AutismKB 2.0

Annotation Detail for XRCC1


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Basic Information Top
Gene Symbol:XRCC1 ( RCC )
Gene Full Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Band: 19q13.2
Quick LinksEntrez ID:7515; OMIM: 194360; Uniprot ID:XRCC1_HUMAN; ENSEMBL ID: ENSG00000073050; HGNC ID: 12828
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03410Base excision repair
Pathway IDPathway Name
DNA Repair
Pathway IDPathway Name
200027E2F transcription factor network
200120FOXM1 transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1739Oral cancer
1759Skin cancer
1781Rheumatoid arthritis
1878Ischemia
1901Endometriosis
1934Cancer
1954Stroke
1969Azoospermia
1979Testicular dysfunction
2050Peptic esophagitis
2098Esophageal disease
2164Barrett's esophagus
Desease Name
chromosome damage
colorectal cancer
endometriosis
prostate cancer
melanoma
pancreatic cancer
DNA repair
CANCER
stomach cancer
radiotherapy response
PHARMACOGENOMIC
cancer
Gastric cardia carcinoma
benzene toxicity
radiation sensitivity
sister-chromatid exchanges
breast cancer
Neoplasms
kidney cancer
METABOLIC
lung cancer
non-small cell lung cancer
leukemia
REPRODUCTION
cervical intraepithelial neoplasia grade 3
cervical cancer
cytogenetic studies
head and neck cancer
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000348 Aflatoxins XRCC1 gene polymorphism results in increased susceptibility to Aflatoxinsincreases response to substance 15734960
D000643 Ammonium Chloride Ammonium Chloride affects the expression of XRCC1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of XRCC1 mRNAincreases expression 12773770
D001194 Asbestos XRCC1 gene polymorphism results in increased susceptibility to Asbestosincreases response to substance 16564556
D001194 Asbestos XRCC1 protein affects the susceptibility to Asbestosaffects response to substance 16944782
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Fenretinide results in decreased expression of XRCC1 protein]decreases expression|decreases reaction 16124896
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Reactive Oxygen Species results in decreased expression of XRCC1 protein]decreases expression|decreases reaction 16124896
D001554 Benzene XRCC1 gene polymorphism affects the susceptibility to Benzeneaffects response to substance 18214807
17095285
D001554 Benzene XRCC1 gene SNP affects the susceptibility to Benzeneaffects response to substance 15612468
D001554 Benzene XRCC1 gene SNP results in decreased susceptibility to Benzenedecreases response to substance 16284386
D001554 Benzene XRCC1 gene SNP results in increased susceptibility to Benzeneincreases response to substance 16284386
D001761 Bleomycin XRCC1 gene polymorphism affects the susceptibility to Bleomycinaffects response to substance 12082022
D003561 Cytarabine Cytarabine results in increased expression of XRCC1 mRNAincreases expression 19194470
D013759 Tetrahydrocannabinol Tetrahydrocannabinol results in decreased expression of XRCC1 mRNAdecreases expression 16039398
D002945 Cisplatin XRCC1 mRNA results in decreased susceptibility to Cisplatindecreases response to substance 15882455
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of XRCC1 mRNAaffects expression 17555576
D005419 Flavonoids Flavonoids results in decreased expression of XRCC1 mRNAdecreases expression 15465739
D019833 Genistein Genistein results in decreased expression of XRCC1 mRNAdecreases expression 16169203
D017313 Fenretinide Ascorbic Acid inhibits the reaction [Fenretinide results in decreased expression of XRCC1 protein]decreases expression|decreases reaction 16124896
D017313 Fenretinide Fenretinide results in decreased expression of XRCC1 proteindecreases expression 16124896
D017313 Fenretinide [Fenretinide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XRCC1 proteindecreases expression|increases abundance 16124896
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of XRCC1 mRNAdecreases expression 15458575
C031895 lead chromate XRCC1 protein results in decreased susceptibility to lead chromatedecreases response to substance 16714390
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of XRCC1 mRNAdecreases expression 17616710
D010269 Paraquat Paraquat results in increased expression of XRCC1 mRNAincreases expression 15458575
D010882 Piperonyl Butoxide Piperonyl Butoxide results in decreased expression of XRCC1 mRNAdecreases expression 17014948
D010936 Plant Extracts Plant Extracts results in decreased expression of XRCC1 mRNAdecreases expression 15465739
D010984 Platinum XRCC1 gene polymorphism affects the susceptibility to Platinumaffects response to substance 18851872
D011084 Polycyclic Hydrocarbons, Aromatic XRCC1 gene affects the susceptibility to Polycyclic Hydrocarbons, Aromaticaffects response to substance 15938845
C025299 polyphenols polyphenols results in decreased expression of XRCC1 mRNAdecreases expression 15465739
D017382 Reactive Oxygen Species Ascorbic Acid inhibits the reaction [Reactive Oxygen Species results in decreased expression of XRCC1 protein]decreases expression|decreases reaction 16124896
D017382 Reactive Oxygen Species [Fenretinide results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XRCC1 proteindecreases expression|increases abundance 16124896
D017382 Reactive Oxygen Species Reactive Oxygen Species results in decreased expression of XRCC1 proteindecreases expression 16124896
C017947 sodium arsenite sodium arsenite results in increased expression of XRCC1 mRNAincreases expression 12634122
C017947 sodium arsenite sodium arsenite results in decreased expression of XRCC1 mRNAdecreases expression 16014739
D020058 Styrene XRCC1 gene polymorphism results in increased susceptibility to Styreneincreases response to substance 15992842
D020058 Styrene XRCC1 protein polymorphism affects the susceptibility to Styreneaffects response to substance 15468052
C013690 styrene oxide XRCC1 protein polymorphism affects the susceptibility to styrene oxideaffects response to substance 15468052
D013629 Tamoxifen Tamoxifen affects the expression of XRCC1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of XRCC1 mRNAdecreases expression 16039398
18762178
D014212 Tretinoin Tretinoin results in decreased expression of XRCC1 mRNAdecreases expression 16604517
D014415 Tunicamycin Tunicamycin results in decreased expression of XRCC1 mRNAdecreases expression 15458575
D014752 Vinyl Chloride GSTM1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]affects mutagenesis|affects reaction 16097394
D014752 Vinyl Chloride GSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]affects mutagenesis|affects reaction 16097394
D014752 Vinyl Chloride XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]affects mutagenesis|affects reaction 16097394
D014752 Vinyl Chloride XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]affects mutagenesis|increases reaction 14602524
D014752 Vinyl Chloride XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]increases mutagenesis|increases reaction 16881598
D014752 Vinyl Chloride XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]increases mutagenesis|increases reaction 12010862
16881598
D014752 Vinyl Chloride XRCC1 gene SNP results in increased susceptibility to Vinyl Chlorideincreases response to substance 20100738
18420361
17555083
D014752 Vinyl Chloride Vinyl Chloride results in decreased expression of XRCC1 proteindecreases expression 15256147
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6812690470 17670903 15814532
MESH:D055371 Acute Lung Injury Bleomycin 4.6017118201
MESH:D000230 Adenocarcinoma Cisplatin 9.5411798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.5414692618
MESH:D000230 Adenocarcinoma Fenretinide 9.5410697514
MESH:D000230 Adenocarcinoma Genistein 9.5411473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3815276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.7417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.7417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4611874814
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000544 Alzheimer Disease Plant Extracts 2.9516962711
MESH:D000690 Amyotrophic Lateral Sclerosis Tetrahydrocannabinol 4.6415204022
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000741 Anemia, Aplastic Benzene 4.1311369114 17661222 14761424
MESH:D000860 Anoxia Bleomycin 5.1015782499
MESH:D020261 Arsenic Poisoning Arsenic 2.7818414634 16251483 12569548 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.2215885639
MESH:D001169 Arthritis, Experimental Plant Extracts 11.2214686799
MESH:D001169 Arthritis, Experimental Tretinoin 11.2216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D050197 Atherosclerosis Arsenic 10.3119371607 12928151
MESH:D050197 Atherosclerosis Asbestos 10.3118795166
MESH:D050197 Atherosclerosis Tetrahydrocannabinol 10.3115815632
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001661 Biliary Tract Neoplasms Vinyl Chloride 6.5511024202
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.0216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9116183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5714601052
MESH:D002545 Brain Ischemia Plant Extracts 4.4216041641
MESH:D001932 Brain Neoplasms Fenretinide 8.7316187019
MESH:D001932 Brain Neoplasms Vinyl Chloride 8.7312562636
MESH:D001943 Breast Neoplasms Ascorbic Acid 5.5016443354
MESH:D001943 Breast Neoplasms Benzene 5.5011921183 17162533
MESH:D001943 Breast Neoplasms Cisplatin 5.5019526202 18382427
