AutismKB 2.0

Annotation Detail for IL1R2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IL1R2 ( CD121b,IL1RB,MGC47725 )
Gene Full Name: interleukin 1 receptor, type II
Band: 2q11.2
Quick LinksEntrez ID:7850; OMIM: 147811; Uniprot ID:IL1R2_HUMAN; ENSEMBL ID: ENSG00000115590; HGNC ID: 5994
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04010MAPK signaling pathway
hsa05146Amoebiasis
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200075IL1-mediated signaling events
No data
Pathway IDPathway Name
500490Interleukin-1 signaling
Related Diseases/Disorders Top
No data
No data
No data
Desease Name
Ankylosing spondylitis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of IL1R2 mRNAdecreases expression 19784758
C031278 2-chloroethyl ethyl sulfide 2-chloroethyl ethyl sulfide results in decreased expression of IL1R2 proteindecreases expression 11428619
11031321
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of IL1R2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of IL1R2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of IL1R2 mRNAaffects expression 19784758
17984051
D000082 Acetaminophen Acetaminophen results in decreased expression of IL1R2 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of IL1R2 mRNAincreases expression 19784758
C430898 AGN 194204 AGN 194204 results in decreased expression of IL1R2 mRNAdecreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IL1R2 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of IL1R2 mRNAaffects expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IL1R2 mRNAincreases expression 20106945
C110904 capecitabine IL1R2 protein results in increased susceptibility to capecitabineincreases response to substance 16734730
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IL1R2 mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of IL1R2 mRNAdecreases expression 19784758
D016572 Cyclosporine Cyclosporine results in decreased expression of IL1R2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of IL1R2 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of IL1R2 mRNAincreases expression 18721800
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IL1R2 mRNAincreases expression 15171707
C472511 dimethylarsinous acid dimethylarsinous acid results in increased expression of IL1R2 mRNAincreases expression 16507463
D004958 Estradiol Estradiol results in increased expression of IL1R2 mRNAincreases expression 12469912
D007213 Indomethacin Indomethacin results in increased expression of IL1R2 mRNAincreases expression 11950807
D008294 Malathion Malathion results in decreased expression of IL1R2 mRNAdecreases expression 19784758
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of IL1R2 mRNAincreases expression 16507463
C029938 nickel sulfate nickel sulfate results in increased expression of IL1R2 mRNAincreases expression 16780908
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of IL1R2 mRNAdecreases expression 19784758
D010126 Ozone Ozone results in increased expression of IL1R2 mRNAincreases expression 14754758
17460151
C041786 palm oil palm oil results in decreased expression of IL1R2 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL1R2 mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite results in increased expression of IL1R2 mRNAincreases expression 16507463
12760830
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IL1R2 mRNAincreases expression 20106945
11489354
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IL1R2 mRNAincreases expression 17035482
16120747
D013853 Thioacetamide Thioacetamide results in decreased expression of IL1R2 mRNAdecreases expression 19784758
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of IL1R2 mRNAincreases expression 16217019
D015054 Zymosan Zymosan results in increased expression of IL1R2 proteinincreases expression 15550091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6111752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D055371 Acute Lung Injury nickel sulfate 8.3916100012 12718980 19131640 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 8.3918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.7511473722
MESH:D000230 Adenocarcinoma Indomethacin 6.7516537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.393712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.396695378
MESH:D000236 Adenoma Indomethacin 10.3911497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.9617306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.9616712894 17306315
MESH:D000382 Agricultural Workers' Diseases Malathion 4.7317119214 11874814
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1217225004
MESH:D000544 Alzheimer Disease Indomethacin 4.2417627676 15579461
MESH:D000544 Alzheimer Disease Ozone 4.2415513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2811748828
MESH:D000740 Anemia Zymosan 8.2818664788
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.6110231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.9119183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.9110388637
MESH:D020261 Arsenic Poisoning Arsenic 2.8012569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 3.6515238619
MESH:D018771 Arthralgia Indomethacin 4.922160914
MESH:D001169 Arthritis, Experimental Zymosan 3.9717659584 15142272 15944321 15188379 16872482
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.6711248219
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6715570426
MESH:D001249 Asthma Ozone 2.5617854713 16373670
MESH:D050197 Atherosclerosis Arsenic 3.1119371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001477 Bartter Syndrome Indomethacin 4.7410684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0712125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 14.0719483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001929 Brain Edema Indomethacin 4.7811481608
MESH:D002545 Brain Ischemia Indomethacin 4.1712524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5320146248 17474063
MESH:D001943 Breast Neoplasms capecitabine 4.5318473752 12972520
MESH:D001943 Breast Neoplasms Dietary Fats 4.5320435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.5315324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 4.5319861407 17289903 16675129 12948864 17018787 17261762 14630087 18497071
MESH:D001943 Breast Neoplasms Indomethacin 4.5317401462
MESH:D001943 Breast Neoplasms Malathion 4.5312762645
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.5320435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4915516495 19059883 18315731 17626835 18417511 16777450 14754758
MESH:D002056 Burns Indomethacin 4.4610459503
MESH:D002100 Cachexia Indomethacin 11.5711239499 15625704 15141370 16537180
MESH:D002100 Cachexia Ozone 11.5716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416011737 15721981 18705752 15673190 10355542 16227642 16124888 16192424 16097048 15700767 3786805 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.087296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.083084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 19.0817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.0818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.0815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 19.0816391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 19.0816507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 19.0817997003
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.4811053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1011352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.247296757
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.2417341418
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.2118922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2120419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.2115482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.2118572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8618640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.2815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.1016973168 18022660
MESH:D002386 Cataract Acetaminophen 2.4410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 19.337505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.3312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.3318566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 19.3319716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.3319524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.8618291259
MESH:D002764 Cholecystitis Indomethacin 4.9211181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.3419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.3419486331
MESH:D002779 Cholestasis pirinixic acid 12.3419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0016354765 15340226 12621046 8697196 15668235
MESH:D003093 Colitis, Ulcerative marker/mechanism 21297633
MESH:D003110 Colonic Neoplasms Indomethacin 2.5515625704 15936596 15963497 15637740 15786552 11260862
MESH:D015179 Colorectal Neoplasms capecitabine 3.1518448328 18473752
MESH:D015179 Colorectal Neoplasms Indomethacin 3.1518059344 12606626 11197048 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D003329 Coronary Vasospasm capecitabine 5.5717465463
MESH:D018352 Coronavirus Infections Indomethacin 5.4717302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3216002989 12952375
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.3512868966 8970840 18759878 11298694 8156756 14531868 2524372 11906362
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.3516780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.1816684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D003967 Diarrhea Indomethacin 3.567907874 7237001
MESH:D056486 Drug-Induced Liver Injury marker/mechanism 17984051
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.2016192314 18289764 8291058 18692083 11289319 9022650 18648102 7440962 6482804 9328219 9653073 1440618 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.2015619225 18071297 14550746 17522070 19164858 12958197 10774834 11461765 12153990 16081117 11529661 17906064 11739529 16781746 11743745 19416960 12540782 16109766 12392966 10915739 19923254 11287661 19420014 15968718 2444490 19739265 16393943 11421492 17562736 19085960 19370779 14986274 12594235 11834606 16485898 16177239 18713872 12705907 10663392 16227642 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.2011566570 19085960 7120509 21278145 19336974 16227642 6623471 9327722 6884620 15968718 15027814 17522070 15998439 10915739 3786805 4309450 10092053 7440962 7179309 2869522 3732212 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 11.2012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9018043480 12774134 18446180 17190690 16133044 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.9017151854 10671773 17045617 17202747 11535926 11595415 17329845 11991626 11595431 17351913 16699067
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004487 Edema Indomethacin 14.6816100529 8273558 7907874 19703484 8985016 10653021 7990266
MESH:D004487 Edema pirinixic acid 14.6812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.6811000095 12711302
MESH:D004487 Edema Zymosan 14.687907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6515322242 18230668 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.0215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.0218566989 11473722 19148513
MESH:D004715 Endometriosis Indomethacin 8.3615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.3610568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.2518509659
MESH:D004751 Enteritis Indomethacin 4.5010567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7417980183
MESH:D004802 Eosinophilia Indomethacin 3.8111298111
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.893581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8916530937
MESH:D004938 Esophageal Neoplasms Indomethacin 6.8911005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4716456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.9412631006 17595544 12795759 16239168 15959796 61145 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 16.9419224547
MESH:D005234 Fatty Liver Dietary Fats 16.9417967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 16.9419236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5116513791 15751030 16611131 16534752 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Indomethacin 3.9111852909 10431976 17627676
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D005354 Fibrosarcoma Indomethacin 4.6510962813
MESH:D005355 Fibrosis Carbon Tetrachloride 25.1618705752
MESH:D005355 Fibrosis Cyclosporine 25.1612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 25.1618296743
MESH:D005355 Fibrosis Indomethacin 25.1617994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.1620067830
MESH:D005499 Folliculitis Indomethacin 4.9211298111
MESH:D005534 Foot Diseases Arsenic 5.316392382
MESH:D005756 Gastritis Acetaminophen 10.3216983495
MESH:D005756 Gastritis Indomethacin 10.3215046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.9916452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.9916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Indomethacin 3.4112870263
MESH:D005910 Glioma Indomethacin 3.1316487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0911849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006073 Gout Indomethacin 5.1011248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.5815482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 10.2015633222
MESH:D006501 Hepatic Encephalopathy Thioacetamide 10.2018665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 20.506705139
MESH:D006505 Hepatitis Carbon Tetrachloride 20.5019900420 19110552
MESH:D006505 Hepatitis Thioacetamide 20.5016456712
MESH:D006505 Hepatitis Zymosan 20.5019110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.4515135802
MESH:D006529 Hepatomegaly pirinixic acid 7.4616221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4615340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9512676792
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.1916870215
MESH:D006930 Hyperalgesia Indomethacin 7.1912727271
MESH:D034321 Hyperamylasemia Indomethacin 5.4717883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D006940 Hyperemia Indomethacin 4.7612524144
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2417050553
MESH:D006949 Hyperlipidemias Dietary Fats 8.5821332399
MESH:D006949 Hyperlipidemias Indomethacin 8.5817546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.0315034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.0312960047 14722030
MESH:D006973 Hypertension Arsenic 8.0316076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 8.0310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D006987 Hypesthesia Arsenic 5.3116093927
MESH:D007021 Hypospadias Diethylstilbestrol 4.3416002989
MESH:D007077 Ileal Diseases Indomethacin 4.7810574470 18306037
MESH:D007079 Ileitis Indomethacin 5.1010647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1216133044
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007248 Infertility, Male sodium arsenite 2.8315346721 12646999
MESH:D007249 Inflammation Dietary Fats 10.9720412841
MESH:D007249 Inflammation Indomethacin 10.9712568917 3291741 7812673
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.9712200463 12878042
MESH:D007249 Inflammation Zymosan 10.978014878 11289658
MESH:D007333 Insulin Resistance Dietary Fats 11.3711836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.3716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.3716306350
MESH:D007410 Intestinal Diseases Indomethacin 4.0811686837 17329856 17994277 15831440 18236018 11713966 11855677 15610444 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.1215241188
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5917553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.779022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007579 Jejunal Diseases Indomethacin 4.7810574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007642 Keratosis Arsenic 4.7412749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 17.5612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 17.5618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 17.5615618244
MESH:D007674 Kidney Diseases Indomethacin 17.5617190690
