AutismKB 2.0

Annotation Detail for WNT2


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Basic Information Top
Gene Symbol:WNT2 ( INT1L1,IRP )
Gene Full Name: wingless-type MMTV integration site family member 2
Band: 7q31.2
Quick LinksEntrez ID:7472; OMIM: 147870; Uniprot ID:WNT2_HUMAN; ENSEMBL ID: ENSG00000105989; HGNC ID: 12780
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200055Wnt signaling network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2124Autistic disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of WNT2 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of WNT2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of WNT2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WNT2 mRNAaffects expression 16483693
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNAaffects cotreatment|decreases expression 12634122
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of WNT2 mRNAdecreases expression 18502319
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNAaffects cotreatment|decreases expression 12634122
D003976 Diazinon Diazinon results in decreased expression of WNT2 mRNAdecreases expression 18502319
D004026 Dieldrin Dieldrin results in decreased expression of WNT2 mRNAdecreases expression 19130878
D004958 Estradiol Estradiol results in increased expression of WNT2 mRNAincreases expression 15072547
C070081 fulvestrant fulvestrant results in decreased expression of WNT2 mRNAdecreases expression 15072547
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of WNT2 mRNAincreases expression 15072547
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNAaffects cotreatment|decreases expression 12634122
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of WNT2 mRNAincreases expression 12634122
D009532 Nickel Nickel results in decreased expression of WNT2 mRNAdecreases expression 19130878
C007350 nitrofen nitrofen results in decreased expression of WNT2 mRNAdecreases expression 17270562
18280291
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNAaffects cotreatment|decreases expression 12634122
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of WNT2 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of WNT2 mRNAincreases expression 18172886
D014212 Tretinoin Tretinoin results in decreased expression of WNT2 mRNAdecreases expression 17045167
D014635 Valproic Acid Valproic Acid results in decreased methylation of WNT2 promoterdecreases methylation 20734317
D014635 Valproic Acid Valproic Acid results in increased expression of WNT2 mRNAincreases expression 20734317
D014635 Valproic Acid Valproic Acid results in increased expression of WNT2 proteinincreases expression 20734317
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 13.647525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.6414514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D055371 Acute Lung Injury Nickel 4.4816166738
MESH:D000230 Adenocarcinoma Estradiol 2.0711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8016712894 17306315
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.8117119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.8116487989
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D001169 Arthritis, Experimental Tretinoin 3.0116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D001284 Atrophy fulvestrant 4.7411514358
MESH:D001321 Autistic Disorder marker/mechanism 11449391
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517688650 18558336 18316065 19232924 18177632 18940202 15238991 16609825 18985861 19460635 17507914 20603192 18396377 17157402 18775368
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0217594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6016197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D001943 Breast Neoplasms Dieldrin 2.9215770527 11859874
MESH:D001943 Breast Neoplasms Estradiol 2.9216675129 17289903 17261762 18497071 14630087 17018787 19861407 12948864
MESH:D001943 Breast Neoplasms fulvestrant 2.9218984771
MESH:D001943 Breast Neoplasms Nickel 2.9215986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9216873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.677296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.673084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6716924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.6717306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.671917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118670907 18850075 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.0014694615
MESH:D002386 Cataract Acetaminophen 12.0010977129
MESH:D002386 Cataract Tretinoin 12.0017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.467505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.4618566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 15.462727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.4619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.069022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6115668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Tretinoin 3.6017035595
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.8715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities lead acetate 7.2419769572
MESH:D019465 Craniofacial Abnormalities nitrofen 7.2411405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.2415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.249211117 10589399 9224671 17551590 9142499 8800419 16925845 14991402 9664655 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.2416575769 17688650 8888407
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.882524372 14531868 12868966 8970840 8156756 11298694 11906362 18759878
MESH:D017449 Dermatitis, Allergic Contact Nickel 6.8817244072 17100760 19470301
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 9.193621924 2952479
MESH:D003877 Dermatitis, Contact Nickel 9.192952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.679022650 7440962 6482804 16192314 18648102 9328219 18692083 1440618 9653073 18289764 8291058 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.6721346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.6712958197 17906064 15619225 12153990 16177239 11739529 17522070 11287661 19085960 19416960 14986274 19164858 16109766 12392966 16227642 18713872 15968718 10663392 10774834 11529661 11421492 11743745 19420014 19370779 11834606 16781746 17562736 16081117 11461765 12594235 12705907 16485898 14550746 10915739 16393943 12540782 14725611 2444490 19739265 19923254 18071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.6719641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004417 Dyspnea Diazinon 4.6916487989
MESH:D004421 Dystonia Valproic Acid 3.941851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5918230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.1711473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.929294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.813922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8820417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.496254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.963659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.569664655 16938888
MESH:D005234 Fatty Liver Valproic Acid 3.2014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation lead acetate 10.8419769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 10.848888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.2620067830
MESH:D005355 Fibrosis Tretinoin 8.2617994277
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5716452187
MESH:D005909 Glioblastoma Tretinoin 2.9317312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital nitrofen 10.9716080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.9714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.236705139
MESH:D006505 Hepatitis Diazinon 9.2316487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7812621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.9017618886 16473863 18958481 11588001 7576705 10693666 10541330 12505043 11051153 9575882 10359170 12746050 10646786 10370017 15764645 11685700 16292651 10898224 9473106 7520565 9698600 10898222 16863852 8863223 12021965 16490937 9859898 12194112 12407540 11409163 17270546 16720372 12547725 18280292 7760232 10370016 11584395 15707848 15756563 16080930 11076806 17245593 9476886 15578192 15088113 12904592 15136996 11057544 11329586 12759764 15793718 18280291 15185205
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D015658 HIV Infections Nickel 3.7617263646
MESH:D006689 Hodgkin Disease sodium arsenite 3.0612676792
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.3316870215
MESH:D006930 Hyperalgesia Tretinoin 7.3316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D007247 Infertility, Female Dieldrin 4.8310630421
MESH:D007248 Infertility, Male Diazinon 11.0616466525 12948887
MESH:D007248 Infertility, Male fulvestrant 11.0611514358
MESH:D007248 Infertility, Male sodium arsenite 11.0612646999 15346721
MESH:D007249 Inflammation Nickel 5.0916166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.8916627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.919022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 13.9512587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 13.9516962696
MESH:D007674 Kidney Diseases Estradiol 13.9515618244
MESH:D007674 Kidney Diseases sodium arsenite 13.9520008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.066582329
MESH:D007680 Kidney Neoplasms Estradiol 7.0615610895
MESH:D007938 Leukemia Tretinoin 2.7217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8219850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0817712046 17368321 17107899 17361223 9834237 17339181 19642359 17301526 19035177 19029980 16140955 16823087 17294898 17649720 16788101 16891316 17217047 15748426 16766008 19075265 16935935 17506722 16331271 12679006 19225113
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.239224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3718397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.1719460945 12969438 11587558 16610002 19014921 16611625 19784758 12587719
MESH:D008107 Liver Diseases Chlorpyrifos 4.1715991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms Dieldrin 7.329539021 8742319
MESH:D008113 Liver Neoplasms sodium arsenite 7.3215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.501399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5012151625
MESH:D008171 Lung Diseases nitrofen 7.659859898 16863852 9614859 17245593
MESH:D008171 Lung Diseases sodium arsenite 7.6519095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms sodium arsenite 2.2716712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4911807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma sodium arsenite 3.2819082730 16487513
MESH:D008545 Melanoma Tretinoin 3.2816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.7817671175
MESH:D008881 Migraine Disorders Valproic Acid 3.1118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1917596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009369 Neoplasms Dieldrin 8.138820588
MESH:D009369 Neoplasms sodium arsenite 8.1311559025
MESH:D009369 Neoplasms Tretinoin 8.1316594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5620056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009421 Nervous System Malformations Estradiol 15.7116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.719125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.746679447
MESH:D009436 Neural Tube Defects sodium arsenite 16.7412854658
MESH:D009436 Neural Tube Defects Tretinoin 16.749142499
MESH:D009436 Neural Tube Defects Valproic Acid 16.748888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7818514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0915081274
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.804026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 8.8014694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010051 Ovarian Neoplasms Estradiol 7.6719401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6717306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.6716936753
MESH:D010146 Pain Acetaminophen 6.2916870215
MESH:D010146 Pain Tretinoin 6.2916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010300 Parkinson Disease Dieldrin 3.4816809432 11181820 11445065 16112328 17291500
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D011041 Poisoning Diazinon 4.2517603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1011896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2716740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2716039940
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.4411422049 12752131
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.5316611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.7916611668 17119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5116283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures Valproic Acid 2.6616876388 11044598 14763951 3137016 15475178 11738929 17978042 1511512
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.986418539
MESH:D012878 Skin Neoplasms sodium arsenite 9.1318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1316192470
MESH:D012878 Skin Neoplasms Tretinoin 9.1316467112
MESH:D016135 Spinal Dysraphism sodium arsenite 9.2612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.2619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.857505956 1399818 6587162 3712494 6582329
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6916051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.958074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.9517306315 16452187 11723127 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014570 Urologic Diseases Diazinon 5.1716487989
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.0816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014652 Vascular Diseases sodium arsenite 4.3217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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