AutismKB 2.0

Annotation Detail for ZBTB16


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ZBTB16 ( PLZF,ZNF145 )
Gene Full Name: zinc finger and BTB domain containing 16
Band: 11q23.2
Quick LinksEntrez ID:7704; OMIM: 176797; Uniprot ID:ZBT16_HUMAN; ENSEMBL ID: ENSG00000109906; HGNC ID: 12930
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00003Acute myeloid leukemia (AML)
No data
Desease Name
Conduct disorder (interaction)
PSYCH
Desease Name
Conduct disorder (interaction)
Desease Name
Skeletal defects, genital hypoplasia, and mental retardation
Leukemia, acute promyelocytic, PL2F/RARA type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ZBTB16 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ZBTB16 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of ZBTB16 mRNAdecreases expression 19654921
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ZBTB16 mRNAaffects cotreatment|increases expression 18164116
D016572 Cyclosporine Cyclosporine results in decreased expression of ZBTB16 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ZBTB16 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ZBTB16 mRNAaffects cotreatment|increases expression 18164116
D004610 Ellagic Acid Ellagic Acid results in decreased expression of ZBTB16 mRNAdecreases expression 12002526
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of ZBTB16 mRNAaffects cotreatment|increases expression 17404688
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of ZBTB16 mRNAincreases expression 16809437
D010126 Ozone Ozone results in increased expression of ZBTB16 mRNAincreases expression 17460151
C041786 palm oil palm oil results in decreased expression of ZBTB16 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of ZBTB16 mRNAincreases expression 18445702
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of ZBTB16 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of ZBTB16 mRNAincreases expression 17404688
D011374 Progesterone Progesterone affects the expression of ZBTB16 mRNAaffects expression 17251523
C059514 resveratrol resveratrol results in decreased expression of ZBTB16 mRNAdecreases expression 12002526
C017947 sodium arsenite sodium arsenite results in increased expression of ZBTB16 mRNAincreases expression 17682005
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZBTB16 mRNAincreases expression 20055451
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.457525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4511752688 14514962 15322242
MESH:D058186 Acute Kidney Injury resveratrol 3.8316538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Estradiol 2.0911473722
MESH:D000236 Adenoma beta-Naphthoflavone 11.2319389873
MESH:D000236 Adenoma Diethylnitrosamine 11.2310737359 6695378
MESH:D000236 Adenoma resveratrol 11.2315688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.2418056438 16434500 17620307 17162532 19061943 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma Arsenic 13.7917306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 13.7917306315 16712894
MESH:D000544 Alzheimer Disease Ozone 4.3715513908
MESH:D000544 Alzheimer Disease resveratrol 4.3716162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8618414634 16251483 12569548 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 3.8715238619
MESH:D001169 Arthritis, Experimental resveratrol 3.4917115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6316373670 17854713
MESH:D050197 Atherosclerosis Arsenic 6.8512928151 19371607
MESH:D050197 Atherosclerosis resveratrol 6.8517967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415380490 15665606 15845082
MESH:D002545 Brain Ischemia resveratrol 4.2717600658
MESH:D001943 Breast Neoplasms Dietary Fats 2.9520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9517474063
MESH:D001943 Breast Neoplasms Estradiol 2.9517261762 16675129 17289903 18497071 12948864 17018787 19861407 14630087
MESH:D001943 Breast Neoplasms Progesterone 2.9516175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 2.9517651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6615516495 14754758 19059883 18417511 16777450 18315731 17626835
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5815504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.363084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.3616507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.363084413 18056438 18506893 16288022 18393292 18788625 18785209 16502159 20084675 19171122 17978847 11831363 19394651 16779866 17761372 3581430 19539802 19335982 19052882 18971187 20524982 16698587 19519916 10737359 16807293 16878318 19701751 20727157 18210153 18665156 20935162 20214788 17138121 17173139 17428255 19418558 10672840 16569478 16328049 16830150 17055752 20514400 20101231 17162532 19208518 19822196 20007298 19383236 19107877 16935385 18978308 20512989 18494052 21159647 20432363 19919837 16540662 16681979 18691550
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.3616924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 11.3616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.3615276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5816675471
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.6218922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.6216227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.6218572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0618640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 7.5215738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases resveratrol 7.5215458977
MESH:D002340 Carotid Artery Diseases Arsenic 4.2916973168 18022660
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.3814694615
