AutismKB 2.0

Annotation Detail for WNT1


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Basic Information Top
Gene Symbol:WNT1 ( INT1 )
Gene Full Name: wingless-type MMTV integration site family, member 1
Band: 12q13.12
Quick LinksEntrez ID:7471; OMIM: 164820; Uniprot ID:WNT1_HUMAN; ENSEMBL ID: ENSG00000125084; HGNC ID: 12774
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200130C-MYB transcription factor network
200052Presenilin action in Notch and Wnt signaling
200055Wnt signaling network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
1934Cancer
2062Neurodegenerative disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of WNT1 mRNAaffects expression 17562736
D001554 Benzene Benzene results in increased expression of WNT1increases expression 15935813
D001554 Benzene Benzene results in increased expression of WNT1 mRNAincreases expression 12928149
D001554 Benzene TP53 protein promotes the reaction [Benzene results in increased expression of WNT1]increases expression|increases reaction 15935813
D001554 Benzene TRP53 protein affects the reaction [Benzene results in increased expression of WNT1 mRNA]affects reaction|increases expression 12928149
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNAaffects cotreatment|decreases expression 12634122
D004390 Chlorpyrifos Chlorpyrifos affects the expression of WNT1 mRNAaffects expression 18502319
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNAaffects cotreatment|decreases expression 12634122
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of WNT1 mRNAaffects cotreatment|increases expression 17183730
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNAaffects cotreatment|decreases expression 12634122
D009151 Mustard Gas Mustard Gas results in decreased expression of WNT1 mRNAdecreases expression 15674843
D009532 Nickel Nickel results in decreased expression of WNT1 mRNAdecreases expression 19130878
D010672 Phenytoin Phenytoin results in decreased expression of WNT1 mRNAdecreases expression 7841657
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNAaffects cotreatment|decreases expression 12634122
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of WNT1 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in decreased methylation of WNT1 promoterdecreases methylation 20734317
D014635 Valproic Acid Valproic Acid results in increased expression of WNT1 mRNAincreases expression 20734317
D014635 Valproic Acid Valproic Acid results in increased expression of WNT1 proteinincreases expression 20734317
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 9.313425630 10563481 9118846 9677735 6195326 8986270
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.318875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D055371 Acute Lung Injury Nickel 4.6716166738
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.4616611668 11874814 17119214
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000741 Anemia, Aplastic Benzene 4.4314761424 11369114 17661222
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D050197 Atherosclerosis Phenytoin 3.9715136057
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 18396377 17157402 18177632 18316065 18940202 20603192 15238991 17688650 16609825 19232924 18985861 19460635 18558336 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.458888407
MESH:D001855 Bone Marrow Diseases Benzene 5.3616183116
MESH:D001943 Breast Neoplasms Benzene 2.7811921183 17162533
MESH:D001943 Breast Neoplasms Nickel 2.7815986119
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.9317306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4018572023
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0419524636 20056578
MESH:D002493 Central Nervous System Diseases Phenytoin 5.404080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.9811748493
MESH:D002971 Cleft Lip Phenytoin 4.192227380
MESH:D002972 Cleft Palate Phenytoin 3.776862529 3877104 1687470 10789828 2227380 6856622
MESH:D003103 Coloboma Phenytoin 5.239212184
MESH:D000013 Congenital Abnormalities Phenytoin 4.7710627286
MESH:D019465 Craniofacial Abnormalities Benzene 5.6415643154
MESH:D019465 Craniofacial Abnormalities lead acetate 5.6419769572
MESH:D019465 Craniofacial Abnormalities Phenytoin 5.6419952982 9212184 8986270
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.648888407 17688650 16575769
MESH:D003872 Dermatitis Benzene 4.8715902427
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.0517244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.722952479
OMIM:607208 DRAVET SYNDROME Phenytoin 5.4911748493
MESH:D003875 Drug Eruptions Phenytoin 5.6015024534
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8616781746 12392966 14550746 17522070 12540782 16177239 11461765 11287661 19416960 11421492 18713872 14986274 11739529 19739265 14725611 19164858 12153990 16081117 11743745 12705907 10663392 17562736 16227642 19420014 16393943 12958197 15619225 11529661 12594235 16109766 18071297 10774834 16485898 19370779 10915739 19923254 11834606 19085960 15968718 2444490 17906064
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.861733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema Mustard Gas 3.3911428647 9260866 11428631 11402378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.7717654737
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.2920235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.376251365 1399206
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.263659116 17275665
MESH:D004828 Epilepsies, Partial Phenytoin 10.8111558140 17116037
MESH:D004828 Epilepsies, Partial Valproic Acid 10.8116628512 3922381
MESH:D004827 Epilepsy Phenytoin 7.1820417680 821787 11434505
MESH:D004827 Epilepsy Valproic Acid 7.1818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenytoin 12.047750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 11.263659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.263659116
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D005234 Fatty Liver Valproic Acid 3.3814986274 19224547
MESH:D005313 Fetal Death Phenytoin 5.2010627286
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation lead acetate 11.5119769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 11.5118558336 8888407
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D005885 Gingival Hyperplasia Phenytoin 5.789029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.3714659971 16390469
MESH:D006402 Hematologic Diseases Benzene 4.7416183116
MESH:D015658 HIV Infections Nickel 3.8517263646
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.7410459572
MESH:D006973 Hypertension Benzene 3.1217940673
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007248 Infertility, Male sodium arsenite 3.0412646999 15346721
MESH:D007249 Inflammation Mustard Gas 5.769357497 11402378 8975870 11428631 17524151 9260866 11428620 11428647 16001271
MESH:D007249 Inflammation Nickel 5.7616166738
MESH:D007674 Kidney Diseases Acetaminophen 10.4212587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 10.4216962696
MESH:D007674 Kidney Diseases sodium arsenite 10.4220008137
MESH:D007938 Leukemia Benzene 3.4314694614 18335105 15935818 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.4017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1619478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1616294345 17596541
MESH:D008107 Liver Diseases Acetaminophen 6.8716610002 16611625 19460945 12969438 19014921 19784758 11587558 12587719
MESH:D008107 Liver Diseases Chlorpyrifos 6.8715991261
MESH:D008107 Liver Diseases Phenytoin 6.8714986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms sodium arsenite 2.4016712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.3412562636
MESH:D008171 Lung Diseases Mustard Gas 7.7218702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 7.7219095001
MESH:D017563 Lung Diseases, Interstitial Benzene 11.8414698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 11.8417228818
MESH:D008175 Lung Neoplasms Benzene 3.6512562636
MESH:D008175 Lung Neoplasms Mustard Gas 3.658781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 3.6515276417 16712894 17077188 19931552 17306315
MESH:D008223 Lymphoma Benzene 3.7917119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.5612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3511921183
MESH:D008545 Melanoma sodium arsenite 2.0419082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008607 Mental Retardation Phenytoin 3.699212184
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009101 Multiple Myeloma Benzene 3.7217119195
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.6417484760
MESH:D009224 Myotonia Congenita Phenytoin 5.531896199
MESH:D009369 Neoplasms sodium arsenite 2.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009436 Neural Tube Defects Benzene 17.8515643154
MESH:D009436 Neural Tube Defects Phenytoin 17.859118846
MESH:D009436 Neural Tube Defects sodium arsenite 17.8512854658
MESH:D009436 Neural Tube Defects Valproic Acid 17.8516359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2215081274
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D009784 Occupational Diseases Benzene 4.2615727169 16737584 15612468 15913788 15935809 17178637 17479406 15576619 17119257
MESH:D010018 Osteomalacia Phenytoin 5.5317016548
MESH:D010051 Ovarian Neoplasms Benzene 5.1912562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1917306315 15276417
MESH:D010146 Pain Acetaminophen 7.2116870215
MESH:D010146 Pain Phenytoin 7.2115215642
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017689 Polydactyly Phenytoin 5.119212184
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9520603192
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2916039940
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D019310 Pseudolymphoma Phenytoin 13.0312752131 8603615 1419762
MESH:D019310 Pseudolymphoma Valproic Acid 13.0312752131 11422049
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517894541 17720292 17620002 17266442 10334151
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.7411874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.0316611668 17119214
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Phenytoin 6.573137016 10029267 11044598 16876388 9844417 15946322 19919933 3691417
MESH:D012640 Seizures Valproic Acid 6.5717978042 16876388 15475178 11044598 1511512 14763951 3137016 11738929
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.226418539
MESH:D012871 Skin Diseases Mustard Gas 2.7316961503 12880345 15451306
MESH:D012878 Skin Neoplasms sodium arsenite 2.7318572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 9.7512854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.7519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.2620235791
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013953 Thymus Neoplasms Benzene 5.0710850423
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5316452187 11723127 16712894 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014594 Uterine Neoplasms Benzene 4.4312562636
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37376
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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