AutismKB 2.0

Annotation Detail for XRCC2


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Basic Information Top
Gene Symbol:XRCC2 ( DKFZp781P0919 )
Gene Full Name: X-ray repair complementing defective repair in Chinese hamster cells 2
Band: 7q36.1
Quick LinksEntrez ID:7516; OMIM: 600375; Uniprot ID:XRCC2_HUMAN; ENSEMBL ID: ENSG00000196584; HGNC ID: 12829
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03440Homologous recombination
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1739Oral cancer
1859Ovarian cancer
1944Breast cancer
2106Pancreas cancer
2154Adenoma
Desease Name
CANCER
breast cancer
overall effect
Neoplasms
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of XRCC2 mRNAdecreases expression 20504355
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]decreases reaction|increases expression 16417649
D005047 Etoposide Etoposide results in increased expression of XRCC2 proteinincreases expression 16417649
C017947 sodium arsenite sodium arsenite results in increased expression of XRCC2 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of XRCC2 mRNAincreases expression 19465110
D014752 Vinyl Chloride XRCC2 gene polymorphism affects the susceptibility to Vinyl Chlorideaffects response to substance 16217922
D014810 Vitamin E Vitamin E results in decreased expression of XRCC2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001661 Biliary Tract Neoplasms Vinyl Chloride 7.3911024202
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.6814601052
MESH:D001932 Brain Neoplasms Vinyl Chloride 5.4712562636
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9117474063 20146248
MESH:D001943 Breast Neoplasms Etoposide 1.9116322251
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.8315276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Vinyl Chloride 3.8312958735 15289165 10699891 12828392
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8520419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8518572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1920056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 15668235 8697196 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D009783 Dermatitis, Occupational Vinyl Chloride 6.2310870345
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Vinyl Chloride 5.2612197357
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.9611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 11.9616080930
MESH:D006390 Hemangioendothelioma Vinyl Chloride 6.6915380572
MESH:D006393 Hemangiopericytoma Vinyl Chloride 7.3910964802
MESH:D006394 Hemangiosarcoma Vinyl Chloride 5.5911217710 12828392 15989139 12762079 12211074 15999577 12958735
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916863852 16490937
MESH:D006561 Herpes Simplex Etoposide 5.0210809021
MESH:D006689 Hodgkin Disease Etoposide 8.6116200630 16135485 17606976 15147373 18180244
MESH:D006689 Hodgkin Disease sodium arsenite 8.6112676792
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 16959395 15340226 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.1915346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases sodium arsenite 6.7420008137
MESH:D007674 Kidney Diseases Vitamin E 6.7412488133
MESH:D007680 Kidney Neoplasms Vinyl Chloride 5.0812562636
MESH:D008103 Liver Cirrhosis Vinyl Chloride 4.7212499459 15289165 15354062 11679801 12958735
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4216169303
MESH:D008107 Liver Diseases Vinyl Chloride 3.9116270392 15211785
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.6220195826 21137059
MESH:D008113 Liver Neoplasms sodium arsenite 11.6215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.6216984957
MESH:D008113 Liver Neoplasms Vinyl Chloride 11.6210629081 11679801 12762079 11024202 10964802 12211074 15999577
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 7.0212151625
MESH:D008114 Liver Neoplasms, Experimental Vinyl Chloride 7.0212562636
MESH:D008171 Lung Diseases sodium arsenite 8.1219095001
MESH:D008171 Lung Diseases Vitamin E 8.1216863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.9320464547 20869020 20064080 6695378 18569708 17053015 18816296 20135361 18520028
MESH:D008175 Lung Neoplasms sodium arsenite 6.9316712894 17306315 17077188 15276417 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.9311884234 19555203
MESH:D008175 Lung Neoplasms Vinyl Chloride 6.9312958735 12562636
MESH:D008175 Lung Neoplasms Vitamin E 6.9311062179
MESH:D008223 Lymphoma Etoposide 4.1412556972 12854902
MESH:D015674 Mammary Neoplasms, Animal Vinyl Chloride 5.9912562636
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms Benzo(a)pyrene 9.3111141357
MESH:D009369 Neoplasms sodium arsenite 9.3111559025
MESH:D009369 Neoplasms Vinyl Chloride 9.3111911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D009784 Occupational Diseases Vinyl Chloride 5.5712061072
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5117306315 15276417
MESH:D010190 Pancreatic Neoplasms Etoposide 3.3619003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017285 Polymyositis Vinyl Chloride 7.3911642524
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Etoposide 2.0717172428
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011928 Raynaud Disease Vinyl Chloride 6.5516977343
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012509 Sarcoma Vinyl Chloride 5.6512828392
MESH:D012512 Sarcoma, Ewing's Etoposide 5.0914601052
MESH:D012595 Scleroderma, Systemic Vinyl Chloride 6.1614979077
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.1519755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 10.1518572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1516192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.032093021 20155912
MESH:D013274 Stomach Neoplasms Vinyl Chloride 3.0312562636
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4017053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.4016452187 17306315 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:03440 Homologous recombination
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37421
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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