AutismKB 2.0

Annotation Detail for TRIM25


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Basic Information Top
Gene Symbol:TRIM25 ( EFP,RNF147,Z147,ZNF147 )
Gene Full Name: tripartite motif-containing 25
Band: 17q23.1
Quick LinksEntrez ID:7706; OMIM: 600453; Uniprot ID:TRI25_HUMAN; ENSEMBL ID: ENSG00000121060; HGNC ID: 12932
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04622RIG-I-like receptor signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRIM25 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]decreases reaction|increases expression 19148513
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]decreases reaction|increases expression 19148513
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of TRIM25 mRNAincreases expression 19148513
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in increased expression of TRIM25 proteinincreases expression 19148513
D000082 Acetaminophen Acetaminophen affects the expression of TRIM25 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TRIM25 mRNAincreases expression 15003993
14729362
D004958 Estradiol 4-hydroxytamoxifen inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]decreases reaction|increases expression 19148513
D004958 Estradiol 4-hydroxytamoxifen inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]decreases reaction|increases expression 19148513
D004958 Estradiol Estradiol results in increased expression of TRIM25 mRNAincreases expression 19148513
D004958 Estradiol Estradiol results in increased expression of TRIM25 proteinincreases expression 19148513
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]decreases reaction|increases expression 19148513
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]decreases reaction|increases expression 19148513
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRIM25 mRNAincreases expression 17557909
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of TRIM25 mRNAincreases expression 14729362
D010656 Phenylephrine Phenylephrine results in decreased expression of TRIM25 mRNAdecreases expression 18158353
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]decreases reaction|increases expression 19148513
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]decreases reaction|increases expression 19148513
D014212 Tretinoin Tretinoin results in decreased expression of TRIM25 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D000419 Albuminuria Raloxifene 4.7917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2717460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5415885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.5416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816197459 16206674
MESH:D001919 Bradycardia Phenylephrine 4.7815306635
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001943 Breast Neoplasms Estradiol 1.9512948864 19861407 16675129 14630087 17261762 17018787 17289903 18497071
MESH:D001943 Breast Neoplasms Raloxifene 1.9516837676 17261762 17595753 15572757 16912660 17952589 17242785 15758505 17440819 17049068 17893378 15775269
MESH:D001943 Breast Neoplasms Tretinoin 1.9516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.751917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2317572228
MESH:D006332 Cardiomegaly Phenylephrine 3.6211754973 16170337 11179087 17287366 17124262 15728586
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.9716936243
MESH:D002318 Cardiovascular Diseases Raloxifene 7.9715775269
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017110522 17681005 15861022 16919318 17333356 11677210 16105132
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829142499 9211117 10589399 16925845 17551590 9224671 14991402 9664655 8800419 9125849
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003928 Diabetic Nephropathies Estradiol 9.5219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.5215920148 17308373 17451421
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.8621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8615619225 17522070 19164858 18713872 2444490 11421492 19923254 10663392 10774834 11529661 12392966 12540782 16485898 17906064 16393943 14725611 17562736 16781746 15968718 16109766 19420014 11287661 19370779 11739529 12594235 19739265 14986274 12153990 19085960 14550746 12958197 11834606 16227642 12705907 16081117 11743745 19416960 10915739 11461765 18071297 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema Raloxifene 3.5115860553
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.7815845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 13.2019148513
MESH:D016889 Endometrial Neoplasms Estradiol 13.2011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 13.2016569247
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4415345470
MESH:D005234 Fatty Liver Raloxifene 8.4417473493
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006973 Hypertension Phenylephrine 5.8512717712 8949925
MESH:D006973 Hypertension Raloxifene 5.8517577099 15787275
MESH:D006984 Hypertrophy Phenylephrine 4.7312791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007333 Insulin Resistance Estradiol 3.0716627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.1912587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2619642359 17712046 17339181 12679006 15748426 17301526 16331271 16788101 16766008 16891316 17217047 9834237 16140955 16935935 17368321 19035177 17107899 19075265 19225113 17506722 19029980 17294898 16823087 17649720 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 16611625 11587558 19784758 12969438 19014921 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6616891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009369 Neoplasms Tretinoin 2.4816594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 10.3411399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.349125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
MESH:D010024 Osteoporosis Raloxifene 3.4917882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4117823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 4.9619401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9616936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.3012065085
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3016740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3016536755 15731164 16220300
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6418551238
MESH:D012852 Sinusitis Phenylephrine 4.947327846
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 10.0012065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.008532709
MESH:D012878 Skin Neoplasms Tretinoin 10.0016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 14.6219048282
MESH:D013978 Tibial Fractures Raloxifene 14.6219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4016049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.4017572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37519
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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