AutismKB 2.0

Annotation Detail for SF1


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Basic Information Top
Gene Symbol:SF1 ( BBP,D11S636,MBBP,ZFM1,ZNF162 )
Gene Full Name: splicing factor 1
Band: 11q13.1
Quick LinksEntrez ID:7536; OMIM: 601516; Uniprot ID:SF01_HUMAN; ENSEMBL ID: ENSG00000168066; HGNC ID: 12950
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SF1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SF1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SF1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SF1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SF1 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SF1 mRNAdecreases expression 12419474
D002392 Catechin Catechin results in decreased expression of SF1 mRNAdecreases expression 15465739
D004041 Dietary Fats Dietary Fats results in decreased expression of SF1 mRNAdecreases expression 18042831
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SF1 mRNAaffects cotreatment|increases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SF1 mRNAdecreases expression 12419474
C041786 palm oil palm oil results in decreased expression of SF1 mRNAdecreases expression 18042831
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of SF1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of SF1 mRNAdecreases expression 19244175
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of SF1 mRNAdecreases expression 18087596
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SF1 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of SF1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of SF1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.897525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.898875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.5915814487
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1919898480
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 18396377 18558336 19232924 18316065 19460635 15238991 17688650 18985861 18177632 17507914 17157402 18940202 16609825 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9716050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.533084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4311212258
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2211212258
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5316936243
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4714694615
MESH:D002386 Cataract Acetaminophen 7.4710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.796135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1815095906
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7216575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.3918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.3921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.3921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.3916393943 14725611 12392966 12958197 10774834 16081117 11529661 19923254 18713872 12594235 12153990 11421492 12705907 14986274 10663392 19420014 11739529 15968718 10915739 19085960 16485898 15619225 18071297 16781746 14550746 16177239 12540782 17906064 11743745 11461765 11287661 19164858 17562736 19416960 19370779 11834606 16109766 16227642 19739265 2444490 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 15.3915131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.3919641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.983922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9520417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D005234 Fatty Liver Dietary Fats 7.9917967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Valproic Acid 7.9919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005355 Fibrosis Dietary Fats 3.5718296743
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0016080930
MESH:D006333 Heart Failure Selenium 3.0917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0314716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D020138 Hyperhomocysteinemia Catechin 5.0017292331
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6716612254
MESH:D007249 Inflammation Dietary Fats 5.5120412841
MESH:D007249 Inflammation Tobacco Smoke Pollution 5.5118590791
MESH:D007251 Influenza, Human Selenium 11.1716624496
MESH:D007251 Influenza, Human Vitamin E 11.1716624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1218457598 11836018
MESH:D007674 Kidney Diseases Acetaminophen 6.0212587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.0212488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 10.1216518626
MESH:D007676 Kidney Failure, Chronic Selenium 10.1216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.4416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.4416705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6311587558 19014921 16610002 19460945 12587719 19784758 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.167678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.562876786 6135515 2876784
MESH:D008171 Lung Diseases Vitamin E 3.1916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.8616288123 3440675 12111688 11091918
MESH:D008175 Lung Neoplasms Vitamin E 2.8611062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7815318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3715006635
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009436 Neural Tube Defects Valproic Acid 3.1416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 2.2917217161 19632207 20518802 18457598 21332399 16723640 20132043 18674790 11836018
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.3212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.3216049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.3214694615
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010212 Papilloma Hydrogen Peroxide 4.1312065085
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8820603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6012752131 11422049
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.6618410779
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.9318551238
MESH:D012640 Seizures Valproic Acid 9.9314763951 16876388 3137016 17978042 11044598 11738929 1511512 15475178
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.7712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.778532709
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 9.7718590791
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4816049721
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 8.4812846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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