AutismKB 2.0

Annotation Detail for VIPR2


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Basic Information Top
Gene Symbol:VIPR2 ( FLJ16511,VPAC2,VPCAP2R )
Gene Full Name: vasoactive intestinal peptide receptor 2
Band: 7q36.3
Quick LinksEntrez ID:7434; OMIM: 601970; Uniprot ID:VIPR2_HUMAN; ENSEMBL ID: ENSG00000106018; HGNC ID: 12695
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1877Multiple sclerosis
1924Gallbladder disease
2025Polyarthritis
2052Infection
2070Cholelithiasis
2231Arthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000242 Cyclic AMP [ADCYAP1 protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMPaffects binding|increases abundance 7733904
D000242 Cyclic AMP [VIP protein binds to VIPR2 protein] which results in increased abundance of Cyclic AMPaffects binding|increases abundance 7733904
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VIPR2 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of VIPR2 mRNAincreases expression 20678512
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of VIPR2 mRNAaffects cotreatment|affects expression 18636392
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VIPR2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of VIPR2 mRNAincreases expression 18035473
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of VIPR2 mRNAdecreases expression 12057914
C030589 methylmercury cysteine methylmercury cysteine results in increased expression of VIPR2 mRNAincreases expression 19465457
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of VIPR2 mRNAaffects cotreatment|affects expression 18636392
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VIPR2 mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VIPR2 mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VIPR2 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000169 Acrodermatitis Zinc 5.5617190629 17202136 16889938
MESH:D055371 Acute Lung Injury Chlorine 9.8820601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.8811850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000544 Alzheimer Disease Ozone 4.5315513908
MESH:D000544 Alzheimer Disease Zinc 4.5316325427 17119284 16410023 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0316916123
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 5.2817854713 16373670
MESH:D001249 Asthma Zinc 5.2817085522
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001930 Brain Injuries Zinc 4.8317109824
MESH:D001943 Breast Neoplasms bisphenol A 2.0417123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7619059883 14754758 18417511 15516495 17626835 16777450 18315731
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.2218922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.2216543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Zinc 3.7316936243
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9516105132 17110522 16919318 15861022 17333356 11677210 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 15668235 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 2.7019302082
MESH:D003920 Diabetes Mellitus Zinc 4.3016479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004417 Dyspnea Chlorine 4.8020016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3211000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.328113982 8273558 11698051 7812673 16716910 15177302 9599246
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5517637181 15328337 15821434
MESH:D004938 Esophageal Neoplasms Zinc 2.8816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005334 Fever Lipopolysaccharides 4.129205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005739 Gas Poisoning Chlorine 5.1820016425
MESH:D005756 Gastritis Zinc 4.9717241300
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006130 Growth Disorders Zinc 4.0317217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006333 Heart Failure Zinc 3.6717162251
MESH:D006335 Heart Injuries Zinc 5.9417074742
MESH:D016481 Helicobacter Infections Zinc 4.6517241300
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8317276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16354765 15340226 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Flavonoids 12.4717296493
MESH:D007249 Inflammation Lipopolysaccharides 12.4717255318 17237260 17963957 9205823 12878042
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.4712878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 12.477812673 15177302 7562506 8273558 11698051
MESH:D007333 Insulin Resistance bisphenol A 3.3616393666
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D007511 Ischemia Zinc 4.7716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Zinc 3.3816960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5316518626
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases Ozone 3.458266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 9.7121114838
MESH:D055370 Lung Injury Ozone 9.7120417186
MESH:D008175 Lung Neoplasms Ozone 3.577614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5719555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.5711807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.748985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.7412773700
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D020326 Migraine without Aura Cyclic AMP 5.2811304026
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009421 Nervous System Malformations bisphenol A 10.0116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0114600291
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.4318922899 18404319 8330346 12065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D011014 Pneumonia Lipopolysaccharides 11.6211605937 12224865
MESH:D011014 Pneumonia Ozone 11.6218007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011225 Pre-Eclampsia Zinc 4.2617114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.0310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0311896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5116740699
MESH:D011471 Prostatic Neoplasms Zinc 3.5116606632 16700911 16517595 12429649
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D012120 Respiration Disorders Chlorine 5.3918579056
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration Zinc 4.2116584753
MESH:D012559 Schizophrenia marker/mechanism 21285140
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9716192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.9718404319 8330346 8985016 12065085 11807781
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416045194 16684133
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014062 Tongue Neoplasms Zinc 4.5016543248
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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