Annotation Detail for MPPED1
Basic Information Top
| Gene Symbol: | MPPED1 ( 239AB,C22orf1,FAM1A,FLJ50009,FLJ54633,FLJ59965,FLJ78907,MGC88045 ) |
|---|---|
| Gene Full Name: | metallophosphoesterase domain containing 1 |
| Band: | 22q13.2 |
| Quick Links | Entrez ID:758; OMIM: 602112; Uniprot ID:MPPD1_HUMAN; ENSEMBL ID: ENSG00000186732; HGNC ID: 1306 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of MPPED1 mRNA | affects expression | 17562736 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MPPED1 mRNA | affects binding|decreases expression|increases activity | 19710929 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.72 | 18653653 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 4.37 | 16434500 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.91 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.70 | 19483382 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.83 | 10977129 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 3.19 | 19176532 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.61 | 18249437 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.68 | 12958197 11743745 11421492 12594235 17522070 10663392 16227642 12153990 14725611 16393943 12392966 14550746 16081117 11739529 11287661 17906064 10774834 12540782 19739265 18713872 12705907 11529661 19416960 19420014 15968718 19923254 10915739 17562736 16109766 2444490 11834606 19370779 18071297 16485898 16177239 19164858 14986274 15619225 16781746 11461765 19085960 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 5.17 | 19426721 | |
| MESH:D004487 | Edema | pirinixic acid | 3.02 | 12083418 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 3.31 | 20131406 19236843 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.74 | 16983495 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.81 | 20558911 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 3.76 | 19176532 16221962 18467677 19772884 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.11 | 16870215 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.69 | 20558911 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.93 | 16306350 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.44 | 15629191 12587719 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 1.35 | 15474484 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 11587558 12969438 16610002 19460945 12587719 19014921 16611625 19784758 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.74 | 17185352 16871587 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 1.95 | 20007298 16377806 15890375 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.33 | 19513568 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 4.27 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.30 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 3.33 | 16411023 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 2.14 | 17405874 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.31 | 18514411 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.90 | 20558911 | |
| MESH:D010146 | Pain | Acetaminophen | 2.82 | 16870215 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.58 | 19058328 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.58 | 10982225 |
| No data |