AutismKB 2.0

Annotation Detail for CA9


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Basic Information Top
Gene Symbol:CA9 ( CAIX,MN )
Gene Full Name: carbonic anhydrase IX
Band: 9p13.3
Quick LinksEntrez ID:768; OMIM: 603179; Uniprot ID:CAH9_HUMAN; ENSEMBL ID: ENSG00000107159; HGNC ID: 1383
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00910Nitrogen metabolism
No data
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2095Vulvar disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]decreases reaction|increases expression 20228066
D001564 Benzo(a)pyrene Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]decreases reaction|increases expression 20228066
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CA9 mRNAdecreases expression 20228066
C400082 bortezomib bortezomib results in decreased expression of CA9 proteindecreases expression 16061869
D001959 Bromates Bromates results in decreased activity of CA9 proteindecreases activity 15664814
C459604 candoxin candoxin results in decreased expression of CA9 mRNAdecreases expression 16309724
D002254 Carbonates Carbonates results in decreased activity of CA9 proteindecreases activity 15664814
C022842 chloric acid chloric acid results in decreased activity of CA9 proteindecreases activity 15664814
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 mRNA]decreases reaction|increases expression 20228066
C018021 cobaltous chloride Benzo(a)pyrene inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]decreases reaction|increases expression 20228066
C018021 cobaltous chloride cobaltous chloride results in increased expression of CA9 mRNAincreases expression 20228066
20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of CA9 proteinincreases expression 20228066
D016572 Cyclosporine Cyclosporine results in decreased expression of CA9 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of CA9 mRNAdecreases expression 20106945
D007452 Iodates Iodates results in decreased activity of CA9 proteindecreases activity 15664814
C044659 molybdate molybdate results in decreased activity of CA9 proteindecreases activity 15664814
D017942 Nitric Acid Nitric Acid results in decreased activity of CA9 proteindecreases activity 15664814
C030110 oxaliplatin oxaliplatin results in decreased expression of CA9 mRNAdecreases expression 17762391
D010100 Oxygen Oxygen deficiency results in increased expression of CA9 mRNAincreases expression 19154183
18924134
D010100 Oxygen Oxygen deficiency results in increased expression of CA9 proteinincreases expression 19154183
D010100 Oxygen Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]decreases reaction|increases expression 19154183
D010100 Oxygen Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]decreases reaction|increases expression 19154183
D010100 Oxygen ARNT protein affects the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]affects reaction|increases expression 19154183
D010100 Oxygen Oxygen deficiency results in increased expression of CA9 mRNAincreases expression 19154183
D010100 Oxygen Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]decreases reaction|increases expression 19154183
C494474 perchlorate perchlorate results in decreased activity of CA9 proteindecreases activity 15664814
C037192 potassium periodate potassium periodate results in decreased activity of CA9 proteindecreases activity 15664814
C025349 sodium metasilicate sodium metasilicate results in decreased activity of CA9 proteindecreases activity 15664814
C005741 sulfamic acid sulfamic acid results in decreased activity of CA9 proteindecreases activity 15664814
D013431 Sulfates Sulfates results in decreased activity of CA9 proteindecreases activity 15664814
D013438 Sulfhydryl Compounds Sulfhydryl Compounds analog binds to and results in decreased activity of CA9 proteinaffects binding|decreases activity 17059166
D013467 Sulindac Sulindac analog results in decreased expression of CA9 mRNAdecreases expression 18924134
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]decreases reaction|increases expression 19154183
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]decreases reaction|increases expression 19154183
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]decreases reaction|increases expression 19154183
C045951 tungstate tungstate results in decreased activity of CA9 proteindecreases activity 15664814
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of CA9 mRNAaffects binding|increases expression 20105288
C002802 tungsten carbide tungsten carbide results in increased expression of CA9 mRNAincreases expression 20105288
D014638 Vanadates Vanadates results in decreased activity of CA9 proteindecreases activity 15664814
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.2914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 11752688 14514962
MESH:D058186 Acute Kidney Injury Sulindac 4.137897758
MESH:D055371 Acute Lung Injury Oxygen 4.3416759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.8611473722
MESH:D000230 Adenocarcinoma Sulindac 6.8611910360
MESH:D000236 Adenoma Benzo(a)pyrene 6.576695378
MESH:D000236 Adenoma Sulindac 6.5710223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1716835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4219003578 16460482 11535846 11874996 15623613 17611924 12394442
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000860 Anoxia marker/mechanism 16954440
MESH:D000860 Anoxia Oxygen 4.8420872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D050197 Atherosclerosis Oxygen 3.6816391483
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001913 Bowen's Disease Sulindac 5.1411207687
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8720146248 17474063
MESH:D001943 Breast Neoplasms Cobalt 2.8715986119
MESH:D001943 Breast Neoplasms Estradiol 2.8719861407 12948864 17261762 16675129 14630087 17018787 17289903 18497071
MESH:D001943 Breast Neoplasms Oxygen 2.8717263869
MESH:D001943 Breast Neoplasms Sulindac 2.8716642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 3.8816052434
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2516120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.1012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Cyclosporine 2.7619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0215340226 8697196 15668235 16354765 12621046
MESH:D003110 Colonic Neoplasms oxaliplatin 4.2916024531 16510598 16004971
MESH:D003110 Colonic Neoplasms Sulindac 4.2912458338 12902858
MESH:D015179 Colorectal Neoplasms oxaliplatin 3.1417695437 18448328 17401013 17594712 17255274 18509181
MESH:D015179 Colorectal Neoplasms Sulindac 3.1418059344 10666051 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.8311298694 15059100 16823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.9817621415 12861449
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004417 Dyspnea Oxygen 4.6220016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6916714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.8519148513 11473722 18566989
MESH:D004715 Endometriosis Sulindac 8.5815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.589294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5516530937
MESH:D004938 Esophageal Neoplasms Sulindac 4.5512235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver Cyclosporine 2.6719224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.2714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.9219069698
MESH:D005355 Fibrosis Cyclosporine 7.7912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7920067830
MESH:D005739 Gas Poisoning Oxygen 5.0120016425
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8111910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D006042 Goiter perchlorate 5.1118801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia oxaliplatin 4.1917418472
MESH:D006934 Hypercalcemia bortezomib 5.2618089816
MESH:D006973 Hypertension Cobalt 8.2517039479
MESH:D006973 Hypertension Cyclosporine 8.2510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2518670907 18850075
MESH:D007249 Inflammation Sulindac 4.883291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.8316393666 16627594
MESH:D007414 Intestinal Neoplasms Sulindac 4.4512584176 12663524 12351151 12628509 10213222 10223192
MESH:D007417 Intestinal Polyps Sulindac 4.7911245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.548314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.5415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7112371664
MESH:D007680 Kidney Neoplasms Estradiol 6.7115610895
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 4.9918089816
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 3.4920471514
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0912468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.1914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Sulindac 2.9816867024 14986274
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.0720195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.0716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9812151625
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.656434250
MESH:D055370 Lung Injury Oxygen 4.3018339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3318816296 18520028 18569708 20135361 20064080 6695378 20869020 17053015 20464547
MESH:D008175 Lung Neoplasms Sulindac 3.3319359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3311884234 19555203
MESH:D008223 Lymphoma bortezomib 4.4116098063
MESH:D016393 Lymphoma, B-Cell bortezomib 5.1216675587
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4311408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008527 Medulloblastoma bortezomib 4.1519213072
MESH:D008545 Melanoma Sulindac 2.8016642371
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D009101 Multiple Myeloma bortezomib 4.3419372569 19112201 19112817
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1216810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.0711141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.7911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7914600291
MESH:D019636 Neurodegenerative Diseases Sulindac 4.1016850258 17266991
MESH:D010051 Ovarian Neoplasms Estradiol 2.1619401270
MESH:D010146 Pain Sulindac 3.633291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.2811504793 16820089
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010437 Peptic Ulcer Sulfhydryl Compounds 7.021488453
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1817292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1816740699
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Cobalt 3.926434250
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.3118339021 17627322
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D013398 Sudden Infant Death Oxygen 5.3312563064
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1017053015
MESH:D014594 Uterine Neoplasms Sulindac 4.4018645019
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00910 Nitrogen metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00562 antagonist Benzthiazide Antihypertensive Agents;Stimulants;Diuretics
DB00774 antagonist Hydroflumethiazide Antihypertensive Agents;Diuretics;Diuretics, Thiazide;Sodium Chloride Symporter Inhibitors
DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
DB00999 antagonist Hydrochlorothiazide Antihypertensive Agents;Diuretics;Sodium Chloride Symporter Inhibitors
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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