AutismKB 2.0

Annotation Detail for XPNPEP2


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Basic Information Top
Gene Symbol:XPNPEP2 ( - )
Gene Full Name: X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Band: Xq26.1
Quick LinksEntrez ID:7512; OMIM: 300145; Uniprot ID:XPP2_HUMAN; ENSEMBL ID: ENSG00000122121; HGNC ID: 12823
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
No data
No data
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Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
Angioedema
No data
Desease Name
Angioedema induced by ACE inhibitors, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of XPNPEP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of XPNPEP2 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone results in increased expression of XPNPEP2 mRNAincreases expression 19774075
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in decreased expression of XPNPEP2 mRNAaffects cotreatment|decreases expression 17639512
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of XPNPEP2 mRNAaffects cotreatment|decreases expression 18164116
D003314 Corn Oil Corn Oil affects the expression of XPNPEP2 mRNAaffects expression 16360708
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of XPNPEP2 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of XPNPEP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPNPEP2 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid pirinixic acid results in decreased expression of XPNPEP2 mRNAdecreases expression 17426115
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in decreased expression of XPNPEP2 mRNAaffects cotreatment|decreases expression 17639512
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of XPNPEP2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of XPNPEP2 mRNAdecreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.146695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.4618056438 16434500 17162532 19052882 17620307 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3817084956
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1715336622
MESH:D001281 Atrial Fibrillation Amiodarone 4.0119698954 18651412
MESH:D001327 Autoimmune Diseases Quercetin 4.5819761891
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.1519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.1519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0116443354
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0117474063
MESH:D001943 Breast Neoplasms Quercetin 2.0118628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002105 Cadmium Poisoning Quercetin 5.7616962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7616705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7617173139 19107877 19208518 19919837 18056438 16328049 18978308 16540662 20084675 17162532 10737359 20727157 16288022 20512989 18785209 18788625 19394651 16698587 19335982 16878318 3581430 18494052 11831363 10672840 19519916 16935385 17138121 20214788 20432363 17055752 18971187 19383236 16807293 20514400 19052882 16830150 17761372 16502159 18665156 16569478 20007298 20101231 21159647 20524982 3084413 18506893 16779866 20935162 19822196 19701751 17428255 19171122 18210153 18393292 19539802 17978847 19418558 18691550 16681979
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.7619519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1317234771
MESH:D006332 Cardiomegaly Quercetin 7.0419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0416120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9319225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.017505956 21159647 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0911677210 17110522 17681005 17333356 16105132 15861022 16919318
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15340226 15668235 12621046 8697196
MESH:D003110 Colonic Neoplasms Quercetin 2.4415741050 11134977 16640504 17191121 19440933 19056647 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.6917323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8519496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 7.3716506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.4318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.4319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Ascorbic Acid 5.699068938
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Amiodarone 19.9714986274
MESH:D005234 Fatty Liver Diethylnitrosamine 19.9721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9715345470
MESH:D005234 Fatty Liver pirinixic acid 19.9719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Quercetin 9.3519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005909 Glioblastoma Quercetin 3.4819804834
MESH:D005910 Glioma Quercetin 3.1017643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.0816080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Amiodarone 15.4815265979
MESH:D006529 Hepatomegaly pirinixic acid 15.4818467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4815340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5116490937 16863852
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 8697196 18606429 16959395 16354765
MESH:D006937 Hypercholesterolemia Amiodarone 4.018137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 9.6820558911
MESH:D006943 Hyperglycemia Quercetin 9.6818262572 11834736
MESH:D006968 Hypersensitivity, Delayed Corn Oil 6.0311484837
MESH:D006973 Hypertension Quercetin 5.3818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.6918020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.7216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007627 Keloid Quercetin 5.1317086741
MESH:D007674 Kidney Diseases Quercetin 3.1716962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007938 Leukemia Quercetin 3.2217468513
MESH:D008064 Lipidoses Amiodarone 3.6117567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918665156 18407596 20032147 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5215474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5212741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5212878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.637678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.6319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.6320434301 19638242 15885732 19690152 20583210 19427195 19294768 2862719 19255062 18754104 18977376 15175105 19850985 16942905 20101389 12771043 19996281 20405173 18648771 10737359 20492335 21047994 19426721 19499222 12112319 19642983 21071580 21167192 20118626 18978307 19073162 19256749 20452335 19812893 19254457 19551842 9163691 21278145 19833225 19090486 20501860 2422723 18644402 20137499
MESH:D008113 Liver Neoplasms pirinixic acid 18.6315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 18.6318980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.6316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 24.532876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 24.5318544905
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 24.5318164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 24.5319009564 9362446 21159647 19126423 16842330 18775883 19539802 18079962 17854601 17942915 16267830 18164116 18282651 3124819 18308698 17174075 19519916 2563599 18544905 18093689 18253720 19004024
MESH:D008114 Liver Neoplasms, Experimental Quercetin 24.5319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 24.5312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 8.1112587719
MESH:D008171 Lung Diseases Ascorbic Acid 8.1116863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D008175 Lung Neoplasms Ascorbic Acid 5.0116401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 5.0120970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Quercetin 5.0116280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0111884234 19555203
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009181 Mycoses Amiodarone 5.1217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 5.9019151258
MESH:D009203 Myocardial Infarction Quercetin 5.9019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8016411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.8019207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009369 Neoplasms Quercetin 5.2615185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.5117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity Ascorbic Acid 4.8517217161
MESH:D009765 Obesity pirinixic acid 4.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7719005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5416540662
MESH:D010190 Pancreatic Neoplasms Quercetin 5.5416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Corn Oil 16.3114668109
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.312563599
MESH:D011230 Precancerous Conditions Quercetin 16.3119056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Quercetin 3.5714715546 17292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.5514606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9011597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3416849425
MESH:D012554 Schistosomiasis japonica Quercetin 5.7616862918
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1818551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D012871 Skin Diseases Ascorbic Acid 3.2418709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 8.0818087811
MESH:D013276 Stomach Ulcer Ascorbic Acid 8.0818726076
MESH:D020521 Stroke Ascorbic Acid 4.4016517955 16403987
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Amiodarone 12.7919731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.7912697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.0418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3817467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6416049721
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.6416720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04974 Protein digestion and absorption
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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