AutismKB 2.0

Annotation Detail for VWF


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Basic Information Top
Gene Symbol:VWF ( F8VWF,VWD )
Gene Full Name: von Willebrand factor
Band: 12p13.31
Quick LinksEntrez ID:7450; OMIM: 613160; Uniprot ID:VWF_HUMAN; ENSEMBL ID: ENSG00000110799; HGNC ID: 12726
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
No data
Pathway IDPathway Name
P00011Blood coagulation
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500302Intrinsic Pathway
500977vWF interaction with collagen
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00219Hemophilia
Desease IDDesease Name
1712Yersinia infection
1832Congenital abnormality
1858Hemorrhagic disorder
1869Behcet syndrome
1904Diabetes mellitus
1918Atherosclerosis
1936Hypercholesterolemia
1944Breast cancer
2091Hypertension
2087Bacterial infection
2111Systemic infection
2182Glycogen storage disease
2227Uterine fibroids
2237Neoplasm metastasis
Desease Name
CARDIOVASCULAR
blood pressure, arterial hypertension
nephropathy
RENAL
type 1 von Willebrand disease
METABOLIC
Stroke
plasma vWF
coronary heart disease
dominant type 1 von Willebrand's disease
No data
Desease Name
von Willebrand disease, autosomal dominant
von Willebrand disease, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of VWF mRNAdecreases expression 18648102
C119737 8-prenylnaringenin 8-prenylnaringenin results in increased expression of VWF mRNAincreases expression 16019205
D000082 Acetaminophen Acetaminophen affects the expression of VWF mRNAaffects expression 17562736
C523074 allylpyrocatechol allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VWF protein]decreases expression|decreases reaction 18431645
D000643 Ammonium Chloride Ammonium Chloride affects the expression of VWF mRNAaffects expression 16483693
D044966 Anti-Retroviral Agents Anti-Retroviral Agents results in decreased expression of VWF proteindecreases expression 19929230
C006632 arsenic trioxide arsenic trioxide results in increased expression of VWF mRNAincreases expression 20458559
D001554 Benzene Benzene results in decreased expression of VWF mRNAdecreases expression 17905399
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VWF mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VWF mRNAdecreases expression 20064835
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNAaffects cotreatment|decreases expression 20360939
C073718 cannabidiol hydroxyquinone cannabidiol hydroxyquinone results in decreased expression of VWF mRNAdecreases expression 16571653
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of VWF proteinincreases expression 14716496
D002251 Carbon Tetrachloride PLG protein inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]decreases reaction|increases expression 14716496
D004041 Dietary Fats Dietary Fats results in increased expression of VWF mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of VWF mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of VWF mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF proteinaffects cotreatment|increases expression 12616983
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of VWF mRNAaffects expression 17555576
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of VWF proteinincreases expression 12616983
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of VWF proteinaffects cotreatment|increases expression 12616983
D007213 Indomethacin allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VWF protein]decreases expression|decreases reaction 18431645
D007213 Indomethacin Indomethacin results in decreased expression of VWF proteindecreases expression 18431645
C470148 nilestriol nilestriol results in decreased expression of VWF proteindecreases expression 12934402
C041786 palm oil palm oil results in increased expression of VWF mRNAincreases expression 18042831
D048789 Phytoestrogens Phytoestrogens results in increased expression of VWF mRNAincreases expression 16019205
D020849 Raloxifene Raloxifene results in increased expression of VWF proteinincreases expression 15850603
C017947 sodium arsenite sodium arsenite results in increased expression of VWF proteinincreases expression 12703962
D013629 Tamoxifen Tamoxifen results in increased expression of VWF proteinincreases expression 15850603
D014241 Trichloroethylene Trichloroethylene results in decreased expression of VWF mRNAdecreases expression 17905399
D014810 Vitamin E Vitamin E results in increased expression of VWF mRNAincreases expression 19244175
C104536 xanthohumol xanthohumol results in increased expression of VWF mRNAincreases expression 16019205
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000230 Adenocarcinoma arsenic trioxide 9.6411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6420464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6414692618
MESH:D000230 Adenocarcinoma Indomethacin 9.6416537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 19.523712494
MESH:D000236 Adenoma Benzo(a)pyrene 19.526695378
MESH:D000236 Adenoma beta-Naphthoflavone 19.5219389873
MESH:D000236 Adenoma Diethylnitrosamine 19.5210737359 6695378
MESH:D000236 Adenoma Indomethacin 19.5211497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.6517620307 19061943 18056438 16434500 19052882 17162532
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6517306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.3617451421 17308373
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1217225004
MESH:D000544 Alzheimer Disease Indomethacin 4.2717627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 4.2715800139
MESH:D000741 Anemia, Aplastic Benzene 4.1811369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.6110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.9119183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.9110388637
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D018771 Arthralgia Indomethacin 4.922160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7711248219
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001477 Bartter Syndrome Indomethacin 4.7410684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.4516206674
MESH:D001855 Bone Marrow Diseases Benzene 4.9816183116
MESH:D001929 Brain Edema Indomethacin 4.7811481608
MESH:D001930 Brain Injuries Raloxifene 4.2316580743
MESH:D002545 Brain Ischemia Indomethacin 4.1712524144
MESH:D001943 Breast Neoplasms Benzene 5.5817162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 5.5820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.5817474063
MESH:D001943 Breast Neoplasms Indomethacin 5.5817401462
MESH:D001943 Breast Neoplasms Phytoestrogens 5.5817176212 17158751
MESH:D001943 Breast Neoplasms Raloxifene 5.5816912660 16837676 17595753 17261762 15572757 17049068 17952589 17440819 15775269 17242785 17893378 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 5.5819059307 19103187 16273361 19288272 17242785 17440819 19244106 20859285 19066611 19189212 19289846 19115204 20005174 20390343 18425577 19189210 18351453 15565566 20135344 21138602 18984771 16873071 18997820 17049068 11161223 20544844 18821012 19200415 20065188 15668708 16818667 19487384 19155303 19084267 17261762 21152245 18855134 19011961 19410462 18815881 17893378 18629630 16202921 19142967 19221464
MESH:D001943 Breast Neoplasms Trichloroethylene 5.5815986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002056 Burns Indomethacin 4.4610459503
MESH:D002100 Cachexia Indomethacin 4.7611239499 16537180 15625704 15141370
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.1316097048 3786805 16124888 15700767 18705752 16050911 16011737 16192424 15721981 10355542 15673190 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.1316050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.197296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.193084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.1914691202 11135700 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.1918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.1918788625 19822196 16540662 19171122 20514400 16288022 20512989 20007298 18691550 18210153 16681979 19701751 20524982 17138121 20214788 21159647 18785209 19539802 19919837 18506893 18056438 19052882 19208518 16779866 16569478 17173139 18494052 3084413 10737359 17978847 19383236 17761372 19107877 18978308 19394651 19418558 19519916 16878318 20727157 11831363 20432363 16502159 20084675 20935162 16698587 17428255 18971187 18393292 18665156 10672840 19335982 16807293 16830150 17055752 16935385 16328049 17162532 20101231 3581430
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 16.1916391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.1917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.1916924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.4811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1011352223 14736730 18791128
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.247296757
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.2417341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1520419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.1512636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1518572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.7917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.7917572228
MESH:D002318 Cardiovascular Diseases marker/mechanism 16332659
MESH:D002318 Cardiovascular Diseases Phytoestrogens 7.5416862667
MESH:D002318 Cardiovascular Diseases Raloxifene 7.5415775269
MESH:D002386 Cataract Acetaminophen 2.4410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.257505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.2521159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.2520056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4819052882
MESH:D002764 Cholecystitis Indomethacin 4.9211181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.269022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2617333356 16919318 15861022 11677210 17110522 17681005 16105132
MESH:D003072 Cognition Disorders Raloxifene 4.3815800139
MESH:D003110 Colonic Neoplasms Indomethacin 2.5515637740 15936596 15786552 11260862 15963497 15625704
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6220501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.6211197048 12606626 18059344 17054584
MESH:D003327 Coronary Disease Phytoestrogens 5.0417367797
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D018352 Coronavirus Infections Indomethacin 5.4717302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7710525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.7715643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7719769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9617474826
MESH:D003872 Dermatitis Benzene 4.5215902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5714531868 12868966 11906362 8970840 2524372 11298694 8156756 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.262952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1320387270
MESH:D003928 Diabetic Nephropathies Raloxifene 8.3515920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3519279558
MESH:D003967 Diarrhea Indomethacin 3.567907874 7237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.229022650 16192314 18692083 6482804 18289764 9328219 11289319 18648102 9653073 6679447 1440618 8291058 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.2216485898 11461765 16393943 12153990 19164858 16109766 19420014 11743745 11834606 15968718 19085960 18713872 16177239 11529661 16227642 10915739 12958197 18071297 2444490 19416960 14986274 12705907 12392966 19739265 15619225 10663392 10774834 16781746 19923254 11739529 12594235 16081117 14550746 19370779 17562736 12540782 11287661 17906064 17522070 14725611 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.227179309 4309450 15027814 16177239 10092053 2869522 6884620 9327722 10915739 3732212 3786805 16227642 19085960 7440962 15998439 17522070 21278145 7120509 6623471 11566570 15968718 19336974
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.2219107877
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 11.227120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9018043480 18446180 17190690 16326151 16133044 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.9016699067 17045617 11535926 17329845 10671773 17351913 17151854 17202747 11595431 11991626 11595415
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:C538011 Eales disease Vitamin E 4.459068938
MESH:D004487 Edema Indomethacin 6.558985016 7907874 16100529 19703484 7990266 10653021 8273558
MESH:D004487 Edema Raloxifene 6.5515860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.9915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.9919031437
MESH:D004714 Endometrial Hyperplasia Phytoestrogens 5.9616402032
MESH:D016889 Endometrial Neoplasms Phytoestrogens 7.6016543667
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6016202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Indomethacin 3.9315652904
MESH:D019446 Endotoxemia Indomethacin 4.2518509659
MESH:D004751 Enteritis Indomethacin 4.5010567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7417980183
MESH:D004802 Eosinophilia Indomethacin 3.8111298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.863581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 9.8612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.8616530937
MESH:D004938 Esophageal Neoplasms Indomethacin 9.8611005569
MESH:D005234 Fatty Liver arsenic trioxide 33.5815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.5861145 16239168 16045604 15959796 19224547 12795759 12631006 17595544
MESH:D005234 Fatty Liver Dietary Fats 33.5819551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 33.5821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.5815345470
MESH:D005234 Fatty Liver Raloxifene 33.5817473493
MESH:D005234 Fatty Liver Tamoxifen 33.5819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005334 Fever Indomethacin 3.9110431976 17627676 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005354 Fibrosarcoma Indomethacin 4.6510962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.5118705752
MESH:D005355 Fibrosis Dietary Fats 13.5118296743
MESH:D005355 Fibrosis Indomethacin 13.5117994277
MESH:D005499 Folliculitis Indomethacin 4.9211298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005756 Gastritis Acetaminophen 10.3216983495
MESH:D005756 Gastritis Indomethacin 10.3215046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4316452187
MESH:D005909 Glioblastoma Indomethacin 3.4112870263
MESH:D005910 Glioma Indomethacin 3.1316487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0911849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006073 Gout Indomethacin 5.1011248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.5815482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2620471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.2616080930
MESH:D006331 Heart Diseases Raloxifene 3.3711110106
MESH:D006402 Hematologic Diseases Benzene 4.4316183116
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.3515633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4419900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.4515135802
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 2.9512676792