MESH:D007674 Kidney Diseases sodium arsenite 17.5620008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.1312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.1315003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 16.1315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7111703811 12228301 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.7510785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5918360721
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.3917339181
MESH:D007964 Leukocytosis Indomethacin 5.1216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.4717980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.4711479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1817174718 16943688 17157831 11408273 11903743 21278145 16221502 17334410 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1818296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.049327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.3212389079 10355542 16638106 12741479 17922224 18395095 12898905 17721639 18054572 12632512 17557913 18263696 17481882 15893842 18412020 20821823 12649538 18705752 12445418 18481824 15931870 18317297 17714472 18156304 16015684 17631135 18376398 16033810 18251166 15959796 18472094 13678700 14512876 14716833 14748882 16116963 15370692 17565644 12666154 17805973 17823541 16192424 18277467 17766677 18395914 18279442 15818738 17525996 12546737 12667390 14716496 15996030 18006644 17976157 16136751 16011737 18472332 15876570 17869086 17640975 14620537 18166357 15925388 16027843 17698563 18205269 15730626 15650968 15673190 16097048 17761835 18418968 12632514 18429990 18210741 15362042 17708605 15123356 16248980 12586293 15338365 12445421 12958196 18187930 18339082 17900296 12609069 15057751 11481614 15052691 14724832 17944888 18420326
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.3218194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.3217127702 15316131 10677585 18380797 15334695 16126171 15465738 11682029 12175628 18295389 12557150 15474484 18416461 15095483 15362042 15288472 16097051 17629604 16511523 18032466 16098781 15158331 12891558 15078482 12531686 16343077 14739098 11172339 12679928 17355460 18263696 18458672 18615449 15716488 16489207 17292413 18606216 18031379 18395095 16248980 11481614 15075984 17050028 15288473 12085344
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 8.8619784758 16611625 19460945 11587558 19014921 12587719 12969438 16610002
MESH:D008107 Liver Diseases Arsenic 8.8611134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8617285989 15720792 16964402 16246199 15830285
MESH:D008107 Liver Diseases Thioacetamide 8.8615158337 16337175 18374380
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.0216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.0214706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 15.0215313186 17276928 12479984 15633222
MESH:D008113 Liver Neoplasms Arsenic 20.4516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.4519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.4515890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 20.4515890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 20.4516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.90598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.9012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.9012151625
MESH:D008171 Lung Diseases 2-chloroethyl ethyl sulfide 11.6218675330 16252256 12815614
MESH:D008171 Lung Diseases Ozone 11.6219066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 11.6219095001
MESH:D055370 Lung Injury Ozone 3.6120417186
MESH:D008175 Lung Neoplasms Arsenic 8.1417306315 19168569 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1420064080 20135361 17053015 6695378 18520028 20464547 20869020 18569708 18816296
MESH:D008175 Lung Neoplasms Indomethacin 8.1411497255 16537180 11053908
MESH:D008175 Lung Neoplasms Ozone 8.148597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 8.1416712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1419555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4116891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008545 Melanoma sodium arsenite 2.0019082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D008679 Metaplasia Ozone 4.8610496685
MESH:D008881 Migraine Disorders Indomethacin 3.5011903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0416381670
MESH:D009062 Mouth Neoplasms Indomethacin 8.0412636206
MESH:D009102 Multiple Organ Failure Zymosan 4.9812879239 15241586 10890648 12130978 15834315 18160304 15259001 10479408 17724436 15213630
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0419151258
MESH:D017202 Myocardial Ischemia Arsenic 8.3615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.183581430
MESH:D009362 Neoplasm Metastasis capecitabine 9.1812972520
MESH:D009362 Neoplasm Metastasis Indomethacin 9.1811239499 16537180 11053908
MESH:D009369 Neoplasms Benzo(a)pyrene 14.4511141357
MESH:D009369 Neoplasms capecitabine 14.4516374040
MESH:D009369 Neoplasms Diethylstilbestrol 14.4515313581
MESH:D009369 Neoplasms pirinixic acid 14.4517405874
MESH:D009369 Neoplasms sodium arsenite 14.4511559025
MESH:D009374 Neoplasms, Experimental Indomethacin 8.4715625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.4720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.0211399458
MESH:D009421 Nervous System Malformations Estradiol 15.0211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.266679447
MESH:D009436 Neural Tube Defects Arsenic 11.2616620997
MESH:D009436 Neural Tube Defects sodium arsenite 11.2612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.7412349958
MESH:D020078 Neurogenic Inflammation Arsenic 4.1517056641
MESH:D020258 Neurotoxicity Syndromes Malathion 4.6415081274
MESH:D009765 Obesity 2-chloroethyl ethyl sulfide 7.2016289378
MESH:D009765 Obesity Dietary Fats 7.2020518802 21332399 17217161 18674790 19632207 18457598 16723640 11836018 20132043
MESH:D009765 Obesity pirinixic acid 7.2020558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.926374098
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.216482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010003 Osteoarthritis Indomethacin 3.527009135
MESH:D010051 Ovarian Neoplasms Arsenic 7.4617306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.4619401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4617306315 15276417
MESH:D010146 Pain Acetaminophen 6.1416870215
MESH:D010146 Pain Indomethacin 6.1417627676 17440234 3291741 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.4318702446 12538197
MESH:D010195 Pancreatitis Indomethacin 3.7015028970 17883296
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.4716537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9112349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.4711903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010437 Peptic Ulcer Indomethacin 4.9011148446
MESH:D010518 Periodontitis Indomethacin 4.6617225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7415371236 6392382 16905509
MESH:D010538 Peritonitis Ozone 9.6116369182
MESH:D010538 Peritonitis Zymosan 9.6118760300 17371808 18977430 18557954 14761945 19641140 11985352 19088179 15979727 17826846 15259001
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4315687265 16977796
MESH:D011014 Pneumonia Ozone 4.1518007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0212371664
MESH:D047928 Premature Birth Indomethacin 4.8817000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.7517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms AGN 194204 1.8816000583
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011507 Proteinuria Arsenic 8.7321343184
MESH:D011507 Proteinuria Indomethacin 8.7311849393
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012128 Respiratory Distress Syndrome, Adult 2-chloroethyl ethyl sulfide 4.8818257742 16292752 12210543
MESH:D012135 Respiratory Sounds Malathion 5.0311874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012140 Respiratory Tract Diseases Malathion 5.2817119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D018805 Sepsis Zymosan 4.4511441115
MESH:D012871 Skin Diseases Arsenic 5.1619834688 15952646 6392382 16353154 17548696 16759981 18709164 17938729 17050553 17453740 16702368
MESH:D012871 Skin Diseases monomethylarsonous acid 5.1617431481
MESH:D012878 Skin Neoplasms Arsenic 12.6119538983 17976673 15504454 17029826 17050553 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.6119755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 12.6119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.6116192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.4616709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013167 Spondylitis, Ankylosing marker/mechanism 20062062
MESH:D013272 Stomach Diseases Indomethacin 4.1715472012 16184426 17207306 18545984 15038085 16113693 17160473 16280098 10486359 17638125 10215738 10192188 18209964
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4920155912 2093021
MESH:D013274 Stomach Neoplasms Indomethacin 2.4915609394
MESH:D013276 Stomach Ulcer Indomethacin 3.3716397915 18193104 16755016 15255614 16150113 12500499 17895592 11595431 10750652 18237397 12077510 18181030 15138204 11523592 15104355 17654042 18543354 16169175 10878458 18209962 10423059 18726076 17977527 17657623 16631530 18299717 18431645 11729361 17918041 12467913 17627676 18087811 17135157 12787963 11906479 16934674 1323529 16252198 11145282 11595415 12498302 14567935
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.733712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms Indomethacin 6.7311352223 14736730 18791128
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014456 Ulcer Indomethacin 4.6517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.628074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 18.6217976673 18640142 19322015 17306315 11144890 15987713 19429237
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.6217053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.6216452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 18.6220375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.6216452187 11723127 17306315 16712894
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.8316175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.8311813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.8315809267 16690809
MESH:D014605 Uveitis Cyclosporine 11.151336536
MESH:D014605 Uveitis Zymosan 11.1511006244
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916513791 16002989
MESH:D014652 Vascular Diseases Arsenic 11.0217056641
MESH:D014652 Vascular Diseases sodium arsenite 11.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D014839 Vomiting Indomethacin 4.5011897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04640 Hematopoietic cell lineage
KEGG:04010 MAPK signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29810
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444818Lung Neoplasms
    Releated drug ID Related drug Name
    PA449383docetaxel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved