AutismKB 2.0

Annotation Detail for ZBTB17


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Basic Information Top
Gene Symbol:ZBTB17 ( MIZ-1,ZNF151,ZNF60,pHZ-67 )
Gene Full Name: zinc finger and BTB domain containing 17
Band: 1p36.13
Quick LinksEntrez ID:7709; OMIM: 604084; Uniprot ID:ZBT17_HUMAN; ENSEMBL ID: ENSG00000116809; HGNC ID: 12936
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200002Regulation of nuclear SMAD2/3 signaling
200093C-MYC pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ZBTB17 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ZBTB17 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ZBTB17 mRNAaffects expression 17562736
D002330 Carmustine Carmustine results in decreased expression of ZBTB17 mRNAdecreases expression 15980968
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZBTB17 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ZBTB17 mRNAaffects binding|increases activity|increases expression 19710929
C436947 T 113242 T 113242 promotes the reaction [ZBTB17 protein results in increased expression of LDLR mRNA]increases expression|increases reaction 11545736
C436947 T 113242 T 113242 promotes the reaction [ZBTB17 protein results in increased expression of LDLR protein]increases expression|increases reaction 11545736
D002762 Cholecalciferol Cholecalciferol results in decreased expression of ZBTB17 mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.3916142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001932 Brain Neoplasms Carmustine 4.6516187019
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5816393943 19739265 14986274 18713872 10774834 16781746 16485898 11743745 19164858 12705907 11834606 15968718 19370779 17522070 12392966 17906064 19085960 12153990 16109766 11287661 16081117 11421492 19420014 2444490 12594235 10915739 16177239 11529661 16227642 14725611 17562736 11461765 18071297 19416960 19923254 14550746 10663392 11739529 15619225 12540782 12958197
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D005234 Fatty Liver pirinixic acid 3.0419236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Carmustine 4.1016187019
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3518467677 19176532 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6816611625 19784758 12969438 19460945 11587558 16610002 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.707678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.7016377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876784 6135515 2876786
MESH:D008545 Melanoma Carmustine 2.8912393984
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D011471 Prostatic Neoplasms Cholecalciferol 4.1717024972
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:15380 Diabetes pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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