AutismKB 2.0

Annotation Detail for PTTG1IP


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Basic Information Top
Gene Symbol:PTTG1IP ( C21orf1,C21orf3,PBF )
Gene Full Name: pituitary tumor-transforming 1 interacting protein
Band: 21q22.3
Quick LinksEntrez ID:754; OMIM: 603784; Uniprot ID:PTTG_HUMAN; ENSEMBL ID: ENSG00000183255; HGNC ID: 13524
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2129Thyroid cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone affects the expression of PTTG1IP mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of PTTG1IP mRNAaffects expression 19483382
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of PTTG1IP mRNA]affects reaction|increases expression 17585979
D002994 Clofibrate Clofibrate affects the expression of PTTG1IP mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of PTTG1IP mRNAaffects expression 17602206
D005001 Ethionine Ethionine affects the expression of PTTG1IP mRNAaffects expression 19483382
C004925 methylmercuric chloride methylmercuric chloride results in decreased expression of PTTG1IP mRNAdecreases expression 19465457
D009853 Omeprazole Omeprazole affects the expression of PTTG1IP mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of PTTG1IP mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of PTTG1IP mRNAaffects expression 19483382
D018038 Sodium Selenite Sodium Selenite results in increased expression of PTTG1IP mRNAincreases expression 18175754
D013853 Thioacetamide Thioacetamide affects the expression of PTTG1IP mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 4.926734493
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.0119698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 53.7219483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 53.7219483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 53.7219483382
MESH:D001778 Blood Coagulation Disorders Ethionine 53.7219483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 53.7219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 53.7219483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 53.7219483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 53.7219483382
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 3.611701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 3.6117997003
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9315710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 3.611399818
MESH:D002637 Chest Pain Omeprazole 5.3215447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.4118291259
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6418218290 15265979
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6415131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 6.6412963478
MESH:D004381 Duodenal Ulcer Omeprazole 4.4921218061 17151854 16613094 15991576
MESH:D050171 Dyslipidemias Clofibrate 4.1616707586
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D005218 Fat Necrosis Thioacetamide 5.9416456712
MESH:D005234 Fatty Liver Amiodarone 14.0614986274
MESH:D005234 Fatty Liver Clofibrate 14.0619224547
MESH:D005234 Fatty Liver pirinixic acid 14.0620131406 19236843
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7115929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.3816456712
MESH:D006529 Hepatomegaly Amiodarone 9.1715265979
MESH:D006529 Hepatomegaly pirinixic acid 9.1718467677 16221962 19176532 19772884
MESH:D006937 Hypercholesterolemia Amiodarone 4.019751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D007037 Hypothyroidism Amiodarone 12.2117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 12.2118031379 8137927
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.2119248655
MESH:D008064 Lipidoses Amiodarone 3.6117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5915075984 18615449 18031379 12085344 15095483 17050028 18395095 12175628 15158331 18380797 15474484 16098781 18032466 10677585 11481614 16489207 12531686 16097051 18295389 12679928 11172339 15334695 11682029 16343077 15716488 17292413 16126171 12891558 17629604 17355460 15078482 14739098 18416461 17127702 18458672 15465738 15316131 15362042 15288473 18263696 15288472 12557150 18606216 16511523 16248980
MESH:D008107 Liver Diseases Thioacetamide 2.7315158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.4417276928 15313186 15633222 12479984
MESH:D008113 Liver Neoplasms Clofibric Acid 4.7617602206
MESH:D008113 Liver Neoplasms pirinixic acid 4.7616377806 20007298 15890375
MESH:D008133 Long QT Syndrome Amiodarone 3.6915350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.4612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009181 Mycoses Amiodarone 5.1217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.119802331
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9012490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D013272 Stomach Diseases Omeprazole 4.8018545984
MESH:D013276 Stomach Ulcer Amiodarone 8.0418087811
MESH:D013276 Stomach Ulcer Omeprazole 8.0418237397 15991576 10750652 16755016 17977527 11906479
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D013959 Thyroid Diseases Amiodarone 4.9819731979
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.7915710170
MESH:D013971 Thyrotoxicosis Amiodarone 5.0418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3811989578 17467628
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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