AutismKB 2.0

Annotation Detail for VRK1


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Basic Information Top
Gene Symbol:VRK1 ( MGC117401,MGC138280,MGC142070,PCH1 )
Gene Full Name: vaccinia related kinase 1
Band: 14q32.2
Quick LinksEntrez ID:7443; OMIM: 602168; Uniprot ID:VRK1_HUMAN; ENSEMBL ID: ENSG00000100749; HGNC ID: 12718
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1989Vaccinia
No data
No data
Desease Name
Pontocerebellar hypoplasia type 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of VRK1 proteinaffects expression 20106945
C015001 arsenite arsenite results in decreased expression of VRK1 mRNAdecreases expression 18929588
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of VRK1 mRNAaffects cotreatment|decreases expression 16443354
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VRK1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VRK1 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of VRK1 mRNAdecreases expression 20106945
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in decreased expression of VRK1 mRNAaffects cotreatment|decreases expression 16443354
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0016443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D001943 Breast Neoplasms Tretinoin 2.0016873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1812619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.181917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7916096774 16051514
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1712371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D003139 Common Cold Ascorbic Acid 5.9217323712
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839211117 9125849 9224671 8800419 16925845 14991402 10589399 9142499 9664655 17551590
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.1516506275
MESH:C538011 Eales disease Ascorbic Acid 5.929068938
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005124 Eye Abnormalities Tretinoin 3.7816938888 9664655
MESH:D005234 Fatty Liver arsenite 8.8918296743
MESH:D005234 Fatty Liver Cyclosporine 8.8919224547
MESH:D005355 Fibrosis arsenite 17.0718296743
MESH:D005355 Fibrosis Cyclosporine 17.0712639820 12168785
MESH:D005355 Fibrosis Tretinoin 17.0717994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 12.0416080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 12.0420471113
MESH:D006330 Heart Defects, Congenital Tretinoin 12.0414991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5516863852 16490937
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4818776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3219642359 16823087 17339181 19029980 17712046 17361223 17368321 17301526 17107899 19035177 16331271 17506722 15748426 9834237 16140955 17649720 16766008 17294898 17217047 19225113 12679006 16935935 16788101 19075265 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008103 Liver Cirrhosis arsenite 3.5518296743
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.8618177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.878603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 6.8718544905
MESH:D008171 Lung Diseases Ascorbic Acid 4.1216863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.1414755239
MESH:D008175 Lung Neoplasms arsenite 5.1416809336
MESH:D008175 Lung Neoplasms Ascorbic Acid 5.1416401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.1417053015 20064080 20135361 20464547 18520028 18816296 6695378 18569708 20869020
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms Tretinoin 5.3916594593 16946489
MESH:D009389 Neovascularization, Pathologic arsenite 4.8115738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D009765 Obesity Ascorbic Acid 3.1917217161
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:C548069 Pontocerebellar Hypoplasia Type 1 marker/mechanism
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.7814606601
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3716849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012871 Skin Diseases Ascorbic Acid 3.2718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0610029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 6.0616467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4017261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.1718726076
MESH:D020521 Stroke Ascorbic Acid 4.5116517955 16403987
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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