AutismKB 2.0

Annotation Detail for WNT7B


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Basic Information Top
Gene Symbol:WNT7B ( - )
Gene Full Name: wingless-type MMTV integration site family, member 7B
Band: 22q13.31
Quick LinksEntrez ID:7477; OMIM: 601967; Uniprot ID:WNT7B_HUMAN; ENSEMBL ID: ENSG00000188064; HGNC ID: 12787
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200055Wnt signaling network
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C096920 AGN 193109 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of WNT7B mRNA]decreases reaction|increases expression 16505366
D003976 Diazinon Diazinon affects the expression of WNT7B mRNAaffects expression 19130878
D002117 Calcitriol Calcitriol results in decreased expression of WNT7B mRNAdecreases expression 16002434
C007350 nitrofen nitrofen results in decreased expression of WNT7B mRNAdecreases expression 17270562
C009166 retinol acetate retinol acetate results in increased expression of WNT7B mRNAincreases expression 16772331
D014212 Tretinoin AGN 193109 inhibits the reaction [Tretinoin results in increased expression of WNT7B mRNA]decreases reaction|increases expression 16505366
D014212 Tretinoin Tretinoin results in increased expression of WNT7B mRNAincreases expression 16505366
D014501 Uranium Uranium affects the expression of WNT7B mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of WNT7B mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.6716487989
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516197459 16206674
MESH:D001943 Breast Neoplasms Calcitriol 2.2911237771
MESH:D001943 Breast Neoplasms Tretinoin 2.2916166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9711237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9716096774 16051514
MESH:D002386 Cataract Tretinoin 3.2217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities nitrofen 3.2011405365
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.2017551590 9125849 9664655 9142499 14991402 9211117 10589399 9224671 16925845 8800419
MESH:D004417 Dyspnea Diazinon 5.1816487989
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2115138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D005124 Eye Abnormalities Tretinoin 3.759664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.8217994277
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital nitrofen 7.6116080930
MESH:D006330 Heart Defects, Congenital Tretinoin 7.6114991402 9664655
MESH:D006505 Hepatitis Diazinon 4.8516487989
MESH:D006548 Hernia, Diaphragmatic nitrofen 4.0012505043 10370017 18280292 16863852 16490937 9473106 15756563 9698600 12194112 12407540 16473863 15185205 11588001 9476886 12547725 18280291 8863223 10370016 7760232 9859898 15136996 15088113 16720372 7576705 15793718 12021965 16080930 10898224 10541330 12904592 11584395 17270546 15764645 18958481 15707848 11685700 11076806 15578192 10359170 12759764 7520565 11051153 11329586 10898222 11057544 10693666 17245593 17618886 10646786 11409163 9575882 12746050 16292651
MESH:D006930 Hyperalgesia Tretinoin 3.4016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D007248 Infertility, Male Diazinon 3.9716466525 12948887
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1417551590 15992940
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1116294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3016891316 17649720 19642359 16788101 17217047 19225113 17712046 12679006 19075265 17301526 19035177 16823087 15748426 19029980 16331271 17294898 17339181 16935935 17368321 17506722 9834237 16766008 17107899 16140955 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008171 Lung Diseases nitrofen 4.5616863852 17245593 9859898 9614859
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009369 Neoplasms Tretinoin 2.5116594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.209142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.1016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D011041 Poisoning Diazinon 4.6117603234
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5016289102 15754350 18247401 16644109 12479363
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D014570 Urologic Diseases Diazinon 5.6516487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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