AutismKB 2.0

Annotation Detail for DDR1


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Basic Information Top
Gene Symbol:DDR1 ( CAK,CD167,DDR,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,RTK6,TRKE )
Gene Full Name: discoidin domain receptor tyrosine kinase 1
Band: 6p21.33
Quick LinksEntrez ID:780; OMIM: 600408; Uniprot ID:DDR1_HUMAN; ENSEMBL ID: ENSG00000204580; HGNC ID: 2730
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1744Vasculitis
1934Cancer
2069Schizophrenia
2192Lung disease
Desease Name
PSYCH
HIV-1 control
schizophrenia
INFECTION
Desease Name
HIV-1 control
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DDR1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DDR1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DDR1 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of DDR1 mRNAincreases expression 18191166
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of DDR1 mRNAdecreases expression 15336504
D002087 Butyrates Butyrates results in increased expression of DDR1 mRNAincreases expression 14674679
D002118 Calcium Calcium affects the expression of DDR1 mRNAaffects expression 15913539
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of DDR1 mRNAaffects expression 17484886
D002945 Cisplatin DDR1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of DDR1 mRNAdecreases expression 17490981
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of DDR1 mRNAincreases expression 15766595
D005419 Flavonoids Flavonoids results in increased expression of DDR1 mRNAincreases expression 18035473
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of DDR1 mRNAincreases expression 17187413
D016685 Mitomycin DDR1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D058186 Acute Kidney Injury Cisplatin 4.0115814532 12690470 17670903
MESH:D000230 Adenocarcinoma Cisplatin 2.7717638652 11798837
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.7710737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.116705139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5415469931
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.9814601052
MESH:D001943 Breast Neoplasms Cisplatin 2.5119526202 18382427
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.5115324884 17129689
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8515673190 10355542 16227642 16124888 15700767 3786805 16050911 16097048 16192424 16011737 15721981 18705752
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 11.5210737359 17761372 3581430 3084413 6705139
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.523084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.5212907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.5218788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 11.5217982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.5216924424 15948411
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0516685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8318337622 6189445 17066447
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D003110 Colonic Neoplasms arsenite 4.3015037631
MESH:D003110 Colonic Neoplasms Butyrates 4.3015936596
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6216002989 12952375
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7914725611 11529661 19739265 12594235 19416960 11834606 16781746 2444490 18713872 15619225 11461765 14550746 11739529 16227642 16081117 12392966 19085960 19370779 15968718 14986274 16177239 19923254 17906064 19420014 12705907 16393943 18071297 10663392 12958197 16485898 11421492 12153990 10915739 17562736 17522070 12540782 16109766 10774834 11287661 19164858 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.7916177239 6623471 4309450 6884620 7440962 15027814 16227642 19336974 19085960 10092053 2869522 21278145 17522070 10915739 9327722 7120509 15968718 11566570 7179309 3732212 15998439 3786805
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Cisplatin 3.8915033597 12649298 12231392 19839026
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.7716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5015700306 16804899
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7915173087 16785472 17638652 16481741 15464296
MESH:D005234 Fatty Liver arsenite 8.2318296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2312631006 19224547 16239168 17595544 15959796 16045604 61145 12795759
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6916534752 16513791 16611131 15751030 16002989
MESH:D005355 Fibrosis arsenite 9.2518296743
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2518705752
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0316452187
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7515464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3419898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.4615464296
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.416705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.466705139
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619900420 19110552
MESH:D006689 Hodgkin Disease Cisplatin 3.6416200630 16170182
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5114722030 12960047
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007021 Hypospadias Diethylstilbestrol 4.6516002989
MESH:D007246 Infertility Diethylstilbestrol 4.4215036965
MESH:D007249 Inflammation Flavonoids 2.6717296493
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.2415464296
MESH:D007674 Kidney Diseases Acetaminophen 6.2312587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 6.2312649298 15190930 12231392 18289764 19839026
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.5115003126 14681315 16762066
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 12.2216316344
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 12.2211231351
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1317184923
MESH:D008103 Liver Cirrhosis arsenite 6.9218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9216239168 16943688 16221502 11408273 11903743 17334410 17157831 17174718 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7415730626 18251166 17631135 17557913 12546737 15370692 18187930 16638106 17525996 17708605 15673190 18006644 18395914 18472332 16192424 17761835 17766677 16011737 13678700 12389079 16248980 12632514 12632512 18263696 18418968 14716496 12667390 12666154 18412020 16097048 18156304 17869086 15876570 17900296 18210741 16136751 12445421 18395095 17640975 14620537 15338365 15925388 17805973 14716833 17944888 15818738 18705752 14512876 15057751 18277467 16116963 12898905 18429990 17481882 14724832 16015684 15996030 18472094 12958196 12649538 15893842 17922224 15650968 12609069 11481614 15959796 16027843 17714472 20821823 15931870 17721639 12445418 12741479 18054572 18339082 17698563 15362042 18420326 12586293 18376398 15123356 17976157 10355542 14748882 18279442 17823541 15052691 16033810 18166357 18481824 18205269 17565644 18317297
MESH:D008107 Liver Diseases Acetaminophen 3.9412969438 19784758 16611625 19014921 12587719 19460945 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9415720792 16246199 17285989 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5814706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 14.5011376686 14678523 10737359 16273603 10672840 18001218
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.5015890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.5019294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.5015890375 16712894
MESH:D008113 Liver Neoplasms Mitomycin 14.5015113037
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.191399818 6150874 534488
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.198603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.1915583823 12014681
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 5.0111376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0114755239
MESH:D008175 Lung Neoplasms arsenite 5.0116809336
MESH:D008175 Lung Neoplasms Cisplatin 5.0117225452 11798837 6189445
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6116002989
MESH:D008545 Melanoma Cisplatin 2.4815577323 18176117 17023156 12374674 16248763 11135225 16432458 18332650 16809738 12883367 17761969 12393984 18505091
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.8615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Cisplatin 3.2617638057
MESH:D009369 Neoplasms Cisplatin 5.4916773208
MESH:D009369 Neoplasms Diethylstilbestrol 5.4915313581
MESH:D009389 Neovascularization, Pathologic arsenite 4.4915738583
MESH:D009395 Nephritis, Interstitial Cisplatin 4.5915464296
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.2011399458
MESH:D009447 Neuroblastoma Cisplatin 3.478761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.788761367
MESH:D010024 Osteoporosis Calcium 3.8117882678
MESH:D010051 Ovarian Neoplasms Cisplatin 2.8917225452 6897625 15464296 19769630
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.8819003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 5.8815113037
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.3715464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7415687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 5.4417638057
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.1917184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.5615046698 17136230 15846301
MESH:D051437 Renal Insufficiency Cisplatin 4.4815464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.4914601052
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.718532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.4415464296
MESH:D013088 Spermatocele Diethylstilbestrol 4.8116709447 16002989
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 18396642 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.6915464296 17225452
MESH:D013964 Thyroid Neoplasms Butyrates 4.1117967635
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.6815867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.6812973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.6816712894 16452187 17306315
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.8816803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.8816175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1316690809 15809267
MESH:D014625 Vaginal Neoplasms Cisplatin 11.3315577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 11.3316002989 16513791
MESH:D014839 Vomiting Cisplatin 4.8111897121
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24348
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00619 inhibitor Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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