AutismKB 2.0

Annotation Detail for ZYX


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Basic Information Top
Gene Symbol:ZYX ( ESP-2,HED-2 )
Gene Full Name: zyxin
Band: 7q34
Quick LinksEntrez ID:7791; OMIM: 602002; Uniprot ID:ZYX_HUMAN; ENSEMBL ID: ENSG00000159840; HGNC ID: 13200
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04510Focal adhesion
No data
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
200125E-cadherin signaling in keratinocytes
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ZYX mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ZYX proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ZYX mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ZYX mRNAdecreases expression 12419474
D002330 Carmustine Carmustine results in decreased expression of ZYX mRNAdecreases expression 15980968
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ZYX mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZYX mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of ZYX mRNAincreases expression 18035473
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ZYX mRNAdecreases expression 12419474
C017557 nickel subsulfide nickel subsulfide results in decreased expression of ZYX mRNAdecreases expression 12760830
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of ZYX mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of ZYX mRNAincreases expression 19244175
C016104 sodium bichromate sodium bichromate results in decreased expression of ZYX mRNAdecreases expression 12760830
D013629 Tamoxifen Tamoxifen results in decreased expression of ZYX mRNAdecreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ZYX mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of ZYX mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of ZYX mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms Tamoxifen 1.9620065188 19011961 19200415 19115204 19289846 19084267 19059307 21152245 17049068 19221464 21138602 18815881 19066611 20859285 16202921 15565566 19103187 16873071 19189212 20544844 19487384 15668708 19410462 17440819 18629630 17893378 17242785 19155303 19244106 16273361 18984771 18821012 16818667 19189210 20135344 18425577 18855134 18351453 20005174 20390343 19142967 19288272 17261762 11161223 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.593084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5912619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.5916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5516936243
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9117681005 11677210 16105132 16919318 15861022 17333356 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 15340226 8697196 15668235 12621046
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4319031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2310663392 11287661 10774834 17906064 17522070 16781746 19370779 19416960 17562736 12153990 11421492 11461765 10915739 18713872 11529661 19739265 16485898 12705907 16393943 14725611 11834606 18071297 19164858 2444490 14986274 15968718 16177239 12540782 15619225 14550746 12958197 12594235 19085960 12392966 11743745 16109766 19420014 19923254 11739529 16081117 16227642
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.1612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0817893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.8715345470
MESH:D005234 Fatty Liver Tamoxifen 7.8719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2619069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Carmustine 3.9616187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6616080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9612621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Flavonoids 8.4617296493
MESH:D007249 Inflammation Tamoxifen 8.4619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4612200463 12878042
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 6.0615629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.0612488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 10.2116518626
MESH:D007676 Kidney Failure, Chronic Selenium 10.2116518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0918625569
MESH:D008064 Lipidoses Tamoxifen 3.1915342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4916169303
MESH:D008107 Liver Diseases Acetaminophen 1.6411587558 16611625 19014921 12969438 16610002 19460945 12587719 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.529163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms Tamoxifen 7.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.918603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8914755239
MESH:D008175 Lung Neoplasms Tamoxifen 4.8918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8919555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.8911062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1611731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6419453300
MESH:D008545 Melanoma Carmustine 3.6512393984
MESH:D008545 Melanoma Tamoxifen 3.6512393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5319410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1019189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.1612065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.6312065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.638532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.8916709447
MESH:D013088 Spermatocele Tamoxifen 11.8916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1219457130
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.3716712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:04510 Focal adhesion
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37765
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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