MESH:D019584 Hot Flashes 8-prenylnaringenin 10.0417088409
MESH:D019584 Hot Flashes Vitamin E 10.0414716179
MESH:D006930 Hyperalgesia Acetaminophen 7.1916870215
MESH:D006930 Hyperalgesia Indomethacin 7.1912727271
MESH:D034321 Hyperamylasemia Indomethacin 5.4717883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D006940 Hyperemia Indomethacin 4.7612524144
MESH:D006949 Hyperlipidemias Dietary Fats 8.5821332399
MESH:D006949 Hyperlipidemias Indomethacin 8.5817546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7015034207
MESH:D006973 Hypertension Benzene 5.3517940673
MESH:D006973 Hypertension Raloxifene 5.3515787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.7818306037 10574470
MESH:D007079 Ileitis Indomethacin 5.1010651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1216133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.5017937319
MESH:D007248 Infertility, Male Phytoestrogens 10.5016731787
MESH:D007248 Infertility, Male sodium arsenite 10.5015346721 12646999
MESH:D007249 Inflammation Dietary Fats 10.9420412841
MESH:D007249 Inflammation Diethylnitrosamine 10.9418785209
MESH:D007249 Inflammation Indomethacin 10.943291741 12568917 7812673
MESH:D007249 Inflammation Tamoxifen 10.9419457130
MESH:D007251 Influenza, Human Vitamin E 3.9716624496
MESH:D007333 Insulin Resistance Dietary Fats 2.9511836018 18457598
MESH:D007410 Intestinal Diseases Indomethacin 4.0811686837 17994277 11855677 11713966 17329856 15610444 10210152 18236018 15831440
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.3710783313
MESH:D019586 Intracranial Hypertension Indomethacin 5.1215241188
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.779022650 8074119
MESH:D007579 Jejunal Diseases Indomethacin 4.7816133968 18306037 10574470
MESH:D007674 Kidney Diseases Acetaminophen 17.5815629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 17.5815369732
MESH:D007674 Kidney Diseases Indomethacin 17.5817190690
MESH:D007674 Kidney Diseases sodium arsenite 17.5820008137
MESH:D007674 Kidney Diseases Vitamin E 17.5812488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.736582329
MESH:D007680 Kidney Neoplasms Tamoxifen 6.7318625569
MESH:D007889 Leiomyoma Raloxifene 4.2716973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7110320625 12228301 11703811
MESH:D007938 Leukemia arsenic trioxide 6.1615070760
MESH:D007938 Leukemia Benzene 6.1618335105 15935818 14694614 17119257
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.9614633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.9610785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9719077051
MESH:D007951 Leukemia, Myeloid Benzene 8.9717506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.9819850784 20471514 16968895 17050201 16467208
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.9819478238
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.9818360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4116823087 12018890 16966277 11468182 19642359 16330433 17649720 17217047 19075265 16331271 15213294 19035177 15622746 15748426 17869043 16112521 15336539 12679006 17712046 19225113 16891316 17107899 9834237 11161223 12712474
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.4116766008
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D007964 Leukocytosis Indomethacin 5.1216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.4717980183
MESH:D008064 Lipidoses Tamoxifen 2.9815342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.4711479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2421278145 11903743 11408273 17157831 17174718 16943688 16221502 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2419638242 20032147 18522880 18665156 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7417525996 14716496 18418968 20821823 17714472 18420326 18481824 16136751 18205269 18054572 12445421 14512876 18210741 14748882 18166357 17698563 15362042 14716833 15673190 12609069 18187930 17922224 18339082 16638106 17557913 12666154 17721639 18395095 15123356 18472094 17631135 17481882 17766677 17823541 12632512 16015684 18376398 11481614 12632514 17869086 16011737 18472332 12389079 12445418 17640975 18277467 18412020 16033810 17708605 15931870 18317297 14724832 17805973 17900296 12546737 15370692 18006644 12649538 15057751 16097048 18705752 16116963 16192424 12898905 15650968 15893842 18279442 18156304 18429990 18251166 15818738 18395914 18263696 15730626 12958196 15925388 15996030 17976157 16027843 15052691 15959796 16248980 15876570 17944888 13678700 10355542 12667390 17761835 12741479 17565644 15338365 14620537 12586293
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.7418194892
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7418564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.7416169303
