AutismKB 2.0

Annotation Detail for TUBA1A


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Basic Information Top
Gene Symbol:TUBA1A ( B-ALPHA-1,FLJ25113,LIS3,TUBA3 )
Gene Full Name: tubulin, alpha 1a
Band: 12q13.12
Quick LinksEntrez ID:7846; OMIM: 602529; Uniprot ID:TBA1A_HUMAN; ENSEMBL ID: ENSG00000167552; HGNC ID: 20766
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Cell Cycle, Mitotic
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016614 1-nitronaphthalene 1-nitronaphthalene metabolite binds to TUBA1A proteinaffects binding 16453347
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of TUBA1A mRNAincreases expression 17547211
D000082 Acetaminophen Acetaminophen affects the expression of TUBA1A mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TUBA1A proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TUBA1A mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of TUBA1A mRNAaffects cotreatment|increases expression 15654877
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TUBA1A mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TUBA1A mRNAdecreases expression 12414654
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TUBA1A mRNAaffects expression 12734012
C099555 CD 437 CD 437 results in decreased expression of TUBA1A mRNAdecreases expression 12958071
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of TUBA1A mRNAaffects cotreatment|decreases expression 18636392
D016572 Cyclosporine Cyclosporine results in increased expression of TUBA1A mRNAincreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNAaffects cotreatment|decreases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D002945 Cisplatin Folic Acid affects the reaction [Cisplatin affects the expression of TUBA1A mRNA]affects expression|affects reaction 16898872
D002117 Calcitriol Calcitriol results in increased expression of TUBA1A mRNAincreases expression 16002434
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of TUBA1A mRNAaffects cotreatment|increases expression 15654877
D004958 Estradiol Estradiol results in increased expression of TUBA1A mRNAincreases expression 20106945
D000431 Ethanol Ethanol results in increased expression of TUBA1A mRNAincreases expression 15353170
D005492 Folic Acid Folic Acid affects the reaction [Cisplatin affects the expression of TUBA1A mRNA]affects expression|affects reaction 16898872
C039281 furan furan results in increased expression of TUBA1A mRNAincreases expression 15120968
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of TUBA1A mRNAdecreases expression 12414654
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNAaffects cotreatment|decreases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of TUBA1A mRNAaffects cotreatment|increases expression 15654877
C525593 JK184 JK184 inhibits the reaction [TUBA1A protein binds to TUBA1A protein]affects binding|decreases reaction 19222062
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of TUBA1A mRNAincreases expression 16966085
C031721 naphthalene naphthalene metabolite binds to TUBA1A proteinaffects binding 16453347
C022838 nickel chloride nickel chloride results in increased expression of TUBA1A mRNAincreases expression 17547211
D015739 Nocodazole Nocodazole inhibits the reaction [TUBA1A protein binds to TUBA1A protein]affects binding|decreases reaction 19222062
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of TUBA1A mRNAaffects cotreatment|decreases expression 18636392
C035988 procymidone procymidone results in increased expression of TUBA1A mRNAincreases expression 15686871
D011794 Quercetin Quercetin results in decreased expression of TUBA1A proteindecreases expression 18095365
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C009250 sevoflurane sevoflurane affects the expression of TUBA1A mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TUBA1A mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TUBA1A mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D014501 Uranium Uranium affects the expression of TUBA1A mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of TUBA1A mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin results in increased expression of TUBA1A mRNAincreases expression 15686871
D024483 Vitamin K 3 Vitamin K 3 results in decreased expression of TUBA1A mRNAdecreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.1718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 9.1618287403
MESH:D000138 Acidosis Ethanol 9.1611192467
MESH:D058186 Acute Kidney Injury Cisplatin 7.9015814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Folic Acid 7.9017003819 16316344 16595132
MESH:D055371 Acute Lung Injury 1-nitronaphthalene 8.8015204773
MESH:D055371 Acute Lung Injury Chlorine 8.8020601635
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.4720464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 6.4717638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.4711473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.206695378
MESH:D000236 Adenoma Folic Acid 6.2016963246
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.9916835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.8411874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9215451040 15451039
MESH:D000544 Alzheimer Disease Folic Acid 6.2217116317
MESH:D000544 Alzheimer Disease Ozone 6.2215513908
MESH:D000544 Alzheimer Disease rosiglitazone 6.2219621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8917084956
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D000853 Anophthalmos Ethanol 4.4315513904
MESH:D001008 Anxiety Disorders Ethanol 7.9811141031
MESH:D001008 Anxiety Disorders vinclozolin 7.9819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6919183758
MESH:D001169 Arthritis, Experimental Dexamethasone 3.2917659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4615570426
MESH:D001249 Asthma Ozone 2.5116373670 17854713
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5815336622
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001327 Autoimmune Diseases Quercetin 4.0219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.6912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4814601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4717474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 3.4711237771
MESH:D001943 Breast Neoplasms Cisplatin 3.4719526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 3.4719861407 17289903 17018787 12948864 18497071 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms Folic Acid 3.4716777985
MESH:D001943 Breast Neoplasms Quercetin 3.4718628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3718315731 16777450 15516495 19059883 18417511 17626835 14754758
MESH:D002056 Burns Ethanol 4.2716374292
MESH:D002100 Cachexia Ozone 4.3516183385
MESH:D002105 Cadmium Poisoning Quercetin 5.1416962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4015721981 16097048 15700767 16124888 16050911 10355542 16227642 3786805 15673190 16011737 16192424 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.933084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 12.9312619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 12.9318788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 12.9317982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.9316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 12.9315763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Quercetin 12.9319519916 12508355
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8912023789 16685392
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5717234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.8620419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 6.8611237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 6.8617066447 18337622 6189445
MESH:D006332 Cardiomegaly Ethanol 10.1619332462
MESH:D006332 Cardiomegaly Quercetin 10.1619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.1616120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Folic Acid 6.8616755160
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.8616936243
MESH:D002386 Cataract Acetaminophen 2.3510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.6712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.6718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8316835633
MESH:D002779 Cholestasis Cyclosporine 2.6319486331
MESH:D002971 Cleft Lip Ethanol 7.1715513904
MESH:D002971 Cleft Lip Folic Acid 7.1721254359
MESH:D002972 Cleft Palate Ethanol 8.9415513904
MESH:D002972 Cleft Palate Folic Acid 8.948946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.9415668235 8697196 12621046 16354765 15340226
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7215824018
MESH:D003110 Colonic Neoplasms Quercetin 3.7216640504 17191121 11134977 19056647 15741050 19440933 17148506
MESH:D015179 Colorectal Neoplasms Cisplatin 3.4115273666
MESH:D015179 Colorectal Neoplasms Folic Acid 3.4117087956 17245555 16963246 16985020 17116713
MESH:D015179 Colorectal Neoplasms Quercetin 3.4118852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7314669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.6017728286
MESH:D019465 Craniofacial Abnormalities Ethanol 3.6010194807 19302082 15451040 15451039 11873399 11198716 15513904
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6015322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 3.9714966744
MESH:D003704 Dementia Methylmercury Compounds 4.6416140633
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0412438553
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9717446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4219496084
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.6416886840
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 6.6412642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0819279558
MESH:D003967 Diarrhea Dexamethasone 3.337237001
MESH:D056486 Drug-Induced Liver Injury 1-nitronaphthalene 10.648212003
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.6411287661 19370779 18071297 16177239 17906064 11739529 12705907 19164858 11461765 19085960 18713872 16393943 19416960 11529661 12153990 15968718 19739265 17522070 14725611 12392966 10915739 16109766 16781746 11743745 16485898 11834606 15619225 19923254 17562736 16081117 14550746 19420014 10774834 16227642 12540782 14986274 12594235 12958197 10663392 11421492 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.6415968718 10915739 4309450 15027814 17522070 19336974 6623471 6884620 16177239 3732212 19085960 7120509 15998439 7179309 7440962 10092053 11566570 3786805 9327722 21278145 16227642 2869522
MESH:D056486 Drug-Induced Liver Injury Ethanol 10.6411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.6420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D004362 Drug Toxicity Cisplatin 7.2115033597 12649298 19839026 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2111462148
MESH:D004417 Dyspnea Chlorine 4.2320016425
MESH:D004485 Eczema Dexamethasone 4.0912438553
MESH:D004487 Edema Dexamethasone 9.5819703484
MESH:D004487 Edema rosiglitazone 9.5812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5016714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.5615138306
MESH:D016889 Endometrial Neoplasms Estradiol 6.8818566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Folic Acid 6.8817301261
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.689294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.6916530937
MESH:D004938 Esophageal Neoplasms Cisplatin 6.6917638652 16481741 15464296 15173087 16785472
MESH:D004938 Esophageal Neoplasms Ethanol 6.6916704527
MESH:D017889 Exfoliation Syndrome Folic Acid 5.1016504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.9615959796 12795759 16045604 17595544 12631006 19224547 61145 16239168
MESH:D005234 Fatty Liver Cyclosporine 15.9619224547
MESH:D005234 Fatty Liver Ethanol 15.9619236843 16409862 18620774
MESH:D005234 Fatty Liver rosiglitazone 15.9619196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9016946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 17.9918705752
MESH:D005355 Fibrosis Cyclosporine 17.9912168785 12639820
MESH:D005355 Fibrosis Quercetin 17.9919474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.9920067830
MESH:D005739 Gas Poisoning Chlorine 4.6120016425
MESH:D005756 Gastritis Acetaminophen 16.7716983495
MESH:D005756 Gastritis Ethanol 16.7715046732
MESH:D005756 Gastritis Folic Acid 16.7717171786
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9016417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.828708960
MESH:D005901 Glaucoma Folic Acid 4.7116504073
MESH:D005909 Glioblastoma Quercetin 3.1419804834
MESH:D005910 Glioma Quercetin 2.8917643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.4515102660 15464296
MESH:D034381 Hearing Loss Cisplatin 3.9719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1015464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.9620471113
MESH:D006330 Heart Defects, Congenital Folic Acid 9.9617286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.9610048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5112621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.937520565
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006679 HIV Seropositivity Folic Acid 5.1017209195
MESH:D006689 Hodgkin Disease Cisplatin 3.2716170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.3517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6415340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 11.3716870215
MESH:D006930 Hyperalgesia Ethanol 11.3718783367
MESH:D006930 Hyperalgesia rosiglitazone 11.3712083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006943 Hyperglycemia Quercetin 3.6911834736 18262572
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.1716395265 16865747 16755160 16397167 16433478
MESH:D006973 Hypertension Cyclosporine 11.0510903974
MESH:D006973 Hypertension Dexamethasone 11.0517042910
MESH:D006973 Hypertension Quercetin 11.0518356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.0518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.0418306037
MESH:D007248 Infertility, Male Atrazine 6.2312948887
MESH:D007248 Infertility, Male vinclozolin 6.2316467254
MESH:D007249 Inflammation Dexamethasone 7.218960868 11099482
MESH:D007249 Inflammation rosiglitazone 7.2112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.2112200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.1116624496
MESH:D007333 Insulin Resistance Estradiol 6.7616393666 16627594
MESH:D007333 Insulin Resistance rosiglitazone 6.7616306350
MESH:D007569 Jaw Abnormalities Ethanol 8.9515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9516580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.0418306037
MESH:D007627 Keloid Quercetin 4.5717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0415604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7415464296
MESH:D007674 Kidney Diseases Acetaminophen 16.5815629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 16.5812649298 12231392 15190930 18289764 19839026
MESH:D007674 Kidney Diseases Cyclosporine 16.5818776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 16.5815618244
MESH:D007674 Kidney Diseases Quercetin 16.5816962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.9216518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 6.2215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3911231351
MESH:D007859 Learning Disorders Ethanol 8.7715451040
MESH:D007859 Learning Disorders sevoflurane 8.7719212262
MESH:D007938 Leukemia Quercetin 2.9617468513
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3416417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5317676605
MESH:D054082 Lissencephaly marker/mechanism
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.0721278145 11903743 11408273 16943688 17334410 16239168 16221502 17157831 17174718
MESH:D008103 Liver Cirrhosis Ethanol 6.0715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7018295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.0218339082 20821823 18418968 17481882 16248980 15052691 18210741 18395095 13678700 17922224 15338365 15959796 12586293 18166357 12741479 16033810 12667390 17708605 17721639 15893842 15362042 14716496 18205269 12389079 15730626 12649538 17640975 18277467 15673190 12666154 15123356 17823541 10355542 18420326 15996030 14512876 18187930 15370692 12445421 15931870 18156304 18317297 15876570 12546737 18429990 18395914 16027843 17698563 17525996 18472332 17766677 17976157 12958196 17761835 17805973 12898905 12632514 16192424 18279442 16011737 18472094 18263696 16638106 18006644 17631135 12609069 12632512 18412020 17557913 18376398 17900296 17944888 18251166 15057751 11481614 14716833 14620537 18054572 15925388 14724832 18481824 17565644 16136751 16116963 12445418 17714472 17869086 15818738 15650968 16097048 14748882 16015684 18705752
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.0216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 10.0218166357
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.0212741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.0215980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0212878042
MESH:D008107 Liver Diseases Acetaminophen 5.9211587558 16611625 19784758 12969438 12587719 19014921 16610002 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.9215720792 17285989 16964402 15830285 16246199
MESH:D008107 Liver Diseases Folic Acid 5.9216877991
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2717207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.2816899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 12.5218177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 12.5221137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.5219294768
MESH:D008113 Liver Neoplasms Quercetin 12.5218980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.5216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.078603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.0715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.0719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.0712151625
MESH:D008171 Lung Diseases 1-nitronaphthalene 7.288212003
MESH:D008171 Lung Diseases Ozone 7.2819066396 8266340
MESH:D055370 Lung Injury 1-nitronaphthalene 13.352384072
MESH:D055370 Lung Injury naphthalene 13.356834280
MESH:D055370 Lung Injury Ozone 13.3520417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 9.8114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.816695378 17053015 18569708 18520028 20135361 20464547 20064080 20869020 18816296
MESH:D008175 Lung Neoplasms Cisplatin 9.8117225452 6189445 11798837
MESH:D008175 Lung Neoplasms Dexamethasone 9.8111195469 15824018
MESH:D008175 Lung Neoplasms Ozone 9.817614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 9.8116280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8111884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2217718048
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.4116891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.4116827153
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.3016832597
MESH:D008545 Melanoma Cisplatin 3.7116432458 12883367 18505091 18332650 15577323 11135225 18176117 16809738 16248763 17023156 12393984 17761969 12374674
MESH:D008545 Melanoma Vitamin K 3 3.7119082730
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D008569 Memory Disorders Ethanol 14.0618411066 15451040
MESH:D008569 Memory Disorders Methylmercury Compounds 14.0618436314
MESH:D008569 Memory Disorders sevoflurane 14.0619212262
MESH:D008654 Mesothelioma Atrazine 6.071916698
MESH:D008654 Mesothelioma Cisplatin 6.0717638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.0617261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3916801185
MESH:D008679 Metaplasia Ozone 4.7010496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8916381670
MESH:D009069 Movement Disorders Methylmercury Compounds 4.9618436314
MESH:D009101 Multiple Myeloma Dexamethasone 3.2315744524 16118317 15867202
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.319809623
MESH:D009203 Myocardial Infarction Quercetin 2.8219595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5616810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.5619207477
MESH:D009369 Neoplasms Benzo(a)pyrene 7.2011141357
MESH:D009369 Neoplasms Cisplatin 7.2016773208
MESH:D009369 Neoplasms Quercetin 7.2015185748
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0915464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.2211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2214600291
MESH:D009436 Neural Tube Defects Folic Acid 3.7017438019
MESH:D009447 Neuroblastoma Cisplatin 3.248761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5518514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.308761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.0017929310
MESH:D009503 Neutropenia Folic Acid 4.1516322990
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8619495926
MESH:D010051 Ovarian Neoplasms CD 437 10.2417474084
MESH:D010051 Ovarian Neoplasms Cisplatin 10.2415464296 19769630 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 10.2419401270
MESH:D010051 Ovarian Neoplasms Quercetin 10.2419005980
MESH:D010146 Pain Acetaminophen 2.0916870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 7.9119003803
MESH:D010190 Pancreatic Neoplasms Ethanol 7.9112384795
MESH:D010190 Pancreatic Neoplasms Quercetin 7.9116965848
MESH:D010212 Papilloma Hydrogen Peroxide 3.7112065085
MESH:D010300 Parkinson Disease Atrazine 3.1217218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9415464296
MESH:D010538 Peritonitis Ozone 3.7516369182
MESH:D010997 Pleural Neoplasms Cisplatin 4.9417638057
MESH:D011014 Pneumonia Ozone 4.0018929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0012371664
MESH:D011230 Precancerous Conditions Quercetin 8.0019056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3221297632
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 14.1118436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.1111222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.1118220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.5418220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1717292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1712479363 16289102 18247401 15754350 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.1716740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.1717292933 14715546
MESH:D011472 Prostatitis vinclozolin 4.5418629315
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D051437 Renal Insufficiency Cisplatin 9.3015464296
MESH:D051437 Renal Insufficiency Folic Acid 9.3015728788
MESH:D012120 Respiration Disorders Chlorine 4.8118579056
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6618379247 11700416
MESH:D012135 Respiratory Sounds Atrazine 4.1311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0614601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.1416862918
MESH:D012559 Schizophrenia Folic Acid 2.8416641680
MESH:D012640 Seizures Ethanol 2.919754883
MESH:D012871 Skin Diseases Folic Acid 3.1418709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.9619755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 11.9612065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 11.968532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.9616192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9415464296
MESH:D013118 Spinal Cord Diseases Folic Acid 5.1016361298
MESH:D013272 Stomach Diseases Dexamethasone 3.9315472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.422093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 4.4217522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Ethanol 4.4218456281
MESH:D013274 Stomach Neoplasms Folic Acid 4.4217171786
MESH:D013276 Stomach Ulcer Dexamethasone 6.4015138204
MESH:D013276 Stomach Ulcer Ethanol 6.4017918041 16755016 11906479 9211565 9562338 17189318
MESH:D020521 Stroke Folic Acid 4.0216517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.919754883
MESH:D013736 Testicular Neoplasms Cisplatin 4.2715464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.6417053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 10.6416720286
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 10.6412973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Quercetin 10.6416720314
MESH:D014581 Urticaria Acetaminophen 2.6210982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 3.8716803524
MESH:D014605 Uveitis Cyclosporine 10.431336536
MESH:D014605 Uveitis Dexamethasone 10.431336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2315577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D014839 Vomiting Cisplatin 4.3211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0417120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04540 Gap junction
REACT:604 Hemostasis
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04145 Phagosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00518 antagonist Albendazole Anthelmintics;Anticestodal Agents;Antiprotozoal Agents;Tubulin Modulators
DB00570 adduct Vinblastine Antineoplastic Agents, Phytogenic;Tubulin Modulators
DB00643 antagonist Telmin B Syringe Formula Antinematodal Agents;Tubulin Modulators
DB01873 - Epothilone D Cytochrome P450Epok inhibitor
DB03010 - Epothilone B Antineoplastic Agents;Tubulin Modulators
DB07574 - 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
DB08417 - 9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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