AutismKB 2.0

Annotation Detail for XRCC4


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Basic Information Top
Gene Symbol:XRCC4 ( - )
Gene Full Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Band: 5q14.2
Quick LinksEntrez ID:7518; OMIM: 194363; Uniprot ID:XRCC4_HUMAN; ENSEMBL ID: ENSG00000152422; HGNC ID: 12831
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
Pathway IDPathway Name
DNA Repair
HIV Infection
No data
No data
Pathway IDPathway Name
500055Nonhomologous End-joining (NHEJ)
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1739Oral cancer
1860Brain tumor
1901Endometriosis
1944Breast cancer
Desease Name
CANCER
breast cancer
Neoplasms
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of XRCC4 mRNAaffects expression 21346803
C030682 3-chlorophenol 3-chlorophenol results in increased expression of XRCC4 mRNAincreases expression 18486366
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of XRCC4 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of XRCC4 mRNAdecreases expression 17530438
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of XRCC4 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of XRCC4 mRNAdecreases expression 20018196
19150397
D005047 Etoposide BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]decreases reaction|increases expression 16417649
D005047 Etoposide Etoposide results in increased expression of XRCC4 proteinincreases expression 16417649
C051890 irinotecan irinotecan metabolite results in decreased expression of XRCC4 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of XRCC4 mRNAdecreases expression 15956246
D018021 Lithium Chloride Lithium Chloride results in increased expression of XRCC4 mRNAincreases expression 19285016
D010416 Pentachlorophenol Pentachlorophenol results in increased expression of XRCC4 mRNAincreases expression 18486366
D010634 Phenobarbital Phenobarbital affects the expression of XRCC4 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of XRCC4 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of XRCC4 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in increased expression of XRCC4 mRNAincreases expression 18070364
C031280 pyrazole pyrazole results in increased expression of XRCC4 mRNAincreases expression 17945193
D013654 Taurine Taurine results in increased expression of XRCC4 mRNAincreases expression 16579726
C003377 taxifolin taxifolin results in increased expression of XRCC4 mRNAincreases expression 17541156
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.466195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.1917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1916434500
MESH:D000310 Adrenal Gland Neoplasms Pentachlorophenol 6.1410696769
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.0116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0119483382
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.1914601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 4.2715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0117474063 20146248
MESH:D001943 Breast Neoplasms Etoposide 2.0116322251
MESH:D001943 Breast Neoplasms Progesterone 2.0115562024 16175315 17614352
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5916705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.5921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5915073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.591701930 6705139 17173139 20935162 20007298
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.656135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6520889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D003110 Colonic Neoplasms irinotecan 2.5917725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6820501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.6818259882 15273666 16391804 18509181 17159606 16303861 17454858
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.0716025228
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury pyrazole 6.5912499123
MESH:D056486 Drug-Induced Liver Injury Taurine 6.599328219
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004487 Edema pirinixic acid 2.4912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7917692515
MESH:D004715 Endometriosis Progesterone 3.7716134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2216530937
MESH:D005234 Fatty Liver arsenic trioxide 7.7415073043
MESH:D005234 Fatty Liver pirinixic acid 7.7419236843 20131406
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6620471113
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006394 Hemangiosarcoma Pentachlorophenol 5.0615200160
MESH:D006529 Hepatomegaly Phenobarbital 8.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 8.5218467677 16221962 19176532 19772884
MESH:D006561 Herpes Simplex Etoposide 4.5810809021
MESH:D006689 Hodgkin Disease Etoposide 3.8715147373 18180244 17606976 16200630 16135485
MESH:D006869 Hydronephrosis Lithium Chloride 6.0519797860
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007249 Inflammation Progesterone 2.6015869954
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9816705839
MESH:D007938 Leukemia arsenic trioxide 2.8315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1416467208 17050201 19850784 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2217712046 12679006 9834237 16891316 15336539 16823087 12018890 19075265 16331271 11161223 16112521 19035177 15748426 19225113 11468182 19642359 17107899 17217047 12712474 15622746 17649720 16966277 17869043 16330433 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9021047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.8815474484
MESH:D008106 Liver Cirrhosis, Experimental Taurine 2.8815893842 15931870
MESH:D008107 Liver Diseases Phenobarbital 2.1719363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.957678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.9515890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 21.9514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.9520195826 21137059
MESH:D008113 Liver Neoplasms Pentachlorophenol 21.9510696769
MESH:D008113 Liver Neoplasms Phenobarbital 21.9519073162 19812893 21047994 8742319 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 21.9520007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.162876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.168603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.1620377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.1617172636 1399818 6150874 18308698 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4511798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4517053015 20135361 20464547 20869020 18569708 18520028 6695378 18816296 20064080
MESH:D008223 Lymphoma Etoposide 8.3412854902 12556972
MESH:D008223 Lymphoma Pentachlorophenol 8.3412669308
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8711408345 17203775
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D052016 Mucositis irinotecan 5.0317159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1114977855 11468182 19549372 19417148 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1416882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.1718259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8211141357
MESH:D009369 Neoplasms pirinixic acid 4.8217405874
MESH:D018301 Neoplasms, Mesothelial Pentachlorophenol 6.6810696769
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1210525206
MESH:D009447 Neuroblastoma irinotecan 3.488761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.758761367
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9419769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Progesterone 4.9416525653 17393432
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.7415580305
MESH:D010190 Pancreatic Neoplasms Etoposide 8.7419003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.7416965848
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D011141 Polyuria Lithium Chloride 6.0219692487
MESH:D011230 Precancerous Conditions Phenobarbital 3.622563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6519131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6517292933
MESH:D011471 Prostatic Neoplasms Etoposide 2.6517172428
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.4816646077
MESH:D012512 Sarcoma, Ewing's Etoposide 10.4814601052
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012640 Seizures Phenobarbital 5.933137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3719755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.3015862959 16503802
MESH:D013160 Splenic Neoplasms Pentachlorophenol 6.3410696769
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4220155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 3.4215723263
MESH:D013733 Testicular Diseases pyrazole 4.846499806
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2219014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.221399818
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.3012973940 11780464 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3017053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
Pathway ID Pathway Name
REACT:216 DNA Repair
REACT:6185 HIV Infection
KEGG:03450 Non-homologous end-joining
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37423
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA444284Glioma
    Releated drug ID Related drug Name
    PA449383docetaxel
    PA449503estradiol
    PA451581tamoxifen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03963 - S-(Dimethylarsenic)Cysteine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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