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.9012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.902727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.9018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.9020056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis Cyclosporine 7.7019486331
MESH:D002779 Cholestasis pirinixic acid 7.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 8697196 15340226 15668235 16354765
MESH:D003092 Colitis resveratrol 4.1116474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4516338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.1315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.1314669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.7416507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7516873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.9619279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.9616286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 8.9321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9316393943 16177239 19370779 18713872 2444490 10915739 15968718 14550746 17522070 14986274 15619225 11739529 16485898 16081117 19923254 19085960 10774834 12594235 12392966 11461765 11421492 17906064 19164858 18071297 17562736 11834606 12540782 16227642 11287661 11743745 14725611 16781746 19420014 16109766 12958197 10663392 19416960 12705907 19739265 11529661 12153990
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004487 Edema pirinixic acid 11.3312083418
MESH:D004487 Edema resveratrol 11.338985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.2917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.2917872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.9718566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 8.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.879294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8317923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 18.6119224547
MESH:D005234 Fatty Liver Dietary Fats 18.6118296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 18.6120387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 18.6119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Cyclosporine 14.6512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 14.6518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6520067830
MESH:D005534 Foot Diseases Arsenic 5.566392382
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2218467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2212621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D006561 Herpes Simplex resveratrol 4.1716876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.1312676792
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 15340226 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006937 Hypercholesterolemia Dietary Fats 9.1521332399
MESH:D006937 Hypercholesterolemia resveratrol 9.1517188708
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4417050553
MESH:D006949 Hyperlipidemias Dietary Fats 9.2321332399
MESH:D006949 Hyperlipidemias resveratrol 9.2316873680
MESH:D006973 Hypertension Arsenic 8.5411953799 9931084 16076760
MESH:D006973 Hypertension Cyclosporine 8.5410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2817488730
MESH:D006987 Hypesthesia Arsenic 5.5616093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 11.4415869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 11.4417600658
MESH:D007248 Infertility, Male sodium arsenite 2.9712646999 15346721
MESH:D007249 Inflammation Dietary Fats 15.7620412841
MESH:D007249 Inflammation Diethylnitrosamine 15.7618785209
MESH:D007249 Inflammation Progesterone 15.7615869954
MESH:D007249 Inflammation resveratrol 15.7616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.7612200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.5416624496
MESH:D007333 Insulin Resistance Dietary Fats 12.2118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.2116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.2116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007642 Keratosis Arsenic 4.9816930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 14.3212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.3218776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 14.3215618244
MESH:D007674 Kidney Diseases sodium arsenite 14.3220008137
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2112371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2115610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.8717339181
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.8716087638
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6018665156 20032147 19638242 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3612878042
MESH:D008107 Liver Diseases Acetaminophen 6.5012587719 16611625 19014921 16610002 11587558 19460945 12969438 19784758
MESH:D008107 Liver Diseases Arsenic 6.5011134558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 21.8116368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.8119389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.8112112319 19551842 19426721 15885732 19638242 19294768 18644402 2422723 10737359 20137499 19499222 19996281 19256749 19073162 20452335 21167192 18754104 19642983 21278145 19090486 20405173 20434301 20492335 18977376 19812893 19850985 9163691 2862719 19255062 16942905 19690152 20101389 15175105 21047994 12771043 19833225 19427195 21071580 20501860 20118626 20583210 18978307 19254457 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 21.8120007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 21.8119812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 21.8115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.8116984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 9.7918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.792563599 18253720 19009564 18544905 9362446 17942915 18308698 18775883 18093689 18079962 19519916 18164116 17854601 19539802 19126423 3124819 17174075 21159647 16842330 18282651 16267830 19004024
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7912151625
MESH:D008171 Lung Diseases Ozone 7.4719066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.4719095001
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Arsenic 6.5719168569 17976673 17306315
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5721163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 6.577614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 6.5717077188 19931552 15276417 16712894 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5719555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2817088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8514749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2415688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.9611408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.9617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.9611606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.4819453300
MESH:D008545 Melanoma resveratrol 3.4817992120
MESH:D008545 Melanoma sodium arsenite 3.4819082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008659 Metabolic Diseases resveratrol 4.3617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009101 Multiple Myeloma resveratrol 3.4517049120 17164350 16490592 16267019 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D009203 Myocardial Infarction resveratrol 5.7116456233 16317513 17015251 16525036 17188708 17125593
MESH:D017202 Myocardial Ischemia Arsenic 15.2015371236
MESH:D017202 Myocardial Ischemia resveratrol 15.2017125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 15.2012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D009205 Myocarditis resveratrol 4.7517322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.563581430 9029167
MESH:D009369 Neoplasms pirinixic acid 4.9117405874
MESH:D009369 Neoplasms sodium arsenite 4.9111559025
MESH:D009374 Neoplasms, Experimental resveratrol 9.188985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.1820056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.4116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D009436 Neural Tube Defects Arsenic 7.4116620997
MESH:D009436 Neural Tube Defects sodium arsenite 7.4112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.9518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.9520387270
MESH:D019636 Neurodegenerative Diseases resveratrol 13.9517652729
MESH:D020078 Neurogenic Inflammation Arsenic 10.6417056641
MESH:D020078 Neurogenic Inflammation resveratrol 10.6417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009765 Obesity Dietary Fats 4.4217217161 21332399 20518802 19632207 18457598 16723640 18674790 11836018 20132043
MESH:D009765 Obesity pirinixic acid 4.4220558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.0814694615
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.2417513867
MESH:D010051 Ovarian Neoplasms Arsenic 11.2717306315
MESH:D010051 Ovarian Neoplasms Estradiol 11.2719401270
MESH:D010051 Ovarian Neoplasms Progesterone 11.2716525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.2715276417 17306315
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9815371236 6392382 16905509
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D011014 Pneumonia Ozone 4.3918007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.8812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.882563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.5616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1116140617
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.1116731767 17804756 15767336 17636462 17675339 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1116039940
MESH:D011507 Proteinuria Arsenic 3.9921343184
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5816325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.5419058328
MESH:D015427 Reperfusion Injury resveratrol 6.5415827377 16317513 16314181 17058453 17520802
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
OMIM:612447 SKELETAL DEFECTS, GENITAL HYPOPLASIA, AND MENTAL RETARDATION marker/mechanism
MESH:D012871 Skin Diseases Arsenic 2.7417938729 16353154 17548696 18709164 17453740 16702368 15952646 17050553 6392382 16759981 19834688
MESH:D012878 Skin Neoplasms Arsenic 13.5217976673 17050553 17029826 19538983 16251483 15504454
MESH:D012878 Skin Neoplasms resveratrol 13.5215837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 13.5219524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.5216192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.2716503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7812854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4616321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.977505956
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D014062 Tongue Neoplasms resveratrol 4.1916227395
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.2617976673 19429237 15987713 17306315 19322015 18640142 11144890
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2616452187 17306315 11723127 16712894
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.5017473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.5011813266
MESH:D014594 Uterine Neoplasms resveratrol 4.1217044934
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014652 Vascular Diseases Arsenic 11.8217056641
MESH:D014652 Vascular Diseases sodium arsenite 11.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2917488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37517
    • Releated gene ID Related gene Name
    PA44AGTR2
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451096prednisolone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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