AutismKB 2.0

Annotation Detail for YES1


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Basic Information Top
Gene Symbol:YES1 ( HsT441,P61-YES,Yes,c-yes )
Gene Full Name: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Band: 18p11.32
Quick LinksEntrez ID:7525; OMIM: 164880; Uniprot ID:YES_HUMAN; ENSEMBL ID: ENSG00000176105; HGNC ID: 12841
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04530Tight junction
hsa04520Adherens junction
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200187Alpha-synuclein signaling
200016Noncanonical Wnt signaling pathway
200121EPHA forward signaling
200127PDGFR-beta signaling pathway
200083CXCR4-mediated signaling events
200069Thromboxane A2 receptor signaling
200098Class I PI3K signaling events
200173Ephrin B reverse signaling
200074Netrin-mediated signaling
200161Signaling events mediated by VEGFR1 and VEGFR2
200108amb2 Integrin signaling
200021Glypican 1 network
200192Signaling events mediated by focal adhesion kinase
200057CDC42 signaling events
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00012Cadherin signaling pathway
P00049Parkinson disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of YES1 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of YES1 mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of YES1 mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of YES1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of YES1 mRNAdecreases expression 18231732
D005472 Fluorouracil YES1 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C051890 irinotecan irinotecan metabolite results in decreased expression of YES1 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of YES1 mRNAdecreases expression 15956246
C006253 pirinixic acid pirinixic acid results in decreased expression of YES1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of YES1 mRNAincreases expression 17426115
C017947 sodium arsenite sodium arsenite results in increased expression of YES1 mRNAincreases expression 12377979
C017947 sodium arsenite sodium arsenite results in decreased expression of YES1 proteindecreases expression 19072884
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6619825857 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.6617638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2216712894 17306315
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.2210965797
MESH:D000740 Anemia Fluorouracil 3.9016511603 17963324 15504547
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Homocysteine 2.2420468076 16297937
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6919483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4518357371 19217205 16110121 16557594 15136595 16595493 18608205
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 3.7317121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.813084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8111135700 14691202 15073043 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8117045692 16332177 17088986 17971768 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8115276417 17306315 16507464
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9316757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.9318572023
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1220056578 19524636
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0717287894 16510598 17169374 15001691 17172411 17725105 16340194 18772588 17018589 17016597
MESH:D003110 Colonic Neoplasms irinotecan 4.0717725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5920501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5917695437 14970324 16282729 18288408 18802399 15289873 18383874 17094418 15148649 17594712 16391804 16331619 18509181 17255274 17401013 17016601 17454858 18949393 16303861 16524972 18448328 20501625
MESH:D015179 Colorectal Neoplasms irinotecan 3.5917454858 18259882 18509181 16391804 17159606 15273666 16303861
MESH:D003324 Coronary Artery Disease Homocysteine 3.8216379339
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6311421492 19923254 17562736 2444490 12594235 11743745 16081117 11287661 16177239 11461765 19164858 14725611 19370779 19416960 17522070 18071297 11834606 12392966 15968718 17906064 14986274 12153990 16109766 10663392 19085960 15619225 16485898 10915739 16227642 12540782 16393943 16781746 14550746 10774834 12705907 19739265 19420014 12958197 18713872 11739529 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7512903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7516785472 16337965 17638652 15173087 16481741
MESH:D017889 Exfoliation Syndrome Homocysteine 5.9916504073
MESH:D005234 Fatty Liver arsenic trioxide 8.4115073043
MESH:D005234 Fatty Liver pirinixic acid 8.4119236843 20131406
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D005901 Glaucoma Homocysteine 5.5116504073
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5215162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Homocysteine 4.1019638421
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519772884 16221962 19176532 18467677
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8918234410 17369066 17292331
MESH:D007248 Infertility, Male sodium arsenite 3.1215346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Acetaminophen 6.3315629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.3320008137
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4816985049
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 16467208 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416331271 17649720 17712046 15622746 19035177 17869043 11468182 19075265 17217047 16330433 15748426 15213294 16112521 11161223 15336539 16891316 9834237 19225113 19642359 12679006 12712474 16823087 17107899 12018890 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12969438 19014921 12587719 19460945 11587558 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2914682389
MESH:D008113 Liver Neoplasms Fluorouracil 11.2915113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 11.2915890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 11.2916712894 15276417
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6111798837 19825857
MESH:D008175 Lung Neoplasms Fluorouracil 3.6115246190
MESH:D008175 Lung Neoplasms sodium arsenite 3.6119931552 17306315 16712894 15276417 17077188
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008591 Meningomyelocele Homocysteine 5.7916602021
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7918986760 16757204
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2515949261 14977855 19549372 19417148 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516105982 16882451
MESH:D009203 Myocardial Infarction Homocysteine 6.2417412321
MESH:D009203 Myocardial Infarction pirinixic acid 6.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009369 Neoplasms Fluorouracil 8.8118239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 8.8117405874
MESH:D009369 Neoplasms sodium arsenite 8.8111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009436 Neural Tube Defects arsenic trioxide 7.7610525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.7612854658
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0912452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0915276417 17306315
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5715580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5716929163 15113037 19003803 16500647
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010300 Parkinson Disease Homocysteine 3.6316275827
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.8211550810
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5719082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918722050 15538739 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Homocysteine 3.1316641680
MESH:D012878 Skin Neoplasms sodium arsenite 2.7819524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5717007042
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5717498489 18396642 17172411 18567086 15786421 16951190 19084572 19015929 17522103 16424979
MESH:D013274 Stomach Neoplasms irinotecan 3.5715723263
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4020435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.4017306315 16452187 16712894 11723127
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.1416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.1411813266
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
Pathway ID Pathway Name
KEGG:04520 Adherens junction
REACT:604 Hemostasis
REACT:6900 Signaling in Immune system
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37432
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01254 inhibitor Dasatinib Protein Kinase Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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