MESH:D008107 Liver Diseases Acetaminophen 6.0812587719 12969438 11587558 16611625 19460945 19014921 16610002 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0817285989 15830285 15720792 16246199 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0817034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7014706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 20.4514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4521137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.4519389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.4519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.4519833225 19090486 20137499 20501860 18754104 18977376 19426721 15885732 12112319 21047994 19427195 15175105 19690152 19642983 19499222 18648771 19812893 21071580 19638242 21167192 12771043 20101389 20452335 20405173 19073162 18978307 21278145 10737359 18644402 20492335 16942905 2862719 19551842 2422723 20118626 19254457 19256749 20583210 9163691 20434301 19996281 19255062 19294768 19850985
MESH:D008113 Liver Neoplasms sodium arsenite 20.4515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 20.4516684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 25.951399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.9520377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 25.9512562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 25.9518164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.9515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 25.9519519916 18093689 17174075 19126423 17854601 18775883 3124819 18544905 16267830 18308698 9362446 16842330 18079962 19004024 17942915 18164116 21159647 18253720 18282651 2563599 19539802 19009564
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 25.957955063
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1715213294
MESH:D008171 Lung Diseases sodium arsenite 6.9019095001
MESH:D008171 Lung Diseases Vitamin E 6.9016863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5614698565
MESH:D008175 Lung Neoplasms arsenic trioxide 12.4311798837 19825857
MESH:D008175 Lung Neoplasms Benzene 12.4312562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.4318520028 20869020 20464547 18816296 17053015 6695378 20064080 20135361 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.436695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Indomethacin 12.4311053908 11497255 16537180
MESH:D008175 Lung Neoplasms sodium arsenite 12.4317077188 19931552 17306315 16712894 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 12.4318625569
MESH:D008175 Lung Neoplasms Vitamin E 12.4311062179
MESH:D008223 Lymphoma Benzene 7.9517584886 17119257
MESH:D008223 Lymphoma cannabidiol hydroxyquinone 7.9517478614
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.2512562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.2519428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 5.7311921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.7319196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3019453300
MESH:D008545 Melanoma sodium arsenite 3.1716487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.1719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008881 Migraine Disorders Indomethacin 7.8011903285
MESH:D008881 Migraine Disorders Phytoestrogens 7.8012224599
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0416381670
MESH:D009062 Mouth Neoplasms Indomethacin 8.0412636206
MESH:D009101 Multiple Myeloma arsenic trioxide 11.2211468182 19417148 19549372 15949261 14977855
MESH:D009101 Multiple Myeloma Benzene 11.2217119195
MESH:D009101 Multiple Myeloma Raloxifene 11.2216497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0016105982 16882451
MESH:D009232 Myxoma Raloxifene 5.3016343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 12.783581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.783581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 12.7816537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.7819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7111141357
MESH:D009369 Neoplasms sodium arsenite 7.7111559025
MESH:D009369 Neoplasms Trichloroethylene 7.7111911487
MESH:D009374 Neoplasms, Experimental Indomethacin 8.4710663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4720056578
MESH:D009376 Neoplasms, Hormone-Dependent Phytoestrogens 10.5216912569
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.5219196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic cannabidiol hydroxyquinone 5.8116571653
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.056679447
MESH:D009436 Neural Tube Defects arsenic trioxide 16.0510525206
MESH:D009436 Neural Tube Defects Benzene 16.0515643154
MESH:D009436 Neural Tube Defects sodium arsenite 16.0512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.9218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.9220387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 12.9212349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D009765 Obesity Dietary Fats 2.2320132043 21332399 20518802 18674790 18457598 19632207 11836018 16723640 17217161
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.926374098
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.456482804 4026338
MESH:D009784 Occupational Diseases Benzene 8.4515935809 17178637 16737584 15612468 15913788 15576619 15727169 17479406 17119257
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010003 Osteoarthritis Indomethacin 3.527009135
