AutismKB 2.0

Annotation Detail for ZIC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ZIC1 ( ZIC,ZNF201 )
Gene Full Name: Zic family member 1 (odd-paired homolog, Drosophila)
Band: 3q24
Quick LinksEntrez ID:7545; OMIM: 600470; Uniprot ID:ZIC1_HUMAN; ENSEMBL ID: ENSG00000152977; HGNC ID: 12872
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
multiple sclerosis
IMMUNE
Desease Name
Multiple sclerosis
Desease Name
Dandy-Walker malformation
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ZIC1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ZIC1 mRNAdecreases expression 20106945
D003520 Cyclophosphamide ZIC1 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
C014347 decitabine decitabine affects the methylation of ZIC1 promoteraffects methylation 17936758
C014347 decitabine decitabine results in increased expression of ZIC1 mRNAincreases expression 17936758
C014347 decitabine trichostatin A promotes the reaction [decitabine results in increased expression of ZIC1 mRNA]increases expression|increases reaction 17936758
D004041 Dietary Fats Dietary Fats results in increased expression of ZIC1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZIC1 mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in increased expression of ZIC1 mRNAincreases expression 18042831
C004648 testosterone enanthate testosterone enanthate affects the expression of ZIC1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZIC1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZIC1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZIC1 mRNAincreases expression 16267337
C012589 trichostatin A trichostatin A promotes the reaction [decitabine results in increased expression of ZIC1 mRNA]increases expression|increases reaction 17936758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 18.3815014928
MESH:D001161 Arteriosclerosis Dietary Fats 18.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 18.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3917474063 20146248
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.3916978400 18234424 18323546 17388661 15093573 11325840 15136595 17020986 12006526
MESH:D001943 Breast Neoplasms decitabine 2.3918320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 2.3920435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 2.6219701751
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1316152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6116201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8219215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 17110522 16105132 15861022 17681005 11677210 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 15340226 15668235 16354765 8697196
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003556 Cystitis Cyclophosphamide 5.2515643279 18093676 18710439 12161096 18433785 10498854 12913760 15276878 17979934 10700343 18483878 18372110 16989017 12388444 18295254 16614059 16413132 17010015 16651033 11948286
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2115331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2618772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.9319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.9319294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 4.4311006010
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Dietary Fats 8.3018296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Dietary Fats 9.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3520067830
MESH:D005909 Glioblastoma trichostatin A 3.9418801729
MESH:D018316 Gliosarcoma Cyclophosphamide 5.7511389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2515172196 16376943 11014644
MESH:D006258 Head and Neck Neoplasms decitabine 3.6019215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006467 Hemophilia A Cyclophosphamide 5.5111918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8014986274
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 16120746 15340226
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0117440010
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.9317606976 16135485
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 8697196 16354765 15340226 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6016076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Cyclophosphamide 11.977193160 16517039
MESH:D007248 Infertility, Male decitabine 11.9717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.9717937319
MESH:D007249 Inflammation Dietary Fats 5.1920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.2111836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007938 Leukemia Cyclophosphamide 6.9510602166
MESH:D007938 Leukemia decitabine 6.9519235587 18980019
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5617802794 17658394 17008537 18587576 17296974 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2110373061
MESH:D007951 Leukemia, Myeloid decitabine 4.1717236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3618460780 18206229 17679729 18704418 19387464 19010910
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.3618206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D007970 Leukopenia Cyclophosphamide 5.2011830472 10052129
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5220195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2220464547 18569708 17053015 18816296 20135361 6695378 18520028 20064080 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2211884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 8.2712854902
MESH:D008223 Lymphoma decitabine 8.2719470736
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.3111911406
MESH:D008545 Melanoma decitabine 3.8116505122 17785578
MESH:D008545 Melanoma trichostatin A 3.8116505122
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.0216388313
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma decitabine 8.0618172295
MESH:D009101 Multiple Myeloma trichostatin A 8.0618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4718608210 19157545 19010910 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 8.8511141357
MESH:D009369 Neoplasms Cyclophosphamide 8.8518854779
MESH:D009369 Neoplasms decitabine 8.8519116145 17925555 19470736
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009447 Neuroblastoma Cyclophosphamide 3.7215176712 8761367 16115947
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.138761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.518291058
MESH:D009765 Obesity Dietary Fats 2.3219632207 18457598 18674790 21332399 20132043 11836018 17217161 16723640 20518802
MESH:D009845 Oligospermia Cyclophosphamide 4.9516517039
MESH:D010051 Ovarian Neoplasms decitabine 5.4219331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 5.4219331143
MESH:D010146 Pain Cyclophosphamide 3.7618093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 9.1811332152
MESH:D010190 Pancreatic Neoplasms decitabine 9.1819294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 9.1819294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8921297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 13.1617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.1617616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7117292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.7117136230
MESH:D011471 Prostatic Neoplasms trichostatin A 2.7119789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3416636934
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0116636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.7516517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.492093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4919037991
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2912837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7917053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.7914692829
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7919087683 17616700
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved