AutismKB 2.0

Annotation Detail for LRP8


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Basic Information Top
Gene Symbol:LRP8 ( APOER2,HSZ75190,MCI1 )
Gene Full Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Band: 1p32.3
Quick LinksEntrez ID:7804; OMIM: 602600; Uniprot ID:LRP8_HUMAN; ENSEMBL ID: ENSG00000157193; HGNC ID: 6700
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
birth weight fetal growth
REPRODUCTION
No data
Desease Name
Myocardial infarction, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LRP8 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LRP8 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRP8 mRNAdecreases expression 20018196
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LRP8 mRNAaffects expression 17484886
C018021 cobaltous chloride cobaltous chloride results in increased expression of LRP8 mRNAincreases expression 20105288
D016572 Cyclosporine Cyclosporine results in increased expression of LRP8 mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil results in decreased expression of LRP8 mRNAdecreases expression 16101138
D012643 Selenium LRP8 protein affects the abundance of Seleniumaffects abundance 17553992
17314095
D012643 Selenium LRP8 protein affects the susceptibility to Seleniumaffects response to substance 18172410
D012643 Selenium LRP8 protein results in increased uptake of Seleniumincreases uptake 19007311
C021751 tanshinone tanshinone results in decreased expression of LRP8 mRNAdecreases expression 15849732
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LRP8 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5320127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5317638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Fluorouracil 9.2317963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.0218608205 16595493 15136595 16557594 19217205 18357371 16110121
MESH:D001943 Breast Neoplasms tanshinone 2.0215849732 19885617
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9918705752 16227642 16050911 15700767 16011737 15721981 16192424 15673190 16097048 10355542 3786805 16124888
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7712907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7716332177 17088986 17045692 18930000 16799960 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7916757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 15340226 16354765 15668235
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617018589 16510598 17016597 15001691 18772588 16340194 17169374 17725105 17172411 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018949393 20501625 17016601 17454858 16391804 18383874 17594712 18802399 15289873 17401013 17255274 15148649 14970324 17695437 17094418 16524972 18448328 16282729 18288408 16331619 18509181 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.2416823706 15059100 11298694
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.479327722 3732212 2869522 19336974 19085960 7120509 10915739 11566570 16227642 7179309 17522070 6884620 16177239 10092053 4309450 21278145 7440962 3786805 15968718 15998439 15027814 6623471
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4616337965 16785472 15173087 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2912795759 17595544 15959796 19224547 12631006 16045604 16239168 61145
MESH:D005234 Fatty Liver Cyclosporine 8.2919224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 16.0218705752
MESH:D005355 Fibrosis Cyclosporine 16.0212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005910 Glioma Fluorouracil 6.7416145905
MESH:D005910 Glioma tanshinone 6.7416955220
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5018337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7211294989 10048152
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1116120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.4019662366
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007251 Influenza, Human Selenium 4.4616624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4310903974 18776723 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.8816985049
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911903743 17174718 17157831 11408273 16221502 16943688 21278145 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3315876570 18006644 12546737 15338365 12632512 14620537 17944888 12632514 18418968 18054572 17976157 16015684 17766677 18263696 16011737 14716833 12741479 17481882 12445421 14748882 16116963 18472332 18205269 18376398 12586293 18251166 15362042 17922224 18156304 17714472 17525996 18210741 18279442 16136751 13678700 17708605 17721639 17805973 18420326 14716496 15959796 15730626 17900296 12445418 18395095 17761835 10355542 15931870 18429990 18472094 18481824 18277467 15057751 12649538 18317297 14512876 15052691 16638106 16033810 15370692 15893842 17869086 18412020 12666154 16097048 17823541 16027843 12389079 18187930 15673190 14724832 16248980 20821823 17698563 15650968 15925388 12667390 12898905 15996030 15818738 15123356 17557913 16192424 18166357 17565644 17640975 18705752 11481614 12609069 12958196 17631135 18339082 18395914
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 15830285 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.872125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.8721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.8719294768
MESH:D008113 Liver Neoplasms Fluorouracil 14.8715113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.418603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9820464547 6695378 18569708 17053015 18816296 20064080 20135361 20869020 18520028
MESH:D008175 Lung Neoplasms Fluorouracil 4.9815246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9811884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.9716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9716757204 18986760
MESH:D009203 Myocardial Infarction marker/mechanism
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3211141357
MESH:D009369 Neoplasms Fluorouracil 5.3218239605 18600527 16928823
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009410 Nerve Degeneration marker/mechanism 18172410
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216500647 19003803 16929163 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1917292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1918626508 19082440
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 18286688 16160472 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4619084572 16424979 15786421 17522103 16951190 18396642 17172411 17498489 18567086 19015929
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30457
    • No data
    Releated disease ID Related disease Name
    PA445019Myocardial Infarction
    PA443796Coronary Artery Disease
    PA444172Fetal Growth Retardation
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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