AutismKB 2.0

Annotation Detail for MAP3K12


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Basic Information Top
Gene Symbol:MAP3K12 ( DLK,MEKK12,MUK,ZPK,ZPKP1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 12
Band: 12q13.13
Quick LinksEntrez ID:7786; OMIM: 600447; Uniprot ID:M3K12_HUMAN; ENSEMBL ID: ENSG00000139625; HGNC ID: 6851
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200054Regulation of p38-alpha and p38-beta
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C021296 2-ethoxyethanol 2-ethoxyethanol results in decreased expression of MAP3K12 mRNAdecreases expression 19643169
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of MAP3K12 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAP3K12 mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in increased expression of MAP3K12 mRNAincreases expression 18585445
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MAP3K12 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K12 mRNA]decreases reaction|increases expression 19152381
C095105 bexarotene bexarotene results in increased expression of MAP3K12 mRNAincreases expression 16648578
D002509 Cephaloridine Cephaloridine results in decreased expression of MAP3K12 mRNAdecreases expression 18172885
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K12 mRNA]decreases reaction|increases expression 19152381
D003024 Clozapine Clozapine results in increased expression of MAP3K12 mRNAincreases expression 15860345
D003520 Cyclophosphamide Cyclophosphamide affects the expression of MAP3K12 mRNAaffects expression 18246545
D016572 Cyclosporine Cyclosporine results in decreased expression of MAP3K12 mRNAdecreases expression 18172885
D016190 Carboplatin Carboplatin results in decreased expression of MAP3K12 mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin results in decreased expression of MAP3K12 mRNAdecreases expression 18172885
D004008 Diclofenac Diclofenac results in decreased expression of MAP3K12 mRNAdecreases expression 18172885
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of MAP3K12 mRNAincreases expression 17011747
D005839 Gentamicins Gentamicins results in decreased expression of MAP3K12 mRNAdecreases expression 18172885
D006220 Haloperidol Haloperidol results in increased expression of MAP3K12 mRNAincreases expression 15860345
C005219 methyl cellosolve methyl cellosolve results in decreased expression of MAP3K12 mRNAdecreases expression 19643169
D009151 Mustard Gas Mustard Gas results in decreased expression of MAP3K12 mRNAdecreases expression 15674843
D011794 Quercetin Quercetin results in decreased expression of MAP3K12 mRNAdecreases expression 15309432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 9.146499820 6499796 6499823 7151721 6499812
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 9.146499812 6474471 3652986
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D058186 Acute Kidney Injury Cisplatin 14.2815814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Diclofenac 14.287897758
MESH:D058186 Acute Kidney Injury Gentamicins 14.2811274264
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4520464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 4.4517638652 11798837
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D000380 Agranulocytosis Clozapine 4.9712649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.1411874814
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3915469931
MESH:D000743 Anemia, Hemolytic Quercetin 4.1617084956
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.273699323
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.5115014928
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 12.326499807 10689203 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 12.323987992
MESH:D001249 Asthma Mustard Gas 2.6810378619
MESH:D001259 Ataxia 2-ethoxyethanol 5.377151721
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8915336622
MESH:D001284 Atrophy 2-ethoxyethanol 11.126499799 15850284
MESH:D001284 Atrophy methyl cellosolve 11.123699323 6705890 2626667
MESH:D001321 Autistic Disorder Haloperidol 2.7518080171 19368416
MESH:D001327 Autoimmune Diseases Quercetin 4.3219761891
MESH:D053713 Azoospermia 2-ethoxyethanol 5.496499807 6492198
MESH:D001724 Birth Weight 2-ethoxyethanol 6.436499823 2884743
MESH:D001768 Blister Mustard Gas 5.0719167455
MESH:D001836 Body Weight Changes 2-ethoxyethanol 5.637151721 6499796
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8014601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9320146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 2.9316818667 16344269
MESH:D001943 Breast Neoplasms Cisplatin 2.9319526202 18382427
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.9312006526 11325840 15136595 18234424 15093573 17388661 17020986 16978400 18323546
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.9315324884 17129689
MESH:D001943 Breast Neoplasms Quercetin 2.9318628248
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9017687719 10378619
MESH:D002105 Cadmium Poisoning Quercetin 5.4616962696
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.5717982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 6.5719701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.5716924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.5712508355 19519916
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.8016152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 9.0616247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 9.0616685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 9.0612023789 16685392
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8717234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.5016201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.6817066447 6189445 18337622
MESH:D006332 Cardiomegaly Quercetin 3.2719794523
MESH:D002375 Catalepsy Haloperidol 4.821977408 15215559
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.4712371664
MESH:D002764 Cholecystitis 2-ethoxyethanol 13.386499794
MESH:D002764 Cholecystitis methyl cellosolve 13.386499794
MESH:D002779 Cholestasis Cyclosporine 2.8519486331
MESH:D003072 Cognition Disorders Clozapine 4.8817123785
MESH:D003110 Colonic Neoplasms Quercetin 2.4119056647 11134977 17148506 16640504 19440933 15741050 17191121
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7715273666
MESH:D015179 Colorectal Neoplasms Quercetin 2.7718852136 18095365
MESH:D000013 Congenital Abnormalities methyl cellosolve 4.746499821 12530607
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4712952375 16002989
MESH:D003556 Cystitis Cyclophosphamide 4.9012388444 18710439 16413132 17010015 16614059 10700343 18093676 12161096 18372110 11948286 10498854 17979934 15276878 18295254 18433785 16651033 12913760 16989017 15643279 18483878
MESH:D003643 Death 2-ethoxyethanol 5.886499796
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7620210726
MESH:D003704 Dementia Haloperidol 4.5011575062
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 8.4215331540 10990075 11751995
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.4219496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1918772604
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9516402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4715331141
MESH:D004362 Drug Toxicity Cisplatin 8.5812649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Gentamicins 8.5811033412 15033597
MESH:D050171 Dyslipidemias Clozapine 4.1216402076
MESH:D004487 Edema Diclofenac 7.3316273134
MESH:D004487 Edema Mustard Gas 7.339260866 11402378 11428631 11428647
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.436499796
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.6116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.4115700306 16804899
MESH:D004802 Eosinophilia Cyclophosphamide 4.1311006010
MESH:D004890 Erythema Mustard Gas 5.079357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5316530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.5316785472 15464296 17638652 15173087 16481741
MESH:D005234 Fatty Liver Cyclosporine 2.7719224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6016534752 15751030 16513791 16002989 16611131
MESH:D005313 Fetal Death 2-ethoxyethanol 5.292884743 7198755 6499820 7151721 6499823
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.326499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 12.406499812 6499820
MESH:D005327 Fetal Resorption methyl cellosolve 12.406474471 3987992 6499821 6499812
MESH:D020567 Fetal Weight 2-ethoxyethanol 13.387151721 2884743 6499820
MESH:D020567 Fetal Weight methyl cellosolve 13.386474471 6499812 6499821
MESH:D005355 Fibrosis Cyclosporine 8.5412639820 12168785
MESH:D005355 Fibrosis Quercetin 8.5419474275
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.393652986
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Quercetin 3.3319804834
MESH:D005910 Glioma Quercetin 3.0217643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.4311389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.9516376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6515102660 15464296
MESH:D034381 Hearing Loss Cisplatin 10.0319898482
MESH:D034381 Hearing Loss Gentamicins 10.0317868369 15968427 19130971 18024279
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3415464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6120471113
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.696499821
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.3020172899 10514026
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006461 Hemolysis 2-ethoxyethanol 12.0719051582 17874071
MESH:D006461 Hemolysis methyl cellosolve 12.0717874071
MESH:D006467 Hemophilia A Cyclophosphamide 5.2011918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.4514986274
MESH:D006521 Hepatitis, Chronic Diclofenac 5.5914986274
MESH:D006689 Hodgkin Disease Cisplatin 7.5216170182 16200630
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.5217606976 16135485
MESH:D053565 Hypercalciuria Gentamicins 5.6217652376
MESH:D006943 Hyperglycemia Quercetin 3.9511834736 18262572
