AutismKB 2.0

Annotation Detail for CA3


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Basic Information Top
Gene Symbol:CA3 ( CAIII,Car3 )
Gene Full Name: carbonic anhydrase III, muscle specific
Band: 8q21.2
Quick LinksEntrez ID:761; OMIM: 114750; Uniprot ID:CAH3_HUMAN; ENSEMBL ID: ENSG00000164879; HGNC ID: 1374
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of CA3 mRNA]affects expression|affects reaction 19414516
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CA3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CA3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of CA3 mRNAdecreases expression 17202762
D000086 Acetazolamide Acetazolamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNAdecreases expression 17785943
16940010
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNAaffects cotreatment|decreases expression 18164116
D001574 Benzolamide Benzolamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D001639 Bicarbonates CA3 protein results in increased chemical synthesis of Bicarbonatesincreases chemical synthesis 17826101
C111827 brinzolamide brinzolamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
C032036 bromobenzene bromobenzene metabolite binds to CA3 proteinaffects binding 17305373
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CA3 mRNAdecreases expression 16239168
C105934 celecoxib celecoxib binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D002713 Chlorine Chlorine results in decreased expression of CA3 mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of CA3 mRNAaffects cotreatment|affects expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of CA3 mRNAdecreases expression 18178546
C030123 coumarin coumarin results in decreased expression of CA3 mRNAdecreases expression 18480146
D004005 Dichlorphenamide Dichlorphenamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CA3 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of CA3 mRNAdecreases expression 17072980
C062765 dorzolamide dorzolamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D000431 Ethanol Ethanol results in increased expression of CA3 mRNAincreases expression 16098508
15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CA3 mRNAdecreases expression 17108234
15953391
D005016 Ethoxzolamide Ethoxzolamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D005419 Flavonoids Flavonoids results in decreased expression of CA3 mRNAdecreases expression 18035473
D008628 Mercury Mercury results in increased expression of CA3 mRNAincreases expression 16823088
D008704 Methazolamide Methazolamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
C439829 N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of CA3 mRNAaffects cotreatment|affects expression 18636392
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CA3 mRNAdecreases expression 16221955
C025299 polyphenols polyphenols results in decreased expression of CA3 mRNAdecreases expression 16293270
C488334 Ro 66-0074 Ro 66-0074 results in decreased expression of CA3 mRNAdecreases expression 14610520
D012439 Saccharin Saccharin binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D012643 Selenium [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNAaffects cotreatment|decreases expression 11444866
C003359 sulfamidochrysoidine sulfamidochrysoidine binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D013469 Sulpiride Sulpiride binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CA3 mRNAdecreases expression 16054898
C052342 topiramate topiramate binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
C406224 valdecoxib valdecoxib binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
C025643 vinclozolin vinclozolin affects the expression of CA3 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of CA3 mRNAaffects cotreatment|decreases expression 11444866
C022189 zonisamide zonisamide binds to and results in decreased activity of CA3 proteinaffects binding|decreases activity 17826101
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.0518926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0511752688 14514962 15322242
MESH:D000138 Acidosis Ethanol 4.0711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D055371 Acute Lung Injury Chlorine 3.9320601635
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.0916033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0914692618
MESH:D000236 Adenoma beta-Naphthoflavone 9.8319389873
MESH:D000236 Adenoma Diethylnitrosamine 9.836695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 9.8319555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.6219052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.6216835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.7119003578 16215675
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8815451039 15451040
MESH:D000437 Alcoholism topiramate 4.6917925516 19331489 18552399
MESH:D000544 Alzheimer Disease Ozone 2.3415513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5811748828
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D000853 Anophthalmos Ethanol 4.4015513904
MESH:D001008 Anxiety Disorders Ethanol 7.8811141031
MESH:D001008 Anxiety Disorders vinclozolin 7.8819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3915885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4515570426
MESH:D001249 Asthma Ozone 2.5016373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.4516634805
MESH:D001714 Bipolar Disorder zonisamide 4.5116855456 15383137
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3415516495 17626835 18417511 14754758 18315731 16777450 19059883
MESH:D002056 Burns Ethanol 4.2316374292
MESH:D002100 Cachexia Ozone 4.3116183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.5415673190 16097048 16227642 18705752 16050911 16011737 15721981 16124888 3786805 15700767 10355542 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.5416050911
MESH:D002277 Carcinoma Dimethylnitrosamine 7.2219555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.2916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.2916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.293084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.2918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.2916328049 3084413 20514400 17978847 16502159 20214788 19919837 18393292 18665156 19822196 10737359 21159647 19418558 19171122 16878318 17761372 18788625 11831363 17055752 19701751 18056438 16288022 18691550 18210153 18971187 16935385 16681979 17138121 10672840 19208518 20432363 20727157 16540662 18506893 19383236 17173139 17428255 16779866 19107877 20524982 16830150 19052882 20935162 19539802 20512989 16569478 20101231 20007298 17162532 18494052 16698587 18978308 19519916 20084675 19394651 19335982 3581430 18785209 16807293
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.2915289165 15763234 18788625
MESH:D002292 Carcinoma, Renal Cell celecoxib 3.9716369983
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.8216033868
MESH:D006332 Cardiomegaly Ethanol 10.2919332462
MESH:D006332 Cardiomegaly Methazolamide 10.2917124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.2918850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.2910334427
MESH:D002386 Cataract Acetaminophen 2.3210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.706135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.707505956 2727394 17174075 21159647
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.9315650499
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.5615861022 16105132 17110522 16919318 17333356 17681005 11677210
MESH:D002971 Cleft Lip Ethanol 3.3515513904
MESH:D002972 Cleft Palate Ethanol 5.3015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3012621046 16354765 15668235 8697196 15340226
MESH:D003092 Colitis Selenium 3.3617936198
MESH:D003110 Colonic Neoplasms celecoxib 4.1116004971
MESH:D003110 Colonic Neoplasms polyphenols 4.1116293270
MESH:D015179 Colorectal Neoplasms celecoxib 3.1611197048 18349538
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7017141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 3.5215451039 15451040 19302082 10194807 11198716 15513904 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5219769572
MESH:D003456 Cryptorchidism vinclozolin 3.9314966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.4918551238
MESH:D003866 Depressive Disorder zonisamide 4.6016855456
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.4016823706
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 9.3119647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.3120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.3117107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 9.3116979414
OMIM:607208 DRAVET SYNDROME zonisamide 5.6311748493
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 33.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 33.8318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 33.8316781746 17906064 18713872 18071297 10663392 16177239 11743745 11287661 19416960 15968718 14725611 19085960 11461765 10915739 19739265 16081117 11739529 16109766 12153990 12705907 11421492 16393943 19164858 11529661 19923254 12958197 14550746 16227642 17562736 2444490 12392966 14986274 19420014 12594235 16485898 11834606 17522070 12540782 19370779 10774834 15619225
MESH:D056486 Drug-Induced Liver Injury bromobenzene 33.8312628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 33.8316177239 7179309 19085960 15998439 7440962 10092053 17522070 6623471 16227642 6884620 2869522 10915739 9327722 7120509 4309450 21278145 3732212 3786805 15968718 15027814 19336974 11566570
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 33.8317851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 33.8319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 33.838172417
MESH:D056486 Drug-Induced Liver Injury Ethanol 33.8311566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 33.8319370779
MESH:D056486 Drug-Induced Liver Injury Selenium 33.8315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 33.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4411462148
MESH:D004417 Dyspnea Chlorine 4.1920016425
MESH:C538011 Eales disease Vitamin E 4.269068938
MESH:D004487 Edema perfluorooctanoic acid 5.6912083418 17259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.6912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4615322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7812538720
MESH:D004715 Endometriosis celecoxib 8.1315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1310568697 9294722
MESH:D004831 Epilepsies, Myoclonic zonisamide 5.403691417 3659116
MESH:D004828 Epilepsies, Partial zonisamide 5.153691417 15140322 11558140
MESH:D004827 Epilepsy topiramate 7.0319148780
MESH:D004827 Epilepsy zonisamide 7.0320196486
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.8316499746
MESH:D004830 Epilepsy, Tonic-Clonic zonisamide 5.303691417 3659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6816302075
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.5117016578
MESH:D004938 Esophageal Neoplasms Ethanol 4.5116704527
MESH:D020329 Essential Tremor zonisamide 5.7618297619 17149715
MESH:D005076 Exanthema zonisamide 5.6515140322
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6911564622
MESH:D005221 Fatigue zonisamide 5.6517149715
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.6516045604 12631006 17595544 16239168 19224547 15959796 12795759 61145
MESH:D005234 Fatty Liver Diethylnitrosamine 15.6520387270 21071580
MESH:D005234 Fatty Liver Ethanol 15.6519236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6515345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2217920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8716946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0411858732
MESH:D005355 Fibrosis Carbon Tetrachloride 7.2118705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.2120067830
MESH:D005739 Gas Poisoning Chlorine 4.5720016425
MESH:D005756 Gastritis Acetaminophen 9.6716983495
MESH:D005756 Gastritis Ethanol 9.6715046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5016973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8616417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006261 Headache zonisamide 5.3117149715
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7811294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 5.7816080930
MESH:D006333 Heart Failure Selenium 2.8117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1919110552 19900420
MESH:D006529 Hepatomegaly perfluorooctanoic acid 7.283609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2815340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.5414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6116354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 11.1916870215
MESH:D006930 Hyperalgesia Ethanol 11.1918783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.1912083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1016899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6715338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.6917937319
MESH:D007248 Infertility, Male vinclozolin 5.6916467254
MESH:D007249 Inflammation Diethylnitrosamine 13.3718785209
MESH:D007249 Inflammation Flavonoids 13.3717296493
MESH:D007249 Inflammation perfluorooctanoic acid 13.3712083418
MESH:D007249 Inflammation polyphenols 13.3716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.3712878042 12200463
MESH:D007251 Influenza, Human Selenium 9.5016624496
MESH:D007251 Influenza, Human Vitamin E 9.5016624496
MESH:D002546 Ischemic Attack, Transient zonisamide 6.469372210
MESH:D007569 Jaw Abnormalities Ethanol 8.8415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8416580747
MESH:D007674 Kidney Diseases Acetaminophen 8.6812587719 15629191
MESH:D007674 Kidney Diseases Mercury 8.6817934191
MESH:D007674 Kidney Diseases Vitamin E 8.6812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.5016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.2116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.2116705839
MESH:D007859 Learning Disorders Ethanol 3.7915451040
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.508812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.5016417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5017676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.6517174718 11903743 21278145 16239168 17334410 16221502 16943688 17157831 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.6518407596 18522880 19638242 20032147 18665156
MESH:D008103 Liver Cirrhosis Ethanol 9.6515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6618295389
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.0617900296 18279442 15959796 11481614 14716833 17721639 18006644 20821823 15052691 12741479 14748882 10355542 17708605 15893842 15925388 12958196 12445418 15650968 12666154 15996030 17698563 14724832 12389079 16097048 15370692 18205269 17922224 17944888 18472332 16027843 18054572 18317297 17869086 15123356 12609069 18705752 17823541 15057751 17976157 16116963 18420326 17565644 18251166 18339082 17714472 18166357 18472094 15362042 18376398 12586293 16033810 18429990 12649538 18481824 16638106 18418968 18395095 18412020 18277467 15730626 16011737 16192424 14716496 15673190 18263696 12667390 17481882 15818738 14620537 16248980 16015684 17761835 15931870 15338365 14512876 17805973 16136751 17640975 12632512 18395914 12445421 17631135 13678700 18187930 17525996 12632514 17766677 15876570 12898905 18210741 18156304 17557913 12546737
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.0617348192 16627068 16544323 14726149 17534399 18095165 15479170 15369754 15798949 17432682 15086199 17719030 18237412 15763062 15366600 15099470 16042886 18364076 15298665 15864749 16270385 15081153 14709902 15492853 15067225 17036385 18371158 17666798 15942678 17201889 17640959 15383259 14659978 16009107 18210741 17198567 18637143 16570917 12918455 14568256 17881167 15504291 15138612 18629640 18672772 15744066 17196135 15723089 17465448 15793283 15339415 16169303 15161499 15571005 15842777 14643895 15733078 15591649 18567088 15577212 12925901 16603200 18239293 17203207 17724770
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.0618166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.0616169303
MESH:D008107 Liver Diseases Acetaminophen 8.3219460945 16611625 12587719 12969438 19014921 19784758 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.3217285989 16246199 16964402 15720792 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 8.3217034775
MESH:D008107 Liver Diseases polyphenols 8.3216698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2317347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.1016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.1014706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.1017457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.147678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 19.1421295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.1419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.1420118626 20452335 21071580 12771043 19642983 18648771 2422723 21278145 19551842 19427195 18978307 19294768 20501860 20137499 19090486 12112319 2862719 18977376 20101389 19499222 20434301 19638242 9163691 19690152 19996281 18644402 19833225 15175105 19256749 19812893 19255062 19073162 20583210 19254457 15885732 18754104 16942905 19426721 20405173 21167192 10737359 20492335 21047994 19850985
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 19.1415890375 3113478
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.1414757943 18709148
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.1416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.796135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 19.7918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.7912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.7917854601 18544905 18093689 19126423 18282651 18775883 16842330 18164116 18308698 18253720 21159647 18079962 17942915 17174075 3124819 9362446 19519916 16267830 19004024 19539802 19009564 2563599
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 19.7915603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.7912151625
MESH:D008171 Lung Diseases Ozone 6.548266340 19066396
MESH:D008171 Lung Diseases Vitamin E 6.5416863852
MESH:D017563 Lung Diseases, Interstitial zonisamide 5.4917228818
MESH:D055370 Lung Injury Ozone 3.4320417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 5.9220970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 5.9216061637 11884234 19555203
MESH:D008175 Lung Neoplasms Ozone 5.927614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.9211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 5.9211062179
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 5.6412104042 19196722
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.6415318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008569 Memory Disorders Ethanol 3.7815451040 18411066
MESH:D001523 Mental Disorders Sulpiride 5.1516856516
MESH:D008654 Mesothelioma Selenium 2.6115107826
MESH:D008679 Metaplasia Ozone 4.6710496685
MESH:D008881 Migraine Disorders topiramate 4.2718803445 16942474 18759728 18765137
MESH:D009101 Multiple Myeloma celecoxib 7.3616123214
MESH:D009101 Multiple Myeloma zonisamide 7.3611868602
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6812213967
MESH:D020191 Myoclonic Epilepsies, Progressive zonisamide 5.769477142
MESH:D009325 Nausea zonisamide 5.5716855456
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.9118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.917678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.399029167 3581430
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 4.9919196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.0218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.0220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6820387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.539802331
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.6512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.6516049721
MESH:D010146 Pain Acetaminophen 6.0916870215
MESH:D010146 Pain zonisamide 6.0917666864 16217643 15140322
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.8716540662
MESH:D010190 Pancreatic Neoplasms Ethanol 4.8712384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010292 Paresthesia zonisamide 6.4617149715
MESH:D010300 Parkinson Disease zonisamide 4.0411755227 13677302 20196486 19594199 17200492
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010538 Peritonitis Ozone 3.7116369182
MESH:D010954 Plasmacytoma Selenium 4.4515087411
MESH:D011014 Pneumonia Ozone 3.9618381685 18007984 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.192563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.8217132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.8211896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.8218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.5018220299
MESH:D011471 Prostatic Neoplasms celecoxib 3.9615570007 17908994
MESH:D011471 Prostatic Neoplasms Vitamin E 3.9615084515
MESH:D011472 Prostatitis vinclozolin 4.5018629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.8916919318 15861022
MESH:D012120 Respiration Disorders Chlorine 4.7718579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 19.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 19.4718551238
MESH:D012640 Seizures Acetazolamide 19.4711879338
MESH:D012640 Seizures Ethanol 19.479754883
MESH:D012640 Seizures topiramate 19.4716499746
MESH:D012640 Seizures zonisamide 19.4711879338 9806000 16876388 11044598 11442880 10029267 9844417 16938433 11518630 16180713 12941455 18455367 11755227 9046859 15946322
MESH:D012871 Skin Diseases Vitamin E 2.3218709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5016709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.8312587719
MESH:D013226 Status Epilepticus zonisamide 5.7712833885
MESH:D013262 Stevens-Johnson Syndrome zonisamide 5.4012239465
MESH:D013274 Stomach Neoplasms celecoxib 4.4115609394
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4118456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.4116033868
MESH:D013274 Stomach Neoplasms Ethanol 4.4118456281
MESH:D013276 Stomach Ulcer Ethanol 3.169562338 11906479 9211565 17918041 17189318 16755016
MESH:D020521 Stroke Vitamin E 3.1816517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.889754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8117997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.667505956
MESH:D020194 Unverricht-Lundborg Syndrome zonisamide 5.7611814737
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.4016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.4016049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.5510091137
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D014594 Uterine Neoplasms celecoxib 8.4918645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D014689 Venous Insufficiency coumarin 5.3412708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1515869587 14671159
MESH:D014839 Vomiting zonisamide 5.4917157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
Pathway ID Pathway Name
KEGG:00910 Nitrogen metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25990
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00819 inhibitor Acetazolamide Anticonvulsants;Diuretics;Carbonic Anhydrase Inhibitors
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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