AutismKB 2.0

Annotation Detail for PXDN


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Basic Information Top
Gene Symbol:PXDN ( D2S448,D2S448E,KIAA0230,MG50,PRG2,PXN,VPO )
Gene Full Name: peroxidasin homolog (Drosophila)
Band: 2p25.3
Quick LinksEntrez ID:7837; OMIM: 605158; Uniprot ID:PXDN_HUMAN; ENSEMBL ID: ENSG00000130508; HGNC ID: 14966
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of PXDN mRNAincreases expression 20406850
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PXDN mRNAdecreases expression 15761015
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of PXDN mRNAaffects cotreatment|affects expression 17330099
D002945 Cisplatin PXDN protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PXDN mRNAincreases expression 19638242
C030110 oxaliplatin oxaliplatin results in increased expression of PXDN mRNAincreases expression 16510598
C004648 testosterone enanthate testosterone enanthate affects the expression of PXDN mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PXDN mRNAincreases expression 20055451
C025643 vinclozolin vinclozolin affects the expression of PXDN mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of PXDN mRNAdecreases expression 19244175
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of PXDN mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 11752688 15322242
MESH:D058186 Acute Kidney Injury Cisplatin 4.1015814532 17670903 12690470
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7411798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 4.7411798837 17638652
MESH:D000236 Adenoma Diethylnitrosamine 2.9310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7117620307 19052882 16434500 19061943 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1014601052
MESH:D001943 Breast Neoplasms Cisplatin 2.4019526202 18382427
MESH:D001943 Breast Neoplasms decitabine 2.4018320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4020435547
MESH:D001943 Breast Neoplasms vorinostat 2.4016144943
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7716705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7711135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.7717982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7720512989 16698587 17761372 18785209 19171122 19519916 17138121 16807293 18665156 3581430 19208518 11831363 16328049 19052882 19418558 16540662 18788625 20524982 16502159 21159647 18971187 20007298 16681979 20084675 18056438 19335982 19107877 18978308 20514400 16779866 18393292 19822196 20101231 20935162 18691550 16830150 18506893 17428255 16878318 3084413 20727157 18210153 17978847 19394651 20432363 19701751 16569478 19539802 18494052 10737359 19383236 10672840 19919837 17162532 16288022 17173139 16935385 20214788 17055752
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0816685392 12023789
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 5.0818337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.0819215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.016135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.017505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 16354765 8697196 12621046
MESH:D003110 Colonic Neoplasms decitabine 4.2917616700
MESH:D003110 Colonic Neoplasms oxaliplatin 4.2916004971 16024531 16510598
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.9620501625
MESH:D015179 Colorectal Neoplasms Cisplatin 4.9615273666
MESH:D015179 Colorectal Neoplasms decitabine 4.9618981723
MESH:D015179 Colorectal Neoplasms oxaliplatin 4.9617401013 18448328 17695437 17255274 17594712 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8419769572
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D003967 Diarrhea vorinostat 4.6520479100
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4020420201
MESH:D004362 Drug Toxicity Cisplatin 8.5215033597 12231392 12649298 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.5211462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 18230668 15322242
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3319294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8312903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.8316481741 17638652 15464296 16785472 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005221 Fatigue vorinostat 5.7920479100
MESH:D005234 Fatty Liver arsenic trioxide 8.3415073043
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3420387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.3315102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 8.3319215824
MESH:D034381 Hearing Loss Cisplatin 4.4219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8016080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9617440010
MESH:D006689 Hodgkin Disease Cisplatin 3.7216200630 16170182
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 18606429 15340226 16354765 8697196
MESH:D006930 Hyperalgesia oxaliplatin 4.4617418472
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007248 Infertility, Male decitabine 7.2317581917
MESH:D007248 Infertility, Male vinclozolin 7.2316467254
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.4316624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3615464296
MESH:D007674 Kidney Diseases Cisplatin 6.6019839026 18289764 15190930 12231392 12649298
MESH:D007674 Kidney Diseases Vitamin E 6.6012488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0111231351
MESH:D007938 Leukemia arsenic trioxide 6.6715070760
MESH:D007938 Leukemia decitabine 6.6718980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.0619077051
MESH:D007951 Leukemia, Myeloid decitabine 10.0617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0716467208 20471514 19850784 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0718460780 18206229 18704418 19010910 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6818055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3015748426 16966277 17107899 12679006 11468182 19075265 12712474 11161223 15213294 15622746 16112521 15336539 16891316 17869043 12018890 16330433 19642359 19225113 16331271 17649720 16823087 17217047 19035177 9834237 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8920032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3816169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.107678174
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1014682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1019850985 19690152 15885732 2862719 15175105 19642983 21278145 18644402 20137499 19996281 19254457 20405173 2422723 19255062 19499222 20583210 20501860 9163691 12771043 19833225 19090486 16942905 20101389 19426721 20452335 21071580 19551842 19256749 18648771 21167192 20118626 19427195 18977376 18754104 19812893 20492335 20434301 10737359 12112319 21047994 19294768 19073162 18978307 19638242
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.822876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.8220377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.8217942915 2563599 18164116 19004024 19126423 21159647 19519916 19539802 9362446 17854601 18308698 18079962 3124819 16267830 18253720 18775883 18093689 19009564 18282651 18544905 17174075 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms arsenic trioxide 6.7511798837 19825857
MESH:D008175 Lung Neoplasms Cisplatin 6.7511798837 17225452 6189445
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.7520970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7519555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.7511062179
MESH:D008223 Lymphoma decitabine 3.5219470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.8620479100
MESH:D008545 Melanoma Cisplatin 3.6816248763 11135225 16432458 12393984 17023156 15577323 17761969 18332650 16809738 12883367 18505091 12374674 18176117
MESH:D008545 Melanoma decitabine 3.6816505122 17785578
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9715990972
MESH:D008654 Mesothelioma Cisplatin 3.2917638057
MESH:D009101 Multiple Myeloma arsenic trioxide 7.7119417148 15949261 14977855 11468182 19549372
MESH:D009101 Multiple Myeloma decitabine 7.7118172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7516105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7518608210 19157545 19010910 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009325 Nausea vorinostat 5.7420479100
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009369 Neoplasms Cisplatin 5.6016773208
MESH:D009369 Neoplasms decitabine 5.6017925555 19470736 19116145
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7115464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D009447 Neuroblastoma Cisplatin 3.518761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.898761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.2316624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 8.236897625 15464296 17225452 19769630
MESH:D010051 Ovarian Neoplasms decitabine 8.2319331143 19259094
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.7515580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 12.7519003803
MESH:D010190 Pancreatic Neoplasms decitabine 12.7519294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.7516540662
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.5617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1411399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.1419015723 18042343 18220299
MESH:D055728 Primary Myelofibrosis decitabine 4.9017616702
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7319131511
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7315084515
MESH:D011471 Prostatic Neoplasms vorinostat 2.7317218635
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D051437 Renal Insufficiency Cisplatin 4.5815464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5519155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.8916646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.8914601052
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5615464296
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.8617007042
MESH:D013274 Stomach Neoplasms Cisplatin 4.8617522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 4.8619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8618456281
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.7815464296 17225452
MESH:D013921 Thrombocytopenia vorinostat 5.1020479100
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.6519014326
MESH:D013964 Thyroid Neoplasms decitabine 12.6517967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.657505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.3916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.3912973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 12.3915464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.3919087683 17616700
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3416803524
MESH:D014604 Uveal Neoplasms decitabine 5.1317785578
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7815577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014839 Vomiting Cisplatin 4.9311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394535
    • No data
    Releated disease ID Related disease Name
    PA445218Pancreatic Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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