AutismKB 2.0

Annotation Detail for WNT7A


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Basic Information Top
Gene Symbol:WNT7A ( - )
Gene Full Name: wingless-type MMTV integration site family, member 7A
Band: 3p25.1
Quick LinksEntrez ID:7476; OMIM: 601570; Uniprot ID:WNT7A_HUMAN; ENSEMBL ID: ENSG00000154764; HGNC ID: 12786
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200055Wnt signaling network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1901Endometriosis
1934Cancer
No data
No data
Desease Name
Ulna and fibula, absence of, with sever limb deficiency
Fuhrmann syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WNT7A mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in increased expression of WNT7A mRNAincreases expression 19304788
D004026 Dieldrin Dieldrin results in decreased expression of WNT7A mRNAdecreases expression 19130878
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of WNT7A mRNAdecreases expression 16534752
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of WNT7A mRNAdecreases expression 15751030
15458790
15591538
15070830
D004054 Diethylstilbestrol ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]affects reaction|decreases expression 15458790
D004054 Diethylstilbestrol WNT5A protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]affects reaction|decreases expression 15073149
D004054 Diethylstilbestrol WNT7A gene mutant form results in increased susceptibility to Diethylstilbestrolincreases response to substance 15070830
D004054 Diethylstilbestrol WNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]affects reaction|decreases expression 15070830
D004054 Diethylstilbestrol WNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]affects reaction|decreases expression 15070830
D004958 Estradiol Estradiol results in decreased expression of WNT7A mRNAdecreases expression 16534752
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT7A mRNA]decreases expression|decreases reaction 16534752
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of WNT7A mRNAdecreases expression 16551644
D015025 Zearalenone Zearalenone results in decreased expression of WNT7A mRNAdecreases expression 16534752
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT7A mRNA]decreases expression|decreases reaction 16534752
D019833 Genistein Genistein results in decreased expression of WNT7A mRNAdecreases expression 16534752
C008493 methylselenic acid methylselenic acid results in decreased expression of WNT7A mRNAdecreases expression 12517777
D010126 Ozone Ozone results in decreased expression of WNT7A mRNAdecreases expression 17460151
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WNT7A mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone NCOA2 protein affects the reaction [Progesterone results in decreased expression of WNT7A mRNA]affects reaction|decreases expression 17556502
D011374 Progesterone Progesterone results in decreased expression of WNT7A mRNAdecreases expression 17556502
D012402 Rotenone Rotenone results in increased expression of WNT7A mRNAincreases expression 19304788
D014212 Tretinoin Tretinoin results in increased expression of WNT7A mRNAincreases expression 17064353
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Estradiol 7.1111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1114692618
MESH:D000230 Adenocarcinoma Genistein 7.1111473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5316434500
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000544 Alzheimer Disease Ozone 2.4415513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5215469931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2615885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.2616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6915570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6916292516
MESH:D001249 Asthma Ozone 4.9817854713 16373670
MESH:D001249 Asthma Tretinoin 4.9816456186
MESH:D001284 Atrophy fulvestrant 4.8811514358
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.0716206674 16197459
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4017868700
MESH:D001930 Brain Injuries Progesterone 4.3015845082 15380490 15665606
MESH:D001943 Breast Neoplasms Dieldrin 3.8011859874 15770527
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.8017129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.8017261762 12948864 17018787 16675129 17289903 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms fulvestrant 3.8018984771
MESH:D001943 Breast Neoplasms Genistein 3.8016541309 16873071 17200150
MESH:D001943 Breast Neoplasms Progesterone 3.8015562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tretinoin 3.8016873071 16166294 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7015516495 19059883 18417511 18315731 16777450 14754758 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002100 Cachexia Ozone 4.7916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.6515948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.651917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3016096774 16051514
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8117110522 16919318 16105132 17681005 17333356 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 7.8119176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tretinoin 2.689407595
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8214991402 9142499 9125849 16925845 8800419 9224671 9664655 10589399 17551590 9211117
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5912952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5317187935
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004489 Edema, Cardiac Tretinoin 4.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.1617692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.0616402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.0616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 17.9516804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 17.9511473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 17.9511473722
MESH:D016889 Endometrial Neoplasms Tretinoin 17.9516569247
MESH:D004715 Endometriosis Progesterone 3.7916134523
MESH:D005124 Eye Abnormalities Tretinoin 3.609664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.6415345470
MESH:D005234 Fatty Liver pirinixic acid 7.6420131406 19236843
MESH:D052776 Female Urogenital Diseases marker/mechanism 16002989
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6716534752 16611131 15751030 16002989 16513791
MESH:D005355 Fibrosis Tretinoin 3.5517994277
OMIM:228930 FIBULAR APLASIA OR HYPOPLASIA, FEMORAL BOWING AND POLY-, SYN-, AND OLIGODACTYLY marker/mechanism
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0016452187
MESH:D005909 Glioblastoma Genistein 7.2716598420
MESH:D005909 Glioblastoma Tretinoin 7.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.0419772884 19176532 18467677 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4812960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 11.3916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.3916945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4415869954
MESH:D007246 Infertility Diethylstilbestrol 4.3915036965
MESH:D007247 Infertility, Female Dieldrin 10.4010630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9817937319
MESH:D007248 Infertility, Male fulvestrant 6.9811514358
MESH:D007249 Inflammation Progesterone 2.6115869954
MESH:D007333 Insulin Resistance Estradiol 7.2616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.2616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9317551590 15992940
MESH:D007674 Kidney Diseases Estradiol 2.6015618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.6216762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 7.6215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1017184923
MESH:D007938 Leukemia Genistein 6.4618980019 17468513
MESH:D007938 Leukemia Tretinoin 6.4617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1712679006 16788101 19642359 16823087 17217047 17361223 17107899 19225113 19035177 17649720 17368321 19075265 9834237 19029980 15748426 17294898 16935935 16891316 16331271 17712046 17506722 16140955 16766008 17301526 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.9917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9916248980 18397230
MESH:D008113 Liver Neoplasms Dieldrin 7.678742319 9539021
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.6716712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 7.6720007298 15890375 16377806
MESH:D008171 Lung Diseases Ozone 3.3919066396 8266340
MESH:D055370 Lung Injury Ozone 3.8920417186
MESH:D008175 Lung Neoplasms Ozone 2.098597069 7614698
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.5816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1217203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.1212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.1217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008679 Metaplasia Ozone 5.1710496685
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D009203 Myocardial Infarction Genistein 5.7117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.3016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.3017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.3016411023
MESH:D009369 Neoplasms Dieldrin 12.048820588
MESH:D009369 Neoplasms Diethylstilbestrol 12.0415313581
MESH:D009369 Neoplasms pirinixic acid 12.0417405874
MESH:D009369 Neoplasms Tretinoin 12.0416946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009410 Nerve Degeneration Rotenone 3.9017356569 18619942 15790535
MESH:D009421 Nervous System Malformations Diethylstilbestrol 23.8111399458
MESH:D009421 Nervous System Malformations Estradiol 23.8111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 23.8116427766
MESH:D009421 Nervous System Malformations Tretinoin 23.819125849
MESH:D009436 Neural Tube Defects Tretinoin 3.079142499
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Estradiol 11.3819401270
MESH:D010051 Ovarian Neoplasms Genistein 11.3819005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.3816525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 11.3816936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010300 Parkinson Disease Dieldrin 5.8716809432 17291500 11181820 16112328 11445065
MESH:D010300 Parkinson Disease Rotenone 5.8716140633 18619942 19114014 15451049 18191903 16412576 19232380 11445065 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 4.1015927086 18197244 15574749 15795934
MESH:D010538 Peritonitis Ozone 4.1716369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7116977796 15687265
MESH:D011014 Pneumonia Ozone 4.4418007984 18929643 18381685
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.1617184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1215846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1215378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1216205645
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3615861022 16919318
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012878 Skin Neoplasms Tretinoin 2.6216467112
MESH:D013088 Spermatocele Diethylstilbestrol 11.9316002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.9316709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3315862959 16503802
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
OMIM:276820 ULNA AND FIBULA, ABSENCE OF, WITH SEVERE LIMB DEFICIENCY marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.7817306315 16712894 16452187
MESH:D014565 Urogenital Neoplasms marker/mechanism 15751030
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.6016175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.6016129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.6015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4816002989 16513791
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5715869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37387
    • No data
    Releated disease ID Related disease Name
    PA446847Arrhythmogenic Right Ventricular Dysplasia
    PA152238082Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome
    PA152238081Fuhrmann Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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