AutismKB 2.0

Annotation Detail for ZAP70


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Basic Information Top
Gene Symbol:ZAP70 ( FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70 )
Gene Full Name: zeta-chain (TCR) associated protein kinase 70kDa
Band: 2q11.2
Quick LinksEntrez ID:7535; OMIM: 176947; Uniprot ID:ZAP70_HUMAN; ENSEMBL ID: ENSG00000115085; HGNC ID: 12858
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa05340Primary immunodeficiency
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00053T cell activation
Pathway IDPathway Name
500481Generation of second messenger molecules
500480Translocation of ZAP-70 to Immunological synapse
500478TCR signaling
Related Diseases/Disorders Top
Desease IDDesease Name
H00093Combined immunodeficiencies
Immune system diseases
Primary immunodeficiency
No data
No data
No data
Desease Name
Selective T-cell defect
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of ZAP70 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ZAP70 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ZAP70 mRNAdecreases expression 20498004
C472777 bisperoxovanadium ZAP70 protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]affects reaction|increases expression 12493747
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of ZAP70 mRNA]affects reaction|decreases expression 17585979
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of ZAP70 geneincreases mutagenesis 17767948
C056933 fumonisin B1 fumonisin B1 results in decreased expression of ZAP70 mRNAdecreases expression 16221962
D006418 Heme Heme results in increased expression of ZAP70 proteinincreases expression 11768235
C029341 oxophenylarsine oxophenylarsine results in increased expression of ZAP70 proteinincreases expression 11768235
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ZAP70 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ZAP70 mRNAdecreases expression 19482888
D010672 Phenytoin Phenytoin results in decreased expression of ZAP70 mRNAdecreases expression 15136057
C006253 pirinixic acid pirinixic acid results in decreased expression of ZAP70 mRNAdecreases expression 11798191
20059764
16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ZAP70 mRNA]decreases expression|increases reaction 20059764
D018038 Sodium Selenite Sodium Selenite results in increased expression of ZAP70 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ZAP70 mRNAaffects binding|decreases expression 16214954
D002762 Cholecalciferol Cholecalciferol results in decreased expression of ZAP70 mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 20.917525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 20.916195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 20.918986270 6195326 9118846 10563481 3425630 9677735
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 20.9115322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9920464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.006695378
MESH:D000236 Adenoma Ethylnitrosourea 7.006695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D050197 Atherosclerosis Phenytoin 3.9415136057
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.0716142846
MESH:D001778 Blood Coagulation Disorders Clofibrate 15.5319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.5319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.5312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9114991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3215144691 18412241 16436596 16651633 16357521
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8920146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.8920007298 1701930 6705139 20935162 17173139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 7.351399818
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.3516003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 11.814080065
MESH:D002493 Central Nervous System Diseases Phenytoin 11.814080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.0517160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis pirinixic acid 2.8519176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.9211748493
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002971 Cleft Lip Phenytoin 4.172227380
MESH:D002972 Cleft Palate Phenytoin 6.2010789828 1687470 6862529 3877104 2227380 6856622
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2015668235 12621046 15340226 16354765 8697196
MESH:D003103 Coloboma Phenytoin 5.189212184
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 15.9415095906
MESH:D000013 Congenital Abnormalities Phenytoin 15.9410627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 15.9417141729 14669216
MESH:D019465 Craniofacial Abnormalities Phenytoin 2.859212184 8986270 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8520055451 15322242 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
OMIM:607208 DRAVET SYNDROME Phenytoin 5.4311748493
MESH:D003875 Drug Eruptions Phenytoin 5.5415024534
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 12.1521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1512392966 11529661 17522070 10915739 19420014 11461765 12958197 19085960 14986274 19739265 16227642 12540782 11421492 14550746 11834606 2444490 16109766 11743745 15619225 12153990 16081117 16177239 19416960 11287661 18713872 17562736 11739529 15968718 19370779 12594235 19923254 16393943 18071297 10663392 16781746 14725611 10774834 19164858 12705907 17906064 16485898
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 12.1516221962
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.1515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Clofibrate 4.0916707586
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.0518357618
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.7117654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.2320235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.301399206 6251365
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 10.553922381 11558140
MESH:D004828 Epilepsies, Partial Phenytoin 10.5511558140 17116037
MESH:D004827 Epilepsy Phenobarbital 7.0820417680
MESH:D004827 Epilepsy Phenytoin 7.08821787 11434505 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.817750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 11.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.023659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 11.023659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Clofibrate 8.0219224547
MESH:D005234 Fatty Liver pirinixic acid 8.0220131406 19236843
MESH:D005313 Fetal Death Phenytoin 10.8810627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.8811858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9920067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Phenytoin 5.729029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.3016390469 14659971
MESH:D005909 Glioblastoma Ethylnitrosourea 3.8516436596
MESH:D005910 Glioma Ethylnitrosourea 3.5016651633 16357521 18412241
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4911294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly fumonisin B1 21.0916221962
MESH:D006529 Hepatomegaly Phenobarbital 21.0916109766
MESH:D006529 Hepatomegaly pirinixic acid 21.0918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.0916120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116354765 16959395 15340226 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.6910459572
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118670907 18850075
MESH:D007153 Immunologic Deficiency Syndromes marker/mechanism 17767948
MESH:D007249 Inflammation Heme 5.6612649161
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.3714714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2115629191 12587719
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.9517379185
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1412878042
MESH:D008107 Liver Diseases Acetaminophen 6.6811587558 12969438 19460945 12587719 16610002 16611625 19014921 19784758
MESH:D008107 Liver Diseases Phenobarbital 6.6819363144
MESH:D008107 Liver Diseases Phenytoin 6.6814986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.7520195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 10.7521047994 15975961 19482888 8742319 19812893 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 10.7515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7516984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.852563599 17172636 1399818 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4820464547 20869020 20135361 18569708 18520028 20064080 17053015 18816296 6695378
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.486695378 16019985 16271038 17703301
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 3.9615790496
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.0915375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5310838139 18041768 10767621
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008579 Meningioma Ethylnitrosourea 6.0517943659
MESH:D008607 Mental Retardation Phenytoin 3.689212184
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 12.6617484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 12.6617484760
MESH:D009224 Myotonia Congenita Phenytoin 5.461896199
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8611141357
MESH:D009369 Neoplasms pirinixic acid 4.8617405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.4416707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009436 Neural Tube Defects Phenytoin 4.159118846
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4716651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.989802331
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.0517160924
MESH:D010018 Osteomalacia Phenobarbital 12.2417016548
MESH:D010018 Osteomalacia Phenytoin 12.2417016548
MESH:D010146 Pain Acetaminophen 7.0616870215
MESH:D010146 Pain Phenytoin 7.0615215642
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5016965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017689 Polydactyly Phenytoin 5.079212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.652563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6917024972
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6918760546
MESH:D019310 Pseudolymphoma Phenobarbital 12.7712752131
MESH:D019310 Pseudolymphoma Phenytoin 12.771419762 8603615 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures Phenobarbital 6.434039156 3137016 16876388 11442880
MESH:D012640 Seizures Phenytoin 6.433137016 19919933 11044598 3691417 10029267 9844417 16876388 15946322
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5116192470
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.2020235791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.2115790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014947 Wounds and Injuries Heme 5.3112649161
Pathway ID Pathway Name
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:05340 Primary immunodeficiency
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37447
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA164743471adenosine triphosphate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02010 - Staurosporine Enzyme Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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