MESH:D001943 Breast Neoplasms Fenretinide 5.5016601279
MESH:D001943 Breast Neoplasms Genistein 5.5016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Styrene 5.5015986119
MESH:D001943 Breast Neoplasms Tamoxifen 5.5019066611 19487384 18425577 17440819 18629630 19288272 19244106 16873071 15668708 21138602 19155303 19189212 20005174 19221464 18821012 21152245 16273361 20390343 18984771 17893378 15565566 18815881 18351453 19200415 19142967 17261762 19103187 17049068 19289846 19115204 17242785 20859285 20544844 19189210 16202921 19410462 19059307 11161223 19011961 18855134 20065188 18997820 19084267 20135344 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5020435547
MESH:D001943 Breast Neoplasms Tretinoin 5.5016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002057 Burns, Chemical Plant Extracts 5.029625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4217687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 18.8117306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 18.8117982673
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 18.8117159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Genistein 18.8116924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 18.8118834353
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.8116507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 18.8116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.811917145
MESH:D006528 Carcinoma, Hepatocellular Vinyl Chloride 18.8115289165 12828392 10699891 12958735
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9316685392 12023789
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 16639733
MESH:D002294 Carcinoma, Squamous Cell Arsenic 16.8418922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 16.846189445
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 16.8418337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 16.8416274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 16.8418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.8416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.6118640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.6117572228
MESH:D006332 Cardiomegaly Plant Extracts 6.4017645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4016120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 11.0217938729 19152805 15738583
MESH:D002318 Cardiovascular Diseases Genistein 11.0216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.0216936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.0518022660 16973168
MESH:D002375 Catalepsy Tetrahydrocannabinol 5.4110318961
MESH:D002386 Cataract Tretinoin 2.9117460283
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 6.598243401
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5919524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 11.9416154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 11.9416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6511677210 17110522 16919318 16105132 17333356 17681005 15861022
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.328697196 16354765 15668235 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.329407595
MESH:D003092 Colitis Tretinoin 3.4017035595
MESH:D003110 Colonic Neoplasms Genistein 3.8017182828
MESH:D003110 Colonic Neoplasms polyphenols 3.8016293270
MESH:D015179 Colorectal Neoplasms Cisplatin 2.8915273666
MESH:D015179 Colorectal Neoplasms Fenretinide 2.8917273769
MESH:D003139 Common Cold Ascorbic Acid 5.1617323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8014669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 5.1715643154
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 5.1715736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1715322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.1714991402 17551590 9142499 10589399 9125849 9664655 9211117 9224671 8800419 16925845
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D003872 Dermatitis Benzene 4.4615902427
MESH:D009783 Dermatitis, Occupational Vinyl Chloride 5.4010870345
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.7416506275
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7416647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7417107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 8.3419706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3419279558
MESH:D056486 Drug-Induced Liver Injury polyphenols 3.6719370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6720420201
MESH:D004362 Drug Toxicity Cisplatin 7.4212231392 19839026 12649298 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4211462148
MESH:C538011 Eales disease Ascorbic Acid 5.169068938
MESH:D004487 Edema Bleomycin 10.1417118201
MESH:D004487 Edema Plant Extracts 10.1412787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.9712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.9719031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2816402032
MESH:D016889 Endometrial Neoplasms Genistein 11.3111473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.3116202921 20544844 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 11.3116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.769294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3715268973
MESH:D004827 Epilepsy Plant Extracts 7.0119700373 19439326
MESH:D004827 Epilepsy Tetrahydrocannabinol 7.01821787
MESH:D004938 Esophageal Neoplasms marker/mechanism 16639733
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6116481741 16785472 15173087 15464296 17638652
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.6115264214 15547733 16510608 15150132 15547721 15878914 16704527 15623463 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0816938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.6315345470
MESH:D005234 Fatty Liver Plant Extracts 16.6315975614
MESH:D005234 Fatty Liver Tamoxifen 16.6314986274 19224547
MESH:D005234 Fatty Liver Vinyl Chloride 16.6312197357
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6120067830
MESH:D005355 Fibrosis Tretinoin 7.6117994277
MESH:D005534 Foot Diseases Arsenic 5.246392382
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3716452187
MESH:D005909 Glioblastoma Fenretinide 10.8416187019
MESH:D005909 Glioblastoma Genistein 10.8416598420
MESH:D005909 Glioblastoma Tretinoin 10.8417312396
MESH:D005911 Gliosis Paraquat 4.8511124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.2215464296 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2216096774
MESH:D034381 Hearing Loss Cisplatin 9.6219898482
MESH:D034381 Hearing Loss Styrene 9.6217420221
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1715464296
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.2816080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.289664655 14991402
MESH:D006333 Heart Failure Plant Extracts 3.6818097624
MESH:D006390 Hemangioendothelioma Vinyl Chloride 5.8615380572
MESH:D006393 Hemangiopericytoma Vinyl Chloride 6.5510964802
MESH:D006394 Hemangiosarcoma Vinyl Chloride 4.9915999577 11217710 12762079 15989139 12958735 12828392 12211074
MESH:D006402 Hematologic Diseases Benzene 4.3716183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5916120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3616863852 16490937
MESH:D006561 Herpes Simplex Plant Extracts 4.3210715843
MESH:D015658 HIV Infections Plant Extracts 3.5212878215
MESH:D006689 Hodgkin Disease Bleomycin 15.4817606976 18501091 15147373
MESH:D006689 Hodgkin Disease Cisplatin 15.4816200630 16170182
MESH:D006689 Hodgkin Disease Cytarabine 15.4816200630
MESH:D006689 Hodgkin Disease sodium arsenite 15.4812676792
MESH:D019584 Hot Flashes Plant Extracts 4.4314716179 16566672 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7318606429 8697196 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 2.9716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.2016484555
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1917050553
MESH:D006949 Hyperlipidemias Plant Extracts 4.1915975614 15268973
MESH:D006973 Hypertension Arsenic 8.0016076760 11953799 9931084
MESH:D006973 Hypertension Benzene 8.0017940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0018670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.2416093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116945680 16569931
MESH:D007035 Hypothermia Tetrahydrocannabinol 5.6210318961
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.0417937319
MESH:D007248 Infertility, Male Paraquat 10.044850670
MESH:D007248 Infertility, Male sodium arsenite 10.0412646999 15346721
MESH:D007249 Inflammation Bleomycin 17.8517118201
MESH:D007249 Inflammation Flavonoids 17.8517296493
MESH:D007249 Inflammation Plant Extracts 17.8515997105 16366677 19332304 12787963
MESH:D007249 Inflammation polyphenols 17.8516366677
MESH:D007249 Inflammation Tamoxifen 17.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.8512878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.3512351151 12584176 12628509
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.7019381132
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0117551590 15992940
MESH:D007642 Keratosis Arsenic 4.6816930632 12749816
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8215464296
MESH:D007674 Kidney Diseases Cisplatin 5.7512231392 18289764 15190930 12649298 19839026
MESH:D007674 Kidney Diseases sodium arsenite 5.7520008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0016518626
MESH:D007680 Kidney Neoplasms Tamoxifen 7.2418625569
MESH:D007680 Kidney Neoplasms Vinyl Chloride 7.2412562636
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4811231351
MESH:D007938 Leukemia Benzene 9.6614694614 18335105 15935818 17119257
MESH:D007938 Leukemia Genistein 9.6617468513 18980019
MESH:D007938 Leukemia Tretinoin 9.6617143497
MESH:D007951 Leukemia, Myeloid Benzene 8.7617506065
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7619285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.8819478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8817596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.0917339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0917649720 16140955 17301526 17217047 16935935 19035177 16788101 17107899 12679006 17361223 17506722 16331271 19029980 19075265 16766008 17339181 19642359 17368321 15748426 17294898 16823087 16891316 9834237 19225113 17712046
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7316707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008064 Lipidoses Tamoxifen 2.9417567588 15342952
MESH:D008103 Liver Cirrhosis Plant Extracts 7.0217157831
MESH:D008103 Liver Cirrhosis Vinyl Chloride 7.0212958735 12499459 11679801 15354062 15289165
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3017823541
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 6.3015479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3018397230 16248980
MESH:D008107 Liver Diseases Arsenic 8.8511134558
MESH:D008107 Liver Diseases Plant Extracts 8.8517034775
MESH:D008107 Liver Diseases polyphenols 8.8516698588
MESH:D008107 Liver Diseases Vinyl Chloride 8.8516270392 15211785
MESH:D008113 Liver Neoplasms Arsenic 20.0216368122
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 20.0219690152 18648771 15890375 20101389
MESH:D008113 Liver Neoplasms Plant Extracts 20.0219168119
MESH:D008113 Liver Neoplasms sodium arsenite 20.0216712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.0216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.0216984957
MESH:D008113 Liver Neoplasms Vinyl Chloride 20.0212762079 10964802 10629081 11679801 12211074 15999577 11024202
MESH:D008114 Liver Neoplasms, Experimental Aflatoxins 20.9015583823
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 20.9018544905
MESH:D008114 Liver Neoplasms, Experimental Benzene 20.9012562636
MESH:D008114 Liver Neoplasms, Experimental styrene oxide 20.9012562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.9012151625
MESH:D008114 Liver Neoplasms, Experimental Vinyl Chloride 20.9012562636
MESH:D008171 Lung Diseases Ascorbic Acid 7.0416863852
MESH:D008171 Lung Diseases sodium arsenite 7.0419095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.4914698565
MESH:D008175 Lung Neoplasms Arsenic 24.9819168569 17976673 17306315
MESH:D008175 Lung Neoplasms Asbestos 24.9812111688
MESH:D008175 Lung Neoplasms Ascorbic Acid 24.9816401635
MESH:D008175 Lung Neoplasms Benzene 24.9812562636
MESH:D008175 Lung Neoplasms Bleomycin 24.986189445
MESH:D008175 Lung Neoplasms Cisplatin 24.9811798837 6189445 17225452
MESH:D008175 Lung Neoplasms Plant Extracts 24.9820869020
MESH:D008175 Lung Neoplasms Polycyclic Hydrocarbons, Aromatic 24.9810814675
MESH:D008175 Lung Neoplasms sodium arsenite 24.9816712894 15276417 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Styrene 24.9812562636
MESH:D008175 Lung Neoplasms Tamoxifen 24.9818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 24.9811884234 19555203
MESH:D008175 Lung Neoplasms Vinyl Chloride 24.9812562636 12958735
MESH:D008223 Lymphoma Benzene 3.5217584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 21.4612562636
MESH:D015674 Mammary Neoplasms, Animal Styrene 21.4612562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 21.4619428831
MESH:D015674 Mammary Neoplasms, Animal Vinyl Chloride 21.4612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 12.7111921183
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 12.7110697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.7112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.7119196723 14580682 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.2319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma Bleomycin 17.4015577320
MESH:D008545 Melanoma Cisplatin 17.4018176117 12883367 16809738 17023156 15577323 16432458 12393984 16248763 12374674 18505091 11135225 18332650 17761969
MESH:D008545 Melanoma Fenretinide 17.4016270382
MESH:D008545 Melanoma Platinum 17.4016814760
MESH:D008545 Melanoma Reactive Oxygen Species 17.4017992120
MESH:D008545 Melanoma sodium arsenite 17.4016487513 19082730
MESH:D008545 Melanoma Tamoxifen 17.4012393984 19393235
MESH:D008545 Melanoma Tretinoin 17.4016752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.4715990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.4715990972
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008654 Mesothelioma marker/mechanism 16564556
MESH:D008654 Mesothelioma Asbestos 6.4118709470 16319530 16564556 16919927 18310086
MESH:D008654 Mesothelioma Cisplatin 6.4117638057
MESH:D009062 Mouth Neoplasms Fenretinide 4.0816274795
MESH:D009101 Multiple Myeloma Benzene 3.4517119195
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9017596541
MESH:D009203 Myocardial Infarction Genistein 2.7317141266
MESH:D017202 Myocardial Ischemia Arsenic 8.1915371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1912213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.4317141266
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Cisplatin 14.1216773208
MESH:D009369 Neoplasms Fenretinide 14.1217353921 15958647
MESH:D009369 Neoplasms sodium arsenite 14.1211559025
MESH:D009369 Neoplasms Tretinoin 14.1216946489 16594593
MESH:D009369 Neoplasms Vinyl Chloride 14.1211911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1815464296
MESH:D009410 Nerve Degeneration Paraquat 3.4816893418
MESH:D009421 Nervous System Malformations Genistein 14.6716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.6714600291
MESH:D009421 Nervous System Malformations Tretinoin 14.679125849
MESH:D009436 Neural Tube Defects Arsenic 20.6616620997
MESH:D009436 Neural Tube Defects Benzene 20.6615643154
MESH:D009436 Neural Tube Defects sodium arsenite 20.6612854658
MESH:D009436 Neural Tube Defects Tetrahydrocannabinol 20.6619040278
MESH:D009436 Neural Tube Defects Tretinoin 20.669142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8817168769
MESH:D009447 Neuroblastoma Cisplatin 7.338761367
MESH:D009447 Neuroblastoma Platinum 7.3316814760
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.398761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.0917056641
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3716303764
MESH:D009765 Obesity Ascorbic Acid 4.9617217161
MESH:D009765 Obesity Plant Extracts 4.9620132043 19056576
MESH:D009784 Occupational Diseases marker/mechanism 15612468
MESH:D009784 Occupational Diseases Benzene 8.9517119257 15576619 15727169 15612468 17479406 15935809 17178637 16737584 15913788
MESH:D009784 Occupational Diseases Vinyl Chloride 8.9512061072
MESH:D010024 Osteoporosis Genistein 3.0619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8016169203
MESH:D010051 Ovarian Neoplasms Arsenic 21.3617306315
MESH:D010051 Ovarian Neoplasms Benzene 21.3612562636
MESH:D010051 Ovarian Neoplasms Cisplatin 21.366897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms Fenretinide 21.3616133793
MESH:D010051 Ovarian Neoplasms Genistein 21.3619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 21.3615276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 21.3616936753
MESH:D010146 Pain Tretinoin 2.6616870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.4919003803
MESH:D010190 Pancreatic Neoplasms Fenretinide 11.4915580305
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 11.4915580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma Hydrogen Peroxide 8.6812065085
MESH:D010212 Papilloma Plant Extracts 8.6816517061 15173996
MESH:D010300 Parkinson Disease Paraquat 2.7015451049 11124998 16510128 16140633 15824117 12911755 11445065 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1316190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 9.0816093927
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 9.0815464296
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6816905509 6392382 15371236
MESH:D010997 Pleural Neoplasms Cisplatin 5.0317638057
MESH:D011014 Pneumonia Bleomycin 10.4018024389 16317386 17071938
MESH:D011014 Pneumonia Paraquat 10.4012504350
MESH:D017285 Polymyositis Vinyl Chloride 6.5511642524
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.2721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8811399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms marker/mechanism 16406883 17196815 17486273
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Fenretinide 1.8917024972
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.8914666653 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Arsenic 8.3321343184
MESH:D011507 Proteinuria Tretinoin 8.3316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0016919318 15861022
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D011654 Pulmonary Edema Bleomycin 5.0015808516
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0214606601
MESH:D011658 Pulmonary Fibrosis Bleomycin 5.8012574379 15541506 18008008 12624602 15322207 16115399 17434272 16314464 17177178 11554783 18162602 17241526 14609568 21435439
MESH:D011658 Pulmonary Fibrosis Paraquat 5.8017997886 16324872
MESH:D011928 Raynaud Disease Vinyl Chloride 5.8316977343
MESH:D051437 Renal Insufficiency Cisplatin 4.1015464296
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6211700416
MESH:D012135 Respiratory Sounds Paraquat 3.7511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration Fenretinide 8.5316303925
MESH:D012162 Retinal Degeneration Paraquat 8.5316458197
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8116283617 16116481
MESH:D012509 Sarcoma Vinyl Chloride 5.0812828392
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.1314601052
MESH:D012595 Scleroderma, Systemic Vinyl Chloride 5.5214979077
MESH:D012871 Skin Diseases Arsenic 5.0416353154 16759981 19834688 16702368 6392382 15952646 17050553 18709164 17938729 17453740 17548696
MESH:D012871 Skin Diseases Ascorbic Acid 5.0418709164
MESH:D012878 Skin Neoplasms Arsenic 24.9317029826 17976673 16251483 15504454 19538983 17050553
MESH:D012878 Skin Neoplasms Fenretinide 24.9316467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 24.9312065085
MESH:D012878 Skin Neoplasms Plant Extracts 24.9315173996 16517061
MESH:D012878 Skin Neoplasms sodium arsenite 24.9318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 24.9316192470
MESH:D012878 Skin Neoplasms Tretinoin 24.9316467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0315464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5116709447
MESH:D013088 Spermatocele Tamoxifen 10.5116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5612854658
MESH:D013274 Stomach Neoplasms Benzene 7.8712562636
MESH:D013274 Stomach Neoplasms Cisplatin 7.8715958060 17522103 18396642
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 7.8712958204 17575124
MESH:D013274 Stomach Neoplasms styrene oxide 7.8712562636
MESH:D013274 Stomach Neoplasms Tretinoin 7.8717261132
MESH:D013274 Stomach Neoplasms Vinyl Chloride 7.8712562636
MESH:D013276 Stomach Ulcer Ascorbic Acid 6.9218726076
MESH:D013276 Stomach Ulcer Plant Extracts 6.9218193104 17135157 12787963 18237397 15255614
MESH:D020521 Stroke Ascorbic Acid 4.0516403987 16517955
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.2217997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.2217997062
MESH:D013736 Testicular Neoplasms Cisplatin 4.3415464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013953 Thymus Neoplasms Benzene 4.6410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8017045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.5216051514
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.4911144890 18640142 19322015 17976673 19429237 15987713 17306315
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.4915464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 14.4916720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.4911723127 17306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.4917572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 20.4616803524
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 20.4616154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 20.4611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 20.4616129372
MESH:D014594 Uterine Neoplasms Benzene 8.5912562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.5914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3115577323
MESH:D014652 Vascular Diseases Arsenic 10.8117056641
MESH:D014652 Vascular Diseases sodium arsenite 10.8117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.4418097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.0018097624
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D014839 Vomiting Cisplatin 4.4011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D015431 Weight Loss Bleomycin 5.3312624602
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
MESH:D014947 Wounds and Injuries Plant Extracts 4.0020213670 19894650
Pathway ID Pathway Name
KEGG:03410 Base excision repair
REACT:216 DNA Repair
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA369
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA446108Colorectal Neoplasms
    PA443937Drug Toxicity
    PA445742Stomach Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    PA445062Neoplasms
    PA445113Neutropenia
    PA443512Urinary Bladder Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443560Breast Neoplasms
    PA443899Diarrhea
    PA446975Neurotoxicity Syndromes
    PA445503Rectal Neoplasms
    Releated drug ID Related drug Name
    PA128406956fluorouracil
    PA450198leucovorin
    PA131285527oxaliplatin
    PA449014cisplatin
    PA449165cyclophosphamide
    PA448803carboplatin
    PA450085irinotecan
    PA452621antineoplastic agents
    PA448073ethanol
    PA448771capecitabine
    PA164713176Platinum compounds
    PA164713220Pyrimidine analogues
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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