MESH:D010024 Osteoporosis Raloxifene 3.2519059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0015758505 17893378 17823083 15579764
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.5216624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Benzene 7.5212562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.5215276417 17306315
MESH:D010146 Pain Acetaminophen 6.1416870215
MESH:D010146 Pain Indomethacin 6.143291741 17627676 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.4318702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.9715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9716540662
MESH:D010195 Pancreatitis Indomethacin 8.4617883296 15028970
MESH:D010195 Pancreatitis Phytoestrogens 8.4617269527
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.4716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9112349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.4711903285
MESH:D010437 Peptic Ulcer Indomethacin 4.9011148446
MESH:D010518 Periodontitis Indomethacin 4.6617225004
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.3817105841
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.352563599
MESH:D047928 Premature Birth Indomethacin 4.8817000239
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Phytoestrogens 2.0716921512
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0715731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011507 Proteinuria Indomethacin 3.9411849393
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D011693 Purpura Raloxifene 5.3015770314
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7316646077
MESH:D012871 Skin Diseases Vitamin E 2.3818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3310029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 5.3318572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013272 Stomach Diseases Indomethacin 4.1716113693 17160473 18545984 10192188 16184426 10486359 16280098 10215738 17638125 18209964 15472012 17207306 15038085
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.1217007042
MESH:D013274 Stomach Neoplasms Benzene 6.1212562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.122093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.1218456281
MESH:D013274 Stomach Neoplasms Indomethacin 6.1215609394
MESH:D013276 Stomach Ulcer allylpyrocatechol 7.5118431645
MESH:D013276 Stomach Ulcer Indomethacin 7.5111729361 16934674 16755016 18181030 15104355 17918041 12498302 11906479 18087811 11595415 10750652 18431645 14567935 10423059 17135157 18237397 18543354 17657623 15138204 18209962 18299717 1323529 11145282 17895592 16150113 16631530 16397915 16252198 12077510 12500499 12467913 12787963 11523592 17977527 10878458 16169175 18193104 11595431 17627676 17654042 18726076 15255614
MESH:D020521 Stroke Raloxifene 8.0716837676
MESH:D020521 Stroke Vitamin E 8.0716517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 17.1511994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 17.1511994571
MESH:D019851 Thrombophilia Gestodene 17.1511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.8615669648
MESH:D013927 Thrombosis Gestodene 8.8615669648
MESH:D013953 Thymus Neoplasms Benzene 4.7110850423
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.606582329 6587162 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.6019014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.607505956
MESH:D013964 Thyroid Neoplasms Indomethacin 15.6011352223 18791128 14736730
MESH:D013978 Tibial Fractures Raloxifene 4.9619048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7215213294
MESH:D014456 Ulcer Indomethacin 4.6517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.618074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.6111780464 12845720 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.6117053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.6117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.6111723127 17306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.6117572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5511813266
MESH:D014594 Uterine Neoplasms Benzene 8.7912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7914692618
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054556 Venous Thromboembolism Raloxifene 4.9616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 10.1014671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 10.1015869587
MESH:D014839 Vomiting Indomethacin 4.5011897121
MESH:D014842 von Willebrand Diseases marker/mechanism
MESH:D056729 von Willebrand Disease, Type 3 marker/mechanism
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3016343187
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37337
    • No data
    Releated disease ID Related disease Name
    PA447264heparin-induced thrombocytopenia
    Releated drug ID Related drug Name
    PA449855heparin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00025 - Antihemophilic Factor Coagulants;Thrombotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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