AutismKB 2.0

Annotation Detail for WRN


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Basic Information Top
Gene Symbol:WRN ( DKFZp686C2056,RECQ3,RECQL2,RECQL3 )
Gene Full Name: Werner syndrome, RecQ helicase-like
Band: 8p12
Quick LinksEntrez ID:7486; OMIM: 604611; Uniprot ID:WRN_HUMAN; ENSEMBL ID: ENSG00000165392; HGNC ID: 12791
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200072Regulation of Telomerase
Pathway IDPathway Name
P00059p53 pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of DNA repair systems
H00296Defects in RecQ helicases
Genetic disorders
Desease IDDesease Name
1818Systemic scleroderma
1904Diabetes mellitus
1918Atherosclerosis
2009Sarcoma
2218Werner syndrome
Desease Name
CARDIOVASCULAR
Coronary Artery Disease
bone density but not spondylosis
CANCER
bone density
spondylosis, lumbar
breast cancer
Waldenstrom macroglobulinaemia
METABOLIC
Stroke
Myocardial Infarction
diabetes, type 2
exercise treadmill test traits
Hypertension/complications*
Desease Name
Exercise treadmill test traits
Desease Name
Werner syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000677 Amsacrine WRN gene mutant form results in increased susceptibility to Amsacrineincreases response to substance 10725663
D001554 Benzene WRN gene SNP results in increased susceptibility to Benzeneincreases response to substance 16728435
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WRN mRNAdecreases expression 19150397
C074702 chromium hexavalent ion chromium hexavalent ion affects the localization of WRN proteinaffects localization 19487340
C074702 chromium hexavalent ion WRN protein mutant form results in increased susceptibility to chromium hexavalent ionincreases response to substance 19487340
D016572 Cyclosporine Cyclosporine results in increased expression of WRN mRNAincreases expression 20106945
D005047 Etoposide WRN gene mutant form results in increased susceptibility to Etoposideincreases response to substance 10725663
C031927 hydroquinone WRN protein affects the reaction [hydroquinone results in increased acetylation of TP53 protein]affects reaction|increases acetylation 17875398
C031927 hydroquinone WRN protein affects the reaction [hydroquinone results in increased expression of H2AFX protein]affects reaction|increases expression 17875398
C031927 hydroquinone WRN protein affects the reaction [hydroquinone results in increased expression of TP53 protein]affects reaction|increases expression 17875398
C031927 hydroquinone WRN protein results in decreased susceptibility to hydroquinonedecreases response to substance 17875398
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of WRN mRNAaffects binding|increases activity|increases expression 19710929
C017947 sodium arsenite sodium arsenite results in increased expression of WRN proteinincreases expression 19072884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2217306315 16712894
MESH:D000741 Anemia, Aplastic Benzene 4.5311369114 14761424 17661222
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001855 Bone Marrow Diseases Benzene 5.5516183116
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.4814601052
MESH:D001943 Breast Neoplasms Benzene 2.7017162533 11921183
MESH:D001943 Breast Neoplasms Etoposide 2.7016322251
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9917306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.9820056578 19524636
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D019465 Craniofacial Abnormalities Benzene 2.4515643154
MESH:D003872 Dermatitis Benzene 5.0215902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005234 Fatty Liver Cyclosporine 8.2519224547
MESH:D005234 Fatty Liver pirinixic acid 8.2520131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.4012168785 12639820
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006402 Hematologic Diseases Benzene 4.8716183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19176532 19772884 18467677
MESH:D006561 Herpes Simplex Amsacrine 11.6010809021
MESH:D006561 Herpes Simplex Etoposide 11.6010809021
MESH:D006689 Hodgkin Disease Etoposide 8.2617606976 18180244 16135485 16200630 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 8.2612676792
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Benzene 5.6117940673
MESH:D006973 Hypertension Cyclosporine 5.6110903974
MESH:D007248 Infertility, Male sodium arsenite 3.1215346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.388314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.3820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia Benzene 3.4814694614 18335105 15935818 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.5217506065
MESH:D015470 Leukemia, Myeloid, Acute Amsacrine 4.8815148258 18043129
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.8819478238
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 4.7116377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 4.7116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.4112562636
MESH:D008171 Lung Diseases chromium hexavalent ion 8.4216775837
MESH:D008171 Lung Diseases sodium arsenite 8.4219095001
MESH:D017563 Lung Diseases, Interstitial Benzene 5.1314698565
MESH:D008175 Lung Neoplasms Benzene 3.8712562636
MESH:D008175 Lung Neoplasms chromium hexavalent ion 3.8716876463 16570259
MESH:D008175 Lung Neoplasms sodium arsenite 3.8717306315 19931552 17077188 16712894 15276417
MESH:D008223 Lymphoma Benzene 8.4917584886 17119257
MESH:D008223 Lymphoma Etoposide 8.4912854902 12556972
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.7312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.4311921183
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009101 Multiple Myeloma Benzene 3.8017119195
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 5.2517405874
MESH:D009369 Neoplasms sodium arsenite 5.2511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009436 Neural Tube Defects Benzene 7.9715643154
MESH:D009436 Neural Tube Defects sodium arsenite 7.9712854658
MESH:D009669 Nose Neoplasms chromium hexavalent ion 5.4016876463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases Benzene 4.3717119257 15913788 15612468 15576619 15727169 17479406 16737584 15935809 17178637
MESH:D010051 Ovarian Neoplasms Benzene 5.3012562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.3017306315 15276417
MESH:D010190 Pancreatic Neoplasms Etoposide 3.3319003803
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Etoposide 3.5217172428
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5216039940
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012512 Sarcoma, Ewing's Etoposide 4.9414601052
MESH:D012878 Skin Neoplasms sodium arsenite 2.7819524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013953 Thymus Neoplasms Benzene 5.2410850423
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5711723127 16712894 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014594 Uterine Neoplasms Benzene 4.5712562636
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D014898 Werner Syndrome marker/mechanism
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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