AutismKB 2.0

Annotation Detail for WHSC1


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Basic Information Top
Gene Symbol:WHSC1 ( FLJ23286,KIAA1090,MGC176638,MMSET,NSD2,REIIBP,TRX5,WHS )
Gene Full Name: Wolf-Hirschhorn syndrome candidate 1
Band: 4p16.3
Quick LinksEntrez ID:7468; OMIM: 602952; Uniprot ID:NSD2_HUMAN; ENSEMBL ID: ENSG00000109685; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00010Multiple myeloma
Desease IDDesease Name
1707Multiple myeloma
2051Leukemia
No data
No data
Desease Name
Wolf-Hirschorn syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WHSC1 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of WHSC1 mRNAincreases expression 20406850
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of WHSC1 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of WHSC1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of WHSC1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WHSC1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WHSC1 mRNAdecreases expression 20382639
19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of WHSC1 mRNAdecreases expression 15336504
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of WHSC1 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of WHSC1 mRNAincreases expression 19465110
D014212 Tretinoin Tretinoin results in increased expression of WHSC1 mRNAincreases expression 16788091
D014635 Valproic Acid Valproic Acid results in decreased expression of WHSC1 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9714514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.978875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618775368 18558336 17507914 15238991 19232924 18985861 18396377 20603192 18316065 18940202 17688650 18177632 19460635 17157402 16609825
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.1816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.1816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.318888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8020146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7214691202 11135700 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.721917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6916096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9415340226 16354765 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.5110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.5114991402 10589399 9125849 9142499 8800419 9224671 9664655 9211117 16925845 17551590
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.518888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2712153990 15619225 14725611 17522070 18713872 11743745 18071297 16485898 19416960 19370779 19739265 19923254 11287661 11739529 11461765 14986274 16781746 12958197 17906064 17562736 10915739 10663392 12705907 12540782 19164858 2444490 11529661 16227642 11421492 16109766 12594235 12392966 16081117 14550746 19085960 16393943 10774834 16177239 19420014 11834606 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.271733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6815322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.133922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.717562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.189664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 8.3915073043
MESH:D005234 Fatty Liver Valproic Acid 8.3914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005355 Fibrosis Tretinoin 9.2117994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.4910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.4914991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 16120746 15340226
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D007938 Leukemia arsenic trioxide 6.5515070760
MESH:D007938 Leukemia Tretinoin 6.5517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.9519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.9516932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.2617050201 19850784 20471514 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.2617596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.2617596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9315213294 19642359 19075265 16331271 16823087 17712046 15622746 12018890 16891316 16112521 11161223 15336539 19035177 17107899 17217047 17649720 16966277 19225113 11468182 16330433 17869043 12679006 12712474 9834237 15748426
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9317294898 17217047 16935935 12679006 16891316 19029980 17361223 17368321 19075265 16766008 17649720 17107899 16823087 16788101 17301526 15748426 17712046 16331271 9834237 17506722 19642359 16140955 19035177 17339181 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6616610002 12969438 19014921 16611625 19784758 19460945 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.097678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0921137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.292876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.2920377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4317053015 20064080 20464547 18816296 18520028 20135361 18569708 6695378 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4311884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008881 Migraine Disorders Valproic Acid 3.2918765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2015949261 11468182 19549372 14977855 19417148
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.7516105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.7517596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.7517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2011141357
MESH:D009369 Neoplasms Tretinoin 5.2016594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 10.069125849
MESH:D009436 Neural Tube Defects arsenic trioxide 12.6710525206
MESH:D009436 Neural Tube Defects Tretinoin 12.679142499
MESH:D009436 Neural Tube Defects Valproic Acid 12.6716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0019769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0016936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4415580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4415976015
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1211399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.1220603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.3716116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.3719155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012640 Seizures Valproic Acid 6.251511512 16876388 15475178 11044598 11738929 14763951 17978042 3137016
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.0510029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.058532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.0516192470
MESH:D012878 Skin Neoplasms Tretinoin 14.0516467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.402093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 3.4017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5719014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.5820435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
MESH:D054877 Wolf-Hirschhorn Syndrome marker/mechanism
Pathway ID Pathway Name
KEGG:00310 Lysine degradation
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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