AutismKB 2.0

Annotation Detail for VIP


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Basic Information Top
Gene Symbol:VIP ( MGC13587,PHM27 )
Gene Full Name: vasoactive intestinal peptide
Band: 6q25.2
Quick LinksEntrez ID:7432; OMIM: 192320; Uniprot ID:VIP_HUMAN; ENSEMBL ID: ENSG00000146469; HGNC ID: 12693
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by GPCR
No data
No data
Pathway IDPathway Name
500430Glucagon-type ligand receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1831Prostate cancer
1943Adenocarcinoma
1944Breast cancer
2025Polyarthritis
1998Enteritis
2091Hypertension
2070Cholelithiasis
2158Pulmonary hypertension
2220Dermatitis
2231Arthritis
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000242 Cyclic AMP [VIP protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMPaffects binding|increases abundance 7733904
D000242 Cyclic AMP VIP protein results in increased abundance of Cyclic AMPincreases abundance 2859561
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VIP mRNAaffects expression 16483693
D001971 Bromocriptine [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]affects cotreatment|decreases reaction|increases expression 15677882
D001971 Bromocriptine Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]decreases reaction|increases expression 15677882
D001971 Bromocriptine Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]decreases reaction|increases expression 15677882
D003474 Curcumin Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]decreases reaction|increases activity 19189304
D003474 Curcumin Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]decreases reaction|increases activity 19189304
D003474 Curcumin Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]decreases reaction|increases expression 19189304
D003474 Curcumin Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]decreases reaction|increases expression 17434257
D003520 Cyclophosphamide VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of CXCL1 protein]decreases reaction|increases expression 18483878
D003520 Cyclophosphamide VIP protein inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]decreases reaction|increases expression 18483878
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of VIP mRNAincreases expression 15620428
D004054 Diethylstilbestrol [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]affects cotreatment|decreases reaction|increases expression 15677882
D004054 Diethylstilbestrol Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]decreases reaction|increases expression 15677882
D004054 Diethylstilbestrol Bromocriptine inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]decreases reaction|increases expression 15677882
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of VIP mRNAincreases expression 15677882
17005392
12960047
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of VIP proteinincreases expression 12960047
15677882
D004054 Diethylstilbestrol vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- promotes the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]increases expression|increases reaction 15677882
C046318 dopexamine VIP protein affects the susceptibility to dopexamineaffects response to substance 9890401
D006632 Histamine VIP protein results in increased secretion of Histamineincreases secretion 11164953
C022838 nickel chloride [nickel chloride co-treated with VIP protein] results in increased secretion of VEGFA proteinaffects cotreatment|increases secretion 16563610
C022838 nickel chloride nickel chloride results in increased expression of VIP mRNAincreases expression 16563610
C022838 nickel chloride nickel chloride results in increased expression of VIP proteinincreases expression 16563610
D010126 Ozone Ozone results in increased expression of VIP proteinincreases expression 15127121
15144609
D010269 Paraquat VIP protein results in decreased susceptibility to Paraquatdecreases response to substance 16999955
D010656 Phenylephrine VIP protein affects the susceptibility to Phenylephrineaffects response to substance 11728430
C006253 pirinixic acid pirinixic acid results in decreased expression of VIP mRNAdecreases expression 17426115
D019257 Quinpirole ADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein]affects cotreatment|increases response to substance 12223546
C048507 vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- [Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of VIP protein]affects cotreatment|decreases reaction|increases expression 15677882
C048507 vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- promotes the reaction [Diethylstilbestrol results in increased expression of VIP mRNA]increases expression|increases reaction 15677882
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5016434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7811874814
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1117887948
MESH:D000544 Alzheimer Disease Curcumin 4.4015590663
MESH:D000544 Alzheimer Disease Ozone 4.4015513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4915469931
MESH:D000855 Anorexia Quinpirole 6.0612183048
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1117460149
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.6115014928
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.8416807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8415570426
MESH:D001249 Asthma Histamine 5.5316387687
MESH:D001249 Asthma Ozone 5.5316373670 17854713
MESH:D050197 Atherosclerosis Curcumin 3.3218704882
MESH:D001321 Autistic Disorder marker/mechanism 17521630
MESH:D001327 Autoimmune Diseases Curcumin 4.5019761891
MESH:D001480 Basal Ganglia Diseases Bromocriptine 6.7815303389
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1519483382
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D002545 Brain Ischemia Curcumin 4.3516770732
MESH:D001932 Brain Neoplasms Curcumin 3.9417596214
MESH:D001943 Breast Neoplasms Curcumin 2.1218593918 19250217 16243823 18462866
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.1215093573 16978400 17020986 18234424 17388661 18323546 15136595 11325840 12006526
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.1217129689 15324884
MESH:D016535 Bronchial Hyperreactivity marker/mechanism 15127121 15144609
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6816777450 18417511 17626835 18315731 14754758 15516495 19059883
MESH:D001986 Bronchial Spasm Histamine 5.8518298128
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002277 Carcinoma Curcumin 3.8418593918
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.4519701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.4516924424 15948411
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.9116152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9818414057
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5416201981
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7618462866
MESH:D006332 Cardiomegaly Phenylephrine 3.5311179087 16170337 17124262 15728586 17287366 11754973
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D003092 Colitis Curcumin 4.1918200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.5518809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5016340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 4.9118497527
MESH:D003456 Cryptorchidism Dibutyl Phthalate 11.8116037377
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.8116002989 12952375
MESH:D003556 Cystitis Cyclophosphamide 5.0216989017 10700343 18093676 11948286 16413132 18483878 10498854 17979934 12388444 15643279 16614059 16651033 15276878 18710439 17010015 12161096 12913760 18295254 18433785 18372110
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.0710990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2218772604
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7018403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.0118204486
MESH:D004314 Down Syndrome marker/mechanism 16289943
MESH:D004381 Duodenal Ulcer Curcumin 4.0617351913
MESH:D004487 Edema pirinixic acid 2.4912083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.4715700306 16804899
MESH:D004802 Eosinophilia Cyclophosphamide 9.6411006010
MESH:D004802 Eosinophilia Histamine 9.6412689652
MESH:D005234 Fatty Liver Curcumin 7.8919297423
MESH:D005234 Fatty Liver pirinixic acid 7.8920131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6616534752 16611131 15751030 16513791 16002989
MESH:D005355 Fibrosis Curcumin 4.0018705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7118462866
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.9716452187
MESH:D005909 Glioblastoma Curcumin 3.4817596214
MESH:D018316 Gliosarcoma Cyclophosphamide 5.5311389073
MESH:D005911 Gliosis Paraquat 5.1911124998
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.0511014644 15172196 16376943
MESH:D006258 Head and Neck Neoplasms Curcumin 3.6618462866 18829502
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006467 Hemophilia A Cyclophosphamide 5.3011918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.5614986274
MESH:D006529 Hepatomegaly pirinixic acid 3.0116221962 19176532 19772884 18467677
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.0517701891
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.7916135485 17606976
MESH:D006937 Hypercholesterolemia Curcumin 4.0618704882
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4512960047 14722030
MESH:D006973 Hypertension Phenylephrine 3.078949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 4.5618502941 12791704
MESH:D007021 Hypospadias Diethylstilbestrol 4.5916002989
MESH:D007154 Immune System Diseases Cyclophosphamide 5.3616076520
MESH:D007246 Infertility Diethylstilbestrol 4.3615036965
MESH:D007248 Infertility, Male Cyclophosphamide 7.1616517039 7193160
MESH:D007248 Infertility, Male Paraquat 7.164850670
MESH:D007249 Inflammation Curcumin 2.8916956363 18403477 17151092
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2118200517 18596194
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007414 Intestinal Neoplasms Curcumin 4.2210783313
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.4614681315 16762066 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0717184923
MESH:D007889 Leiomyoma Curcumin 4.5818555241
MESH:D007938 Leukemia Curcumin 6.7618462866
MESH:D007938 Leukemia Cyclophosphamide 6.7610602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5018587576 18172266 17802794 17008537 17296974 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.2116106398
