AutismKB 2.0

Annotation Detail for CA12


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Basic Information Top
Gene Symbol:CA12 ( CAXII,FLJ20151,HsT18816 )
Gene Full Name: carbonic anhydrase XII
Band: 15q22.2
Quick LinksEntrez ID:771; OMIM: 603263; Uniprot ID:CAH12_HUMAN; ENSEMBL ID: ENSG00000074410; HGNC ID: 1371
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
1841Stomach cancer
2060Glaucoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CA12 mRNAaffects expression 20382639
C006780 bisphenol A bisphenol A affects the expression of CA12 mRNAaffects expression 20170705
C006780 bisphenol A bisphenol A results in increased expression of CA12 mRNAincreases expression 16474171
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of CA12 mRNAincreases expression 17720352
D003520 Cyclophosphamide CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in increased expression of CA12 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of CA12 mRNAincreases expression 14996990
D004317 Doxorubicin CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004958 Estradiol Estradiol affects the expression of CA12 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA12 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of CA12 mRNAincreases expression 16474171
15223131
19619570
15913882
D005472 Fluorouracil CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D019833 Genistein Genistein results in increased expression of CA12 mRNAincreases expression 16474171
C071834 glycidamide glycidamide results in decreased expression of CA12 mRNAdecreases expression 17822822
D017239 Paclitaxel CA12 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CA12 mRNAaffects binding|increases activity|increases expression 19710929
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of CA12 mRNAincreases expression 16474171
D020849 Raloxifene Raloxifene affects the expression of CA12 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of CA12 mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of CA12 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of CA12 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of CA12 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CA12 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CA12 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CA12 mRNAincreases expression 20106945
19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Doxorubicin 10.1817418594
MESH:D000230 Adenocarcinoma Estradiol 10.1811473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.1817638652
MESH:D000230 Adenocarcinoma Genistein 10.1811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000419 Albuminuria Doxorubicin 11.4121441931
MESH:D000419 Albuminuria Raloxifene 11.4117451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Fluorouracil 8.6217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6211748828
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.5815014928
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7014601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.5515867366
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D001930 Brain Injuries Raloxifene 4.4616580743
MESH:D001932 Brain Neoplasms Doxorubicin 3.7917150277
MESH:D001943 Breast Neoplasms bisphenol A 9.7417123778
MESH:D001943 Breast Neoplasms Cacodylic Acid 9.7417474063
MESH:D001943 Breast Neoplasms Calcitriol 9.7411237771
MESH:D001943 Breast Neoplasms Cyclophosphamide 9.7416978400 11325840 15136595 18234424 17020986 12006526 18323546 17388661 15093573
MESH:D001943 Breast Neoplasms Doxorubicin 9.7415692762 16096432 15993339 19526202 15634643 18628466 18234424 15136595 15567936 11325840 17426702 15668708 16322301 17369602 16935488 17983394 16826403 16115903 16595493 18382427 18695136 15939500 15994142 16264153
MESH:D001943 Breast Neoplasms Estradiol 9.7414630087 19861407 17289903 16675129 17261762 12948864 17018787 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 9.7415136595 16595493 16557594 18357371 16110121 19217205 18608205
MESH:D001943 Breast Neoplasms Genistein 9.7416873071 17200150 16541309
MESH:D001943 Breast Neoplasms Paclitaxel 9.7416273361 18323546 15136595 16115903 16244791 11325840 18223236 18234424
MESH:D001943 Breast Neoplasms Raloxifene 9.7417893378 15758505 15572757 16912660 15775269 17242785 17261762 17049068 17952589 17595753 17440819 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 9.7419189212 18984771 19189210 19142967 19410462 19103187 21138602 16202921 19084267 18855134 20390343 19155303 19288272 18351453 19011961 11161223 18815881 15565566 17893378 19289846 19221464 20544844 17261762 18425577 17242785 19115204 19244106 18629630 16818667 15668708 20859285 20005174 17049068 20135344 19066611 19487384 20065188 18997820 18821012 21152245 16873071 16273361 19200415 17440819 19059307
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.7420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 12.3516051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.3516051944
MESH:D002277 Carcinoma Fluorouracil 8.1317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 14.0619701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 14.0616023760 16234567 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.0616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.0617088986 16799960 17045692 18930000 16332177 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.0616924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 14.0616313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.0616924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.8816152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 10.8416201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.8416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.8418695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.6211237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.626189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.6216280240 17066447 16757204 18986760
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.4417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5117382496 17007740 15811867 16242529 18627295 15476868 15792986 17308081 16731534 17329180 16651473 16269455 16455267 15505089 17928571 17351982 17974986 17131338 16952015 16364871 16278810 16109756 16612575 17519947 17924179
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9417334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 7.4516332659
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4515775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.0518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 7.7019486331
MESH:D002779 Cholestasis pirinixic acid 7.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915668235 15340226 16354765 12621046 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8417287894 17018589 17172411 17016597 16340194 17169374 16510598 17725105 15001691 18772588
MESH:D003110 Colonic Neoplasms Genistein 3.8417182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.8618802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.8617695437 18949393 17401013 17094418 16331619 17594712 16524972 18383874 16282729 17255274 15148649 15289873 18448328 17454858 20501625 18288408 18802399 16303861 16391804 17016601 14970324 18509181
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.8618802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.8615531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D003556 Cystitis Cyclophosphamide 4.9916989017 18093676 18710439 11948286 16651033 15276878 17010015 10498854 12161096 16614059 12388444 18295254 12913760 18483878 10700343 18372110 18433785 15643279 16413132 17979934
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.6816140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.0515331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2118772604
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3117107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.9217451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.9219279558
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.8517416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8520420201
MESH:D004362 Drug Toxicity Doxorubicin 8.0618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0611462148
MESH:D004487 Edema pirinixic acid 11.3212083418
MESH:D004487 Edema Raloxifene 11.3215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.3715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.3715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.3719031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.5816402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.6917359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.6919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 17.6911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 17.6916202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1618037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.2011006010
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3220426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3216785472 16481741 15173087 17638652 16337965
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.3216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 18.6319224547
MESH:D005234 Fatty Liver pirinixic acid 18.6320131406 19236843
MESH:D005234 Fatty Liver Raloxifene 18.6317473493
MESH:D005234 Fatty Liver Tamoxifen 18.6314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.4119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.4119069698
MESH:D005355 Fibrosis Cyclosporine 8.4412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005909 Glioblastoma Doxorubicin 7.2917150277
MESH:D005909 Glioblastoma Genistein 7.2916598420
MESH:D005910 Glioma Fluorouracil 2.8616145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.5111389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.0211014644 15172196 16376943
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.8715692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8718337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 7.7916244372 14766674 17875725 16144979 16330681 16495754 16707910 12587719 18674790 17888722 18006777 16879835 16244371
MESH:D006331 Heart Diseases Raloxifene 7.7911110106
MESH:D006333 Heart Failure Doxorubicin 7.0117481944
MESH:D006333 Heart Failure pirinixic acid 7.0120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.2811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.5314986274
MESH:D006529 Hepatomegaly pirinixic acid 8.2218467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2212621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.6516135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 7.6518501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 16354765 8697196 18606429 15340226
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006973 Hypertension Cyclosporine 8.5410903974
MESH:D006973 Hypertension Raloxifene 8.5415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.3316076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.617193160 16517039
MESH:D007249 Inflammation Tamoxifen 4.8519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8512878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 12.2416393666
MESH:D007333 Insulin Resistance Estradiol 12.2416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.2416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 10.0218776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 10.0215699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 10.0215618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1316707910
MESH:D007680 Kidney Neoplasms Cyclosporine 17.6212371664
MESH:D007680 Kidney Neoplasms Estradiol 17.6215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.6216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.6218625569
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D007938 Leukemia Cyclophosphamide 6.6410602166
MESH:D007938 Leukemia Genistein 6.6418980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1616085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4918587576 17802794 17658394 17008537 17296974 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0710373061
MESH:D007970 Leukopenia Cyclophosphamide 4.9611830472 10052129
MESH:D008064 Lipidoses Tamoxifen 3.1415342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.8017353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.7216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.7214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.7217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.7215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.7218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.7212878042
MESH:D008113 Liver Neoplasms Fluorouracil 10.6218383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 10.6215890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 10.6216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6216984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.9017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 9.901423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9012151625
MESH:D008175 Lung Neoplasms Doxorubicin 4.846189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 4.8415246190
MESH:D008175 Lung Neoplasms Tamoxifen 4.8418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D008223 Lymphoma Cyclophosphamide 7.8312854902
MESH:D008223 Lymphoma Doxorubicin 7.8316098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.5816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 14.5711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 14.5717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 14.5714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5515621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.1815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.1811807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.1812929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.1819196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008545 Melanoma Doxorubicin 5.2016827129
MESH:D008545 Melanoma Paclitaxel 5.2016342250 12040289 12025231
MESH:D008545 Melanoma Tamoxifen 5.2019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.7916388313
MESH:D008654 Mesothelioma Doxorubicin 3.0517638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4815792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6118986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.7817415656
MESH:D009101 Multiple Myeloma Paclitaxel 7.5714749477
MESH:D009101 Multiple Myeloma Raloxifene 7.5716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.4419429709 15857846
MESH:D009203 Myocardial Infarction Genistein 9.4417141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.4419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.0816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.0817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.0816411023
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.5718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.5715867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms Cyclophosphamide 8.2918854779
MESH:D009369 Neoplasms Fluorouracil 8.2916928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 8.2917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009401 Nephrosis Doxorubicin 4.7516899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.2319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.2315640375 16889571
MESH:D009421 Nervous System Malformations bisphenol A 23.3316427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 23.3316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 23.3316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.3314600291
MESH:D009447 Neuroblastoma Cyclophosphamide 7.1816115947 8761367 15176712
MESH:D009447 Neuroblastoma Doxorubicin 7.1815555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.888761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D009503 Neutropenia Cyclophosphamide 4.318291058
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009845 Oligospermia Cyclophosphamide 4.7016517039
MESH:D010014 Osteolysis Paclitaxel 4.9715867366
MESH:D010024 Osteoporosis Genistein 7.2919401787
MESH:D010024 Osteoporosis Raloxifene 7.2917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.0816169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.0815579764 15758505 17893378 17823083
MESH:D012516 Osteosarcoma Doxorubicin 4.0915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.9519401270
MESH:D010051 Ovarian Neoplasms Genistein 7.9519005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.9511161223
MESH:D010146 Pain Cyclophosphamide 3.6112161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.5811332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5816929163 16500647 15113037 19003803
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3816702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1617983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7921297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4811118676 11399792 11896295 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.4920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 4.2816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 4.2815754350 12479363 18247401 16644109 16289102
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 4.2817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 4.2815749863 16729912 16868541 18437689 16888761 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 4.2816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.2819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 4.2815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Paclitaxel 4.2816356831 17136230 17172428 16729912
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 4.2815721890
MESH:D011471 Prostatic Neoplasms Raloxifene 4.2815731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.2815067354
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2716636934
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9918722050 15538739 18286688 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.2117922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012509 Sarcoma Doxorubicin 3.9717710206 16767912 15675481 17203757 18313854 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2316326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7817846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.8016636934
MESH:D012878 Skin Neoplasms Doxorubicin 5.6515692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6516192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5515625365 16767912 17203757
MESH:D013088 Spermatocele Tamoxifen 4.2916709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.5116517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7419015929 16424979 16951190 18396642 18567086 17172411 19084572 17522103 17498489 15786421
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7418396642 18506536
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716045194 16684133
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.0512837982
MESH:D024801 Tauopathies Paclitaxel 4.8016930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3516010429 17909728
MESH:D013978 Tibial Fractures Estradiol 13.7119048282
MESH:D013978 Tibial Fractures Raloxifene 13.7119048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9716280240
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 15.7715537745
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.7714692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.7717653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.7717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.778653321 17572228 16712894
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8616803524
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2117638931 17334414 16364871 17678736
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:00910 Nitrogen metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00562 antagonist Benzthiazide Antihypertensive Agents;Stimulants;Diuretics
DB00774 antagonist Hydroflumethiazide Antihypertensive Agents;Diuretics;Diuretics, Thiazide;Sodium Chloride Symporter Inhibitors
DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
DB00999 antagonist Hydrochlorothiazide Antihypertensive Agents;Diuretics;Sodium Chloride Symporter Inhibitors
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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