Gene Symbol:	VIM ( FLJ36605 )
Gene Full Name:	vimentin
Band:	10p13
Quick Links	Entrez ID:7431; OMIM: 193060; Uniprot ID:VIME_HUMAN; ENSEMBL ID: ENSG00000026025; HGNC ID: 12692
Relate to Another Database:	SFARIGene; denovo-db

Desease ID	Desease Name
1990	Skin disease, Genetic
1827	Bone metastases
1831	Prostate cancer
1847	Alimentary system disease
1860	Brain tumor
1944	Breast cancer
2009	Sarcoma
2027	Connective tissue disease
2029	Tuberculosis

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C097240	15-deoxy-delta(12,14)-prostaglandin J2	15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of VIM	decreases expression	15254749
C024709	2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone	2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to VIM protein	affects binding	16533022
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of VIM mRNA	increases expression	14600272
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of VIM mRNA	increases expression	18648102
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of VIM mRNA	decreases expression	18289764
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of VIM mRNA	increases expression	14600272
D000082	Acetaminophen	Acetaminophen affects the expression of VIM mRNA	affects expression	17562736
D000109	Acetylcholine	VIM protein affects the susceptibility to [Acetylcholine co-treated with Cyclic GMP co-treated with Indomethacin]	affects cotreatment\|affects response to substance	11588525
D000109	Acetylcholine	VIM protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin]	affects cotreatment\|affects response to substance	11588525
D020106	Acrylamide	Acrylamide inhibits the reaction [VIM protein binds to VIM protein]	affects binding\|decreases reaction	16876394
D006710	Homocysteine	Homocysteine results in increased expression of VIM protein	increases expression	17485853
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of VIM mRNA	decreases expression	18247414
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of VIM mRNA	affects expression	16483693
D001149	Arsenates	Arsenates results in decreased expression of VIM mRNA	decreases expression	12773770
D001414	Bacitracin	Bacitracin results in increased expression of VIM mRNA	increases expression	18289764
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VIM mRNA	affects cotreatment\|increases expression	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of VIM mRNA	decreases expression	18247414
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of VIM protein	decreases expression	15050405
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of VIM mRNA	affects cotreatment\|decreases expression	12634122
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of VIM mRNA	increases expression	15056808 18038451
D002251	Carbon Tetrachloride	PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of VIM mRNA]	affects reaction\|increases expression	18038451
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of VIM mRNA	affects expression	12734012
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of VIM protein	increases expression	12629582
C023600	chromium oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of VIM mRNA	affects cotreatment\|decreases expression	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of VIM mRNA	affects cotreatment\|decreases expression	12634122
D002995	Clofibric Acid	Clofibric Acid affects the expression of VIM mRNA	affects expression	17602206
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of VIM mRNA	affects expression	10859244
C014347	decitabine	decitabine results in increased expression of VIM mRNA	increases expression	19194470
C014347	decitabine	decitabine results in increased expression of VIM protein	increases expression	18025290
D016190	Carboplatin	Carboplatin results in decreased expression of VIM mRNA	decreases expression	18172885
D002945	Cisplatin	Cisplatin results in decreased expression of VIM mRNA	decreases expression	18172885
D002945	Cisplatin	Cisplatin results in increased expression of VIM mRNA	increases expression	18289764
D002945	Cisplatin	Cisplatin results in increased expression of VIM protein	increases expression	15033597 16837816
D002945	Cisplatin	Selenium inhibits the reaction [Cisplatin results in increased expression of VIM protein]	decreases reaction\|increases expression	16837816
D004041	Dietary Fats	Dietary Fats results in increased expression of VIM mRNA	increases expression	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of VIM protein	decreases expression	19344669
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of VIM mRNA	increases expression	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of VIM mRNA]	decreases reaction\|increases expression	17942915
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VIM mRNA	affects cotreatment\|increases expression	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of VIM mRNA	increases expression	19638242
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of VIM protein	affects cotreatment\|increases expression	20935162
D002117	Calcitriol	Calcitriol results in decreased expression of VIM mRNA	decreases expression	16129123
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of VIM mRNA	increases expression	14600272
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of VIM protein	affects cotreatment\|decreases expression	16144979
D004317	Doxorubicin	Doxorubicin results in decreased expression of VIM mRNA	decreases expression	16243910
D004317	Doxorubicin	Doxorubicin results in increased expression of VIM protein	increases expression	16144979
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VIM mRNA	affects cotreatment\|increases expression	17942748
D005839	Gentamicins	Gentamicins results in decreased expression of VIM mRNA	decreases expression	18172885
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins affects the expression of VIM protein	affects expression	16414080
D006152	Cyclic GMP	VIM protein affects the susceptibility to [Acetylcholine co-treated with Cyclic GMP co-treated with Indomethacin]	affects cotreatment\|affects response to substance	11588525
D017313	Fenretinide	Cholecalciferol promotes the reaction [Fenretinide results in decreased expression of VIM]	decreases expression\|increases reaction	17024972
D017313	Fenretinide	Fenretinide results in decreased expression of VIM	decreases expression	17024972
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of VIM protein	decreases expression	18025290
D007213	Indomethacin	VIM protein affects the susceptibility to [Acetylcholine co-treated with Cyclic GMP co-treated with Indomethacin]	affects cotreatment\|affects response to substance	11588525
D007213	Indomethacin	VIM protein affects the susceptibility to [Acetylcholine co-treated with Indomethacin]	affects cotreatment\|affects response to substance	11588525
D007213	Indomethacin	Indomethacin results in increased expression of VIM mRNA	increases expression	18299717
D007654	Ketoconazole	Ketoconazole affects the expression of VIM mRNA	affects expression	18289764
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of VIM mRNA	affects cotreatment\|decreases expression	12634122
D019216	Metals, Heavy	Metals, Heavy results in decreased expression of VIM mRNA	decreases expression	12773770
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of VIM protein	decreases expression	18959786
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of VIM mRNA	increases expression	12773770 12634122
C008493	methylselenic acid	methylselenic acid results in increased expression of VIM mRNA	increases expression	18548127
C001478	N(6)-(delta(2)-isopentenyl)adenine	N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of VIM mRNA	decreases expression	16129123
D009255	Nafenopin	Nafenopin results in increased expression of VIM protein	increases expression	10903494
D009538	Nicotine	Nicotine results in decreased expression of VIM mRNA	decreases expression	18247414
D009588	Nitrogen Mustard Compounds	Nitrogen Mustard Compounds results in decreased expression of VIM mRNA	decreases expression	17192600
D009588	Nitrogen Mustard Compounds	Nitrogen Mustard Compounds results in decreased expression of VIM protein	decreases expression	17192600
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of VIM protein	increases expression	15816005
C510003	nordy	nordy results in decreased expression of VIM protein	decreases expression	18232056
D010126	Ozone	Ozone results in increased expression of VIM mRNA	increases expression	16716893
C041786	palm oil	palm oil results in increased expression of VIM mRNA	increases expression	18042831
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of VIM protein	affects cotreatment\|increases expression	20935162
C006253	pirinixic acid	pirinixic acid results in increased expression of VIM mRNA	increases expression	18301758
C052785	rebamipide	rebamipide results in increased expression of VIM mRNA	increases expression	18299717
D012643	Selenium	Selenium results in increased expression of VIM mRNA	increases expression	19244175
D012643	Selenium	Selenium deficiency results in increased expression of VIM protein	increases expression	17109141
D012643	Selenium	Selenium inhibits the reaction [Cisplatin results in increased expression of VIM protein]	decreases reaction\|increases expression	16837816
C009277	sodium arsenate	sodium arsenate results in decreased expression of VIM mRNA	decreases expression	16882884
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of VIM mRNA	affects cotreatment\|decreases expression	12634122
D018038	Sodium Selenite	Sodium Selenite results in increased expression of VIM mRNA	increases expression	18175754
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of VIM mRNA	decreases expression	16443690
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VIM mRNA	affects cotreatment\|increases expression	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of VIM mRNA	decreases expression	20159946
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of VIM protein	decreases expression	16548065
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of VIM protein	increases expression	19201780
D019772	Topotecan	VIM protein affects the susceptibility to Topotecan	affects response to substance	16217747
D014112	Toxaphene	CAT protein inhibits the reaction [Toxaphene results in increased degradation of VIM protein]	decreases reaction\|increases degradation	12139946
D014112	Toxaphene	Toxaphene results in increased degradation of VIM protein	increases degradation	12139946
D014212	Tretinoin	Tretinoin results in decreased expression of VIM mRNA	decreases expression	16129123 17218384 17045167
D014212	Tretinoin	Tretinoin results in decreased expression of VIM mRNA	decreases expression	16604517
D014640	Vancomycin	Vancomycin results in increased expression of VIM mRNA	increases expression	18289764
C025643	vinclozolin	vinclozolin affects the expression of VIM mRNA	affects expression	19015723
D002762	Cholecalciferol	Cholecalciferol promotes the reaction [Fenretinide results in decreased expression of VIM]	decreases expression\|increases reaction	17024972
D002762	Cholecalciferol	Cholecalciferol results in decreased expression of VIM	decreases expression	17024972

Pathway ID	Pathway Name
	Apoptosis
	Muscle contraction

Pathway ID	Pathway Name
200148	Caspase cascade in apoptosis
200010	Aurora B signaling

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Diethylhexyl Phthalate	10.54	6734493
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	10.54	6195326
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	10.54	11752688 14514962 15322242
MESH:D000138	Acidosis	Ammonium Chloride	2.90	18287403
MESH:D000152	Acne Vulgaris	Ethinyl Estradiol	3.27	17505938
MESH:D058186	Acute Kidney Injury	Cisplatin	7.16	12690470 15814532 17670903
MESH:D058186	Acute Kidney Injury	Gentamicins	7.16	11274264
MESH:D055371	Acute Lung Injury	pirinixic acid	2.51	18653653
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	17.39	20127859 20464547
MESH:D000230	Adenocarcinoma	Cisplatin	17.39	17638652 11798837
MESH:D000230	Adenocarcinoma	Dimethylnitrosamine	17.39	16033868
MESH:D000230	Adenocarcinoma	Doxorubicin	17.39	17418594
MESH:D000230	Adenocarcinoma	Ethinyl Estradiol	17.39	14692618
MESH:D000230	Adenocarcinoma	Fenretinide	17.39	10697514
MESH:D000230	Adenocarcinoma	Indomethacin	17.39	16537180
MESH:D000236	Adenoma	4,4'-diaminodiphenylmethane	25.20	3712494
MESH:D000236	Adenoma	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	25.20	16176798
MESH:D000236	Adenoma	Benzo(a)pyrene	25.20	6695378
MESH:D000236	Adenoma	beta-Naphthoflavone	25.20	19389873
MESH:D000236	Adenoma	Diethylnitrosamine	25.20	10737359 6695378
MESH:D000236	Adenoma	Dimethylnitrosamine	25.20	19555203
MESH:D000236	Adenoma	Indomethacin	25.20	11497255
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	19.44	17620307 17162532 18056438 19061943 19052882 16434500
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	19.44	17620307
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	19.44	16434500
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	19.44	16835633
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	4.02	15276417
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	4.22	17306315 16712894
MESH:D000382	Agricultural Workers' Diseases	Toxaphene	4.60	16132792
MESH:D000419	Albuminuria	Doxorubicin	3.91	21441931
MESH:D000505	Alopecia	Tretinoin	3.08	15955085
MESH:D016301	Alveolar Bone Loss	Indomethacin	4.69	17225004
MESH:D000544	Alzheimer Disease	Indomethacin	7.88	17627676 15579461
MESH:D000544	Alzheimer Disease	Metals, Heavy	7.88	17430250
MESH:D000544	Alzheimer Disease	Nicotine	7.88	16627626
MESH:D000544	Alzheimer Disease	Ozone	7.88	15513908
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	2.37	11748828
MESH:D000799	Angioedema	Acetaminophen	3.17	10982225
MESH:D001008	Anxiety Disorders	vinclozolin	3.10	19015723
MESH:D001014	Aortic Aneurysm	Indomethacin	4.22	10231640

Pathway ID	Pathway Name
REACT:578	Apoptosis
REACT:17044	Muscle contraction

AutismKB 2.0

Annotation Detail for VIM

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics