AutismKB 2.0

Annotation Detail for ZP2


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Basic Information Top
Gene Symbol:ZP2 ( ZPA,Zp-2 )
Gene Full Name: zona pellucida glycoprotein 2 (sperm receptor)
Band: 16p12.3-p12.2
Quick LinksEntrez ID:7783; OMIM: 182888; Uniprot ID:ZP2_HUMAN; ENSEMBL ID: ENSG00000103310; HGNC ID: 13188
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016392 3,3'-diindolylmethane 3,3'-diindolylmethane results in increased expression of ZP2 mRNAincreases expression 16192472
C041594 4-nonylphenol 4-nonylphenol results in increased expression of ZP2 mRNAincreases expression 17912697
D001104 Arbutin Arbutin results in decreased expression of ZP2 mRNAdecreases expression 17103032
C006780 bisphenol A bisphenol A results in decreased expression of ZP2 mRNAdecreases expression 17912697
D004958 Estradiol Estradiol results in increased expression of ZP2 mRNAincreases expression 11254367
D004958 Estradiol Estradiol results in increased expression of ZP2 mRNAincreases expression 16192472
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ZP2 mRNAincreases expression 17912697
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ZP2 mRNAaffects expression 12505378
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ZP2 mRNAincreases expression 17555559
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ZP2 mRNAincreases expression 15288540
D005419 Flavonoids Flavonoids results in decreased expression of ZP2 mRNAdecreases expression 18035473
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of ZP2 mRNAincreases expression 16192472
C011890 kojic acid kojic acid results in decreased expression of ZP2 mRNAdecreases expression 16595896
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of ZP2 mRNAincreases expression 16966085
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ZP2 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms bisphenol A 2.1017123778
MESH:D001943 Breast Neoplasms Estradiol 2.1017289903 12948864 17261762 16675129 14630087 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms indole-3-carbinol 2.1016082211
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0911677210 17333356 16105132 17110522 16919318 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D003704 Dementia Methylmercury Compounds 5.1316140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 19148513 18566989
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0115345470
MESH:D005234 Fatty Liver pirinixic acid 8.0120131406 19236843
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 18467677 16221962 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Flavonoids 2.7117296493
MESH:D007333 Insulin Resistance bisphenol A 12.8316393666
MESH:D007333 Insulin Resistance Estradiol 12.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.8316306350
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8616377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.4118544905
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6417203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008569 Memory Disorders Methylmercury Compounds 5.0718436314
MESH:D009069 Movement Disorders Methylmercury Compounds 5.4718436314
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6116411023
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations bisphenol A 10.2911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 10.2911399458 16427766
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.8210548101
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 10.8218436314
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.0220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.0220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2316740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.2316740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 5.1516082211
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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