Gene Symbol:	CACNB1 ( CAB1,CACNLB1,CCHLB1,MGC41896 )
Gene Full Name:	calcium channel, voltage-dependent, beta 1 subunit
Band:	17q12
Quick Links	Entrez ID:782; OMIM: 114207; Uniprot ID:CACB1_HUMAN; ENSEMBL ID: ENSG00000067191; HGNC ID: 1401
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414	Dilated cardiomyopathy
hsa04260	Cardiac muscle contraction

Pathway ID	Pathway Name
P00003	Alzheimer disease-amyloid secretase pathway
P04378	Beta2 adrenergic receptor signaling pathway
P00039	Metabotropic glutamate receptor group III pathway
P04391	Oxytocin receptor mediated signaling pathway
P04377	Beta1 adrenergic receptor signaling pathway
P00044	Nicotinic acetylcholine receptor signaling pathway
P04394	Thyrotropin-releasing hormone receptor signaling pathway
P04374	5HT2 type receptor mediated signaling pathway
P00040	Metabotropic glutamate receptor group II pathway

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D000082	Acetaminophen	Acetaminophen affects the expression of CACNB1 mRNA	affects expression	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CACNB1 mRNA	affects expression	16483693
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CACNB1 mRNA	decreases expression	20360939
D018038	Sodium Selenite	Sodium Selenite results in increased expression of CACNB1 mRNA	increases expression	18175754
C025643	vinclozolin	vinclozolin affects the expression of CACNB1 mRNA	affects expression	19015723

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000138	Acidosis	Ammonium Chloride	4.10	18287403
MESH:D000236	Adenoma	Diethylnitrosamine	3.03	10737359 6695378
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	4.44	18056438 19061943 19052882 17620307 17162532 16434500
MESH:D000799	Angioedema	Acetaminophen	4.45	10982225
MESH:D001008	Anxiety Disorders	vinclozolin	3.93	19015723
MESH:D001321	Autistic Disorder	Acetaminophen	1.40	18445737
MESH:D001943	Breast Neoplasms	Diethylnitrosamine	2.19	17474063
MESH:D006528	Carcinoma, Hepatocellular	Acetaminophen	2.98	3084413
MESH:D006528	Carcinoma, Hepatocellular	Diethylnitrosamine	2.98	19171122 3581430 17761372 17428255 17138121 16878318 19208518 18785209 16502159 18691550 16328049 19394651 20514400 19919837 18393292 16698587 18506893 19107877 20727157 19418558 16569478 16807293 17978847 18665156 16288022 16681979 17173139 17162532 16935385 20432363 20214788 20512989 18210153 10672840 19822196 10737359 3084413 17055752 11831363 20935162 19701751 19519916 19052882 18978308 21159647 16830150 16779866 18056438 20007298 20084675 20524982 18494052 19539802 18788625 16540662 19383236 19335982 18971187 20101231
MESH:D002386	Cataract	Acetaminophen	2.77	10977129
MESH:D002471	Cell Transformation, Neoplastic	Diethylnitrosamine	3.09	2727394 7505956 21159647 17174075
MESH:D018281	Cholangiocarcinoma	Diethylnitrosamine	4.01	19052882
MESH:D019457	Chromosome Breakage	Sodium Selenite	5.24	15894690
MESH:D003456	Cryptorchidism	vinclozolin	4.78	14966744
MESH:D003920	Diabetes Mellitus	Sodium Selenite	4.10	16285004
MESH:D003924	Diabetes Mellitus, Type 2	Diethylnitrosamine	2.25	20387270
MESH:D056486	Drug-Induced Liver Injury	Acetaminophen	6.73	19739265 12392966 19416960 11529661 11287661 16393943 14725611 11743745 11739529 10663392 16109766 19370779 16781746 17562736 11461765 15619225 12705907 16485898 18713872 10774834 10915739 14550746 18071297 19420014 16081117 12153990 17906064 12540782 19923254 16227642 12958197 15968718 11421492 16177239 12594235 2444490 11834606 17522070 19164858 14986274 19085960
MESH:D056486	Drug-Induced Liver Injury	Diethylnitrosamine	6.73	19107877
MESH:D056486	Drug-Induced Liver Injury	Sodium Selenite	6.73	15131321
MESH:D056487	Drug-Induced Liver Injury, Chronic	Acetaminophen	4.71	19426721
MESH:D004931	Esophageal Achalasia	Diethylnitrosamine	5.73	16302075
MESH:D005234	Fatty Liver	Diethylnitrosamine	3.56	20387270 21071580
MESH:D005756	Gastritis	Acetaminophen	4.29	16983495
MESH:D030342	Genetic Diseases, Inborn	vinclozolin	5.47	16973722
MESH:D005832	Genital Diseases, Male	vinclozolin	5.91	16417039
MESH:D006930	Hyperalgesia	Acetaminophen	2.99	16870215
MESH:D007248	Infertility, Male	vinclozolin	3.26	16467254
MESH:D007249	Inflammation	Diethylnitrosamine	2.53	18785209
MESH:D007333	Insulin Resistance	Sodium Selenite	3.49	14714311
MESH:D007674	Kidney Diseases	Acetaminophen	2.38	12587719 15629191
MESH:D007984	Leydig Cell Tumor	vinclozolin	5.27	16417039
MESH:D008103	Liver Cirrhosis	Diethylnitrosamine	2.99	20032147 19638242 18522880 18407596 18665156
MESH:D008107	Liver Diseases	Acetaminophen	4.15	12587719 12969438 19784758 16611625 19014921 11587558 19460945 16610002
MESH:D008107	Liver Diseases	Diethylnitrosamine	4.15	17034775
MESH:D017114	Liver Failure, Acute	Acetaminophen	3.58	17185352 16871587
MESH:D008113	Liver Neoplasms	Diethylnitrosamine	2.34	21071580 19638242 20118626 15175105 19833225 12771043 2862719 19499222 10737359 19254457 19642983 20137499 2422723 20101389 19996281 18648771 20405173 21278145 19256749 20452335 20492335 18977376 18978307 19812893 15885732 19294768 19090486 12112319 20501860 19690152 20434301 16942905 20583210 19073162 21167192 18754104 19850985 18644402 9163691 19427195 21047994 19426721 19255062 19551842
MESH:D008114	Liver Neoplasms, Experimental	Diethylnitrosamine	2.83	19126423 17942915 18164116 2563599 18253720 19519916 18093689 18308698 18079962 19009564 18775883 19539802 18544905 17174075 21159647 16267830 9362446 3124819 16842330 19004024 17854601 18282651
MESH:D008175	Lung Neoplasms	Diethylnitrosamine	1.76	21163286 20970405 20512841 6695378
MESH:D016393	Lymphoma, B-Cell	Sodium Selenite	4.46	14737004
MESH:D008546	Melanoma, Experimental	Acetaminophen	4.05	19513568
MESH:D009362	Neoplasm Metastasis	Diethylnitrosamine	2.68	3581430 9029167
MESH:D019636	Neurodegenerative Diseases	Acetaminophen	9.22	18514411
MESH:D019636	Neurodegenerative Diseases	Diethylnitrosamine	9.22	20387270
MESH:D009461	Neurologic Manifestations	Diethylnitrosamine	5.73	20387270
MESH:D010146	Pain	Acetaminophen	2.69	16870215
MESH:D010190	Pancreatic Neoplasms	Diethylnitrosamine	2.52	16540662
MESH:D011230	Precancerous Conditions	Diethylnitrosamine	3.88	2563599
MESH:D011297	Prenatal Exposure Delayed Effects	vinclozolin	4.44	18042343 18220299 19015723
MESH:D011469	Prostatic Diseases	vinclozolin	5.47	18220299
MESH:D011471	Prostatic Neoplasms	Sodium Selenite	3.34	18760546
MESH:D011472	Prostatitis	vinclozolin	5.47	18629315
MESH:D013274	Stomach Neoplasms	Diethylnitrosamine	1.76	18456281
MESH:D013964	Thyroid Neoplasms	Diethylnitrosamine	3.25	7505956
MESH:D014581	Urticaria	Acetaminophen	3.38	10982225

Pathway ID	Pathway Name
KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266	Axon guidance
KEGG:04260	Cardiac muscle contraction
KEGG:05414	Dilated cardiomyopathy
KEGG:05410	Hypertrophic cardiomyopathy (HCM)
KEGG:04010	MAPK signaling pathway
REACT:13685	Synaptic Transmission

Drugbank ID	Action	Drug Name	Description
DB00308	activator	Ibutilide	Anti-Arrhythmia Agents
DB00393	blocker	Nimodipine	Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
DB00653	-	Tetra Fungistop	Anticonvulsants;Analgesics;Calcium Channel Blockers;Anesthetics;Anti-Arrhythmia Agents;Tocolytic Agents
DB00661	blocker	Tarka	Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
DB01388	antagonist	Mibefradil	Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers

AutismKB 2.0

Annotation Detail for CACNB1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics