction|increases phosphorylation 16873375
D015741 Metribolone Metribolone promotes the reaction [EZR protein binds to PRKCA protein]affects binding|increases reaction 16873375
D015741 Metribolone Metribolone results in increased expression of EZR mRNAincreases expression 16873375
D015741 Metribolone Metribolone results in increased phosphorylation of EZR proteinincreases phosphorylation 16873375
D015741 Metribolone PRKCA protein affects the reaction [Metribolone results in increased phosphorylation of EZR protein]affects reaction|increases phosphorylation 16873375
D009538 Nicotine Nicotine results in increased expression of EZR mRNAincreases expression 18247414
C041786 palm oil palm oil results in increased expression of EZR mRNAincreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in increased expression of EZR mRNAincreases expression 15728792
C410733 scriptaid scriptaid affects the expression of EZR mRNAaffects expression 18813790
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of EZR mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of EZR mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of EZR proteinincreases expression 19072884
C004648 testosterone enanthate testosterone enanthate affects the expression of EZR mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in increased expression of EZR mRNAincreases expression 16604517
16236135
C025643 vinclozolin vinclozolin affects the expression of EZR mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of EZR mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of EZR mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.7020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 12.7011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.7014692618
MESH:D000230 Adenocarcinoma Genistein 12.7011473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 12.7015688392 15113128
MESH:D000236 Adenoma Benzo(a)pyrene 10.216695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.2119389873
MESH:D000236 Adenoma Diethylnitrosamine 10.2110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.6119061943 17620307 16434500 19052882 18056438 17162532
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6017306315 16712894
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease Nicotine 3.2216627626
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2015469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9210965797
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4119015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.1620106747
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.3516197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.4820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 4.4820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.4817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.4817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 4.4812948864 16675129 17289903 18497071 14630087 17018787 19861407 17261762
MESH:D001943 Breast Neoplasms Genistein 4.4816873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylnitrosourea 4.4816253758 11306469 14633655
MESH:D001943 Breast Neoplasms Tretinoin 4.4816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.9716097048 15721981 16124888 16227642 3786805 15673190 18705752 15700767 10355542 16192424 16011737 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.9716050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.013084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.0118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.0116569478 17138121 18971187 16878318 18665156 17761372 16935385 16288022 19919837 19171122 20512989 20514400 19418558 18393292 10737359 16328049 20214788 16502159 17055752 20727157 10672840 18210153 20084675 17173139 18494052 19539802 19107877 19052882 16779866 18788625 19383236 3084413 20101231 17978847 16540662 19208518 18691550 16830150 3581430 20935162 17162532 19822196 18506893 18785209 11831363 21159647 20432363 19701751 20007298 20524982 17428255 18978308 16681979 16807293 19519916 19335982 18056438 19394651 16698587
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.0116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.0117306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.011917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.9820419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.9818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.9816051514 16096774
MESH:D002318 Cardiovascular Diseases Genistein 3.1016332659
MESH:D002386 Cataract Acetaminophen 11.4210977129
MESH:D002386 Cataract Methylnitrosourea 11.4212484553
MESH:D002386 Cataract Tretinoin 11.4217460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.9720889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.972727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.9718566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 18.972727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.9719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4419052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6617681005 17333356 15861022 11677210 16919318 17110522 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002972 Cleft Palate Tretinoin 2.549407595
MESH:D003092 Colitis Selenium 8.5417936198
MESH:D003092 Colitis Tretinoin 8.5417035595
MESH:D003110 Colonic Neoplasms Genistein 2.2417182828
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.599664655 9211117 14991402 8800419 9125849 9142499 10589399 9224671 17551590 16925845
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5919769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.4312952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.4314966744
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2616647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.2117522070 12153990 15968718 11461765 12958197 18713872 17906064 19416960 16227642 18071297 19923254 11529661 11287661 19164858 16781746 16393943 19739265 19420014 2444490 12392966 12705907 16485898 14725611 17562736 16081117 19370779 11834606 12594235 14986274 11743745 16109766 10663392 16177239 14550746 10915739 10774834 11421492 12540782 15619225 11739529 19085960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.213732212 17522070 7179309 21278145 19336974 2869522 15027814 15968718 7120509 4309450 3786805 6884620 6623471 16177239 11566570 9327722 15998439 16227642 7440962 10092053 19085960 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.2119107877
MESH:D056486 Drug-Induced Liver Injury Selenium 8.2115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D020821 Dystonic Disorders Nicotine 5.6317881519
MESH:C538011 Eales disease Vitamin E 4.409068938
MESH:D004489 Edema, Cardiac Tretinoin 4.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9112538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.9116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.9116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.2215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.2218566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 16.2211473722
MESH:D016889 Endometrial Neoplasms Tretinoin 16.2216569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.0820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.0816530937
MESH:D005124 Eye Abnormalities Tretinoin 3.3616938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.6116045604 61145 17595544 12795759 16239168 15959796 19224547 12631006
MESH:D005234 Fatty Liver Dietary Fats 16.6117967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 16.6120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.6115345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4816534752 16611131 15751030 16513791 16002989
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.9411555667
MESH:D005355 Fibrosis Carbon Tetrachloride 13.1618705752
MESH:D005355 Fibrosis Dietary Fats 13.1618296743
MESH:D005355 Fibrosis Tretinoin 13.1617994277
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6416973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0016417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.8316452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.8316452187
MESH:D005909 Glioblastoma Genistein 6.5716598420
MESH:D005909 Glioblastoma Tretinoin 6.5717312396
MESH:D005910 Glioma Methylnitrosourea 3.459825942
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2720471113
MESH:D006330 Heart Defects, Congenital Tretinoin 10.2714991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 10.2716080930
MESH:D006333 Heart Failure Selenium 2.9017162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3219110552 19900420
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6016863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4517440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.9112676792
MESH:D019584 Hot Flashes Estradiol 9.0517088409
MESH:D019584 Hot Flashes Vitamin E 9.0514716179
MESH:D006930 Hyperalgesia Acetaminophen 6.8616870215
MESH:D006930 Hyperalgesia Tretinoin 6.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.3421332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1514722030 12960047
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.2816002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.2816945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.0715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.4717937319
MESH:D007248 Infertility, Male Methylnitrosourea 14.477193160
MESH:D007248 Infertility, Male sodium arsenite 14.4712646999 15346721
MESH:D007248 Infertility, Male vinclozolin 14.4716467254
MESH:D007249 Inflammation Dietary Fats 7.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 7.4818785209
MESH:D007249 Inflammation Flavonoids 7.4817296493
MESH:D007251 Influenza, Human Selenium 9.9616624496
MESH:D007251 Influenza, Human Vitamin E 9.9616624496
MESH:D007333 Insulin Resistance Dietary Fats 6.7311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.7316393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.6417551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 13.0312587719 15629191
MESH:D007674 Kidney Diseases Estradiol 13.0315618244
MESH:D007674 Kidney Diseases sodium arsenite 13.0320008137
MESH:D007674 Kidney Diseases Vitamin E 13.0312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6216518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 6.7615003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 6.7615610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7717184923
MESH:D007938 Leukemia Genistein 5.9218980019 17468513
MESH:D007938 Leukemia Tretinoin 5.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9616140955 17649720 16766008 16891316 16331271 9834237 19029980 17339181 15748426 16788101 12679006 17368321 17506722 17712046 17217047 19035177 19225113 17107899 16935935 19642359 17301526 19075265 16823087 17361223 17294898
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4416417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.7615526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.769224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.0711408273 11903743 16943688 16239168 17334410 17157831 21278145 16221502 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 10.0718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.0719638242 18665156 20032147 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3218472094 15996030 17708605 16638106 14716496 16116963 17823541 16033810 12666154 13678700 15370692 15123356 14512876 15959796 12898905 17565644 16136751 17900296 17698563 14724832 15818738 17944888 18395914 15362042 17761835 15893842 12389079 12958196 14620537 10355542 18006644 11481614 15925388 18481824 17869086 17721639 18277467 12632512 12546737 12609069 18251166 18317297 18412020 16011737 12649538 18187930 18376398 18705752 18472332 15931870 17557913 18263696 18054572 20821823 17714472 12741479 12445418 18279442 16015684 18339082 14748882 18166357 17481882 15057751 16027843 17976157 15338365 14716833 17805973 16097048 17525996 18205269 12632514 17766677 15876570 17631135 16248980 15650968 17640975 12586293 15730626 17922224 18210741 16192424 12667390 18395095 18418968 15052691 18156304 18420326 12445421 18429990 15673190
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3217823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3218397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.3216169303
MESH:D008107 Liver Diseases Acetaminophen 5.9912587719 19784758 19014921 12969438 16610002 16611625 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.9915720792 16964402 17285989 16246199 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 5.9917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5614706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.1220195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.1221295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.1219294768
MESH:D008113 Liver Neoplasms Clofibric Acid 20.1217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.1218644402 20405173 12112319 20501860 19690152 10737359 15175105 20492335 19812893 19426721 20452335 9163691 18648771 20118626 12771043 19499222 20101389 19256749 20137499 16942905 19294768 21071580 18754104 21047994 19254457 19642983 19850985 19073162 2422723 19996281 19090486 21167192 19551842 15885732 18977376 19833225 20434301 19427195 19255062 19638242 21278145 2862719 20583210 18978307
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.1215890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 20.1215276417 16712894
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 8.8718164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.8712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.8717174075 18775883 19004024 16267830 18164116 18544905 21159647 19539802 3124819 18079962 18093689 19009564 18253720 17854601 19126423 2563599 18282651 19519916 18308698 9362446 17942915 16842330
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.1716080182
MESH:D008171 Lung Diseases sodium arsenite 6.7919095001
MESH:D008171 Lung Diseases Vitamin E 6.7916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.1918520028 18816296 20464547 20135361 17053015 20064080 18569708 20869020 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.1920970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Methylnitrosourea 6.1918062963
MESH:D008175 Lung Neoplasms sodium arsenite 6.1919931552 17306315 17077188 16712894 15276417
MESH:D008175 Lung Neoplasms Vitamin E 6.1911062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8515166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.2615700306
MESH:D008223 Lymphoma Methylnitrosourea 7.2616257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5014633661
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2216002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.7717203775 16891317 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.7714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 12.7714999141 10767621 16944150 16827153 11751437 17131329 15313902 12931682 16619500 15688392 15113128 17020996 11807958 19196723 16051031 14633655 10838139
MESH:D008325 Mammary Neoplasms, Experimental Selenium 12.7715318939
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma sodium arsenite 3.1616487513 19082730
MESH:D008545 Melanoma Tretinoin 3.1616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D008654 Mesothelioma Selenium 2.6715107826
MESH:D009041 Motion Sickness Dextroamphetamine 5.221613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9117596541
MESH:D009203 Myocardial Infarction Genistein 2.7417141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.7717141266
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.459029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 17.8911141357
MESH:D009369 Neoplasms Diethylstilbestrol 17.8915313581
MESH:D009369 Neoplasms Methylnitrosourea 17.8915533788
MESH:D009369 Neoplasms Nicotine 17.8916365874
MESH:D009369 Neoplasms sodium arsenite 17.8911559025
MESH:D009369 Neoplasms Tretinoin 17.8916594593 16946489
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.4412696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4420056578
MESH:D009389 Neovascularization, Pathologic Estradiol 9.3817289903
MESH:D009389 Neovascularization, Pathologic Nicotine 9.3816365874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.1711399458
MESH:D009421 Nervous System Malformations Estradiol 21.1716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.1716427766
MESH:D009421 Nervous System Malformations Tretinoin 21.179125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.6812854658
MESH:D009436 Neural Tube Defects Tretinoin 6.689142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.1911555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009765 Obesity Dietary Fats 2.2121332399 19632207 18457598 20132043 16723640 18674790 11836018 20518802 17217161
MESH:D010024 Osteoporosis Genistein 3.0719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8116169203
MESH:D010051 Ovarian Neoplasms Estradiol 10.4919401270
MESH:D010051 Ovarian Neoplasms Genistein 10.4919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.4917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 10.4916936753
MESH:D010146 Pain Acetaminophen 5.8116870215
MESH:D010146 Pain Tretinoin 5.8116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.0816540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.0816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.0815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2011550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3815687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.5915087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.312563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.8417184923
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.8418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.6418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881 17566973
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3917292933
MESH:D011471 Prostatic Neoplasms bicalutamide 2.3919011039 17914592 15638997 19240160 18487222
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3915846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.3916740699
MESH:D011471 Prostatic Neoplasms Genistein 2.3916925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.3912376480 15682402
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3916039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.3915084515
MESH:D011472 Prostatitis vinclozolin 4.6418629315
MESH:D011507 Proteinuria Tretinoin 3.3316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0215861022 16919318
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1918172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1911555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8316116481 16283617
MESH:D012640 Seizures Nicotine 3.6117873105
MESH:D012871 Skin Diseases Vitamin E 2.3618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.4110029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 12.4119524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.418532709
MESH:D012878 Skin Neoplasms Tretinoin 12.4116467112
MESH:D013088 Spermatocele Diethylstilbestrol 10.7116709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.482093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4818456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.4815930296 16257854 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 4.4817261132
MESH:D020521 Stroke Vitamin E 3.2916517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.9411418001
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.817505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 10.813078959 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.8116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5216785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.1617979512 18041664 15735609 18305452
MESH:D014062 Tongue Neoplasms Tretinoin 3.5316051514
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 11.0211144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.0217053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.0216452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.0217306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.4116175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.4111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.4116129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.5415809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2815869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04971 Gastric acid secretion
KEGG:04670 Leukocyte transendothelial migration
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162385512
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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