AutismKB 2.0

Annotation Detail for WT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:WT1 ( AWT1,GUD,NPHS4,WAGR,WIT-2,WT33 )
Gene Full Name: Wilms tumor 1
Band: 11p13
Quick LinksEntrez ID:7490; OMIM: 607102; Uniprot ID:WT1_HUMAN; ENSEMBL ID: ENSG00000184937; HGNC ID: 12796
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200072Regulation of Telomerase
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1740Alzheimer's disease
1863Aplastic anemia
1901Endometriosis
1934Cancer
1955Urogenital abnormalities
2107Proteinuria
2108Nephritis
1920Hyperparathyroidism
2233Cirrhosis
1846Pleural effusion, Malignant
Desease Name
wilms' tumor and congenital male genitourinary malformation
hypospadias
abnormal urogenital development
Alzheimer's disease
CANCER
RENAL
NEUROLOGICAL
Denys-Drash syndrome
glomerulosclerosis, focal
WAGR Syndrome
Wilm's tumor
DEVELOPMENTAL
nephrotic syndrome
No data
Desease Name
Frasier syndrome
Nephrotic syndrome, typ 4
Wilms tumor, type 1
Meacham syndrome
Denys-Drash syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of WT1 mRNAdecreases expression 19933214
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of WT1 mRNAincreases expression 19643169
D000643 Ammonium Chloride Ammonium Chloride affects the expression of WT1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of WT1 mRNAdecreases expression 16966277
C006632 arsenic trioxide arsenic trioxide results in decreased expression of WT1 proteindecreases expression 16966277
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the splicing of WT1 mRNAaffects splicing 19530133
C034786 bis(4-hydroxycinnamoyl)methane bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 mRNAdecreases expression 18034345
C034786 bis(4-hydroxycinnamoyl)methane bis(4-hydroxycinnamoyl)methane results in decreased expression of WT1 proteindecreases expression 18034345
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of WT1 mRNAaffects expression 17484886
C018021 cobaltous chloride [cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNAaffects cotreatment|increases expression 12738801
D003474 Curcumin Curcumin results in decreased expression of WT1 mRNAdecreases expression 18034345
19196508
D003474 Curcumin Curcumin results in decreased expression of WT1 proteindecreases expression 19196508
18034345
D003676 Deferoxamine [cobaltous chloride co-treated with Deferoxamine] results in increased expression of WT1 mRNAaffects cotreatment|increases expression 12738801
C050229 demethoxycurcumin demethoxycurcumin results in decreased expression of WT1 mRNAdecreases expression 18034345
C050229 demethoxycurcumin demethoxycurcumin results in decreased expression of WT1 proteindecreases expression 18034345
D004958 Estradiol WT1 protein results in decreased susceptibility to Estradioldecreases response to substance 20204298
D005419 Flavonoids Flavonoids results in decreased expression of WT1 mRNAdecreases expression 18035473
D005576 Forskolin Forskolin results in increased expression of WT1 mRNAincreases expression 15961562
C070081 fulvestrant WT1 protein results in decreased susceptibility to fulvestrantdecreases response to substance 20204298
C097613 imatinib imatinib results in decreased expression of WT1 mRNAdecreases expression 15329907
D008345 Manganese Manganese results in decreased expression of WT1 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of WT1 mRNAdecreases expression 17175027
C005219 methyl cellosolve methyl cellosolve results in increased expression of WT1 mRNAincreases expression 19643169
D010100 Oxygen Oxygen deficiency results in decreased expression of WT1 mRNAdecreases expression 17175027
D010100 Oxygen Oxygen deficiency results in increased expression of WT1 mRNAincreases expression 12738801
D010269 Paraquat Paraquat results in increased expression of WT1 mRNAincreases expression 16797015
D011374 Progesterone Progesterone results in increased expression of WT1 mRNAincreases expression 14662165
D011374 Progesterone Progesterone results in increased expression of WT1 mRNA alternative formincreases expression 14662165
D011374 Progesterone Progesterone results in increased expression of WT1 proteinincreases expression 14662165
D020123 Sirolimus Sirolimus results in decreased expression of WT1 protein mutant formdecreases expression 15782132
C017947 sodium arsenite sodium arsenite results in decreased expression of WT1 mRNAdecreases expression 16966277
C017947 sodium arsenite sodium arsenite results in decreased expression of WT1 proteindecreases expression 16966277
C017947 sodium arsenite sodium arsenite results in increased expression of WT1 mRNAincreases expression 12016162
C017947 sodium arsenite sodium arsenite results in increased expression of WT1 mRNAincreases expression 16876216
11241755
C017947 sodium arsenite sodium arsenite results in increased expression of WT1 proteinincreases expression 16876216
D019311 Staurosporine Staurosporine results in increased expression of WT1 proteinincreases expression 12914969
D013629 Tamoxifen WT1 protein results in decreased susceptibility to Tamoxifendecreases response to substance 20204298
20944147
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of WT1 mRNAdecreases expression 19933214
D014212 Tretinoin PDCD4 protein promotes the reaction [Tretinoin results in decreased expression of WT1 protein]decreases expression|increases reaction 17259349
D014212 Tretinoin Tretinoin results in decreased expression of WT1 mRNAdecreases expression 15770638
15749674
D014212 Tretinoin Tretinoin results in decreased expression of WT1 mRNA alternative formdecreases expression 15749674
D014212 Tretinoin Tretinoin results in decreased expression of WT1 proteindecreases expression 15770638
D014212 Tretinoin Tretinoin results in increased expression of WT1 mRNAincreases expression 14646600
D014212 Tretinoin Tretinoin results in increased expression of WT1 proteinincreases expression 12644474
D014212 Tretinoin Tretinoin results in decreased expression of WT1 proteindecreases expression 15855632
D014212 Tretinoin Tretinoin results in increased expression of WT1 mRNAincreases expression 16604517
D014810 Vitamin E Vitamin E affects the expression of WT1 mRNAaffects expression 15370891
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2814745880
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 13.006499796 6499820 6499823 6499812 7151721
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 13.006499812 3652986 6474471
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.0015322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple imatinib 5.0218322153
MESH:D000022 Abortion, Spontaneous imatinib 5.9518322153
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D055371 Acute Lung Injury Oxygen 4.2916759491
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6519825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6520464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.6511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.506695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5111874814
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8117887948
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000544 Alzheimer Disease bis(4-hydroxycinnamoyl)methane 4.7719090986
MESH:D000544 Alzheimer Disease Curcumin 4.7715590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.083699323
MESH:D000756 Anemia, Sideroblastic Manganese 10.2516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.2516910769
MESH:D000860 Anoxia Oxygen 4.7920872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.9216412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.5116807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5116292516
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 11.7210689203 6499823 6499807
MESH:D053627 Asthenozoospermia methyl cellosolve 11.723987992
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001259 Ataxia 2-ethoxyethanol 5.217151721
MESH:D050197 Atherosclerosis Curcumin 6.6018704882
MESH:D050197 Atherosclerosis Oxygen 6.6016391483
MESH:D001284 Atrophy 2-ethoxyethanol 16.7915850284 6499799
MESH:D001284 Atrophy fulvestrant 16.7911514358
MESH:D001284 Atrophy methyl cellosolve 16.792626667 3699323 6705890
MESH:D001321 Autistic Disorder Sirolimus 3.2321115397
MESH:D001327 Autoimmune Diseases Curcumin 4.2319761891
MESH:D053713 Azoospermia 2-ethoxyethanol 5.326492198 6499807
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001724 Birth Weight 2-ethoxyethanol 6.256499823 2884743
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.9816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9816206674 16197459
MESH:D001836 Body Weight Changes 2-ethoxyethanol 11.147151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.1415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001859 Bone Neoplasms imatinib 5.0815867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 4.0015665606 15845082 15380490
MESH:D002545 Brain Ischemia Curcumin 4.0716770732
MESH:D001932 Brain Neoplasms Curcumin 3.7117596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.9920146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 7.9918593918 18462866 16243823 19250217
MESH:D001943 Breast Neoplasms Deferoxamine 7.9915993339
MESH:D001943 Breast Neoplasms Estradiol 7.9917261762 12948864 17018787 16675129 14630087 17289903 19861407 18497071
MESH:D001943 Breast Neoplasms fulvestrant 7.9918984771
MESH:D001943 Breast Neoplasms imatinib 7.9917614352
MESH:D001943 Breast Neoplasms Oxygen 7.9917263869
MESH:D001943 Breast Neoplasms Progesterone 7.9916175315 17614352 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 7.9919142967 19011961 19244106 19221464 18351453 18425577 19155303 19410462 19103187 19115204 18855134 15565566 18629630 21138602 11161223 17242785 16202921 19189210 19200415 16873071 21152245 15668708 17893378 16818667 20859285 19487384 17049068 18997820 20544844 18821012 20005174 19288272 19189212 19084267 18984771 17440819 20065188 19289846 17261762 19059307 20135344 18815881 16273361 19066611 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 7.9916166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.0816192424 16097048 3786805 16011737 15700767 15673190 10355542 16124888 16227642 18705752 16050911 15721981
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.0816050911
MESH:D002277 Carcinoma Curcumin 7.6018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.3911135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.3918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3916924424
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 13.3919335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.3915276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.391917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8918414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.5020419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 13.5018462866
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 13.5019435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.5018572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.5016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2216120746 18850075 18670907
MESH:D002386 Cataract Tretinoin 2.9417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.1520056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 12.766499794
MESH:D002764 Cholecystitis methyl cellosolve 12.766499794
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4015340226 15668235 16354765 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.409407595
MESH:D003092 Colitis Curcumin 8.7816782535 18200517 16804969
MESH:D003092 Colitis Tretinoin 8.7817035595
MESH:D003103 Coloboma Curcumin 4.3118809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4616340194 19359593
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.706499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7014669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.6418497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.0110525206
MESH:D019465 Craniofacial Abnormalities imatinib 7.0118322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.0120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.019224671 8800419 9142499 16925845 9211117 10589399 17551590 14991402 9664655 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin E 7.0119769572
MESH:D003643 Death 2-ethoxyethanol 5.706499796
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1019031437
MESH:D030321 Denys-Drash Syndrome marker/mechanism
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.7811298694 16823706 15059100
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.1818403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.7618204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.7619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.7619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.467179309 19336974 2869522 4309450 21278145 16177239 10915739 17522070 7120509 6884620 15998439 3786805 19085960 15027814 15968718 10092053 6623471 9327722 3732212 11566570 16227642 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.4620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8017351913
MESH:D004417 Dyspnea Oxygen 4.5720016425
MESH:C538011 Eales disease Vitamin E 4.449068938
MESH:D004487 Edema bis(4-hydroxycinnamoyl)methane 19.2718449507
MESH:D004487 Edema demethoxycurcumin 19.2718449507
MESH:D004487 Edema imatinib 19.2719703484
MESH:D004487 Edema Staurosporine 19.278273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 19.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0518230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.0518230668
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.256499796
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.3317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3319031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.4411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.4417893378 16202921 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 11.4416569247
MESH:D004715 Endometriosis Progesterone 8.1716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.179294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1911564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1916938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 16.8815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.8812795759 19224547 16045604 17595544 12631006 16239168 15959796 61145
MESH:D005234 Fatty Liver Curcumin 16.8819297423
MESH:D005234 Fatty Liver Tamoxifen 16.8814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0816709447
MESH:D005313 Fetal Death 2-ethoxyethanol 9.987198755 6499820 2884743 6499823 7151721
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.9811858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.166499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 11.786499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 11.786499821 6474471 6499812 3987992
MESH:D020567 Fetal Weight 2-ethoxyethanol 12.762884743 7151721 6499820
MESH:D020567 Fetal Weight methyl cellosolve 12.766499821 6499812 6474471
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2614745880
MESH:D018222 Fibromatosis, Aggressive imatinib 10.9517453242
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.9519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.0518705752
MESH:D005355 Fibrosis Curcumin 19.0518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.0520067830
MESH:D005355 Fibrosis Tretinoin 19.0517994277
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.233652986
MESH:D052159 Frasier Syndrome marker/mechanism
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0116904648
MESH:D005739 Gas Poisoning Oxygen 4.9520016425
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4418462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4216452187
MESH:D005909 Glioblastoma Curcumin 11.0517596214
MESH:D005909 Glioblastoma Manganese 11.0517043766
MESH:D005909 Glioblastoma Tretinoin 11.0517312396
MESH:D005911 Gliosis Paraquat 4.9011124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Curcumin 12.1318829502 18462866
MESH:D006258 Head and Neck Neoplasms Sirolimus 12.1319435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.1316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.8320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.8310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 14.8314991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 14.8316080930
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.526499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.1420172899 10514026
MESH:D006461 Hemolysis 2-ethoxyethanol 11.4519051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 11.4517874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3519110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6412621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7817701891
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 17436238
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6116490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9412676792
MESH:D019584 Hot Flashes Estradiol 9.1617088409
MESH:D019584 Hot Flashes Vitamin E 9.1614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7816354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.0116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2716899240
MESH:D006937 Hypercholesterolemia Curcumin 3.8218704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8315338365
MESH:D006984 Hypertrophy Sirolimus 4.9919211884
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007247 Infertility, Female 2-ethoxyethanol 4.996499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 19.336499823
MESH:D007248 Infertility, Male fulvestrant 19.3311514358
MESH:D007248 Infertility, Male methyl cellosolve 19.333987992
MESH:D007248 Infertility, Male Paraquat 19.334850670
MESH:D007248 Infertility, Male sodium arsenite 19.3315346721 12646999
MESH:D007249 Inflammation Curcumin 14.4117151092 16956363 18403477
MESH:D007249 Inflammation Flavonoids 14.4117296493
MESH:D007249 Inflammation Progesterone 14.4115869954
MESH:D007249 Inflammation Tamoxifen 14.4119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.4112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1018596194 18200517
MESH:D007251 Influenza, Human Vitamin E 3.9516624496
MESH:D007333 Insulin Resistance Estradiol 2.8016393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5117994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9910783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1515992940 17551590
MESH:D007674 Kidney Diseases Estradiol 9.2415618244
MESH:D007674 Kidney Diseases sodium arsenite 9.2420008137
MESH:D007674 Kidney Diseases Vitamin E 9.2412488133
MESH:D007680 Kidney Neoplasms Estradiol 6.6915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6918625569
MESH:D007889 Leiomyoma Curcumin 4.3318555241
MESH:D007938 Leukemia arsenic trioxide 9.7715070760
MESH:D007938 Leukemia Curcumin 9.7718462866
MESH:D007938 Leukemia Tretinoin 9.7717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.9817077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.9816106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.2314633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 8.2315748426 17301526 15107311 19208803
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.7919077051
MESH:D007951 Leukemia, Myeloid imatinib 14.7917236224
MESH:D007951 Leukemia, Myeloid Tretinoin 14.7916482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0016467208 17050201 19850784 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Deferoxamine 6.0020368581
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.0019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0715748426 15622746 17217047 12679006 17712046 17649720 16331271 16112521 12712474 11468182 19035177 17869043 17107899 19075265 19642359 11161223 9834237 12018890 15336539 15213294 19225113 16966277 16330433 16823087 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0717107899 9834237 19642359 16788101 17217047 17361223 15748426 16823087 16766008 16891316 17339181 17649720 19035177 17368321 16331271 19075265 16935935 16140955 17301526 17712046 19029980 12679006 17506722 19225113 17294898
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.8816882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.8816106398
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 7.956499821
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.959224671
MESH:D008064 Lipidoses Tamoxifen 2.9717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6721278145 11903743 17157831 17334410 17174718 16221502 11408273 16943688 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 15.0215893842 18472094 18472332 18339082 18395095 12898905 20821823 12632514 14716833 17714472 18317297 18205269 15057751 15362042 15052691 17805973 15959796 17922224 16116963 17766677 17944888 12389079 15650968 14620537 14748882 15996030 16015684 12445421 18705752 15338365 17823541 18412020 18420326 16033810 18277467 16192424 17565644 18006644 16011737 15876570 12609069 18251166 17976157 18395914 18263696 16638106 14724832 16248980 18166357 15925388 12666154 12958196 11481614 17631135 14716496 12632512 18481824 18429990 13678700 12649538 12586293 17708605 18187930 15931870 15730626 16097048 17640975 18376398 17869086 12667390 12741479 16027843 10355542 18054572 17481882 15370692 12546737 14512876 12445418 18279442 15673190 17721639 18156304 17525996 17900296 18418968 16136751 15123356 17557913 15818738 17761835 18210741 17698563
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 15.0218705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 15.0214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental imatinib 15.0216596278
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 15.0217050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 15.0218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 15.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 15.0218397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 15.0216169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0316964402 15830285 16246199 15720792 17285989
MESH:D008107 Liver Diseases Curcumin 4.0316956363
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4616899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 16.6514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.6521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.6519294768
MESH:D008113 Liver Neoplasms sodium arsenite 16.6515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 16.6516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.6516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.8620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.8612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1515213294
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D008171 Lung Diseases Vitamin E 6.8616863852
MESH:D055370 Lung Injury Oxygen 4.2518339021
MESH:D008175 Lung Neoplasms arsenic trioxide 10.1711798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.1720464547 20135361 18520028 18569708 20869020 17053015 18816296 20064080 6695378
MESH:D008175 Lung Neoplasms Curcumin 10.1716243823 18462866 19359593
MESH:D008175 Lung Neoplasms sodium arsenite 10.1716712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 10.1718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 10.1711062179
MESH:D008223 Lymphoma Curcumin 3.4018462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.4416173963
MESH:D008231 Lymphopenia methyl cellosolve 5.523699323
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.0016891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.0017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.0011731420 16827153 19196723 19196722 14580682
MESH:D020149 Manganese Poisoning Estradiol 20.8419453300
MESH:D020149 Manganese Poisoning Manganese 20.8416551646 19453300 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 20.8419453300
OMIM:608978 MEACHAM SYNDROME marker/mechanism
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Curcumin 9.2818462866 17885582
MESH:D008545 Melanoma Sirolimus 9.2819282848
MESH:D008545 Melanoma sodium arsenite 9.2819082730 16487513
MESH:D008545 Melanoma Tamoxifen 9.2819393235 12393984
MESH:D008545 Melanoma Tretinoin 9.2816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9215990972
MESH:D008569 Memory Disorders Curcumin 3.9017263510
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.2616381670
MESH:D009062 Mouth Neoplasms Sirolimus 8.2619435901
MESH:D009069 Movement Disorders Manganese 4.7716551646
MESH:D009101 Multiple Myeloma arsenic trioxide 6.8219417148 11468182 19549372 15949261 14977855
MESH:D009101 Multiple Myeloma Curcumin 6.8219372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6517962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0816810080
MESH:D009336 Necrosis 2-ethoxyethanol 5.0820172899
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 22.6816624393
MESH:D009361 Neoplasm Invasiveness bis(4-hydroxycinnamoyl)methane 22.6818495463
MESH:D009361 Neoplasm Invasiveness Curcumin 22.6818495463
MESH:D009361 Neoplasm Invasiveness demethoxycurcumin 22.6818495463
MESH:D009362 Neoplasm Metastasis imatinib 5.9115867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4319410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.5011141357
MESH:D009369 Neoplasms sodium arsenite 7.5011559025
MESH:D009369 Neoplasms Tretinoin 7.5016946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4120056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 16.8612497104
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 16.8617614352
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 16.8619196722 19200415 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
OMIM:256370 NEPHROTIC SYNDROME, TYPE 4 marker/mechanism
MESH:D009410 Nerve Degeneration Manganese 8.1316551646
MESH:D009410 Nerve Degeneration Paraquat 8.1316893418
MESH:D009421 Nervous System Malformations Estradiol 14.8811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.8814600291
MESH:D009421 Nervous System Malformations Tretinoin 14.889125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.3618462866
