AutismKB 2.0

Annotation Detail for CXCR4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CXCR4 ( CD184,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM )
Gene Full Name: chemokine (C-X-C motif) receptor 4
Band: 2q22.1
Quick LinksEntrez ID:7852; OMIM: 162643; Uniprot ID:CXCR4_HUMAN; ENSEMBL ID: ENSG00000121966; HGNC ID: 2561
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa04670Leukocyte transendothelial migration
hsa04360Axon guidance
hsa04144Endocytosis
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
HIV Infection
Pathway IDPathway Name
200035S1P3 pathway
200083CXCR4-mediated signaling events
200172HIF-1-alpha transcription factor network
200173Ephrin B reverse signaling
200115Syndecan-4-mediated signaling events
Pathway IDPathway Name
P00008Axon guidance mediated by Slit/Robo
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00097Chemokine receptor defect
Immune system diseases
Primary immunodeficiency
No data
Desease Name
multiple sclerosis
IMMUNE
Desease Name
Multiple sclerosis
Telomere length
Desease Name
Myelokathexis, isolated
WHIM syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of CXCR4 mRNAincreases expression 20359517
C029728 4-phenylenediamine 4-phenylenediamine results in decreased expression of CXCR4 proteindecreases expression 15924226
D000181 Acrylonitrile Acrylonitrile results in decreased expression of CXCR4 mRNAdecreases expression 16173056
C000188 alachlor alachlor results in increased expression of CXCR4 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CXCR4 mRNAaffects expression 16483693
C004984 apocarotenal apocarotenal results in increased expression of CXCR4 mRNAincreases expression 17034753
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of CXCR4 mRNAaffects cotreatment|increases expression 18585445
C006632 arsenic trioxide arsenic trioxide affects the expression of CXCR4 mRNAaffects expression 20458559
C015001 arsenite arsenite results in decreased expression of CXCR4 mRNAdecreases expression 18191166
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of CXCR4 mRNAaffects cotreatment|increases expression 18585445
D001554 Benzene Benzene results in increased expression of CXCR4 mRNAincreases expression 20359517
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CXCR4 mRNAincreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CXCR4 proteinincreases expression 20064835
D019207 beta Carotene beta Carotene results in increased expression of CXCR4 mRNAincreases expression 17034753
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 12634122
D002118 Calcium CXCR4 protein affects the abundance of Calciumaffects abundance 12055238
D002251 Carbon Tetrachloride [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 proteinaffects cotreatment|increases expression 12626097
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 18636392
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 12634122
D003474 Curcumin Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]decreases reaction|increases expression 18660423
D003474 Curcumin Curcumin results in decreased expression of CXCR4 mRNAdecreases expression 17198877
D003474 Curcumin Curcumin results in decreased expression of CXCR4decreases expression 18462866
D003561 Cytarabine Cytarabine results in increased expression of CXCR4 mRNAincreases expression 19194470
D016047 Zalcitabine Zalcitabine results in increased expression of CXCR4 mRNAincreases expression 17292584
C014347 decitabine decitabine affects the expression of CXCR4 mRNAaffects expression 17145863
C014347 decitabine [decitabine affects the methylation of CXCR4 promoter] which affects the expression of CXCR4 mRNAaffects expression|affects methylation 18320071
C014347 decitabine [decitabine co-treated with trichostatin A] results in increased expression of CXCR4 mRNAaffects cotreatment|increases expression 17616702
D003907 Dexamethasone Dexamethasone results in increased expression of CXCR4 mRNAincreases expression 12732289
11872090
D003907 Dexamethasone Dexamethasone results in increased expression of CXCR4 proteinincreases expression 11872090
D004139 Dinitrofluorobenzene Dinitrofluorobenzene results in decreased expression of CXCR4 proteindecreases expression 15924226
D004391 Dust Dust results in decreased expression of CXCR4 mRNAdecreases expression 17805423
D004917 Erythromycin Erythromycin results in increased expression of CXCR4 proteinincreases expression 19502290
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of CXCR4 mRNAdecreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CXCR4 mRNAaffects expression 17351261
C004912 ethylbenzene ethylbenzene results in increased expression of CXCR4 mRNAincreases expression 20359517
D017308 Etodolac Etodolac results in decreased expression of CXCR4 proteindecreases expression 16046235
D005419 Flavonoids Flavonoids results in decreased expression of CXCR4 mRNAdecreases expression 18035473
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 proteinaffects cotreatment|increases expression 12626097
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CXCR4 mRNAincreases expression 15579440
D005472 Fluorouracil Fluorouracil affects the expression of CXCR4 mRNAaffects expression 16584549
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of CXCR4 mRNAincreases expression 15159207
C088327 JM 3100 JM 3100 binds to and results in decreased activity of CXCR4 proteinaffects binding|decreases activity 12220670
C088327 JM 3100 JM 3100 inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]affects localization|decreases reaction 12220670
C088327 JM 3100 JM 3100 binds to and results in decreased activity of CXCR4 proteinaffects binding|decreases activity 17292584
C088327 JM 3100 JM 3100 results in decreased activity of CXCR4 proteindecreases activity 18660423
16005638
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 12634122
C533894 LG 100815 LG 100815 results in increased expression of CXCR4 mRNAincreases expression 16951191
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of CXCR4 proteindecreases expression 15924226
D008466 Mechlorethamine Mechlorethamine results in increased expression of CXCR4 mRNAincreases expression 17107856
D008752 Methylene Chloride Methylene Chloride results in increased expression of CXCR4 mRNAincreases expression 20359517
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of CXCR4 mRNAdecreases expression 12634122
D009151 Mustard Gas Mustard Gas results in increased expression of CXCR4 mRNAincreases expression 18988085
C029938 nickel sulfate nickel sulfate results in increased expression of CXCR4 mRNAincreases expression 16780908
C029938 nickel sulfate nickel sulfate results in decreased expression of CXCR4 proteindecreases expression 15924226
C510003 nordy nordy inhibits the reaction [CXCR4 protein results in increased expression of IL8 protein]decreases reaction|increases expression 17415525
C510003 nordy nordy inhibits the reaction [CXCR4 protein results in increased expression of VEGFA protein]decreases reaction|increases expression 17415525
C510003 nordy nordy results in decreased expression of CXCR4 proteindecreases expression 17415525
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of CXCR4 mRNAincreases expression 16951191
D010081 Oxazolone Oxazolone results in decreased expression of CXCR4 mRNAdecreases expression 11379042
D010100 Oxygen Oxygen deficiency results in increased expression of CXCR4 mRNAincreases expression 17517823
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 18636392
D017239 Paclitaxel CXCR4 mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 16322897
D010852 Picrotoxin Picrotoxin results in increased expression of CXCR4 mRNAincreases expression 15170462
C121565 pifithrin pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA]decreases reaction|increases expression 20064835
D015232 Dinoprostone Dinoprostone results in increased expression of CXCR4 mRNAincreases expression 16303787
D015232 Dinoprostone Dinoprostone results in increased expression of CXCR4 proteinincreases expression 16303787
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 12634122
D019311 Staurosporine Staurosporine inhibits the reaction [[IL8 protein binds to and results in increased activity of IL8RA protein] which results in increased phosphorylation of CXCR4 protein]affects binding|decreases reaction|increases activity|increases phosphorylation 12594210
D013629 Tamoxifen DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 mRNA]affects reaction|decreases expression 19019622
D013629 Tamoxifen DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 protein]affects reaction|decreases expression 19019622
D013629 Tamoxifen Tamoxifen results in decreased expression of CXCR4 mRNAdecreases expression 19019622
D013629 Tamoxifen Tamoxifen results in decreased expression of CXCR4 proteindecreases expression 19019622
D013629 Tamoxifen Tamoxifen results in increased methylation of CXCR4 promoterincreases methylation 19019622
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CXCR4 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA]decreases reaction|increases expression 20064835
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CXCR4 mRNAdecreases expression 17517823
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CXCR4 proteindecreases expression 17517823
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNAincreases expression 12377990
D014050 Toluene Toluene results in increased expression of CXCR4 mRNAincreases expression 20359517
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of CXCR4 mRNAincreases expression 11379042
D014241 Trichloroethylene Trichloroethylene results in increased expression of CXCR4 mRNAincreases expression 20359517
C012589 trichostatin A [decitabine co-treated with trichostatin A] results in increased expression of CXCR4 mRNAaffects cotreatment|increases expression 17616702
C025643 vinclozolin vinclozolin affects the expression of CXCR4 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of CXCR4 mRNAdecreases expression 18220299
C509592 Zn(II) dipicolylamine Zn(II) dipicolylamine analog inhibits the reaction [CXCL12 protein binds to and results in increased activity of CXCR4 protein]affects binding|decreases reaction|increases activity 16722661
C509592 Zn(II) dipicolylamine Zn(II) dipicolylamine analog results in decreased activity of CXCR4 proteindecreases activity 16722661
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.2211752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.9218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2917505938
MESH:D058186 Acute Kidney Injury pifithrin 4.3117670903
MESH:D055371 Acute Lung Injury Chlorine 17.0320601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 17.0311850527 18653653
MESH:D055371 Acute Lung Injury nickel sulfate 17.0311954676 12718980 19131640 16100012
MESH:D055371 Acute Lung Injury Oxygen 17.0316759491
MESH:D000230 Adenocarcinoma arsenic trioxide 11.2319825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.2320464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 11.2311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.2314692618
MESH:D000230 Adenocarcinoma Fluorouracil 11.2317638652
MESH:D000236 Adenoma 2-Acetylaminofluorene 5.6110737359
MESH:D000236 Adenoma Benzo(a)pyrene 5.616695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.356705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.7416835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.4717942926
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.0515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.2516712894 17306315
MESH:D000382 Agricultural Workers' Diseases alachlor 7.1414769641 11874814
MESH:D000382 Agricultural Workers' Diseases Atrazine 7.1411874814
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4317887948
OMIM:607154 ALLERGIC RHINITIS Etodolac 5.2216979129
MESH:D000544 Alzheimer Disease Curcumin 3.7615590663
MESH:D000544 Alzheimer Disease Ozone 3.7615513908
MESH:D000740 Anemia Fluorouracil 6.8217963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.8211748828
MESH:D000741 Anemia, Aplastic Benzene 3.8611369114 17661222 14761424
MESH:D000860 Anoxia Oxygen 4.4220872349
MESH:D001008 Anxiety Disorders vinclozolin 3.1219015723
MESH:D001014 Aortic Aneurysm Dinoprostone 5.0010231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.9119183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 9.9110388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8411256880
MESH:D001169 Arthritis, Experimental Dexamethasone 5.9517659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.9515885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1716807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1715570426
MESH:D001249 Asthma Mustard Gas 6.6510378619
MESH:D001249 Asthma Ozone 6.6516373670 17854713
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 6.6511467998 19187332 16210060 12762349 11742282 12585506 6091946 7684630 12684321 15590891 8156442 15855793 11077013 20032816 10797510 15590890 18394133 17015710 16792590 6091945 170078 3040596 10934080
MESH:D050197 Atherosclerosis Curcumin 5.7418704882
MESH:D050197 Atherosclerosis Oxygen 5.7416391483
MESH:D001327 Autoimmune Diseases Curcumin 3.8719761891
MESH:D001477 Bartter Syndrome Dinoprostone 5.1115976003
MESH:D001768 Blister Mustard Gas 4.5219167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.0516206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.0512125929
MESH:D001836 Body Weight Changes 2-xylene 9.937457028
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 9.9315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3215746008
MESH:D001855 Bone Marrow Diseases Benzene 4.5816183116
MESH:D001859 Bone Neoplasms Paclitaxel 3.9715867366
MESH:D002545 Brain Ischemia beta Carotene 8.5016157235
MESH:D002545 Brain Ischemia Curcumin 8.5016770732
MESH:D001932 Brain Neoplasms Acrylonitrile 7.7212562636
MESH:D001932 Brain Neoplasms Curcumin 7.7217596214
MESH:D001943 Breast Neoplasms Benzene 11.0811921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.0817474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 11.0819250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms decitabine 11.0818320071 19208741
MESH:D001943 Breast Neoplasms Estradiol 11.0817018787 12948864 19861407 16675129 17289903 17261762 18497071 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 11.0816110121 18357371 19217205 18608205 15136595 16557594 16595493
MESH:D001943 Breast Neoplasms Hexachlorobenzene 11.0815061365 12709520
MESH:D001943 Breast Neoplasms Methylene Chloride 11.0815986119
MESH:D001943 Breast Neoplasms Oxygen 11.0817263869
MESH:D001943 Breast Neoplasms Paclitaxel 11.0816115903 18323546 11325840 16273361 15136595 16244791 18223236 18234424
MESH:D001943 Breast Neoplasms Tamoxifen 11.0811161223 21152245 19189210 19288272 15668708 19200415 19155303 17261762 15565566 19011961 18629630 20859285 19115204 20390343 18815881 19084267 19142967 18351453 17893378 19103187 16202921 18984771 20135344 16818667 19221464 21138602 19189212 18425577 20544844 19059307 19487384 17440819 19289846 20065188 19410462 16273361 20005174 18821012 19244106 17242785 18997820 17049068 19066611 18855134 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.0820435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 11.0811921183
MESH:D001943 Breast Neoplasms Trichloroethylene 11.0815986119
MESH:D016535 Bronchial Hyperreactivity Ozone 7.2016777450 15516495 14754758 18315731 17626835 18417511 19059883
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 7.2012507178 8156442 15590891
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.5215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.3210378619 17687719
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7311589617
MESH:D002057 Burns, Chemical Mechlorethamine 5.589625245
MESH:D002100 Cachexia Ozone 4.1016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1616227642 16011737 10355542 16097048 15700767 16050911 3786805 18705752 15721981 16124888 15673190 16192424
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0116051944
MESH:D002277 Carcinoma Curcumin 10.9818593918
MESH:D002277 Carcinoma Fluorouracil 10.9817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 10.9816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8819066611
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 14.313581430 17761372 6705139 3084413 10737359
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 14.3111135700 15553829 14691202 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.3118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.3116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.3116799960 17045692 17088986 16332177 17971768 18930000
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 14.3116313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.3117306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.3116924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7218414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2219014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.6818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.7720419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 11.7718462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 11.7719215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 11.7717066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 11.7718572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 1.9818850075 18670907 16120746
MESH:D009202 Cardiomyopathies Zalcitabine 4.2710591146
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 16.268243401
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 16.2616192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.2618566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 16.262727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.2619524636 20056578
MESH:D002547 Cerebral Palsy Toluene 5.219294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.3917681005 17333356 16919318 15861022 11677210 17110522 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8016354765 8697196 15668235 15340226 12621046
MESH:D003092 Colitis Curcumin 3.5618200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 3.9718809619
MESH:D003110 Colonic Neoplasms arsenite 11.8915037631
MESH:D003110 Colonic Neoplasms Curcumin 11.8919359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 11.8917616700
MESH:D003110 Colonic Neoplasms Dexamethasone 11.8915824018
MESH:D003110 Colonic Neoplasms Etodolac 11.8916004971
MESH:D003110 Colonic Neoplasms Fluorouracil 11.8916510598 18772588 17725105 15001691 17016597 16340194 17169374 17172411 17018589 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 5.5420501625
MESH:D015179 Colorectal Neoplasms decitabine 5.5418981723
MESH:D015179 Colorectal Neoplasms Etodolac 5.5411076880
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.5417695437 18949393 20501625 18448328 16524972 17255274 16391804 14970324 16303861 18288408 17594712 17094418 17016601 16331619 18509181 18383874 15148649 16282729 15289873 17454858 18802399 17401013
MESH:D015179 Colorectal Neoplasms Paclitaxel 5.5418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.2718497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 8.1110525206
MESH:D019465 Craniofacial Abnormalities Benzene 8.1115643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 8.1117728286
MESH:D019465 Craniofacial Abnormalities lead acetate 8.1119769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.1110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Toluene 8.119294310
MESH:D003456 Cryptorchidism vinclozolin 3.7314966744
MESH:D007644 Darier Disease Fluorouracil 4.1516733453
MESH:D003643 Death Toluene 5.016431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7419031437
MESH:D003872 Dermatitis Benzene 4.1415902427
MESH:D017449 Dermatitis, Allergic Contact 4-phenylenediamine 15.2916533241 19470301 16823706 11906362 18759875 11298694
MESH:D017449 Dermatitis, Allergic Contact alachlor 15.298428444
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 15.2912438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 15.2916823706 16780908 11298694
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 15.2912956900 18759878 15491423
MESH:D003877 Dermatitis, Contact 4-phenylenediamine 12.7011531941
MESH:D003877 Dermatitis, Contact Oxazolone 12.7015944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 12.7017010967
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 3.7318403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7317107852
MESH:D003928 Diabetic Nephropathies Curcumin 11.8718204486
MESH:D003928 Diabetic Nephropathies Estradiol 11.8719279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.8719279558
MESH:D003967 Diarrhea Dexamethasone 6.567237001
MESH:D003967 Diarrhea Dinoprostone 6.5611488427 10446763 7237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.9721278145 7179309 10915739 7120509 7440962 10092053 19085960 11566570 16227642 2869522 16177239 6884620 15998439 15027814 9327722 19336974 3732212 15968718 4309450 17522070 6623471 3786805
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.9720420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 4.977120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.9111462148
MESH:D004362 Drug Toxicity Zalcitabine 6.917515130
MESH:D004381 Duodenal Ulcer Curcumin 3.4517351913
MESH:D004417 Dyspnea Chlorine 8.5220016425
MESH:D004417 Dyspnea Oxygen 8.5220016425
MESH:D004485 Eczema Dexamethasone 3.8512438553
MESH:D004487 Edema Dexamethasone 11.8819703484
MESH:D004487 Edema Mustard Gas 11.889260866 11428647 11402378 11428631
MESH:D004487 Edema Staurosporine 11.888273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.8812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.2515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 6.9312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 6.9319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 11.8619294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 11.8619294695
MESH:D016889 Endometrial Neoplasms Estradiol 5.9111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.9116202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.469294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 3.7615328337 17637181 15821434
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.048156442
MESH:D004890 Erythema Mustard Gas 4.529357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 8.6212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.6216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.6215173087 16785472 16337965 17638652 16481741
MESH:D004938 Esophageal Neoplasms Paclitaxel 8.6216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5211564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.1018447907
MESH:D005234 Fatty Liver arsenic trioxide 28.2015073043
MESH:D005234 Fatty Liver arsenite 28.2018296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.2017595544 61145 15959796 12631006 12795759 16045604 19224547 16239168
MESH:D005234 Fatty Liver Curcumin 28.2019297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.2015345470
MESH:D005234 Fatty Liver Tamoxifen 28.2014986274 19224547
MESH:D005234 Fatty Liver Zalcitabine 28.2018299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8311858732
MESH:D005317 Fetal Growth Retardation lead acetate 4.7719769572
MESH:D005334 Fever Dinoprostone 7.7716997862 11852909
MESH:D005334 Fever Lipopolysaccharides 7.779205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.5419069698
MESH:D005355 Fibrosis arsenite 16.1018296743
MESH:D005355 Fibrosis Carbon Tetrachloride 16.1018705752
MESH:D005355 Fibrosis Curcumin 16.1018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.1020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.6516904648
MESH:D005739 Gas Poisoning Chlorine 9.8620016425
MESH:D005739 Gas Poisoning Oxygen 9.8620016425
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0718462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.2916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.6516417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.0416452187
MESH:D005909 Glioblastoma Curcumin 6.1217596214
MESH:D005909 Glioblastoma trichostatin A 6.1218801729
MESH:D005910 Glioma Fluorouracil 2.5816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 10.3818462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 10.3819215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 10.3815102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.1920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.1910048152 11294989
MESH:D006331 Heart Diseases pifithrin 4.1314766674
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.666705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 3.836705139
MESH:D006402 Hematologic Diseases Benzene 4.0616183116
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.8216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 2.9919900420 19110552
MESH:D006529 Hepatomegaly 2-xylene 6.957457028 7457013
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9516120746 12621046 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4117701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.817520565
MESH:D006558 Herpes Genitalis Estradiol 4.3815709030
MESH:D015658 HIV Infections beta Carotene 6.2316960176
MESH:D015658 HIV Infections Zalcitabine 6.2317457083
MESH:D006689 Hodgkin Disease Cytarabine 6.0716200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.0712676792
MESH:D019584 Hot Flashes Estradiol 3.1017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3916354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Dinoprostone 4.0216793879
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8916899240
MESH:D006937 Hypercholesterolemia Curcumin 3.4818704882
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.0511019492 10880147
MESH:D006973 Hypertension Benzene 7.0117940673
MESH:D006973 Hypertension Dexamethasone 7.0117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.0118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.1816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery pifithrin 5.0519475672
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8712013081
MESH:D007248 Infertility, Male alachlor 20.5217049205 12948887 16466525
MESH:D007248 Infertility, Male Atrazine 20.5212948887
MESH:D007248 Infertility, Male decitabine 20.5217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 20.5217937319
MESH:D007248 Infertility, Male sodium arsenite 20.5215346721 12646999
MESH:D007248 Infertility, Male vinclozolin 20.5216467254
MESH:D007249 Inflammation Curcumin 22.0517151092 16956363 18403477
MESH:D007249 Inflammation Dexamethasone 22.0511099482 8960868
MESH:D007249 Inflammation Erythromycin 22.0519502290
MESH:D007249 Inflammation Flavonoids 22.0517296493
MESH:D007249 Inflammation Lipopolysaccharides 22.0512878042 17237260 9205823 17255318 17963957
MESH:D007249 Inflammation Mustard Gas 22.059357497 17524151 16001271 11428620 11428647 8975870 11428631 9260866 11402378
MESH:D007249 Inflammation Tamoxifen 22.0519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.0512200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9118200517 18596194
MESH:D007333 Insulin Resistance Estradiol 2.5316627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 3.6610783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.0317255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.7616580747
MESH:D007674 Kidney Diseases Cadmium Chloride 7.8616962696
MESH:D007674 Kidney Diseases Estradiol 7.8615618244
MESH:D007674 Kidney Diseases sodium arsenite 7.8620008137
MESH:D007680 Kidney Neoplasms Estradiol 9.4015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 9.4016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 9.4018625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.3916316344
MESH:D007889 Leiomyoma Curcumin 3.9818555241
MESH:D007938 Leukemia alachlor 15.8914769641
MESH:D007938 Leukemia arsenic trioxide 15.8915070760
MESH:D007938 Leukemia Benzene 15.8915935818 17119257 14694614 18335105
MESH:D007938 Leukemia Curcumin 15.8918462866
MESH:D007938 Leukemia decitabine 15.8918980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.8512560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 7.8516106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.6716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.9414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 12.7519077051
MESH:D007951 Leukemia, Myeloid Benzene 12.7517506065
MESH:D007951 Leukemia, Myeloid decitabine 12.7517236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 7.4520471514 16968895 16467208 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Benzene 7.4519478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 7.4518206229 17679729 19387464 19010910 18704418 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 7.4518206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.779834237 17217047 19642359 17869043 19035177 15336539 17712046 15622746 11468182 12712474 16823087 12679006 16112521 15748426 17649720 16330433 17107899 16331271 16891316 12018890 15213294 19075265 19225113 16966277 11161223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.6816882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.6816106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.0615821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.0916417039
MESH:D008064 Lipidoses Tamoxifen 2.6815342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.2317353645
MESH:D008103 Liver Cirrhosis arsenite 5.5318296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.5316221502 11408273 16239168 16943688 17157831 21278145 11903743 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 11.1718156304 18054572 15123356 18472332 18429990 15338365 14716833 12389079 18263696 15650968 15959796 15925388 15996030 12546737 16027843 15673190 18420326 17805973 12609069 16136751 18395095 18412020 15876570 20821823 16116963 18395914 17640975 14716496 12445421 17481882 17976157 11481614 16011737 15931870 12667390 12898905 18705752 16015684 17525996 17557913 18418968 12632514 18205269 18166357 12741479 12649538 16033810 17869086 15057751 14724832 18279442 15893842 17721639 17823541 12586293 14512876 16097048 18210741 10355542 15370692 17900296 14620537 18339082 12666154 18317297 15730626 17944888 18472094 15362042 17698563 17565644 12445418 15052691 17922224 17631135 14748882 17708605 18481824 15818738 18277467 12632512 18006644 16192424 16638106 18251166 16248980 17761835 18187930 17766677 12958196 13678700 17714472 18376398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 11.1718705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 11.1716718785
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 11.1715816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.1714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 11.1712878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.1718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.1712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.5216246199 15720792 15830285 17285989 16964402
MESH:D008107 Liver Diseases Curcumin 5.5216956363
MESH:D008107 Liver Diseases Dinoprostone 5.5215816358
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.1314706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 20.7618001218 14678523 16273603 10737359 10672840 11376686
MESH:D008113 Liver Neoplasms arsenic trioxide 20.7614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.7619294768
MESH:D008113 Liver Neoplasms Fluorouracil 20.7616603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 20.7615276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 20.7616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7616984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 25.746150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.7420377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 25.7412562636
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 25.7417113696
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.7415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 25.741423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.7412151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 25.747955063
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8515213294
MESH:D008171 Lung Diseases Mustard Gas 9.7618702808 18161513
MESH:D008171 Lung Diseases Ozone 9.7619066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 9.7619095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.1614698565
MESH:D055370 Lung Injury Lipopolysaccharides 11.7221114838
MESH:D055370 Lung Injury Oxygen 11.7218339021
MESH:D055370 Lung Injury Ozone 11.7220417186
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 30.8311376686
MESH:D008175 Lung Neoplasms Acrylonitrile 30.8317372256
MESH:D008175 Lung Neoplasms arsenic trioxide 30.8311798837 19825857
MESH:D008175 Lung Neoplasms arsenite 30.8316809336
MESH:D008175 Lung Neoplasms Benzene 30.8312562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 30.8320064080 18816296 17053015 18569708 20135361 20869020 20464547 18520028 6695378
MESH:D008175 Lung Neoplasms beta Carotene 30.8316401635
MESH:D008175 Lung Neoplasms Curcumin 30.8319359593 18462866 16243823
MESH:D008175 Lung Neoplasms Dexamethasone 30.8311195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 30.8315246190
MESH:D008175 Lung Neoplasms Methylene Chloride 30.8315172992
MESH:D008175 Lung Neoplasms Mustard Gas 30.833148597 8781369
MESH:D008175 Lung Neoplasms Ozone 30.838597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 30.8317306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 30.8318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 30.8319555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.1515086387
MESH:D008223 Lymphoma Benzene 14.0717584886 17119257
MESH:D008223 Lymphoma Curcumin 14.0718462866
MESH:D008223 Lymphoma decitabine 14.0719470736
MESH:D008223 Lymphoma Zalcitabine 14.0718798262 17941976 9205081 9488045 8840982 8764131 11980663
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.5614749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.0716173963
MESH:D015674 Mammary Neoplasms, Animal Acrylonitrile 13.3412562636
MESH:D015674 Mammary Neoplasms, Animal Benzene 13.3412562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 13.3419428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 7.5011921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.5016891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 7.5019196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 10.4819453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.4819453300
MESH:D008545 Melanoma Curcumin 10.4117885582 18462866
MESH:D008545 Melanoma decitabine 10.4117785578 16505122
MESH:D008545 Melanoma Paclitaxel 10.4112040289 12025231 16342250
MESH:D008545 Melanoma sodium arsenite 10.4116487513 19082730
MESH:D008545 Melanoma Tamoxifen 10.4112393984 19393235
MESH:D008545 Melanoma trichostatin A 10.4116505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5415990972
MESH:D008569 Memory Disorders Curcumin 3.5517263510
MESH:D008607 Mental Retardation Toluene 3.399294310
MESH:D008654 Mesothelioma Atrazine 3.231916698
MESH:D008679 Metaplasia Ozone 4.4510496685
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.2517671175
MESH:D020326 Migraine without Aura Dinoprostone 4.6511304026
MESH:D019957 Motor Skills Disorders Toluene 4.649294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 6.8516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 6.8516757204 18986760
MESH:D009101 Multiple Myeloma alachlor 31.6014769641
MESH:D009101 Multiple Myeloma arsenic trioxide 31.6015949261 19417148 19549372 14977855 11468182
MESH:D009101 Multiple Myeloma Benzene 31.6017119195
MESH:D009101 Multiple Myeloma Curcumin 31.6019372569
MESH:D009101 Multiple Myeloma decitabine 31.6018172295
MESH:D009101 Multiple Myeloma Dexamethasone 31.6015867202 16118317 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 31.6014749477
MESH:D009101 Multiple Myeloma trichostatin A 31.6018172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.2817962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.0616105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 10.0616882708 18608210 19157545 19010910
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 10.069809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7816810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.3016624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.3018495463
MESH:D009362 Neoplasm Metastasis Paclitaxel 4.9715867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 15.1311141357
MESH:D009369 Neoplasms beta Carotene 15.1317051425
MESH:D009369 Neoplasms decitabine 15.1317925555 19470736 19116145
MESH:D009369 Neoplasms Fluorouracil 15.1318600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 15.1311559025
MESH:D009369 Neoplasms Trichloroethylene 15.1311911487
MESH:D009374 Neoplasms, Experimental sodium arsenite 11.9920056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 11.991670384
MESH:D009374 Neoplasms, Experimental Zalcitabine 11.999205081 9488045 8764131
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.6812497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.6819189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 8.0315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.0317289903
MESH:D009421 Nervous System Malformations Estradiol 7.4416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.4414600291
MESH:D009423 Nervous System Neoplasms Curcumin 4.9818462866
MESH:D009437 Neuralgia marker/mechanism 17292584
MESH:D009437 Neuralgia Zalcitabine 5.6717292584
MESH:D009436 Neural Tube Defects arsenic trioxide 9.6510525206
MESH:D009436 Neural Tube Defects Benzene 9.6515643154
MESH:D009436 Neural Tube Defects sodium arsenite 9.6512854658
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 2.9816436463
MESH:D009503 Neutropenia Mustard Gas 3.387688884 16761898
MESH:D009669 Nose Neoplasms alachlor 4.1915580706 16698726 14563481 11127290 16178123
MESH:D009765 Obesity Curcumin 2.5619297423
MESH:D009784 Occupational Diseases Benzene 7.7715576619 17119257 16737584 17178637 15612468 17479406 15913788 15727169 15935809
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 7.778156442 18394133 6091946 3040596 12585506 6091945 11077013
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 5.8218500342
MESH:D010014 Osteolysis Paclitaxel 4.3415867366
MESH:D010024 Osteoporosis Calcium 6.1417882678
MESH:D010024 Osteoporosis Curcumin 6.1418719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 22.6516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Benzene 22.6512562636
MESH:D010051 Ovarian Neoplasms Curcumin 22.6518462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 22.6519259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 22.6519401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 22.6511161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 22.6515276417 17306315
MESH:D010051 Ovarian Neoplasms trichostatin A 22.6519331143
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 13.3415580305
MESH:D010190 Pancreatic Neoplasms Curcumin 13.3417440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 13.3419294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 13.3415113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms trichostatin A 13.3419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0911578682
MESH:D010235 Paraganglioma arsenic trioxide 3.5719927285
MESH:D010300 Parkinson Disease Atrazine 3.0117218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5912520081
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 4.7018606552
MESH:D010538 Peritonitis Ozone 3.5116369182
MESH:D011014 Pneumonia Lipopolysaccharides 8.9812224865 11605937
MESH:D011014 Pneumonia Ozone 8.9818929643 18381685 18007984
MESH:D011041 Poisoning Mustard Gas 3.2115727166
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.089918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.0818163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 6.7321297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.7321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.3711222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 7.3718042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 10.3417616702
MESH:D055728 Primary Myelofibrosis trichostatin A 10.3417616702
MESH:D011469 Prostatic Diseases vinclozolin 4.2918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6217292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.6211398177 18156803 15129424 12497104 10851300 18226269 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 2.6216740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6218626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.6217136230 16356831 17172428 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6215067354
MESH:D011471 Prostatic Neoplasms trichostatin A 2.6219789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.2918629315
MESH:D011537 Pruritus Ethinyl Estradiol 7.4115861022 16919318
MESH:D011537 Pruritus Mustard Gas 7.4118058305
MESH:D011656 Pulmonary Emphysema Curcumin 3.9619168576
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 4.9714606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.6517894541 17620002 10334151 17720292 17266442
MESH:D012004 Rectal Neoplasms Fluorouracil 3.4618722050 18286688 15538739 16160472
MESH:D012120 Respiration Disorders Chlorine 4.5618579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 11.9218379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 11.9218379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 11.9218339021 17627322
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 7.1310835634
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 7.1316940033 7692837 20219652
MESH:D012135 Respiratory Sounds alachlor 8.1611874814
MESH:D012135 Respiratory Sounds Atrazine 8.1611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2318990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.4718447907
MESH:D012208 Rhabdomyosarcoma decitabine 3.8119155313
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.0319050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.6312617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 4.8619075512
MESH:D012509 Sarcoma Curcumin 3.5618462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.3516646077
MESH:D012640 Seizures Acrylonitrile 7.8020127315
MESH:D012640 Seizures Picrotoxin 7.808635557 8954991
MESH:D012640 Seizures Toluene 7.806431079 9294310
MESH:D018805 Sepsis Curcumin 3.5418389075
MESH:D012871 Skin Diseases Mustard Gas 2.5216961503 15451306 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.3819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 7.3819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.3816192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 4.8619075512 19050374
MESH:D013088 Spermatocele Ethinyl Estradiol 9.3916709447
MESH:D013088 Spermatocele Tamoxifen 9.3916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.2912854658
MESH:D013272 Stomach Diseases beta Carotene 8.5017638125
MESH:D013272 Stomach Diseases Dexamethasone 8.5015472012
MESH:D013274 Stomach Neoplasms Acrylonitrile 8.8912562636
MESH:D013274 Stomach Neoplasms arsenic trioxide 8.8917007042
MESH:D013274 Stomach Neoplasms Benzene 8.8912562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.892093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 8.8919037991
MESH:D013274 Stomach Neoplasms Fluorouracil 8.8919084572 19015929 16424979 17172411 17522103 17498489 15786421 16951190 18396642 18567086
MESH:D013274 Stomach Neoplasms Paclitaxel 8.8918506536 18396642
MESH:D013276 Stomach Ulcer beta Carotene 9.0012500499
MESH:D013276 Stomach Ulcer Curcumin 9.0016631530 19188055
MESH:D013276 Stomach Ulcer Dexamethasone 9.0015138204
MESH:D013345 Subarachnoid Hemorrhage pifithrin 5.4118364113
MESH:D013398 Sudden Infant Death Oxygen 4.9012563064
MESH:D024801 Tauopathies Paclitaxel 4.1716930453
MESH:D013733 Testicular Diseases Toluene 4.3210048760 10514026
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.6015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6115669648
MESH:D013953 Thymus Neoplasms Benzene 4.3210850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2512697716
MESH:D013964 Thyroid Neoplasms alachlor 9.308812207
MESH:D013964 Thyroid Neoplasms arsenic trioxide 9.3019014326
MESH:D013964 Thyroid Neoplasms decitabine 9.3017967635
MESH:D013978 Tibial Fractures Estradiol 4.0319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.4316280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.3215213294
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 19.5115289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 19.5112973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.5117053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 19.5118593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 19.5119087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 19.5111723127 16712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 19.5116712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.6218462866
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 7.6216803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.6211813266
MESH:D014594 Uterine Neoplasms Benzene 7.5512562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.5514692618
MESH:D014604 Uveal Neoplasms decitabine 4.2617785578
MESH:D014605 Uveitis Dexamethasone 4.161336536
MESH:D014652 Vascular Diseases sodium arsenite 3.7817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9412125929
MESH:D020301 Vasospasm, Intracranial pifithrin 4.9818364113
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9615869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5915886252
MESH:C536697 WHIM syndrome marker/mechanism
Pathway ID Pathway Name
KEGG:04360 Axon guidance
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04144 Endocytosis
REACT:6185 HIV Infection
KEGG:04672 Intestinal immune network for IgA production
KEGG:04670 Leukocyte transendothelial migration
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27058
    • No data
    Releated disease ID Related disease Name
    PA447230HIV
    Releated drug ID Related drug Name
    PA448081aldesleukin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00452 antagonist Framycetin Anti-Bacterial Agents;Antibiotics;Aminoglycosides
    DB06809 antagonist Plerixafor
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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