MESH:D006948 Hyperkinesis Clozapine 4.8216046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.3512960047 14722030
MESH:D006973 Hypertension Cyclosporine 5.1810903974
MESH:D006973 Hypertension Quercetin 5.1818356687
MESH:D007021 Hypospadias Diethylstilbestrol 4.4916002989
MESH:D007154 Immune System Diseases Cyclophosphamide 5.2516076520
MESH:D007246 Infertility Diethylstilbestrol 4.2715036965
MESH:D007247 Infertility, Female 2-ethoxyethanol 5.146499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 15.766499823
MESH:D007248 Infertility, Male Atrazine 15.7612948887
MESH:D007248 Infertility, Male Cyclophosphamide 15.767193160 16517039
MESH:D007248 Infertility, Male methyl cellosolve 15.763987992
MESH:D007249 Inflammation Diclofenac 5.6516273134
MESH:D007249 Inflammation Mustard Gas 5.659260866 9357497 8975870 16001271 11428620 11428631 17524151 11428647 11402378
MESH:D007251 Influenza, Human Quercetin 4.4316624496
MESH:D007627 Keloid Quercetin 4.8717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 13.0515464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 13.0518842672
MESH:D007674 Kidney Diseases Cisplatin 14.1212649298 12231392 18289764 19839026 15190930
MESH:D007674 Kidney Diseases Cyclosporine 14.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Gentamicins 14.1218289764 19349640 17934191
MESH:D007674 Kidney Diseases Quercetin 14.1216962696
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.2116762066 15003126 14681315
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 11.7411231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 11.7411231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9717184923
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.3910219319
MESH:D007938 Leukemia Cyclophosphamide 6.5810602166
MESH:D007938 Leukemia Quercetin 6.5817468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4617802794 17296974 18587576 17658394 17008537 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0210373061
MESH:D007970 Leukopenia Cyclophosphamide 4.8810052129 11830472
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.436499821
MESH:D008064 Lipidoses Clozapine 3.9017567588
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.1912741479
MESH:D008107 Liver Diseases Diclofenac 3.6116867024 14566034
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3620195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.3615890375 16712894
MESH:D008113 Liver Neoplasms Quercetin 7.3618980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.0019519916
MESH:D008171 Lung Diseases Mustard Gas 3.3918161513 18702808
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.516695378 18569708 17053015 20869020 20135361 18816296 20064080 20464547 18520028
MESH:D008175 Lung Neoplasms bexarotene 6.5117849452
MESH:D008175 Lung Neoplasms Cisplatin 6.5111798837 17225452 6189445
MESH:D008175 Lung Neoplasms Mustard Gas 6.518781369 3148597
MESH:D008175 Lung Neoplasms Quercetin 6.5116280456
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0615166399
MESH:D008223 Lymphoma Cyclophosphamide 7.6712854902
MESH:D008223 Lymphoma Diethylstilbestrol 7.6715700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.5116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0911911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0611161223
MESH:D008231 Lymphopenia methyl cellosolve 5.693699323
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4316002989
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.3519196723 19196722 15591091
MESH:D008545 Melanoma Carboplatin 4.0011712820 16225601 12040289 16342250
MESH:D008545 Melanoma Cisplatin 4.0018176117 12393984 16809738 18332650 16432458 17023156 18505091 11135225 15577323 12883367 16248763 12374674 17761969
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6915990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.7116388313
MESH:D001523 Mental Disorders Clozapine 8.0816856516
MESH:D001523 Mental Disorders Haloperidol 8.0816856516
MESH:D008654 Mesothelioma Atrazine 6.511916698
MESH:D008654 Mesothelioma Cisplatin 6.5117638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.3419142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.1918694830
MESH:D009203 Myocardial Infarction Quercetin 2.9519595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7219207477
MESH:D009336 Necrosis 2-ethoxyethanol 5.2620172899
MESH:D009369 Neoplasms Benzo(a)pyrene 19.2711141357
MESH:D009369 Neoplasms Carboplatin 19.2717925555 18854779
MESH:D009369 Neoplasms Cisplatin 19.2716773208
MESH:D009369 Neoplasms Cyclophosphamide 19.2718854779
MESH:D009369 Neoplasms Diethylstilbestrol 19.2715313581
MESH:D009369 Neoplasms Quercetin 19.2715185748
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.7019196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2119348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.0511399458
MESH:D009447 Neuroblastoma Cisplatin 7.138761367
MESH:D009447 Neuroblastoma Cyclophosphamide 7.1315176712 8761367 16115947
MESH:D017599 Neuroectodermal Tumors Carboplatin 18.7412837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 18.748761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 18.748761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 4.2817929310
MESH:D009503 Neutropenia Cyclophosphamide 9.258291058
MESH:D009503 Neutropenia Mustard Gas 9.257688884 16761898
MESH:D009765 Obesity Clozapine 3.0018515891 19142110
MESH:D009845 Oligospermia 2-ethoxyethanol 17.6720172899
MESH:D009845 Oligospermia Cyclophosphamide 17.6716517039
MESH:D009845 Oligospermia methyl cellosolve 17.673987992
MESH:D010003 Osteoarthritis Diclofenac 4.5418287210
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1319495926
MESH:D010051 Ovarian Neoplasms Cisplatin 5.106897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Quercetin 5.1019005980
MESH:D010146 Pain Cyclophosphamide 7.3418093676 12161096
MESH:D010146 Pain Diclofenac 7.3413679232
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.6519003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.6511332152
MESH:D010190 Pancreatic Neoplasms Quercetin 8.6516965848
MESH:D010300 Parkinson Disease Atrazine 3.2417218051
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2215464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5815687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 5.2617638057
MESH:D011041 Poisoning Mustard Gas 3.7115727166
MESH:D011230 Precancerous Conditions Cyclosporine 8.8512371664
MESH:D011230 Precancerous Conditions Quercetin 8.8519056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7521297632
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 16.197198755 6499817 2884743
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.1917184923
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 16.197974496 12530607 6499817
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1417292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1417136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1415846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Quercetin 2.1414715546 17292933
MESH:D011507 Proteinuria Gentamicins 4.6415033597
MESH:D011537 Pruritus Mustard Gas 4.0118058305
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.8711575062
MESH:D011618 Psychotic Disorders Clozapine 8.9415331141
MESH:D011618 Psychotic Disorders Haloperidol 8.9411575062
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.8916636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.8917720292 17266442 17620002 17894541 10334151
MESH:D051437 Renal Insufficiency Cisplatin 10.3715464296
MESH:D051437 Renal Insufficiency Gentamicins 10.3715728788 17132701
MESH:D012135 Respiratory Sounds Atrazine 4.4311874814
MESH:D012173 Retinitis Gentamicins 6.1918644591
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3414601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.4616862918
MESH:D012559 Schizophrenia Clozapine 4.0517667964 18855531 19369910 20107430 16141801 17726453 17123785 20580759 18806925 11763009 20521320 20521326 11151749 20168265 20452607
MESH:D012559 Schizophrenia Haloperidol 4.0520107430 19369910 1830565 18513383
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7416636934
MESH:D012871 Skin Diseases Mustard Gas 2.6915451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3319755658 10029692
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2615464296
MESH:D013088 Spermatocele Diethylstilbestrol 4.6316709447 16002989
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.4316517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5220155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 2.5217522103 18396642 15958060
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.306499799
MESH:D015173 Supratentorial Neoplasms Carboplatin 12.1912837982
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 12.1912837982
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6220210726
MESH:D013733 Testicular Diseases 2-ethoxyethanol 10.786499806 10048760 10514026
MESH:D013733 Testicular Diseases methyl cellosolve 10.786499806
MESH:D013736 Testicular Neoplasms Cisplatin 4.5517225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.4717053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 15.4715464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 15.4714692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.4716452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.4716720314
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.4416803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.4416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.9815809267 16690809
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014625 Vaginal Neoplasms Cisplatin 10.7915577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.7916002989 16513791
MESH:D015837 Vestibular Diseases Gentamicins 5.4318776599
MESH:D014839 Vomiting Cisplatin 4.6411897121
MESH:D015430 Weight Gain Clozapine 4.3920107430 16141801 17502770 20521320 20564506 16402076
MESH:D015431 Weight Loss Clozapine 4.9917933447
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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