AutismKB 2.0

Annotation Detail for WNT2B


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Basic Information Top
Gene Symbol:WNT2B ( WNT13,XWNT2 )
Gene Full Name: wingless-type MMTV integration site family, member 2B
Band: 1p13.2
Quick LinksEntrez ID:7482; OMIM: 601968; Uniprot ID:WNT2B_HUMAN; ENSEMBL ID: ENSG00000134245; HGNC ID: 12781
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04310Wnt signaling pathway
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WNT2B mRNAaffects expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of WNT2B mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of WNT2B mRNAaffects cotreatment|increases expression 18585445
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of WNT2B mRNAaffects cotreatment|increases expression 18164116
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of WNT2B mRNAincreases expression 18502319
D003976 Diazinon Diazinon affects the expression of WNT2B mRNAaffects expression 19130878
D003976 Diazinon Diazinon results in increased expression of WNT2B mRNAincreases expression 18502319
D004026 Dieldrin Dieldrin results in decreased expression of WNT2B mRNAdecreases expression 19130878
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of WNT2B mRNAaffects cotreatment|increases expression 18164116
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of WNT2B mRNAincreases expression 19371625
D005419 Flavonoids Flavonoids results in decreased expression of WNT2B mRNAdecreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in decreased expression of WNT2B mRNAdecreases expression 16807920
D009532 Nickel Nickel results in decreased expression of WNT2B mRNAdecreases expression 19130878
D014212 Tretinoin Tretinoin results in increased expression of WNT2B mRNAincreases expression 16790478
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury Nickel 4.6716166738
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0217620307 19061943 18056438 16434500 17162532 19052882
MESH:D000382 Agricultural Workers' Diseases Atrazine 15.3311874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 15.3311874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 15.3316487989
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6916197459 16206674
MESH:D001943 Breast Neoplasms Dieldrin 2.4015770527 11859874
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4017474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.4015324884 17129689
MESH:D001943 Breast Neoplasms Nickel 2.4015986119
MESH:D001943 Breast Neoplasms Tretinoin 2.4016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7219208518 17761372 10737359 11831363 16807293 3084413 19107877 19171122 18691550 17978847 18785209 19701751 18393292 19539802 16569478 19052882 19822196 18210153 10672840 17428255 18494052 16288022 18978308 17173139 16935385 17138121 20007298 18506893 20432363 20935162 16878318 20524982 20101231 19394651 17162532 18056438 20514400 19519916 17055752 19919837 21159647 18971187 16698587 20214788 19335982 19383236 19418558 16502159 16681979 20084675 20512989 16779866 3581430 16328049 16830150 18665156 20727157 18788625 16540662
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.7215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.721917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3116051514 16096774
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9121159647 7505956 2727394 17174075
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tretinoin 2.709407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8216925845 14991402 9211117 9664655 9224671 17551590 10589399 9142499 8800419 9125849
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6512952375 16002989
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.0517244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.722952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.0819107877
MESH:D004417 Dyspnea Diazinon 4.9316487989
MESH:D004489 Edema, Cardiac Tretinoin 4.6018230668
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.7616804899 15700306
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7616569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D005124 Eye Abnormalities Tretinoin 3.649664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 3.2720387270 21071580
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7016513791 16611131 15751030 16002989 16534752
MESH:D005355 Fibrosis Tretinoin 3.6217994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0616452187
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9314991402 9664655
MESH:D006505 Hepatitis Diazinon 4.6716487989
MESH:D015658 HIV Infections Nickel 3.8517263646
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5414722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 4.6816002989
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007247 Infertility, Female Dieldrin 5.0210630421
MESH:D007248 Infertility, Male Atrazine 7.5812948887
MESH:D007248 Infertility, Male Diazinon 7.5812948887 16466525
MESH:D007249 Inflammation Diethylnitrosamine 8.7618785209
MESH:D007249 Inflammation Flavonoids 8.7617296493
MESH:D007249 Inflammation Nickel 8.7616166738
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.9815992940 17551590
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.5314681315 16762066 15003126
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1617184923
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2019642359 19225113 17107899 16891316 16766008 17301526 16331271 17506722 17217047 16788101 17368321 16935935 16140955 17361223 17712046 9834237 15748426 17649720 19075265 16823087 17294898 19035177 19029980 12679006 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718407596 18522880 18665156 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8016248980 18397230
MESH:D008107 Liver Diseases Chlorpyrifos 4.5015991261
MESH:D008107 Liver Diseases Diethylnitrosamine 4.5017034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.0619389873 21295105
MESH:D008113 Liver Neoplasms Dieldrin 11.068742319 9539021
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0620137499 20118626 19690152 20501860 18754104 21167192 19638242 21071580 9163691 2422723 18644402 19254457 12112319 19642983 21278145 16942905 19812893 20452335 19426721 21047994 19256749 20434301 19499222 2862719 12771043 18978307 19850985 15885732 20101389 19090486 20492335 10737359 19294768 20405173 18648771 19833225 19551842 20583210 19073162 19427195 19255062 19996281 18977376 15175105
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.0616712894 15890375
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.3018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3019519916 18164116 19126423 18253720 19004024 18544905 18093689 18775883 19009564 18079962 19539802 3124819 18308698 17174075 9362446 17942915 16842330 18282651 17854601 21159647 2563599 16267830
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 6695378 21163286 20512841
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Dieldrin 8.708820588
MESH:D009369 Neoplasms Diethylstilbestrol 8.7015313581
MESH:D009369 Neoplasms Tretinoin 8.7016594593 16946489
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.1711399458
MESH:D009421 Nervous System Malformations Tretinoin 10.179125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2215081274
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3416540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3415976015
MESH:D010300 Parkinson Disease Atrazine 6.0417218051
MESH:D010300 Parkinson Disease Dieldrin 6.0416809432 17291500 16112328 11445065 11181820
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7716977796 15687265
MESH:D011041 Poisoning Diazinon 4.4417603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.2317184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5617136230 15846301 15046698
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D012135 Respiratory Sounds Atrazine 10.4611874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 10.4616611668 11874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.0317119214 16611668
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.226418539
MESH:D012878 Skin Neoplasms Tretinoin 2.6416467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.8516709447 16002989
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4418456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4417261132
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.387505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8016712894 16452187 17306315
MESH:D014570 Urologic Diseases Diazinon 5.4116487989
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.7716175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.7716129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1616690809 15809267
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5416513791 16002989
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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