AutismKB 2.0

Annotation Detail for WIPF1


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Basic Information Top
Gene Symbol:WIPF1 ( MGC111041,PRPL-2,WASPIP,WIP )
Gene Full Name: WAS/WASL interacting protein family, member 1
Band: 2q31.1
Quick LinksEntrez ID:7456; OMIM: 602357; Uniprot ID:WIPF1_HUMAN; ENSEMBL ID: ENSG00000115935; HGNC ID: 12736
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1730Disseminated cancer
2114Thrombocytopenia
2177Wiskott-Aldrich syndrome
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of WIPF1 mRNAdecreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of WIPF1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WIPF1 mRNAaffects expression 16483693
D002330 Carmustine Carmustine results in decreased expression of WIPF1 mRNAdecreases expression 15980968
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WIPF1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WIPF1 mRNAaffects cotreatment|affects expression 17602206
C010327 salinomycin salinomycin results in decreased expression of WIPF1 mRNAdecreases expression 19682730
C004648 testosterone enanthate testosterone enanthate affects the expression of WIPF1 mRNAaffects expression 17440010
D014212 Tretinoin Tretinoin results in increased expression of WIPF1 mRNAincreases expression 16140955
C025643 vinclozolin vinclozolin affects the expression of WIPF1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000236 Adenoma Diethylnitrosamine 2.946695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1418056438 19052882 17162532 16434500 17620307 19061943
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816197459 16206674
MESH:D001932 Brain Neoplasms Carmustine 4.5516187019
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0517474063
MESH:D001943 Breast Neoplasms salinomycin 2.0519682730
MESH:D001943 Breast Neoplasms Tretinoin 2.0516873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6721159647 20727157 17138121 16681979 19394651 19539802 17428255 16569478 19335982 18691550 20935162 16502159 17173139 19919837 11831363 20512989 16288022 19418558 20007298 17162532 19519916 16878318 16779866 16328049 20524982 19208518 17978847 18494052 19822196 3084413 20084675 16540662 3581430 16807293 18506893 10672840 19171122 17055752 18971187 10737359 17761372 20514400 19701751 20101231 18785209 20432363 18210153 19052882 20214788 18665156 19383236 16935385 16698587 18788625 18393292 16830150 19107877 18056438 18978308
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.671917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316096774 16051514
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9717174075 21159647 7505956 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8419052882
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829211117 17551590 9142499 10589399 9224671 9125849 16925845 8800419 9664655 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8916081117 16485898 16177239 19164858 19420014 19370779 16227642 16393943 19085960 14725611 14986274 2444490 11834606 17562736 10774834 10663392 15619225 11529661 12958197 11743745 11421492 12705907 15968718 19739265 17522070 11287661 18071297 18713872 19416960 16109766 19923254 12392966 12540782 10915739 12153990 16781746 12594235 11739529 17906064 11461765 14550746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3816302075
MESH:D005124 Eye Abnormalities Tretinoin 3.7016938888 9664655
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3521071580 20387270
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Carmustine 7.8116187019
MESH:D005909 Glioblastoma Tretinoin 7.8117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9814991402 9664655
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0117440010
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4618785209
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2616140955 16891316 9834237 17294898 17712046 16766008 19642359 17361223 19035177 16935935 17339181 17301526 19029980 17649720 19225113 16823087 17368321 16331271 17506722 17107899 12679006 16788101 19075265 17217047 15748426
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9118522880 19638242 18665156 20032147 18407596
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.0316610002 12969438 11587558 19014921 12587719 19784758 19460945 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 4.9517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9520452335 19638242 19551842 20405173 21167192 16942905 18648771 19427195 20434301 19833225 19254457 12771043 19426721 19499222 20101389 21278145 19642983 20137499 19812893 10737359 18644402 20492335 20583210 19073162 19690152 12112319 21047994 9163691 19090486 19256749 15175105 18754104 19255062 18978307 2862719 2422723 19294768 19850985 20118626 19996281 18977376 20501860 21071580 15885732
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7318775883 19004024 19126423 3124819 18079962 16842330 18253720 21159647 18164116 18308698 18093689 9362446 17942915 19539802 19519916 16267830 18544905 17174075 17854601 18282651 19009564 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 6695378 20512841 21163286
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 3.8719682730
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Carmustine 3.7312393984
MESH:D008545 Melanoma Tretinoin 3.7316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.629029167 3581430
MESH:D009369 Neoplasms Tretinoin 2.4816594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3820387270
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4316540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4315976015
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.702563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1318042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4518456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4517261132
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.617505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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