AutismKB 2.0

Annotation Detail for ZNF22


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Basic Information Top
Gene Symbol:ZNF22 ( HKR-T1,KOX15,ZNF422,Zfp422 )
Gene Full Name: zinc finger protein 22 (KOX 15)
Band: 10q11.21
Quick LinksEntrez ID:7570; OMIM: 194529; Uniprot ID:ZNF22_HUMAN; ENSEMBL ID: ENSG00000165512; HGNC ID: 13012
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014347 decitabine decitabine inhibits the reaction [tobacco tar results in decreased expression of ZNF22 mRNA]decreases expression|decreases reaction 19559774
D004317 Doxorubicin Doxorubicin results in decreased expression of ZNF22 mRNAdecreases expression 16404146
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ZNF22 mRNAdecreases expression 17557909
D015735 Mifepristone Mifepristone results in increased expression of ZNF22 mRNAincreases expression 17584828
C024746 tobacco tar decitabine inhibits the reaction [tobacco tar results in decreased expression of ZNF22 mRNA]decreases expression|decreases reaction 19559774
C024746 tobacco tar tobacco tar results in decreased expression of ZNF22 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Doxorubicin 4.6317418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6314692618
MESH:D000419 Albuminuria Doxorubicin 4.9821441931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.3114601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1617150277
MESH:D001943 Breast Neoplasms decitabine 2.4019208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 2.4016264153 15994142 15939500 15993339 16935488 18382427 17426702 16115903 18695136 17369602 15567936 16595493 16826403 15692762 16096432 18234424 17983394 19526202 11325840 15668708 18628466 15136595 15634643 16322301
MESH:D002276 Carcinoid Tumor Doxorubicin 5.4216051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2616234567 17876044 16023760 18059187
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.3016201981 1485588
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1719215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.176189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.7416242529 16612575 17007740 17928571 16455267 15811867 16364871 16269455 17519947 15792986 17131338 17974986 17308081 16278810 17351982 16651473 17924179 16731534 17382496 18627295 15476868 16952015 15505089 16109756 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0417334414 16243910
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.1819559774
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1317110522 17681005 17333356 16919318 11677210 16105132 15861022
MESH:D003110 Colonic Neoplasms decitabine 2.3817616700
MESH:D015179 Colorectal Neoplasms decitabine 2.7518981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7518259882 18802399
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5217416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9318602426
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.7319294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6717359293
MESH:D004715 Endometriosis Mifepristone 4.7116134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.7718037988
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.1319069698
MESH:D005909 Glioblastoma Doxorubicin 3.5617150277
MESH:D006258 Head and Neck Neoplasms decitabine 8.7219215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.7215692506
MESH:D006331 Heart Diseases Doxorubicin 3.7216244371 16495754 12587719 18006777 16144979 16879835 14766674 17875725 16707910 16244372 17888722 18674790 16330681
MESH:D006333 Heart Failure Doxorubicin 3.5417481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2715692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.7317606976 15147373 18501091
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male decitabine 7.4817581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.4817937319
MESH:D007674 Kidney Diseases Doxorubicin 3.2315369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.5316707910
MESH:D007938 Leukemia decitabine 3.2219235587 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.7716085563
MESH:D007951 Leukemia, Myeloid decitabine 4.3718454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4218704418 18460780 17679729 19010910 18206229 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.0718055864
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516439617 16595196
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2117085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.156189445 17418594
MESH:D008223 Lymphoma decitabine 8.5619470736
MESH:D008223 Lymphoma Doxorubicin 8.5616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.0515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2415458769
MESH:D008545 Melanoma decitabine 3.7016505122 17785578
MESH:D008545 Melanoma Doxorubicin 3.7016827129
MESH:D008654 Mesothelioma Doxorubicin 3.1717638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8715792986
MESH:D052016 Mucositis Doxorubicin 5.3317415656
MESH:D009101 Multiple Myeloma decitabine 3.5918172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5618608210 16882708 19010910 19157545
MESH:D009203 Myocardial Infarction Doxorubicin 3.0715857846 19429709
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0718259882
MESH:D009369 Neoplasms decitabine 2.8619116145 19470736 17925555
MESH:D009401 Nephrosis Doxorubicin 5.2516899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.3315640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.4215555623
MESH:D012516 Osteosarcoma Doxorubicin 4.4015930896
MESH:D010051 Ovarian Neoplasms decitabine 5.5519259094 19331143
MESH:D010051 Ovarian Neoplasms Mifepristone 5.5516525653
MESH:D010190 Pancreatic Neoplasms decitabine 2.8619294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D003557 Phyllodes Tumor Doxorubicin 5.7717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.7717638057
MESH:D055728 Primary Myelofibrosis decitabine 5.2117616702
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5016868541 16888761 16729912 15897917 18437689 15749863
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D051437 Renal Insufficiency Doxorubicin 4.7017922066
MESH:D012208 Rhabdomyosarcoma decitabine 4.8119155313
MESH:D012509 Sarcoma Doxorubicin 4.3415625365 18313854 15675481 16767912 17203757 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.3317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.0915692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.0516767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013964 Thyroid Neoplasms decitabine 8.3417967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.3417909728 16010429
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.7317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.7317653716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014604 Uveal Neoplasms decitabine 5.5217785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.7017638931 17334414 17678736 16364871
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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