MESH:D009436 Neural Tube Defects arsenic trioxide 11.1710525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.1712854658
MESH:D009436 Neural Tube Defects Tretinoin 11.179142499
MESH:D009765 Obesity Curcumin 2.6819297423
MESH:D009845 Oligospermia 2-ethoxyethanol 10.5020172899
MESH:D009845 Oligospermia methyl cellosolve 10.503987992
MESH:D010014 Osteolysis imatinib 5.4715867366
MESH:D010024 Osteoporosis Curcumin 3.3118719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.7616624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 17.7618462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 17.7619401270
MESH:D010051 Ovarian Neoplasms Progesterone 17.7616525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.7615276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 17.7616936753
MESH:D010146 Pain Tretinoin 2.7016870215
MESH:D010190 Pancreatic Neoplasms marker/mechanism 19196508
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.1215580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.1217440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1215976015
MESH:D010235 Paraganglioma arsenic trioxide 3.9219927285
MESH:D010300 Parkinson Disease Manganese 8.3611181820
MESH:D010300 Parkinson Disease Paraquat 8.3611124998 11181820 15451049 15824117 16140633 11445065 16510128 12911755
MESH:D010300 Parkinson Disease Sirolimus 8.3619682553
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1716190885
MESH:D020734 Parkinsonian Disorders Manganese 4.2416140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D011014 Pneumonia Paraquat 4.1912504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.3412476293
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 15.027198755 2884743 6499817
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 15.0212530607 7974496 6499817
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.0211896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.0615129424 18226269 10851300 18769126 12497104 11398177 18156803
MESH:D011471 Prostatic Neoplasms Estradiol 2.0616740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D011507 Proteinuria Tretinoin 3.3616636307
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.3019168576
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8116324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 13.9218379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 13.9217627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 13.9211700416
MESH:D012135 Respiratory Sounds Paraquat 3.8011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012162 Retinal Degeneration Paraquat 3.6716458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8616116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012509 Sarcoma Curcumin 3.8918462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7116646077
MESH:D018805 Sepsis Curcumin 3.8618389075
MESH:D012871 Skin Diseases Vitamin E 2.3718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5219755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 12.5218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5216192470
MESH:D012878 Skin Neoplasms Tretinoin 12.5216467112
MESH:D013088 Spermatocele Tamoxifen 4.0316709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6012854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5520155912 2093021
MESH:D013274 Stomach Neoplasms imatinib 4.5515786421
MESH:D013274 Stomach Neoplasms Tretinoin 4.5517261132
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 11.146499799
MESH:D013276 Stomach Ulcer bis(4-hydroxycinnamoyl)methane 11.1419188055
MESH:D013276 Stomach Ulcer Curcumin 11.1419188055 16631530
MESH:D020521 Stroke Vitamin E 3.3216517955
MESH:D013398 Sudden Infant Death Oxygen 5.2812563064
MESH:D013733 Testicular Diseases 2-ethoxyethanol 10.1910048760 6499806 10514026
MESH:D013733 Testicular Diseases methyl cellosolve 10.196499806
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.0319014326
MESH:D013964 Thyroid Neoplasms imatinib 11.0316940797
MESH:D013964 Thyroid Neoplasms Tretinoin 11.0316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7015213294
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D014402 Tuberous Sclerosis Sirolimus 5.3218495876 21115397
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.6912973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.6917053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 14.6918593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.6911723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.6916712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 5.0018462866
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.6511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.6516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3416752155
MESH:D014605 Uveitis Sirolimus 5.361336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D017624 WAGR Syndrome marker/mechanism
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D009396 Wilms Tumor marker/mechanism
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37395
    • No data
    Releated disease ID Related disease Name
    PA152241952Congenital diaphragmatic hernia
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved