AutismKB 2.0

Annotation Detail for ZMYM2


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Basic Information Top
Gene Symbol:ZMYM2 ( FIM,MYM,RAMP,SCLL,ZNF198 )
Gene Full Name: zinc finger, MYM-type 2
Band: 13q12.11
Quick LinksEntrez ID:7750; OMIM: 602221; Uniprot ID:ZMYM2_HUMAN; ENSEMBL ID: ENSG00000121741; HGNC ID: 12989
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Stem-cell leukemia/lymphoma syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ZMYM2 mRNAincreases expression 20406850
D000111 Acetylcysteine Acetylcysteine results in decreased expression of ZMYM2 mRNAdecreases expression 16084531
C006632 arsenic trioxide arsenic trioxide results in decreased phosphorylation of ZMYM2 protein mutant formdecreases phosphorylation 17027752
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZMYM2 mRNAdecreases expression 19150397
D004317 Doxorubicin Doxorubicin results in increased expression of ZMYM2 mRNAincreases expression 16579640
D004610 Ellagic Acid Ellagic Acid results in increased expression of ZMYM2 mRNAincreases expression 12002526
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of ZMYM2 mRNAdecreases expression 16084531
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ZMYM2 mRNAincreases expression 12832660
D020849 Raloxifene Raloxifene results in increased expression of ZMYM2 mRNAincreases expression 16497877
C059514 resveratrol resveratrol results in increased expression of ZMYM2 mRNAincreases expression 12569576
D012643 Selenium Selenium results in decreased expression of ZMYM2 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of ZMYM2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 3.9616538975
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6519825857 11798837
MESH:D000230 Adenocarcinoma Doxorubicin 4.6517418594
MESH:D000236 Adenoma resveratrol 3.3815688382
MESH:D000419 Albuminuria Doxorubicin 11.8921441931
MESH:D000419 Albuminuria Raloxifene 11.8917308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 4.5015800139
MESH:D000544 Alzheimer Disease resveratrol 4.5016162502 16183991
MESH:D001169 Arthritis, Experimental resveratrol 3.5617115116
MESH:D001249 Asthma epigallocatechin gallate 3.4216516891
MESH:D050197 Atherosclerosis resveratrol 3.3317967414 16873680
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.2019761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7816206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8714601052
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D002545 Brain Ischemia resveratrol 4.4417600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0719526202 17426702 15668708 15692762 16096432 16264153 18628466 16826403 18234424 15993339 15136595 16115903 16322301 17369602 18382427 18695136 11325840 15634643 15939500 16935488 15994142 17983394 15567936 16595493
MESH:D001943 Breast Neoplasms Raloxifene 2.0715758505 17049068 17261762 16912660 15572757 15775269 17952589 17595753 17893378 17440819 16837676 17242785
MESH:D001943 Breast Neoplasms resveratrol 2.0717534123 16393696 17651959
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9816051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7516705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7515553829 16217749 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.7518059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.7519321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7516675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2016201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.9417015178
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.946189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.9416227395
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.6015476868 17351982 16612575 15792986 17329180 17928571 17131338 17974986 17308081 15811867 16455267 16952015 16109756 16651473 15505089 17382496 17924179 16278810 16269455 18627295 16364871 16242529 16731534 17007740 17519947
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9816243910 17334414
MESH:D002318 Cardiovascular Diseases Raloxifene 7.8115775269
MESH:D002318 Cardiovascular Diseases resveratrol 7.8115458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.766135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7620889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 11.7618226522
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.3812912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 4.4116629650 15500046 7624871 18590720 15913567 12927374 19486331 18164287
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 6.0310220858 19407337
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D003092 Colitis resveratrol 10.1216474422
MESH:D003092 Colitis Selenium 10.1217936198
MESH:D003110 Colonic Neoplasms resveratrol 2.4716338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5620501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5618802399 18259882
MESH:D015179 Colorectal Neoplasms resveratrol 3.5616550006
MESH:D003327 Coronary Disease resveratrol 3.8216507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7410525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7419769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.4819747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8616873680
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 3.3016988119
MESH:D003928 Diabetic Nephropathies Raloxifene 9.5417308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies resveratrol 9.5416286809
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 12.4020133375 7624871 17522070 18289764
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 12.4011287661
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.4017416283
MESH:D056486 Drug-Induced Liver Injury Selenium 12.4015131321
MESH:D004362 Drug Toxicity Doxorubicin 3.7518602426
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Raloxifene 7.5815860553
MESH:D004487 Edema resveratrol 7.588985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.8515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.8517872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9917923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005234 Fatty Liver arsenic trioxide 8.4015073043
MESH:D005234 Fatty Liver Raloxifene 8.4017473493
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6015692506
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0416080930
MESH:D006331 Heart Diseases Doxorubicin 8.0916495754 16244371 16244372 16144979 14766674 16879835 16707910 18006777 16330681 17888722 18674790 12587719 17875725
MESH:D006331 Heart Diseases Raloxifene 8.0911110106
MESH:D006333 Heart Failure Doxorubicin 7.4617481944
MESH:D006333 Heart Failure Selenium 7.4617162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 4.8218590720
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006561 Herpes Simplex resveratrol 4.3316876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.5015147373 18501091 17606976
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006937 Hypercholesterolemia resveratrol 4.1117188708
MESH:D006949 Hyperlipidemias resveratrol 4.1416873680
MESH:D006973 Hypertension Raloxifene 2.9015787275 17577099
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4117488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7817600658
MESH:D007249 Inflammation resveratrol 2.8916366677
MESH:D007251 Influenza, Human resveratrol 19.6916624496
MESH:D007251 Influenza, Human Selenium 19.6916624496
MESH:D007251 Influenza, Human Vitamin E 19.6916624496
MESH:D007674 Kidney Diseases Doxorubicin 6.4815699352 15369732 16775033
MESH:D007674 Kidney Diseases Vitamin E 6.4812488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.3516707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.3516518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0716705839
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1517050201 16968895 20471514 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.0216966277 12018890 17649720 15213294 16823087 16331271 15622746 19035177 11161223 19642359 17869043 12712474 19225113 17217047 12679006 16330433 17712046 16112521 19075265 11468182 16891316 9834237 15336539 17107899 15748426
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 8.0216087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.8016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 3.8017481882
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.8016169303
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 3.2117184895
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.757678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7514682389
MESH:D008113 Liver Neoplasms resveratrol 7.7520405173 19812893 19321006 19073162
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.312876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.3120377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.3117085340 16842330
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008171 Lung Diseases Acetylcysteine 8.0112815614
MESH:D008171 Lung Diseases Vitamin E 8.0116863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5919825857 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 3.596189445 17418594
MESH:D008175 Lung Neoplasms Vitamin E 3.5911062179
MESH:D008223 Lymphoma Doxorubicin 3.5416098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4217088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.1917654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 9.1914749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4015688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.4915458769
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 10.498985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.4915318939
MESH:D008545 Melanoma Doxorubicin 5.4416827129
MESH:D008545 Melanoma epigallocatechin gallate 5.4417992120 11746506
MESH:D008545 Melanoma resveratrol 5.4417992120
MESH:D008654 Mesothelioma Doxorubicin 6.4217638057
MESH:D008654 Mesothelioma Selenium 6.4215107826
MESH:D008659 Metabolic Diseases resveratrol 4.4917112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009101 Multiple Myeloma arsenic trioxide 12.6514977855 15949261 19417148 11468182 19549372
MESH:D009101 Multiple Myeloma Raloxifene 12.6516497877
MESH:D009101 Multiple Myeloma resveratrol 12.6514749477 16267019 17935668 17049120 17164350 16490592
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 13.1517962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 13.1517962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 6.1719429709 15857846
MESH:D009203 Myocardial Infarction resveratrol 6.1717015251 16525036 16317513 17188708 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 4.0917125593 17015251
MESH:D009205 Myocarditis resveratrol 4.9117322642
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.017678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 6.3914720322
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.3918259882
MESH:D009374 Neoplasms, Experimental resveratrol 4.148985016
MESH:D009401 Nephrosis Doxorubicin 4.9116899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1016889571 15640375
MESH:D009436 Neural Tube Defects Acetylcysteine 7.8919446573
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8910525206
MESH:D009447 Neuroblastoma Doxorubicin 3.3115555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9017652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5217929310
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010024 Osteoporosis Raloxifene 3.4619059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 10.6017893378 15758505 17823083 15579764
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.6017513867
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4416624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 6.0320133375
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.3316679765
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8818437689 16868541 15897917 16888761 16729912 15749863
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8815731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817718901 17804756 17675339 17636462 15767336 16731767
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3216317513 17058453 16314181 17520802 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.6412210543
MESH:D012509 Sarcoma Doxorubicin 4.0916767912 17203757 15675481 17710206 18313854 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.7116646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.7114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Doxorubicin 6.2115692506
MESH:D012878 Skin Neoplasms resveratrol 6.2115837718 8985016
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7017203757 16767912 15625365
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Acetylcysteine 4.1017918041
MESH:D020521 Stroke Raloxifene 9.0116837676
MESH:D020521 Stroke Vitamin E 9.0116517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5816321402
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.8620133375
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.6219014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.6216010429 17909728
MESH:D013978 Tibial Fractures Raloxifene 5.3819048282
MESH:D014062 Tongue Neoplasms resveratrol 4.3116227395
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3016049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.3012973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 12.3017653716
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.3017572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2017473185
MESH:D014594 Uterine Neoplasms resveratrol 4.2617044934
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.8117638931 16364871 17678736 17334414
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.8117488730
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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