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0910373061
MESH:D015458 Leukemia, T-Cell Curcumin 4.7716106398
MESH:D007970 Leukopenia Cyclophosphamide 4.9910052129 11830472
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5215474484
MESH:D008107 Liver Diseases Curcumin 2.6116956363
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.5915890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 4.5916377806 15890375 20007298
MESH:D008171 Lung Diseases Ozone 3.388266340 19066396
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms Curcumin 2.7619359593 16243823 18462866
MESH:D008175 Lung Neoplasms Ozone 2.768597069 7614698
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1715166399
MESH:D008223 Lymphoma Curcumin 12.7218462866
MESH:D008223 Lymphoma Cyclophosphamide 12.7212854902
MESH:D008223 Lymphoma Diethylstilbestrol 12.7215700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.6016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.1711911406
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7116173963
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5516002989
MESH:D008545 Melanoma Curcumin 4.0517885582 18462866
MESH:D008545 Melanoma Histamine 4.0517709802
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.8116388313
MESH:D008569 Memory Disorders Curcumin 4.1617263510
MESH:D008607 Mental Retardation marker/mechanism 11357950
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D020326 Migraine without Aura Cyclic AMP 5.1611304026
MESH:D009101 Multiple Myeloma Curcumin 3.5119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.9417962980
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.3818495463
MESH:D009362 Neoplasm Metastasis marker/mechanism 19189304
MESH:D009369 Neoplasms Cyclophosphamide 8.3818854779
MESH:D009369 Neoplasms Diethylstilbestrol 8.3815313581
MESH:D009369 Neoplasms pirinixic acid 8.3817405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.5612497104
MESH:D009410 Nerve Degeneration Paraquat 3.7216893418
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.1411399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.6618462866
MESH:D009447 Neuroblastoma Cyclophosphamide 3.6415176712 8761367 16115947
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.918761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.338291058
MESH:D009765 Obesity Curcumin 4.6019297423
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D009845 Oligospermia Cyclophosphamide 4.7316517039
MESH:D010024 Osteoporosis Curcumin 3.4718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8219020741 18462866
MESH:D010146 Pain Cyclophosphamide 3.6312161096 18093676
MESH:D010190 Pancreatic Neoplasms Curcumin 5.7117440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.7111332152
MESH:D010300 Parkinson Disease Bromocriptine 6.2418328768 9918342
MESH:D010300 Parkinson Disease Paraquat 6.2411124998 16140633 15451049 16510128 12911755 15824117 11181820 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.4416190885
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6816977796 15687265
MESH:D011014 Pneumonia Ozone 11.1318007984 18381685 18929643
MESH:D011014 Pneumonia Paraquat 11.1312504350
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8021297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.1317184923
MESH:D011471 Prostatic Neoplasms marker/mechanism 19189304
MESH:D011471 Prostatic Neoplasms Curcumin 2.7718226269 11398177 18156803 18769126 12497104 15129424 10851300
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.7717136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.7717136230 15846301 15046698
MESH:D011656 Pulmonary Emphysema Curcumin 4.5319168576
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 6.0016636934
MESH:D011658 Pulmonary Fibrosis Paraquat 6.0016324872 17997886
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 9.2918379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 9.2911700416
MESH:D012135 Respiratory Sounds Paraquat 4.0711874814
MESH:D012162 Retinal Degeneration Paraquat 3.8716458197
MESH:D012220 Rhinitis marker/mechanism 12746121
MESH:D012220 Rhinitis Histamine 4.9812689652
MESH:D012509 Sarcoma Curcumin 4.1218462866
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.8316636934
MESH:D018805 Sepsis Curcumin 4.0818389075
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D013088 Spermatocele Diethylstilbestrol 4.7416709447 16002989
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.5316517039
MESH:D013276 Stomach Ulcer Curcumin 3.5016631530 19188055
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.0812837982
MESH:D013610 Tachycardia marker/mechanism 3261545
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.5518593936
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.5514692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.5517306315 16712894 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 5.2818462866
MESH:D014581 Urticaria Histamine 5.0518298128
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.0815809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4516002989 16513791
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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