AutismKB 2.0

Annotation Detail for RNF103


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Basic Information Top
Gene Symbol:RNF103 ( KF1,MGC102815,MGC41857,ZFP103,hkf-1 )
Gene Full Name: ring finger protein 103
Band: 2p11.2
Quick LinksEntrez ID:7844; OMIM: 602507; Uniprot ID:RN103_HUMAN; ENSEMBL ID: ENSG00000115561; HGNC ID: 12859
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RNF103 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone affects the expression of RNF103 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RNF103 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of RNF103 mRNAincreases expression 18687144
D001553 Benzbromarone Benzbromarone affects the expression of RNF103 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RNF103 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RNF103 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RNF103 mRNAdecreases expression 15003993
D002994 Clofibrate Clofibrate affects the expression of RNF103 mRNAaffects expression 19483382
D005001 Ethionine Ethionine affects the expression of RNF103 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of RNF103 mRNAaffects expression 19483382
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RNF103 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of RNF103 mRNAincreases expression 18445702
C006253 pirinixic acid pirinixic acid affects the expression of RNF103 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of RNF103 mRNAaffects expression 19483382
D020280 Sertraline Sertraline results in increased expression of RNF103 mRNAincreases expression 11071867
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RNF103 mRNAincreases expression 18796159
15358164
D013853 Thioacetamide Thioacetamide affects the expression of RNF103 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9820464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.656695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders Sertraline 5.1018822694
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8018057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.9018651412 19698954
MESH:D001321 Autistic Disorder Sertraline 3.5318775368
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.8619483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.8619483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.8619483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.8619483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.8619483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.8619483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 58.8612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.8619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9017474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 4.781701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7817997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8915710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1018974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9320889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.931399818
MESH:D002637 Chest Pain Omeprazole 5.1415447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.5618291259
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 8697196 12621046 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0318551238
MESH:D003866 Depressive Disorder Sertraline 4.7720305041 18822694 15014590
MESH:D003865 Depressive Disorder, Major Sertraline 5.3716968574
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.0215265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0220420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.0212963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.3415991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 4.0716707586
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005218 Fat Necrosis Thioacetamide 5.7516456712
MESH:D005234 Fatty Liver Amiodarone 13.2614986274
MESH:D005234 Fatty Liver Clofibrate 13.2619224547
MESH:D005234 Fatty Liver pirinixic acid 13.2620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5815929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.2216456712
MESH:D006529 Hepatomegaly Amiodarone 14.5115265979
MESH:D006529 Hepatomegaly pirinixic acid 14.5119176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.5115340226 16120746 12621046
MESH:D006816 Huntington Disease Sertraline 6.0318403212
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0815340226 16959395 8697196 16354765 18606429
MESH:D006937 Hypercholesterolemia Amiodarone 3.889751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 11.6618020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.6618031379 8137927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.9816705839
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1019248655
MESH:D008064 Lipidoses Amiodarone 8.5315342952 17567588
MESH:D008064 Lipidoses Sertraline 8.5317567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.4718606216 12679928 15316131 17050028 16343077 15362042 15474484 16098781 17355460 11481614 18031379 15465738 16126171 12175628 18295389 15078482 18380797 15075984 12891558 18263696 18615449 18416461 10677585 17127702 16489207 12531686 18032466 18395095 11172339 15334695 15158331 11682029 15716488 14739098 17292413 15288473 15095483 12085344 18458672 17629604 12557150 16248980 16511523 15288472 16097051
MESH:D008107 Liver Diseases Thioacetamide 2.7018374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Thioacetamide 4.3112479984 15633222 15313186 17276928
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.3216377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5815350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5118516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0417365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1820464547 20064080 6695378 20135361 18520028 18816296 20869020 18569708 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1811884234 19555203
MESH:D001523 Mental Disorders Sertraline 4.8216856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1816966607 16166281 18303189
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009181 Mycoses Amiodarone 4.9317974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8818551238
MESH:D009369 Neoplasms Benzo(a)pyrene 4.8211141357
MESH:D009369 Neoplasms pirinixic acid 4.8217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.959802331
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4316049721 12819281
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9817292933
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.8911597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.8915814490 17322281 17975199 17365031
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5318551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4010029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.408532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4016192470
MESH:D013272 Stomach Diseases Omeprazole 4.6318545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 7.5918087811
MESH:D013276 Stomach Ulcer Omeprazole 7.5918237397 17977527 10750652 11906479 15991576 16755016
MESH:D013610 Tachycardia Amiodarone 4.3011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2019225199
MESH:D013959 Thyroid Diseases Amiodarone 12.1519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.1512697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.6815710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8719584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.2111989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.9716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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