AutismKB 2.0

Annotation Detail for VLDLR


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Basic Information Top
Gene Symbol:VLDLR ( CARMQ1,CHRMQ1,FLJ35024,VLDLRCH )
Gene Full Name: very low density lipoprotein receptor
Band: 9p24.2
Quick LinksEntrez ID:7436; OMIM: 192977; Uniprot ID:VLDLR_HUMAN; ENSEMBL ID: ENSG00000147852; HGNC ID: 12698
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1840Macular degeneration
2052Infection
2069Schizophrenia
2259Hereditary disease
Desease Name
Alzheimer's disease
Lp(a)
PSYCH
NEUROLOGICAL
METABOLIC
diabetes, type 2
Dementia
No data
Desease Name
Cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of VLDLR mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of VLDLR mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of VLDLR mRNAaffects expression 15030884
17562736
C103505 AM 251 AM 251 results in increased expression of VLDLR mRNAincreases expression 16500647
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VLDLR mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of VLDLR mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VLDLR mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VLDLR mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of VLDLR mRNAincreases expression 12075121
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of VLDLR proteinincreases expression 12629582
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of VLDLR mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of VLDLR mRNAincreases expression 20105288
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of VLDLR mRNA]decreases expression|decreases reaction 11007951
D016572 Cyclosporine Cyclosporine affects the expression of VLDLR mRNAaffects expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of VLDLR mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of VLDLR mRNAdecreases expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of VLDLR mRNAincreases expression 15901920
12075121
D005473 Fluoxetine Fluoxetine results in increased expression of VLDLR proteinincreases expression 19359144
D005485 Flutamide Flutamide analog results in increased expression of VLDLR mRNAincreases expression 17702527
D005485 Flutamide Flutamide results in increased expression of VLDLR mRNAincreases expression 17702527
C001277 geldanamycin geldanamycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]decreases expression|decreases reaction 15808840
C056507 gemcitabine gemcitabine results in increased expression of VLDLR mRNAincreases expression 17039268
D019833 Genistein Genistein results in increased expression of VLDLR mRNAincreases expression 12075121
D006220 Haloperidol Haloperidol results in increased expression of VLDLR proteinincreases expression 19359144
C020754 herbimycin herbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]decreases expression|decreases reaction 15808840
C005219 methyl cellosolve methyl cellosolve results in increased expression of VLDLR mRNAincreases expression 19643169
C035359 monorden monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]decreases expression|decreases reaction 15808840
C076029 olanzapine olanzapine results in increased expression of VLDLR proteinincreases expression 19359144
C041786 palm oil palm oil results in decreased expression of VLDLR mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of VLDLR mRNAincreases expression 17681415
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of VLDLR mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital affects the expression of VLDLR mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of VLDLR mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of VLDLR mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid affects the expression of VLDLR mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of VLDLR mRNAincreases expression 18301758
17426115
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of VLDLR mRNA]increases expression|increases reaction 17950772
C009159 rapeseed oil rapeseed oil affects the expression of VLDLR mRNAaffects expression 16177195
D012402 Rotenone Rotenone results in increased expression of VLDLR mRNAincreases expression 17702527
D014284 Triiodothyronine Triiodothyronine results in increased expression of VLDLR mRNAincreases expression 17403546
D013629 Tamoxifen Tamoxifen affects the expression of VLDLR mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of VLDLR mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VLDLR mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of VLDLR mRNAincreases expression 19933214
16960034
18372398
16120747
19465110
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of VLDLR mRNAaffects binding|increases expression 20105288
D014635 Valproic Acid Valproic Acid results in decreased expression of VLDLR mRNAdecreases expression 19359144
D014635 Valproic Acid Valproic Acid results in decreased expression of VLDLR proteindecreases expression 19359144
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1614745880
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 17.253652986 6499812 6474471
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.256195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.2511752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 17.258875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5919490988
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.2611798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.2614692618
MESH:D000230 Adenocarcinoma Genistein 9.2611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.843712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.846695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.0817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.0816835633
MESH:D000550 Amblyopia Valproic Acid 4.8417688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 5.963699323
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001008 Anxiety Disorders Fluoxetine 8.3318083778
MESH:D001008 Anxiety Disorders Valproic Acid 8.3317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7019183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.6715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4315885639
MESH:D053627 Asthenozoospermia methyl cellosolve 5.143987992
MESH:D001284 Atrophy methyl cellosolve 4.832626667 3699323 6705890
MESH:D001321 Autistic Disorder marker/mechanism 15820235
MESH:D001321 Autistic Disorder Acetaminophen 3.3518445737
MESH:D001321 Autistic Disorder Fluoxetine 3.3519232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 3.3518080171 19368416
MESH:D001321 Autistic Disorder olanzapine 3.3518685284 17069543
MESH:D001321 Autistic Disorder Valproic Acid 3.3518558336 18316065 15238991 17157402 18940202 17507914 18985861 20603192 16609825 18775368 19460635 17688650 19232924 18177632 18396377
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.631440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.8817594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.3116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.208888407
MESH:D001862 Bone Resorption bisphenol A 3.5211985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.3817474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 4.3817123778
MESH:D001943 Breast Neoplasms Cobalt 4.3815986119
MESH:D001943 Breast Neoplasms Dietary Fats 4.3820435547
MESH:D001943 Breast Neoplasms gemcitabine 4.3818382427 17039268
MESH:D001943 Breast Neoplasms Genistein 4.3816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tamoxifen 4.3819011961 18984771 16873071 19200415 21138602 18855134 20390343 18997820 19288272 19244106 17049068 19189210 15668708 19142967 20859285 20135344 19487384 19155303 19410462 17242785 17440819 18821012 16273361 20065188 16202921 17261762 19059307 19066611 19084267 18629630 18425577 17893378 18815881 19103187 20005174 19221464 19289846 11161223 16818667 20544844 18351453 19189212 19115204 15565566 21152245
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9811589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4110355542 16192424 16124888 16050911 16011737 15673190 15700767 16227642 16097048 3786805 18705752 15721981
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 12.987296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.983084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 12.9815073043 16217749 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 12.9818788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 12.9816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 12.9817173139 1701930 20007298 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.9816924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6117123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.497296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9420419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.0416332659
MESH:D002375 Catalepsy Haloperidol 4.5315215559 1977408
MESH:D002386 Cataract Acetaminophen 2.3610977129
MESH:D002389 Catatonia olanzapine 5.8616772815 18071103
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.617505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.6112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.884080065
OMIM:224050 CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 1 marker/mechanism
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002764 Cholecystitis methyl cellosolve 5.416499794
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.9019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 16.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.9017681005 17333356 16105132 17110522 16919318 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 16.9019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9416354765 15668235 12621046 15340226 8697196
MESH:D003110 Colonic Neoplasms Genistein 2.2217182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8520501625
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.3712530607 6499821
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.3714669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.5016575769 8888407 17688650
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 9.7515213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 9.7520210726
MESH:D003704 Dementia Haloperidol 4.2411575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003866 Depressive Disorder Fluoxetine 4.3315014590
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.0611298694 12868966 8970840 2524372 14531868 11906362 18759878 8156756
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 6.0616823706 11298694 15059100
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.143621924 2952479
MESH:D002658 Developmental Disabilities olanzapine 4.4317069543
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.9816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 10.667440962 18648102 6679447 11289319 16192314 6482804 9022650 9653073 1440618 18289764 18692083 9328219 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.6611743745 19923254 14550746 17562736 12540782 11834606 12153990 12958197 18713872 16081117 19416960 12594235 11739529 16109766 14725611 10663392 16781746 11421492 11529661 16393943 11461765 12392966 2444490 11287661 19739265 19420014 19370779 17522070 15968718 19085960 18071297 19164858 17906064 12705907 16177239 10915739 14986274 16485898 15619225 16227642 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.6617522070 7440962 11566570 10092053 15998439 16177239 4309450 2869522 3786805 16227642 19336974 21278145 6623471 7179309 15968718 3732212 7120509 10915739 6884620 15027814 9327722 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.6620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.6619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1818367378
MESH:D004421 Dystonia Phenobarbital 9.271851702
MESH:D004421 Dystonia Valproic Acid 9.271851702
MESH:D004487 Edema Fluoxetine 13.7412798668
MESH:D004487 Edema perfluorooctanoic acid 13.7412083418 17259670
MESH:D004487 Edema pirinixic acid 13.7412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.7519031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2116402032
MESH:D016889 Endometrial Neoplasms Genistein 6.6911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.6919155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.699294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.553659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.5517275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.6811558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 8.6816628512 3922381
MESH:D004827 Epilepsy Phenobarbital 5.9920417680
MESH:D004827 Epilepsy Valproic Acid 5.9918234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.806401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.807562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.067750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.213659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.213659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.463581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.4620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.4612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.4616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005234 Fatty Liver arsenic trioxide 37.3815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 37.3816045604 17595544 61145 16239168 19224547 15959796 12795759 12631006
MESH:D005234 Fatty Liver Cyclosporine 37.3819224547
MESH:D005234 Fatty Liver Dietary Fats 37.3818296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 37.3815345470
MESH:D005234 Fatty Liver pirinixic acid 37.3819236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 37.3819224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 37.3819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.7718558336 8888407
MESH:D005327 Fetal Resorption methyl cellosolve 5.166499821 6499812 3987992 6474471
MESH:D020567 Fetal Weight methyl cellosolve 5.416474471 6499812 6499821
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.636705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.0718705752
MESH:D005355 Fibrosis Cyclosporine 18.0712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 18.0718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.0720067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.123652986
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9016904648
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D005909 Glioblastoma Genistein 3.0116598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.697505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.406499821
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006461 Hemolysis methyl cellosolve 5.0717874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.026705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.0219110552 19900420
MESH:D006529 Hepatomegaly perfluorooctanoic acid 17.643609246
MESH:D006529 Hepatomegaly Phenobarbital 17.6416109766
MESH:D006529 Hepatomegaly pirinixic acid 17.6418467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.6412621046 15340226 16120746
MESH:D019584 Hot Flashes Fluoxetine 4.9214716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6618606429 15340226 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.8716870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.8712083418
MESH:D017588 Hyperandrogenism Flutamide 5.0715356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2621332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2721332399
MESH:D006963 Hyperphagia olanzapine 5.8517933447
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5715034207
MESH:D006973 Hypertension Cobalt 7.8217039479
MESH:D006973 Hypertension Cyclosporine 7.8210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2017937319
MESH:D007248 Infertility, Male methyl cellosolve 6.203987992
MESH:D007249 Inflammation Dietary Fats 13.7020412841
MESH:D007249 Inflammation Fluoxetine 13.7012798668
MESH:D007249 Inflammation perfluorooctanoic acid 13.7012083418
MESH:D007249 Inflammation Tamoxifen 13.7019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.7012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 10.8816393666
MESH:D007333 Insulin Resistance Dietary Fats 10.8818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 10.8816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.638074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 5.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.058314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.596582329
MESH:D007680 Kidney Neoplasms Cyclosporine 10.5912371664
MESH:D007680 Kidney Neoplasms Tamoxifen 10.5918625569
MESH:D007938 Leukemia arsenic trioxide 5.7815070760
MESH:D007938 Leukemia Genistein 5.7818980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4617077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6420471514 16968895 17050201 19850784 16467208
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9617869043 19642359 15622746 15213294 12679006 12712474 16966277 17107899 19075265 11468182 19225113 19035177 9834237 16330433 16891316 16112521 12018890 11161223 15748426 16331271 17712046 17217047 16823087 17649720 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9916882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.858812269
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.226499821
MESH:D008064 Lipidoses Fluoxetine 7.4317567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.4315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.7717334410 11903743 16239168 17157831 16221502 11408273 17174718 16943688 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 9.7718296743
MESH:D008103 Liver Cirrhosis Phenobarbital 9.7721047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1415673190 17869086 17640975 16027843 17557913 12666154 12898905 18277467 15730626 15925388 18376398 15052691 15338365 15931870 12667390 16097048 18418968 17766677 13678700 18054572 18412020 16015684 12445421 18205269 12546737 17823541 17525996 18420326 18210741 17922224 12958196 18481824 17708605 15818738 17805973 15123356 16248980 17976157 18156304 18166357 18395914 17565644 18251166 15370692 15876570 17761835 12632514 18263696 17714472 16033810 14716496 16638106 12649538 18006644 18317297 16136751 10355542 14748882 16011737 18395095 17721639 12632512 16192424 17631135 18429990 12445418 18279442 18472332 15996030 12609069 12741479 15057751 14724832 18705752 15650968 18472094 15959796 15893842 16116963 14716833 12586293 20821823 17481882 15362042 14512876 18339082 17944888 14620537 18187930 17698563 12389079 11481614 17900296
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.1417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.1418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1412878042
MESH:D008107 Liver Diseases Acetaminophen 5.8311587558 12969438 12587719 16611625 19014921 19784758 19460945 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.8316964402 15720792 16246199 15830285 17285989
MESH:D008107 Liver Diseases Phenobarbital 5.8319363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3116899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 23.2214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.2221137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 23.2219294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 23.2218709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 23.2219812893 8742319 19482888 15975961 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 23.2216377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 23.2216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.2216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 16.086587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.0820377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.0815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.082563599 1399818 18308698 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 7.6615213294
MESH:D008133 Long QT Syndrome olanzapine 7.6620210726
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8717228818
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.496434250
MESH:D008175 Lung Neoplasms arsenic trioxide 4.3919825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.3920064080 17053015 20135361 18569708 20869020 20464547 18816296 18520028 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 4.3918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.3911884234 19555203
MESH:D008231 Lymphopenia methyl cellosolve 5.403699323
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.2914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.2919196723 14580682 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.1619453300
MESH:D008545 Melanoma Tamoxifen 1.8319393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D001523 Mental Disorders Fluoxetine 11.3416856516
MESH:D001523 Mental Disorders Haloperidol 11.3416856516
MESH:D001523 Mental Disorders olanzapine 11.3416856516
MESH:D008659 Metabolic Diseases olanzapine 5.0519142110
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9218765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8415949261 19417148 14977855 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.698888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.6816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.6817596541
MESH:D009203 Myocardial Infarction Genistein 5.1217141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.4217141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0917484760
MESH:D009207 Myoclonus Fluoxetine 5.508041377
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.153581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.1519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.1811141357
MESH:D009369 Neoplasms pirinixic acid 4.1817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9719348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.5915790535 18619942 17356569
MESH:D009421 Nervous System Malformations bisphenol A 14.3116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 14.3116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.686679447
MESH:D009436 Neural Tube Defects arsenic trioxide 10.6810525206
MESH:D009436 Neural Tube Defects Valproic Acid 10.6816359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5618514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.589802331
MESH:D009765 Obesity Dietary Fats 6.9418674790 17217161 20132043 18457598 20518802 16723640 11836018 19632207 21332399
MESH:D009765 Obesity olanzapine 6.9418515891
MESH:D009765 Obesity pirinixic acid 6.9420558911
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.1020418887
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.094026338 6482804
MESH:D009845 Oligospermia methyl cellosolve 4.803987992
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.633988306
MESH:D010018 Osteomalacia Phenobarbital 3.9817016548
MESH:D010024 Osteoporosis Genistein 3.0219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7416169203
MESH:D010049 Ovarian Diseases bisphenol A 4.6111985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.5316624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Genistein 4.5319005980
MESH:D010146 Pain Acetaminophen 9.8116870215
MESH:D010146 Pain AM 251 9.8118987195
MESH:D010146 Pain Fluoxetine 9.8112798668
MESH:D010190 Pancreatic Neoplasms AM 251 11.2316500647
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.2315580305
MESH:D010190 Pancreatic Neoplasms gemcitabine 11.2318992248 11504793 16929163 17440100 18383843
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.2316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.117296757
MESH:D010235 Paraganglioma arsenic trioxide 3.8119927285
MESH:D010300 Parkinson Disease Rotenone 2.8319114014 16412576 18191903 11445065 16140633 11535288 15451049 18619942 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 3.7515927086 15574749 15795934 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.086228378
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.638041377
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.6715356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.9112371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.912563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 26.4210548101
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 26.427974496 12530607 6499817
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 26.4217132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 26.4211118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 26.4220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Flutamide 1.883169114
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9316919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 10.9012752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.9011422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0916882103
MESH:D011595 Psychomotor Agitation Haloperidol 10.5811575062
MESH:D011595 Psychomotor Agitation olanzapine 10.5818685284
MESH:D011618 Psychotic Disorders Haloperidol 3.9811575062
MESH:D011629 Puberty, Precocious bisphenol A 4.4010548101
MESH:D011658 Pulmonary Fibrosis Cobalt 3.856434250
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.093692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6016646077
MESH:D012559 Schizophrenia Haloperidol 5.4119369910 20107430 1830565 18513383
MESH:D012559 Schizophrenia olanzapine 5.4120521326 20107430 17726453
MESH:D012559 Schizophrenia Valproic Acid 5.4115737665 19110320
MESH:D012640 Seizures Phenobarbital 5.143137016 11442880 4039156 16876388
MESH:D012640 Seizures Valproic Acid 5.1411044598 11738929 3137016 14763951 15475178 16876388 17978042 1511512
MESH:D003294 Seizures, Febrile Phenobarbital 4.446407741
MESH:D020230 Serotonin Syndrome Fluoxetine 5.518704074
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.8516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.2716709447
MESH:D013088 Spermatocele Tamoxifen 10.2716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6619457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1512833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.2617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2620155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 3.6016684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.7520210726
MESH:D017180 Tachycardia, Ventricular olanzapine 9.7520210726
MESH:D013733 Testicular Diseases methyl cellosolve 4.716499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.301399818 3712494 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.3019014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.301399818
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5815213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.8417262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.143119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.598074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.5911780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.5917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.598653321 17572228 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.278888407
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D014591 Uterine Diseases bisphenol A 4.6214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9414692618
MESH:D014605 Uveitis Cyclosporine 3.601336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 9.0216723640
MESH:D015430 Weight Gain olanzapine 9.0220107430 17933447 19434072
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37317
    • Releated gene ID Related gene Name
    PA37317VLDLR
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03017 - Lauric Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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