AutismKB 2.0

Annotation Detail for VRK2


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Basic Information Top
Gene Symbol:VRK2 ( - )
Gene Full Name: vaccinia related kinase 2
Band: 2p16.1
Quick LinksEntrez ID:7444; OMIM: 602169; Uniprot ID:VRK2_HUMAN; ENSEMBL ID: ENSG00000028116; HGNC ID: 12719
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1989Vaccinia
Desease Name
PSYCH
schizophrenia
Desease Name
Schizophrenia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A results in decreased expression of VRK2 mRNAdecreases expression 20678512
D016572 Cyclosporine Cyclosporine results in increased expression of VRK2 mRNAincreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of VRK2 mRNAincreases expression 17547211
D019800 Phenol Phenol results in increased expression of VRK2 mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VRK2 mRNAaffects binding|decreases expression|increases activity 19710929
D011794 Quercetin Quercetin results in decreased expression of VRK2 mRNAdecreases expression 15309432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 2.9416033868
MESH:D000236 Adenoma Dimethylnitrosamine 3.7119555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001859 Bone Neoplasms Phenol 5.5610556009
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001913 Bowen's Disease Phenol 6.2719293009
MESH:D001943 Breast Neoplasms bisphenol A 2.3817123778
MESH:D001943 Breast Neoplasms Quercetin 2.3818628248
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D002277 Carcinoma Dimethylnitrosamine 4.2819555203
MESH:D006528 Carcinoma, Hepatocellular Quercetin 2.3012508355 19519916
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 3.0216033868
MESH:D006332 Cardiomegaly Quercetin 3.4719794523
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002779 Cholestasis Cyclosporine 8.5319486331
MESH:D002779 Cholestasis pirinixic acid 8.5319176532
MESH:D003110 Colonic Neoplasms Quercetin 2.4616640504 17191121 19440933 19056647 17148506 11134977 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918095365 18852136
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0019496084
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 2.828172417
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.9717016578
MESH:D005234 Fatty Liver Cyclosporine 8.6619224547
MESH:D005234 Fatty Liver pirinixic acid 8.6620131406 19236843
MESH:D005355 Fibrosis Cyclosporine 10.2612168785 12639820
MESH:D005355 Fibrosis Quercetin 10.2619474275
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 16221962 19772884
MESH:D006943 Hyperglycemia pirinixic acid 10.2720558911
MESH:D006943 Hyperglycemia Quercetin 10.2718262572 11834736
MESH:D006973 Hypertension Cyclosporine 5.6310903974
MESH:D006973 Hypertension Quercetin 5.6318356687
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007333 Insulin Resistance bisphenol A 7.9616393666
MESH:D007333 Insulin Resistance pirinixic acid 7.9616306350
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D055623 Keratosis, Actinic Phenol 6.9619293009
MESH:D007674 Kidney Diseases Cyclosporine 6.678314463 18776723 10903974
MESH:D007674 Kidney Diseases Quercetin 6.6716962696
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.7717534399 15864749 15591649 17666798 14659978 17196135 15086199 15067225 15744066 16042886 18237412 15942678 18629640 17724770 15138612 15081153 18637143 15733078 15793283 14643895 17203207 17640959 17881167 17036385 15504291 17719030 15161499 14568256 15723089 16544323 18567088 15577212 16603200 18371158 15798949 15339415 16627068 15298665 16270385 15366600 17201889 14709902 18210741 16009107 17465448 16570917 15571005 16169303 14726149 15099470 15383259 17348192 12918455 15479170 15763062 15369754 18672772 12925901 17432682 18364076 18095165 15842777 15492853 17198567 18239293
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.7715474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.7712741479
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.7117457977
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 8.153113478 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 8.1515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 8.1518980244
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 6.9815603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.9819519916
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 2.9416061637 11884234 19555203
MESH:D008175 Lung Neoplasms Quercetin 2.9416280456
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 6.0919151258
MESH:D009203 Myocardial Infarction Quercetin 6.0919595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.2519207477
MESH:D009369 Neoplasms pirinixic acid 5.5117405874
MESH:D009369 Neoplasms Quercetin 5.5115185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.3511399458 16427766
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010146 Pain Phenol 4.4517610455
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9416965848
MESH:D010392 Pemphigus Phenol 6.9617163923 16522979
MESH:D010864 Pilonidal Sinus Phenol 6.9619655223 15622588
MESH:D011041 Poisoning Phenol 5.068825745
MESH:D011230 Precancerous Conditions Cyclosporine 10.0712371664
MESH:D011230 Precancerous Conditions Quercetin 10.0719056647
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4110548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3916740699
MESH:D011471 Prostatic Neoplasms Quercetin 3.3917292933 14715546
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D013088 Spermatocele Phenol 6.1618646496
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.7912587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4616033868
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516684133 16045194
MESH:D014277 Trigeminal Neuralgia Phenol 6.9610223447 16527771
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9016720314
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014860 Warts Phenol 6.6219122958
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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